Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001433.1:
Cluster 1Polyketide168295

BGC0001433, argimycin P biosynthetic gene cluster from Streptomyces argillaceus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: argimycin PI
SMILES string: Copy to clipboard
Molecular formula: C17H18N2O3S
Exact molecular mass: 330.1 Da ([M+H]+)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Malonyl-CoA
Thioesterase type:
Type II
Release / cyclization type:
Reductive release

Modular polyketide synthases:
arpPI (SCO70308)
Module 0
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Scaffold-modifying domain: None
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: D-OH
Scaffold-modifying domain: None
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: D-OH
Scaffold-modifying domain: None

arpPII (SCO70309)
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: D-OH
Scaffold-modifying domain: None
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Inactive
Scaffold-modifying domain: None

arpPIII (SCO70310)
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: D-OH
Scaffold-modifying domain: Other

Gene cluster description

argimycin P (BGC0001433). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank LT615255, positions 5044-50325. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Comments:No coments
Contact for this cluster:Suhui Ye (University of Oviedo)

Literature references

1. Suhui Ye, Brian Molloy, Alfredo F. Brana, Daniel Zabala, Carlos Olano, Jesus Cortes, Francisco Moris, Jose A. Salas, Carmen Mendez. (2017) Identification by Genome Mining of a Type I Polyketide Gene Cluster from Streptomyces argillaceus Involved in the Biosynthesis of Pyridine and Piperidine Alkaloids Argimycins P. Frontiers in Microbiology, vol. 8