BGC0001428: myxochromide A biosynthetic gene cluster from Myxococcus xanthus
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Location: 1 - 44,682 nt. (total: 44,682 nt).
This entry is originally from NCBI GenBank KX622598.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001428
Short description myxochromide A biosynthetic gene cluster from Myxococcus xanthus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
KX622598.1
via
Compounds
  • myxochromide A
Species Myxococcus xanthus [taxonomy]
References
Chemical products information
myxochromide A Evidence: Mass spectrometry
Copy SMILES
C45H63N7O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78802.1
 1 - 1272 (-) glycosyl hydrolase
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    • APZ78803.1
    		 1279 - 2220 (+) multidrug ABC transporter ATP-binding protein
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      • APZ78804.1
      		 2230 - 5832 (+) membrane protein
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        • APZ78805.1
        		 5837 - 6373 (-) uncharacterized protein
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          • APZ78806.1
          		 6455 - 7270 (-) AraC family transcriptional regulator
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            • APZ78807.1
            • mchA
            		 7597 - 14055 (+) polyketide synthase
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              • APZ78808.1
              • mchB
              		 14052 - 23195 (+) nonribosomal peptide synthetase
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                • APZ78809.1
                • mchC
                		 23228 - 36622 (+) nonribosomal peptide synthetase
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                  • APZ78810.1
                  • mchD
                  		 36619 - 37086 (+) membrane protein
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                    • APZ78811.1
                    		 37172 - 38659 (-) ATP-dependent RNA helicase RhlE
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                      • APZ78812.1
                      		 38984 - 41092 (-) elongation factor G
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                        • APZ78813.1
                        		 41530 - 42720 (-) cyclic nucleotide-binding protein
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                          • APZ78814.1
                          		 42839 - 43315 (-) peptidyl-prolyl cis-trans isomerase
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                            • APZ78815.1
                            		 43486 - 44682 (+) metallophosphatase
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              2
                              Type
                              nrps-type1
                              Genes
                              mchB
                              Substrates
                              threonine (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation, methyltransferase
                              Name
                              3
                              Type
                              nrps-type1
                              Genes
                              mchB
                              Substrates
                              alanine (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation, epimerase
                              Name
                              4
                              Type
                              nrps-type1
                              Genes
                              mchC
                              Substrates
                              leucine (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (DCL), adenylation
                              Name
                              5
                              Type
                              nrps-type1
                              Genes
                              mchC
                              Substrates
                              proline (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation
                              Name
                              6
                              Type
                              nrps-type1
                              Genes
                              mchC
                              Substrates
                              alanine (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation
                              Name
                              7
                              Type
                              nrps-type1
                              Genes
                              mchC
                              Substrates
                              glutamine (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation
                              Name
                              1
                              Type
                              pks-modular
                              Genes
                              mchA
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                              Annotation changelog

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Corrected NRP module activity
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Changed gene identifiers used to consistently be 'gene' names
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Changed amino acid substrates to lower case
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2018-08-06
                              Submitted
                              • (ID: W3AST4BMPVTIWZ3NNIXB2T6Y)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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