BGC0001433 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001433 (Streptomyces argillaceus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	68,295	High	argimycin PI/argimycin PII/nigrifactin/argimycin PIV/argimycin PV/argimycin PVI/argimycin PIX	PKS:Type I

BGC0001433 - Region 1 - T1PKS

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Location: 1 - 68,295 nt. (total: 68,295 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 68,296
Label		BGC0001433

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase reductase

arpDHI: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

arpDHII: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

arpK: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

arpO: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

orf10: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

orf4: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

orf6: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

orf8: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Transferases: PPTase aminotransferase methyltransferase

arpN: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

orf15: methyltransferase

smcogs: SMCOG1089: methyltransferase

orf17: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: esterase

arpT: thioesterase

smcogs: SMCOG1004: thioesterase

orf20: thioesterase superfamily protein

smcogs: SMCOG1144: thioesterase superfamily protein

Ligases: ligase synthase

arpPI: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

arpPII: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

arpPIII: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

orf11: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

orf21: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001433.5	0.99	PKS	argimycin PI, argimycin PII, nigrifactin, argimycin PIV, argimycin PV, argimycin PVI, argimycin PIX	Streptomyces argillaceus
BGC0001296.3	0.85	PKS	streptazone E	Streptomyces sp. MSC090213JE08
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000041.3	0.66	PKS	oronofacic acid	Pseudomonas syringae
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001268.4	0.64	NRPS, PKS	fusarin C	Fusarium fujikuroi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001433.5	1.00	PKS	argimycin PI, argimycin PII, nigrifactin, argimycin PIV, argimycin PV, argimycin PVI, argimycin PIX	Streptomyces argillaceus
BGC0001296.3	0.85	PKS	streptazone E	Streptomyces sp. MSC090213JE08
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000041.3	0.66	PKS	oronofacic acid	Pseudomonas syringae
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001268.4	0.64	NRPS, PKS	fusarin C	Fusarium fujikuroi

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 67456:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal) + (ccmal - ccmal) + (ccmal)
Non-colinear ordering:: arpPI + arpPII + arpPIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

arpPI: mal - mal - mal

PKS_AT (586..879): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.3
inactive: 80.0
Methoxymalonyl-CoA: 66.6
Methylmalonyl-CoA: 62.6
Ethylmalonyl-CoA: 33.1
Isobutyryl-CoA: 31.8
Propionyl-CoA: 30.0
Acetyl-CoA: 25.3
2-Methylbutyryl-CoA: 20.9
Benzoyl-CoA: 13.5
trans-1,2-CPDA: 13.1
CHC-CoA: 10.3
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1612..1910): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.4
inactive: 93.6
Methoxymalonyl-CoA: 73.1
Methylmalonyl-CoA: 66.6
Isobutyryl-CoA: 30.7
Propionyl-CoA: 29.6
Ethylmalonyl-CoA: 27.8
2-Methylbutyryl-CoA: 21.3
Acetyl-CoA: 17.9
fatty_acid: 14.5
Benzoyl-CoA: 9.6
trans-1,2-CPDA: 6.4
3-Methylbutyryl-CoA: 5.5
CHC-CoA: 2.9

PKS_AT (3376..3677): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.8
inactive: 116.7
Methoxymalonyl-CoA: 65.9
Methylmalonyl-CoA: 57.6
Propionyl-CoA: 35.0
2-Methylbutyryl-CoA: 27.5
Isobutyryl-CoA: 24.2
Ethylmalonyl-CoA: 21.5
Benzoyl-CoA: 17.7
CHC-CoA: 14.5
Acetyl-CoA: 13.4
fatty_acid: 12.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

arpPII: mal - mal

PKS_AT (592..883): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.3
inactive: 74.7
Methoxymalonyl-CoA: 71.7
Methylmalonyl-CoA: 69.4
Propionyl-CoA: 49.5
Isobutyryl-CoA: 39.1
Ethylmalonyl-CoA: 33.0
2-Methylbutyryl-CoA: 25.1
Acetyl-CoA: 21.7
Benzoyl-CoA: 19.0
fatty_acid: 17.8
CHC-CoA: 17.7
trans-1,2-CPDA: 10.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (2291..2583): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.4
inactive: 73.3
Methylmalonyl-CoA: 72.1
Methoxymalonyl-CoA: 70.0
Propionyl-CoA: 40.0
Isobutyryl-CoA: 35.7
Ethylmalonyl-CoA: 30.5
Acetyl-CoA: 23.6
CHC-CoA: 19.9
2-Methylbutyryl-CoA: 19.6
Benzoyl-CoA: 18.6
fatty_acid: 14.5
trans-1,2-CPDA: 8.3
3-Methylbutyryl-CoA: 8.0

arpPIII: mal

PKS_AT (579..871): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.9
inactive: 69.9
Methoxymalonyl-CoA: 69.5
Methylmalonyl-CoA: 69.2
Propionyl-CoA: 43.4
Isobutyryl-CoA: 34.4
Ethylmalonyl-CoA: 28.1
Acetyl-CoA: 23.8
2-Methylbutyryl-CoA: 22.1
CHC-CoA: 19.5
Benzoyl-CoA: 18.6
fatty_acid: 13.7
trans-1,2-CPDA: 8.1
3-Methylbutyryl-CoA: 0.0

orf11: NH2

CAL_domain (152..468): NH2

minowa: NH2

Prediction, score:

NH2: 69.4
fatty_acid: 27.8
Acetyl-CoA: 19.6
shikimic_acid: 0.0
AHBA: 0.0

Link to PARAS substrate predictor