BGC0001438: warkmycin CS1 biosynthetic gene cluster from Streptomyces sp. CS057
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Location: 1,756,999 - 1,795,313 nt. (total: 38,315 nt).
This entry is originally from NCBI GenBank KZ195572.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001438
Short description warkmycin CS1 biosynthetic gene cluster from Streptomyces sp. CS057
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Angucycline)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: KZ195572.1
Compounds
  • warkmycin CS1
  • warkmycin CS2
Species Streptomyces sp. CS057 [taxonomy]
References
Chemical products information
warkmycin CS1
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C48H65N1O22
warkmycin CS2
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C50H67N1O23
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • B9W61_07160
  • OWA25221.1
 1757000 - 1758787 (-) carbamoyltransferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07165
  • OWA25222.1
 1758810 - 1760039 (-) methyltransferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07170
  • OWA25223.1
 1760101 - 1760877 (-) dTDP-6-deoxy-L-hexose 3-O-methyltransferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07175
  • OWA25224.1
 1760917 - 1761945 (-) hypothetical protein
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07180
  • OWA25225.1
 1761902 - 1762831 (-) glucose-1-phosphate thymidylyltransferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07185
  • OWA25226.1
 1762828 - 1763463 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07190
  • OWA25227.1
 1763649 - 1764806 (-) C-glycosyltransferase SaqGT5
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07195
  • OWA25228.1
 1764897 - 1766030 (-) hypothetical protein
  • Tailoring (Glycosylation)
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  • B9W61_07200
  • OWA25229.1
 1766044 - 1767231 (-) cytochrome P450
  • Unknown
Sequence-based prediction
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  • B9W61_07205
  • OWA25230.1
 1767298 - 1768503 (-) glycosyl transferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07210
  • OWA25231.1
 1768562 - 1769806 (-) protein IroB
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07215
  • OWA25232.1
 1769898 - 1770479 (+) TetR family transcriptional regulator
  • Regulation
Sequence-based prediction
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  • B9W61_07220
  • OWA25233.1
 1770533 - 1771336 (-) hypothetical protein
  • Tailoring (Glycosylation)
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  • B9W61_07225
  • OWA25234.1
 1771336 - 1772403 (-) oxidoreductase
  • Tailoring (Glycosylation)
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  • B9W61_07230
  • OWA25479.1
 1772400 - 1773800 (-) NDP-hexose 2,3-dehydratase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07235
  • OWA25235.1
 1773827 - 1774582 (-) NAD-dependent epimerase/dehydratase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07240
  • OWA25236.1
 1774674 - 1775984 (-) lipopolysaccharide biosynthesis protein RfbH
  • Tailoring (Glycosylation)
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  • B9W61_07245
  • OWA25237.1
 1775995 - 1776993 (-) dTDP-glucose 4,6-dehydratase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • B9W61_07250
  • OWA25480.1
 1777089 - 1778138 (-) aldo/keto reductase
  • Tailoring (Unknown)
Sequence-based prediction
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  • B9W61_07255
  • OWA25238.1
 1778150 - 1778734 (-) NADPH-dependent oxidoreductase
  • Tailoring (Unknown)
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  • B9W61_07260
  • OWA25239.1
 1778789 - 1779982 (-) acyltransferase
  • Tailoring (Acetylation)
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  • B9W61_07265
  • OWA25240.1
 1780069 - 1781340 (-) hypothetical protein
  • Transport
Sequence-based prediction
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  • B9W61_07270
 1781422 - 1783706 (-) monooxygenase
  • Unknown
Sequence-based prediction
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  • B9W61_07275
  • OWA25241.1
 1783771 - 1784718 (-) cyclase
  • Scaffold biosynthesis
Sequence-based prediction
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  • B9W61_07280
  • OWA25242.1
 1784759 - 1785541 (-) ketoacyl reductase
  • Scaffold biosynthesis
Sequence-based prediction
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  • B9W61_07285
  • OWA25243.1
 1785610 - 1785873 (-) actinorhodin polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • B9W61_07290
  • OWA25244.1
 1785870 - 1787099 (-) ketosynthase chain-length factor
  • Scaffold biosynthesis
Sequence-based prediction
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  • B9W61_07295
  • OWA25245.1
 1787096 - 1788400 (-) beta-ACP synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • B9W61_07300
  • OWA25246.1
 1788397 - 1788726 (-) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • B9W61_07305
  • OWA25247.1
 1788775 - 1790244 (-) monooxygenase
  • Unknown
Sequence-based prediction
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  • B9W61_07310
  • OWA25248.1
 1791109 - 1791594 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • B9W61_07315
  • OWA25481.1
 1791790 - 1792530 (-) DNA-binding response regulator
  • Regulation
Other in vivo study
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  • B9W61_07320
  • OWA25249.1
 1793121 - 1793723 (-) NADPH-dependent oxidoreductase
  • Unknown
Sequence-based prediction
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  • B9W61_07325
  • OWA25250.1
 1793720 - 1795312 (-) MFS transporter
  • Transport
Sequence-based prediction
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Polyketide-specific information
Subclass Angucycline
Cyclic? yes
Saccharide-specific information
Subclass hybrid/tailoring
Glycosyltransferases
B9W61_07190
Evidence:
  • Sequence-based prediction
B9W61_07195
Evidence:
  • Sequence-based prediction
B9W61_07205
Evidence:
  • Sequence-based prediction
B9W61_07210
Evidence:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: IZJNS6CU5DLATL4TXZ3XDCFK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Remove negative ketide_length
  • Added missing id in gene annotation
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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