Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001437.1:
Cluster 1NRP119561

BGC0001437, obafluorin biosynthetic gene cluster from Pseudomonas fluorescens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Obafluorin
PubChem ID: 146354
SMILES string: Copy to clipboard
Molecular formula: C17H14N2O7
Average molecular mass: 358.306 Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP
Other (cyclic)
Thioesterase type:
Type I
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
obaI (AQZ26587.1)
Module 0
A specificity: 2,3-Dihydroxybenzoic acid
Evidence for specificity: Structure-based inference
C domain subtype: N/A
Module 1
A specificity: (2S,3R)-2-amino-3-hydroxy-4-(4-nitrophenyl)butanoate
Evidence for specificity: Other
C domain subtype: LCL

Gene cluster description

obafluorin (BGC0001437). Gene Cluster 1. Biosynthetic class = NRP. GenBank Not derived from GenBank. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Professor Barrie Wilkinson (John Innes Centre)

Literature references

1. Thomas A. Scott, Daniel Heine, Zhiwei Qin, Barrie Wilkinson. (2017) An L-threonine transaldolase is required for L-threo-b-hydroxy-a-amino acid assembly during obafluorin biosynthesis. Nature Communications, vol. 8, p. 15935