BGC0001429: myxochromide S1 biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 39,989 nt. (total: 39,989 nt).
This entry is originally from NCBI GenBank KX622599.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001429
Short description myxochromide S1 biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
KX622599.1
via Knock-out studies, Heterologous expression
Compounds
  • myxochromide S1
Species Stigmatella aurantiaca DW4/3-1 [taxonomy]
References
Chemical products information
myxochromide S1 Evidence:
Copy SMILES
C38H54N6O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78816.1
 1 - 2154 (-) cation/H(+) antiporter
    copy AA seq
    copy Nt seq
    • APZ78817.1
    		 2276 - 3481 (-) hydrolase
      copy AA seq
      copy Nt seq
      • APZ78818.1
      		 3485 - 6025 (-) ABC transporter permease
        copy AA seq
        copy Nt seq
        • APZ78819.1
        		 6022 - 6723 (-) ABC transporter ATP-binding protein
          copy AA seq
          copy Nt seq
          • APZ78820.1
          • mchA
          		 7105 - 13605 (+) polyketide synthase
            copy AA seq
            copy Nt seq
            • APZ78821.1
            • mchB
            		 13602 - 22775 (+) nonribosomal peptide synthetase
              copy AA seq
              copy Nt seq
              • APZ78822.1
              • mchC
              		 22809 - 36215 (+) nonribosomal peptide synthetase
                copy AA seq
                copy Nt seq
                • APZ78823.1
                • mchD
                		 36219 - 36701 (+) membrane protein
                  copy AA seq
                  copy Nt seq
                  • APZ78824.1
                  		 36764 - 37582 (-) alpha/beta hydrolase
                    copy AA seq
                    copy Nt seq
                    • APZ78825.1
                    		 37753 - 38511 (+) uncharacterized protein
                      copy AA seq
                      copy Nt seq
                      • APZ78826.1
                      		 38520 - 39443 (+) coproporphyrinogen III oxidase
                        copy AA seq
                        copy Nt seq
                        • APZ78827.1
                        		 39453 - 39989 (+) uncharacterized protein
                          copy AA seq
                          copy Nt seq
                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          2
                          Type
                          nrps-type1
                          Genes
                          mchB
                          Substrates
                          threonine (evidence: Structure-based inference)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation, methyltransferase
                          Name
                          3
                          Type
                          nrps-type1
                          Genes
                          mchB
                          Substrates
                          leucine (evidence: Structure-based inference)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation, epimerase
                          Name
                          4
                          Type
                          nrps-type1
                          Genes
                          mchC
                          Substrates
                          alanine (evidence: Structure-based inference)
                          Integrated Monomers
                          Domains
                          condensation (DCL), adenylation
                          Name
                          6
                          Type
                          nrps-type1
                          Genes
                          mchC
                          Substrates
                          alanine (evidence: Structure-based inference)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation
                          Name
                          7
                          Type
                          nrps-type1
                          Genes
                          mchC
                          Substrates
                          glutamine (evidence: Structure-based inference)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation
                          Name
                          1
                          Type
                          pks-modular
                          Genes
                          mchA
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                          Annotation changelog

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Corrected NRP module activity
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Changed gene identifiers used to consistently be 'gene' names
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Changed amino acid substrates to lower case
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2019-10-16
                          Updated compound(s) information (NPAtlas curation)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2018-08-06
                          Submitted
                          • (ID: W3AST4BMPVTIWZ3NNIXB2T6Y)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                          A domain glossary is available here, and an explanation of the visualisation is available here.
                          Selected features only
                          Show module domains
                          Similar known gene clusters from MIBiG 4.0
                          Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                          Click on reference genes to show details of similarities to genes within the current region.
                          Click on an accession to open that entry in the MiBIG database.