BGC0001434 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001434 (Xenorhabdus budapestensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	14,218	nematophin	NRPS:Type I	26%

BGC0001434 - Region 1 - NRPS

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Location: 1 - 14,218 nt. (total: 14,218 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,219
Label		BGC0001434

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001434	1.00	NRP	nematophin	Xenorhabdus budapestensis
BGC0002713	0.54	NRP	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000416	0.44	NRP	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0001133	0.36	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0000465	0.35	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001629	0.34	NRP	jessenipeptin	Pseudomonas sp. QS1027
BGC0000426	0.34	NRP	sevadicin	Paenibacillus larvae
BGC0002071	0.33	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000342	0.33	NRP	enniatin	Fusarium equiseti
BGC0000438	0.31	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001434	1.00	NRP	nematophin	Xenorhabdus budapestensis
BGC0002713	0.81	NRP	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000416	0.74	NRP	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0001133	0.69	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0000465	0.68	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001629	0.67	NRP	jessenipeptin	Pseudomonas sp. QS1027
BGC0000426	0.67	NRP	sevadicin	Paenibacillus larvae
BGC0002071	0.67	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000342	0.66	NRP	enniatin	Fusarium equiseti
BGC0000438	0.65	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 14218:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val) + (NMe-Val) + (NMe-Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ANG60379.1

Search NORINE for peptide: strict or relaxed

AMP-binding (553..948): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVAIK
Nearest Stachelhaus code(s):: Val DALVLAVAIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ANG60380.1

Search NORINE for peptide: strict or relaxed

AMP-binding (550..949): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVSIK
Nearest Stachelhaus code(s):: Val DALVLAVSIK (100% 8Å match); Leu DALVLAVSIK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

ANG60381.1

Search NORINE for peptide: strict or relaxed

AMP-binding (552..947): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVSIK
Nearest Stachelhaus code(s):: Val DALVLAVSIK (97% 8Å match); Leu DALVLAVSIK (91% 8Å match)
Stachelhaus code match:: 100% (strong)