BGC0001427: myxochromide A biosynthetic gene cluster from Myxococcus xanthus
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Location: 1 - 44,152 nt. (total: 44,152 nt).
This entry is originally from NCBI GenBank KX622597.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001427
Short description myxochromide A biosynthetic gene cluster from Myxococcus xanthus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
KX622597.1
via
Compounds
  • myxochromide A
Species Myxococcus xanthus [taxonomy]
References
Chemical products information
myxochromide A Evidence: Mass spectrometry
Copy SMILES
C45H63N7O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78789.1
 1 - 1272 (-) glycosyl hydrolase
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    • APZ78790.1
    		 1279 - 2220 (+) multidrug ABC transporter ATP-binding protein
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      • APZ78791.1
      		 2230 - 5832 (+) membrane protein
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        • APZ78792.1
        		 5837 - 6373 (-) uncharacterized protein
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          • APZ78793.1
          • mchA
          		 7003 - 13482 (+) polyketide synthase
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            • APZ78794.1
            • mchB
            		 13479 - 22625 (+) nonribosomal peptide synthetase
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              • APZ78795.1
              • mchC
              		 22658 - 36055 (+) nonribosomal peptide synthetase
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                • APZ78796.1
                • mchD
                		 36052 - 36516 (+) membrane protein
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                  • APZ78797.1
                  		 36566 - 38107 (-) ATP-dependent RNA helicase RhlE
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                    • APZ78798.1
                    		 38457 - 40565 (-) elongation factor G
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                      • APZ78799.1
                      		 41000 - 42190 (-) cyclic nucleotide-binding protein
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                        • APZ78800.1
                        		 42309 - 42785 (-) peptidyl-prolyl cis-trans isomerase
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                          • APZ78801.1
                          		 42956 - 44152 (+) metallophosphatase
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            2
                            Type
                            nrps-type1
                            Genes
                            mchB
                            Substrates
                            threonine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation, methyltransferase
                            Name
                            3
                            Type
                            nrps-type1
                            Genes
                            mchB
                            Substrates
                            alanine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation, epimerase
                            Name
                            4
                            Type
                            nrps-type1
                            Genes
                            mchC
                            Substrates
                            leucine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (DCL), adenylation
                            Name
                            5
                            Type
                            nrps-type1
                            Genes
                            mchC
                            Substrates
                            proline (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Name
                            6
                            Type
                            nrps-type1
                            Genes
                            mchC
                            Substrates
                            alanine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Name
                            7
                            Type
                            nrps-type1
                            Genes
                            mchC
                            Substrates
                            glutamine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Name
                            1
                            Type
                            pks-modular
                            Genes
                            mchA
                            Substrates
                            Integrated Monomers
                            Domains
                            acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                            Annotation changelog

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Corrected NRP module activity
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Changed gene identifiers used to consistently be 'gene' names
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Changed amino acid substrates to lower case
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2018-08-06
                            Submitted
                            • (ID: W3AST4BMPVTIWZ3NNIXB2T6Y)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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