BGC0001433: argimycin PI biosynthetic gene cluster from Streptomyces argillaceus
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Location: 1 - 68,295 nt. (total: 68,295 nt).
This entry is originally from NCBI GenBank LT615255.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001433
Short description argimycin PI biosynthetic gene cluster from Streptomyces argillaceus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: LT615255.1
Compounds
  • argimycin PI
  • argimycin PII
  • nigrifactin
  • argimycin PIV
  • argimycin PV
  • argimycin PVI
  • argimycin PIX
Species Streptomyces argillaceus [taxonomy]
References
Chemical products information
argimycin PI
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C17H18N2O3S1
argimycin PII
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C17H18N2O3S1
nigrifactin
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C12H17N1
Chemical database entries
NPAtlas
argimycin PIV
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C12H17N1O2
argimycin PV
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C12H17N1O1
argimycin PVI
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C12H17N1
argimycin PIX
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C12H21N1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCO70297.1
  • orf1
 1 - 1083 (-) SARP-like transcriptional regulator
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  • SCO70298.1
  • orf2
 1266 - 3587 (+) Xre-like transcriptional regulator
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  • SCO70299.1
  • orf3
 3688 - 4452 (+) Hypothetical protein
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  • SCO70300.1
  • arpRI
 5044 - 7530 (-) SARP-like transcriptional regulator
  • Regulation
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  • SCO70301.1
  • arpO
 7867 - 9318 (-) Dehydrogenase
  • Tailoring (Reduction)
Sequence-based prediction
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  • SCO70302.1
  • arpDHI
 9694 - 10872 (+) Dehydrogenase/hydroxylase
  • Tailoring (Reduction)
Sequence-based prediction
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  • SCO70303.1
  • arpDHII
 10927 - 11808 (+) Imine reductase
  • Tailoring (Reduction)
Sequence-based prediction
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  • SCO70304.1
  • arpN
 12579 - 14183 (-) Aminotransferase
  • Scaffold biosynthesis
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  • SCO70305.1
  • arpK
 14364 - 14912 (+) Flavin reductase
  • Unknown
Sequence-based prediction
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  • SCO70306.1
  • arpHI
 14998 - 15411 (+) Cyclase
  • Tailoring (Unknown)
Sequence-based prediction
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  • SCO70307.1
  • arpHII
 15515 - 15925 (-) Cyclase
  • Tailoring (Unknown)
Sequence-based prediction
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  • SCO70308.1
  • arpPI
 16117 - 29994 (+) Type I polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • SCO70309.1
  • arpPII
 30065 - 40786 (+) Type I polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • SCO70310.1
  • arpPIII
 40845 - 47456 (+) Type I polyketide synthase
  • Scaffold biosynthesis
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  • SCO70311.1
  • arpT
 47550 - 48323 (+) Type II thioesterase
  • Activation / processing
Sequence-based prediction
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  • SCO70312.1
  • arpX
 48574 - 49107 (-) Hypothetical protein
  • Unknown
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  • SCO70313.1
  • arpRII
 49693 - 50325 (-) TetR-like transcriptional repressor
  • Regulation
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  • SCO70314.1
  • orf4
 50762 - 51409 (+) Reductase
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  • SCO70315.1
  • orf5
 51568 - 51948 (-) Hypothetical protein
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  • SCO70316.1
  • orf6
 51962 - 53107 (-) Oxidase
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  • SCO70317.1
  • orf7
 53104 - 53742 (-) Putative transcriptional repressor
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  • SCO70318.1
  • orf8
 53836 - 54981 (-) Monooxygenase
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  • SCO70319.1
  • orf9
 55828 - 56331 (-) N-acetyltransferase
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  • SCO70320.1
  • orf10
 56550 - 57770 (+) Cytochrome P450
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  • SCO70321.1
  • orf11
 57809 - 59488 (+) AMP-dependent synthetase/ligase
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  • SCO70322.1
  • orf12
 59520 - 60377 (+) Hypothetical protein
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  • SCO70323.1
  • orf13
 60377 - 60889 (+) Thioesterase
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  • SCO70324.1
  • orf14
 60886 - 61176 (+) Acyl carrier protein
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  • SCO70325.1
  • orf15
 61178 - 62101 (+) Methyltransferase
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  • SCO70326.1
  • orf16
 62098 - 62973 (+) Thioesterase
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  • SCO70327.1
  • orf17
 62970 - 63674 (+) Phosphopantetheinyl transferase
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  • SCO70328.1
  • orf18
 63947 - 64573 (+) Pyrophosphorylase
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  • SCO70329.1
  • orf19
 64588 - 65001 (-) Dehydratase
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  • SCO70330.1
  • orf20
 64998 - 65402 (-) Thioesterase
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  • SCO70331.1
  • orf21
 65813 - 66814 (+) 3-oxoacyl-ACP synthase
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  • SCO70332.1
  • orf22
 66983 - 67468 (-) Xre-like transcriptional regulator
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  • SCO70333.1
  • orf23
 67804 - 68295 (+) LuxR-like transcriptional regulator
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Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? no
Release type
  • Reductive release
Polyketide-synthases
Genes Properties Modules
arpPIII
+
arpPI
+
arpPII
+
arpT 		Synthase subclass: Modular type I
Thioesterases:
  • arpT (Type II)
Module 0
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: arpPI
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: arpPI
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: arpPI
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: arpPII
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: arpPII
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Inactive
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: arpPIII
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP), Thiol reductase
KR-domain stereochemistry: D-OH
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: L5O3YFAALLUDBRU543OIOUC6, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed comment with no information
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Fixed incorrect gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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