BGC0001437 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001437 (Pseudomonas fluorescens)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,hserlactone	1	19,561	obafluorin	NRPS:Type I	100%

BGC0001437 - Region 1 - NRPS,hserlactone

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Location: 1 - 19,561 nt. (total: 19,561 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
hserlactone: Autoind_synth

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,562
Label		BGC0001437

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001437	1.29	NRP	obafluorin	Pseudomonas fluorescens
BGC0001897	0.43	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000922	0.35	Other	pseudomonas quinolone signal (PQS)	Pseudomonas aeruginosa PAO1
BGC0002031	0.33	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000894	0.33	Other	citrinin	Monascus aurantiacus
BGC0002075	0.32	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001444	0.30	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0002493	0.29	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0001529	0.28	Alkaloid	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001599	0.28	NRP	fragin	Burkholderia cenocepacia H111

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001437	1.00	NRP	obafluorin	Pseudomonas fluorescens
BGC0000894	0.66	Other	citrinin	Monascus aurantiacus
BGC0002075	0.65	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002493	0.63	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0001897	0.61	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000343	0.61	NRP	enterobactin	Pseudomonas sp. J465
BGC0002474	0.59	NRP	agrobactin	Agrobacterium tumefaciens
BGC0000913	0.59	Other	MK-8	Enterobacter cloacae
BGC0001825	0.57	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833	0.57	NRP	icosalide A, icosalide B	Burkholderia gladioli

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19561:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (diOH-Bz)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

obaI

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AMP-binding (460..871): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWGCGLINK
Nearest Stachelhaus code(s):: diOH-Bz DAWGCGLINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1412..1813): X

nrpys: n-oh-nitropheBut

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: TLPSQGVVCK
Nearest Stachelhaus code(s):: n-oh-nitropheBut TLPSQGVVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)