BGC0001435: ikarugamycin biosynthetic gene cluster from Streptomyces sp. ZJ306
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Location: 1 - 36,760 nt. (total: 36,760 nt).
This entry is originally from NCBI GenBank KF954512.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001435
Short description ikarugamycin biosynthetic gene cluster from Streptomyces sp. ZJ306
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Please note that I was not involved in the studies on the mechanism and genes involved in the biosynthesis of Ikarugamycin, I am submitting this entry as part of study on the evolution of polycyclic tetramate macromalctams."
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
KF954512.1
via Heterologous expression
Compounds
  • ikarugamycin
Species Streptomyces sp. ZJ306 [taxonomy]
References
Chemical products information
ikarugamycin Evidence: Mass spectrometry
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C29H38N2O4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AJD77019.1
 201 - 1010 (-) hydroxylase
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    • AJD77020.1
    		 1105 - 1860 (-) deacetylase
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      • AJD77021.1
      		 2023 - 2394 (+) hypothetical protein
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        • AJD77022.1
        		 2455 - 3036 (+) hypothetical protein
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          • AJD77023.1
          		 3411 - 12785 (+) IkaA
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            • AJD77024.1
            		 12782 - 14614 (+) IkaB
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              • AJD77025.1
              		 14614 - 15678 (+) IkaC
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                • AJD77026.1
                		 15811 - 16281 (-) GCN5-related N-acetyltransferase
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                  • AJD77027.1
                  		 16379 - 17107 (-) hypothetical protein
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                    • AJD77028.1
                    		 17100 - 18908 (-) asparagine synthase
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                      • AJD77029.1
                      		 19327 - 20634 (+) transcriptional regulator
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                        • AJD77030.1
                        		 20762 - 21157 (-) ABC transporter
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                          • AJD77031.1
                          		 21353 - 22717 (+) hypothetical protein
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                            • AJD77032.1
                            		 22885 - 23628 (+) hypothetical protein
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                              • AJD77033.1
                              		 23766 - 24341 (+) putative membrane transport protein
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                                • AJD77034.1
                                		 24945 - 25427 (+) putative acetyltransferase
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                                  • AJD77035.1
                                  		 25512 - 26912 (-) cytochrome P450
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                                    • AJD77036.1
                                    		 26969 - 28987 (-) putative alpha-glucosidase
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                                      • AJD77037.1
                                      		 28974 - 31478 (+) phosphoketolase
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                                        • AJD77038.1
                                        		 31491 - 32369 (-) helix-turn-helix domain-containing protein
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                                          • AJD77039.1
                                          		 32494 - 33048 (-) membrane protein
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                                            • AJD77040.1
                                            		 33153 - 34250 (+) NAD-dependent epimerase/dehydratase
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                                              • AJD77041.1
                                              		 34251 - 34805 (+) RNA polymerase, sigma-24 subunit
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                                                • AJD77042.1
                                                		 34802 - 35674 (+) hypothetical protein
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                                                  • AJD77043.1
                                                  		 35748 - 36599 (+) hypothetical protein
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                                                    Biosynthesis information
                                                    Annotation changelog

                                                    Entry version: 3

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-10-07
                                                    Update chemical activity to schema version 2.11
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2019-10-16
                                                    Migrated from v1.4
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2019-10-16
                                                    Updated compound(s) information (NPAtlas curation)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2018-08-06
                                                    Submitted
                                                    • (ID: FLY65ZCPMC2MOEEXU6QSP7DO)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    Detailed domain annotation
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