BGC0001433: argimycin PI biosynthetic gene cluster from Streptomyces argillaceus
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Location: 1 - 68,295 nt. (total: 68,295 nt).
This entry is originally from NCBI GenBank LT615255.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001433
Short description argimycin PI biosynthetic gene cluster from Streptomyces argillaceus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
LT615255.1
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • argimycin PI
  • argimycin PII
  • nigrifactin
  • argimycin PIV
  • argimycin PV
  • argimycin PVI
  • argimycin PIX
Species Streptomyces argillaceus [taxonomy]
References
Chemical products information
argimycin PI Evidence: NMR, Mass spectrometry
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C17H18N2O3S1
argimycin PII Evidence: NMR, Mass spectrometry
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C17H18N2O3S1
nigrifactin Evidence:
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C12H17N1
Chemical database entries
NPAtlas
argimycin PIV Evidence: NMR, Mass spectrometry
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C12H17N1O2
argimycin PV Evidence: NMR, Mass spectrometry
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C12H17N1O1
argimycin PVI Evidence: NMR, Mass spectrometry
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C12H17N1
argimycin PIX Evidence: NMR, Mass spectrometry
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C12H21N1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCO70297.1
  • orf1
 1 - 1083 (-) SARP-like transcriptional regulator
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    • SCO70298.1
    • orf2
    		 1266 - 3587 (+) Xre-like transcriptional regulator
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      • SCO70299.1
      • orf3
      		 3688 - 4452 (+) Hypothetical protein
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        • SCO70300.1
        • arpRI
        		 5044 - 7530 (-) SARP-like transcriptional regulator
        • Regulation
        • Knock-out
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        • SCO70301.1
        • arpO
        		 7867 - 9318 (-) Dehydrogenase
        • Tailoring
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        • SCO70302.1
        • arpDHI
        		 9694 - 10872 (+) Dehydrogenase/hydroxylase
        • Tailoring
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        • SCO70303.1
        • arpDHII
        		 10927 - 11808 (+) Imine reductase
        • Tailoring
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        • SCO70304.1
        • arpN
        		 12579 - 14183 (-) Aminotransferase
        • Scaffold biosynthesis
        • Knock-out Other in vivo study
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        • SCO70305.1
        • arpK
        		 14364 - 14912 (+) Flavin reductase
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          • SCO70306.1
          • arpHI
          		 14998 - 15411 (+) Cyclase
          • Tailoring
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          • SCO70307.1
          • arpHII
          		 15515 - 15925 (-) Cyclase
          • Tailoring
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          • SCO70308.1
          • arpPI
          		 16117 - 29994 (+) Type I polyketide synthase
          • Scaffold biosynthesis
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          • SCO70309.1
          • arpPII
          		 30065 - 40786 (+) Type I polyketide synthase
          • Scaffold biosynthesis
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          • SCO70310.1
          • arpPIII
          		 40845 - 47456 (+) Type I polyketide synthase
          • Scaffold biosynthesis
          • Knock-out
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          • SCO70311.1
          • arpT
          		 47550 - 48323 (+) Type II thioesterase
          • Activation / processing
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          • SCO70312.1
          • arpX
          		 48574 - 49107 (-) Hypothetical protein
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            • SCO70313.1
            • arpRII
            		 49693 - 50325 (-) TetR-like transcriptional repressor
            • Regulation
            • Knock-out
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            • SCO70314.1
            • orf4
            		 50762 - 51409 (+) Reductase
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              • SCO70315.1
              • orf5
              		 51568 - 51948 (-) Hypothetical protein
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                • SCO70316.1
                • orf6
                		 51962 - 53107 (-) Oxidase
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                  • SCO70317.1
                  • orf7
                  		 53104 - 53742 (-) Putative transcriptional repressor
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                    • SCO70318.1
                    • orf8
                    		 53836 - 54981 (-) Monooxygenase
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                      • SCO70319.1
                      • orf9
                      		 55828 - 56331 (-) N-acetyltransferase
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                        • SCO70320.1
                        • orf10
                        		 56550 - 57770 (+) Cytochrome P450
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                          • SCO70321.1
                          • orf11
                          		 57809 - 59488 (+) AMP-dependent synthetase/ligase
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                            • SCO70322.1
                            • orf12
                            		 59520 - 60377 (+) Hypothetical protein
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                              • SCO70323.1
                              • orf13
                              		 60377 - 60889 (+) Thioesterase
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                                • SCO70324.1
                                • orf14
                                		 60886 - 61176 (+) Acyl carrier protein
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                                  • SCO70325.1
                                  • orf15
                                  		 61178 - 62101 (+) Methyltransferase
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                                    • SCO70326.1
                                    • orf16
                                    		 62098 - 62973 (+) Thioesterase
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                                      • SCO70327.1
                                      • orf17
                                      		 62970 - 63674 (+) Phosphopantetheinyl transferase
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                                        • SCO70328.1
                                        • orf18
                                        		 63947 - 64573 (+) Pyrophosphorylase
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                                          • SCO70329.1
                                          • orf19
                                          		 64588 - 65001 (-) Dehydratase
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                                            • SCO70330.1
                                            • orf20
                                            		 64998 - 65402 (-) Thioesterase
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                                              • SCO70331.1
                                              • orf21
                                              		 65813 - 66814 (+) 3-oxoacyl-ACP synthase
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                                                • SCO70332.1
                                                • orf22
                                                		 66983 - 67468 (-) Xre-like transcriptional regulator
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                                                  • SCO70333.1
                                                  • orf23
                                                  		 67804 - 68295 (+) LuxR-like transcriptional regulator
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                                                    Biosynthesis information

                                                    Biosynthetic modules

                                                    Name
                                                    0
                                                    Type
                                                    pks-modular
                                                    Genes
                                                    arpPI
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                    Name
                                                    1
                                                    Type
                                                    pks-modular
                                                    Genes
                                                    arpPI
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                    Name
                                                    2
                                                    Type
                                                    pks-modular
                                                    Genes
                                                    arpPI
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                    Name
                                                    3
                                                    Type
                                                    pks-modular
                                                    Genes
                                                    arpPII
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                    Name
                                                    4
                                                    Type
                                                    pks-modular
                                                    Genes
                                                    arpPII
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                    Name
                                                    5
                                                    Type
                                                    pks-modular
                                                    Genes
                                                    arpPIII
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, thioreductase, carrier (ACP)
                                                    Annotation changelog

                                                    Entry version: 4

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-10-07
                                                    Update chemical activity to schema version 2.11
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 3

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-09-15
                                                    Removed comment with no information
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Fixed incorrect gene identifiers
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Updated bioactivity data
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2019-10-16
                                                    Migrated from v1.4
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2019-10-16
                                                    Updated compound(s) information (NPAtlas curation)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2018-08-06
                                                    Submitted
                                                    • (ID: L5O3YFAALLUDBRU543OIOUC6)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    Detailed domain annotation
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