BGC0001438: warkmycin CS1 biosynthetic gene cluster from Streptomyces sp. CS057
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Location: 1,756,999 - 1,795,313 nt. (total: 38,315 nt).
This entry is originally from NCBI GenBank KZ195572.1.

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core biosynthetic genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001438
Short description warkmycin CS1 biosynthetic gene cluster from Streptomyces sp. CS057
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • saccharide (hybrid/tailoring)
Loci
KZ195572.1
1756999 - 1795313
via Gene expression correlated with compound production
Compounds
  • warkmycin CS1
  • warkmycin CS2
Species Streptomyces sp. CS057 [taxonomy]
References
Chemical products information
warkmycin CS1 Evidence: NMR
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C48H65N1O22
warkmycin CS2 Evidence: NMR
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C50H67N1O23
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • B9W61_07160
  • OWA25221.1
 1757000 - 1758787 (-) carbamoyltransferase
  • Tailoring
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  • B9W61_07165
  • OWA25222.1
 1758810 - 1760039 (-) methyltransferase
  • Tailoring
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  • B9W61_07170
  • OWA25223.1
 1760101 - 1760877 (-) dTDP-6-deoxy-L-hexose 3-O-methyltransferase
  • Tailoring
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  • B9W61_07175
  • OWA25224.1
 1760917 - 1761945 (-) hypothetical protein
  • Tailoring
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  • B9W61_07180
  • OWA25225.1
 1761902 - 1762831 (-) glucose-1-phosphate thymidylyltransferase
  • Tailoring
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  • B9W61_07185
  • OWA25226.1
 1762828 - 1763463 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
  • Tailoring
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  • B9W61_07190
  • OWA25227.1
 1763649 - 1764806 (-) C-glycosyltransferase SaqGT5
  • Tailoring
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  • B9W61_07195
  • OWA25228.1
 1764897 - 1766030 (-) hypothetical protein
  • Tailoring
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  • B9W61_07200
  • OWA25229.1
 1766044 - 1767231 (-) cytochrome P450
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    • B9W61_07205
    • OWA25230.1
    		 1767298 - 1768503 (-) glycosyl transferase
    • Tailoring
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    • B9W61_07210
    • OWA25231.1
    		 1768562 - 1769806 (-) protein IroB
    • Tailoring
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    • B9W61_07215
    • OWA25232.1
    		 1769898 - 1770479 (+) TetR family transcriptional regulator
    • Regulation
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    • B9W61_07220
    • OWA25233.1
    		 1770533 - 1771336 (-) hypothetical protein
    • Tailoring
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    • B9W61_07225
    • OWA25234.1
    		 1771336 - 1772403 (-) oxidoreductase
    • Tailoring
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    • B9W61_07230
    • OWA25479.1
    		 1772400 - 1773800 (-) NDP-hexose 2,3-dehydratase
    • Tailoring
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    • B9W61_07235
    • OWA25235.1
    		 1773827 - 1774582 (-) NAD-dependent epimerase/dehydratase
    • Tailoring
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    • B9W61_07240
    • OWA25236.1
    		 1774674 - 1775984 (-) lipopolysaccharide biosynthesis protein RfbH
    • Tailoring
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    • B9W61_07245
    • OWA25237.1
    		 1775995 - 1776993 (-) dTDP-glucose 4,6-dehydratase
    • Tailoring
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    • B9W61_07250
    • OWA25480.1
    		 1777089 - 1778138 (-) aldo/keto reductase
    • Tailoring
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    • B9W61_07255
    • OWA25238.1
    		 1778150 - 1778734 (-) NADPH-dependent oxidoreductase
    • Tailoring
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    • B9W61_07260
    • OWA25239.1
    		 1778789 - 1779982 (-) acyltransferase
    • Tailoring
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    • B9W61_07265
    • OWA25240.1
    		 1780069 - 1781340 (-) hypothetical protein
    • Transport
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    • B9W61_07270
    		 1781422 - 1783706 (-) monooxygenase
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      • B9W61_07275
      • OWA25241.1
      		 1783771 - 1784718 (-) cyclase
      • Scaffold biosynthesis
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      • B9W61_07280
      • OWA25242.1
      		 1784759 - 1785541 (-) ketoacyl reductase
      • Scaffold biosynthesis
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      • B9W61_07285
      • OWA25243.1
      		 1785610 - 1785873 (-) actinorhodin polyketide synthase
      • Scaffold biosynthesis
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      • B9W61_07290
      • OWA25244.1
      		 1785870 - 1787099 (-) ketosynthase chain-length factor
      • Scaffold biosynthesis
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      • B9W61_07295
      • OWA25245.1
      		 1787096 - 1788400 (-) beta-ACP synthase
      • Scaffold biosynthesis
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      • B9W61_07300
      • OWA25246.1
      		 1788397 - 1788726 (-) polyketide synthase
      • Scaffold biosynthesis
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      • B9W61_07305
      • OWA25247.1
      		 1788775 - 1790244 (-) monooxygenase
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        • B9W61_07310
        • OWA25248.1
        		 1791109 - 1791594 (+) hypothetical protein
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          • B9W61_07315
          • OWA25481.1
          		 1791790 - 1792530 (-) DNA-binding response regulator
          • Regulation
          • Other in vivo study
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          • B9W61_07320
          • OWA25249.1
          		 1793121 - 1793723 (-) NADPH-dependent oxidoreductase
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            • B9W61_07325
            • OWA25250.1
            		 1793720 - 1795312 (-) MFS transporter
            • Transport
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            Biosynthesis information
            Annotation changelog

            Entry version: 4

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Remove negative ketide_length
            • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Added missing id in gene annotation
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Updated bioactivity data
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2018-08-06
            Submitted
            • (ID: IZJNS6CU5DLATL4TXZ3XDCFK)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            Detailed domain annotation
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