BGC0001433 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001433 (Streptomyces argillaceus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	68,295	argimycin PI/argimycin PII/nigrifactin/argimycin PIV/argimycin PV/argimycin PVI/argimycin PIX	PKS:Type I	100%

BGC0001433 - Region 1 - T1PKS

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Location: 1 - 68,295 nt. (total: 68,295 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 68,296
Label		BGC0001433

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001433	0.98	Polyketide	argimycin PI, argimycin PII, nigrifactin, argimycin PIV, argimycin PV, argimycin PVI, argimycin PIX	Streptomyces argillaceus
BGC0001296	0.61	Polyketide	streptazone E	Streptomyces sp. MSC090213JE08
BGC0000016	0.36	Other	amphotericin B	Streptomyces nodosus
BGC0000919	0.33	Other	phaseolotoxin	Pseudomonas syringae
BGC0000041	0.32	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000204	0.28	Polyketide	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000286	0.27	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000261	0.27	Polyketide	R1128	Streptomyces sp. R1128
BGC0002711	0.27	Polyketide	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001850	0.27	Other (Shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001433	1.00	Polyketide	argimycin PI, argimycin PII, nigrifactin, argimycin PIV, argimycin PV, argimycin PVI, argimycin PIX	Streptomyces argillaceus
BGC0001296	0.85	Polyketide	streptazone E	Streptomyces sp. MSC090213JE08
BGC0000016	0.69	Other	amphotericin B	Streptomyces nodosus
BGC0000919	0.66	Other	phaseolotoxin	Pseudomonas syringae
BGC0000041	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000204	0.61	Polyketide	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000286	0.61	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000195	0.61	Polyketide	alnumycin A, alnumycin B, alnumycin C, alnumycin P, prealnumycin, thalnumycin A, thalnumycin B, K1115A, 1,6-dihydro-8-propylanthraquinone	Streptomyces sp. CM020
BGC0000261	0.61	Polyketide	R1128	Streptomyces sp. R1128
BGC0002711	0.60	Polyketide	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 67456:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal) + (ccmal - ccmal) + (ccmal)
Non-colinear ordering:: arpPI + arpPII + arpPIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

arpPI

PKS_AT (586..879): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.3
inactive: 80.0
Methoxymalonyl-CoA: 66.6
Methylmalonyl-CoA: 62.6
Ethylmalonyl-CoA: 33.1
Isobutyryl-CoA: 31.8
Propionyl-CoA: 30.0
Acetyl-CoA: 25.3
2-Methylbutyryl-CoA: 20.9
Benzoyl-CoA: 13.5
trans-1,2-CPDA: 13.1
CHC-CoA: 10.3
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1612..1910): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.4
inactive: 93.6
Methoxymalonyl-CoA: 73.1
Methylmalonyl-CoA: 66.6
Isobutyryl-CoA: 30.7
Propionyl-CoA: 29.6
Ethylmalonyl-CoA: 27.8
2-Methylbutyryl-CoA: 21.3
Acetyl-CoA: 17.9
fatty_acid: 14.5
Benzoyl-CoA: 9.6
trans-1,2-CPDA: 6.4
3-Methylbutyryl-CoA: 5.5
CHC-CoA: 2.9

PKS_AT (3376..3677): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.8
inactive: 116.7
Methoxymalonyl-CoA: 65.9
Methylmalonyl-CoA: 57.6
Propionyl-CoA: 35.0
2-Methylbutyryl-CoA: 27.5
Isobutyryl-CoA: 24.2
Ethylmalonyl-CoA: 21.5
Benzoyl-CoA: 17.7
CHC-CoA: 14.5
Acetyl-CoA: 13.4
fatty_acid: 12.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

arpPII

PKS_AT (592..883): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.3
inactive: 74.7
Methoxymalonyl-CoA: 71.7
Methylmalonyl-CoA: 69.4
Propionyl-CoA: 49.5
Isobutyryl-CoA: 39.1
Ethylmalonyl-CoA: 33.0
2-Methylbutyryl-CoA: 25.1
Acetyl-CoA: 21.7
Benzoyl-CoA: 19.0
fatty_acid: 17.8
CHC-CoA: 17.7
trans-1,2-CPDA: 10.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (2291..2583): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.4
inactive: 73.3
Methylmalonyl-CoA: 72.1
Methoxymalonyl-CoA: 70.0
Propionyl-CoA: 40.0
Isobutyryl-CoA: 35.7
Ethylmalonyl-CoA: 30.5
Acetyl-CoA: 23.6
CHC-CoA: 19.9
2-Methylbutyryl-CoA: 19.6
Benzoyl-CoA: 18.6
fatty_acid: 14.5
trans-1,2-CPDA: 8.3
3-Methylbutyryl-CoA: 8.0

arpPIII

PKS_AT (579..871): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.9
inactive: 69.9
Methoxymalonyl-CoA: 69.5
Methylmalonyl-CoA: 69.2
Propionyl-CoA: 43.4
Isobutyryl-CoA: 34.4
Ethylmalonyl-CoA: 28.1
Acetyl-CoA: 23.8
2-Methylbutyryl-CoA: 22.1
CHC-CoA: 19.5
Benzoyl-CoA: 18.6
fatty_acid: 13.7
trans-1,2-CPDA: 8.1
3-Methylbutyryl-CoA: 0.0

orf11

CAL_domain (152..468): pk

minowa: NH2

Prediction, score:

NH2: 69.4
fatty_acid: 27.8
Acetyl-CoA: 19.6
shikimic_acid: 0.0
AHBA: 0.0