BGC0001437: obafluorin biosynthetic gene cluster from Pseudomonas fluorescens
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Location: 1 - 19,561 nt. (total: 19,561 nt).
This entry is originally from NCBI GenBank KX931446.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001437
Short description obafluorin biosynthetic gene cluster from Pseudomonas fluorescens
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KX931446.1
via Knock-out studies, Enzymatic assays
Compounds
  • obafluorin
Species Pseudomonas fluorescens [taxonomy]
References
Chemical products information
obafluorin Evidence: NMR, Mass spectrometry
Copy SMILES
C17H14N2O7
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AQZ26579.1
  • obaA
 452 - 1165 (+) ObaA
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    • AQZ26580.1
    • obaB
    		 1385 - 1894 (+) N-acylhomoserine lactone synthase
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      • AQZ26581.1
      • obaC
      		 1982 - 2932 (+) N-oxygenase
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        • AQZ26582.1
        • obaD
        		 2958 - 3557 (+) 4-Amino-4-deoxychorismate synthase component II
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          • AQZ26583.1
          • obaE
          		 3598 - 5058 (+) 4-Amino-4-deoxychorismate synthase component I
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            • AQZ26584.1
            • obaF
            		 5055 - 6317 (+) 4-Amino-4-deoxychorismate mutase/prephenate dehydrogenase
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              • AQZ26585.1
              • obaG
              		 6314 - 7636 (+) threonine transaldolase PLP-dependent
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                • AQZ26586.1
                • obaH
                		 7633 - 9336 (+) nitrophenylpyruvate decarboxylase ThDP-dependent
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                  • AQZ26587.1
                  • obaI
                  		 9378 - 15110 (+) obafluorin dimodular nonribosomal peptide synthetase
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                    • AQZ26588.1
                    • obaJ
                    		 15153 - 15797 (+) isochorismatase
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                      • AQZ26589.1
                      • obaK
                      		 15794 - 16060 (+) obafluorin aryl carrier protein
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                        • AQZ26590.1
                        • obaL
                        		 16057 - 16827 (+) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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                          • AQZ26591.1
                          • obaM
                          		 16947 - 18020 (+) DAHP synthase
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                            • AQZ26592.1
                            • obaN
                            		 18017 - 19435 (+) isochorismate synthase
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              0
                              Type
                              nrps-type1
                              Genes
                              obaI
                              Substrates
                              2,3-dihydroxybenzoic acid (evidence: Structure-based inference)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              1
                              Type
                              nrps-type1
                              Genes
                              obaI
                              Substrates
                              (2S,3R)-2-amino-3-hydroxy-4-(4-nitrophenyl)butanoic acid (evidence: )
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Corrected NRP module activity
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Merged annotations from duplicate entry BGC0001710
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Updated NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2019-10-16
                              Updated compound(s) information (NPAtlas curation)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2018-08-06
                              Submitted
                              • (ID: SOJ5J6FNXPWDFJNGJGPS2QRA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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