BGC0001439: antibiotic HKI 10311129 biosynthetic gene cluster from Streptomyces sp. CS113
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Location: 7,078,663 - 7,118,727 nt. (total: 40,065 nt).
This entry is originally from NCBI GenBank KZ195574.1.

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core biosynthetic genes
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General
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001439
Short description antibiotic HKI 10311129 biosynthetic gene cluster from Streptomyces sp. CS113
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • saccharide (hybrid/tailoring)
Loci
KZ195574.1
7078663 - 7118727
via Gene expression correlated with compound production
Compounds
  • antibiotic HKI 10311129
  • antibiotic A2121-1
  • cervimycin D
  • cervimycin C
  • cervimycin A
Species Streptomyces sp. CS113 [taxonomy]
References
Chemical products information
antibiotic HKI 10311129 Evidence:
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C56H75N1O22
antibiotic A2121-1 Evidence:
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C59H77N1O25
cervimycin D Evidence:
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C60H79N1O25
Chemical database entries
NPAtlas
cervimycin C Evidence:
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C61H81N1O25
Chemical database entries
NPAtlas
cervimycin A Evidence:
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C62H82O25
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • B9W62_31925
  • OWA01596.1
 7078664 - 7079944 (+) beta-ACP synthase
  • Scaffold biosynthesis
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  • B9W62_31930
  • OWA01597.1
 7079941 - 7081158 (+) ketosynthase chain-length factor
  • Scaffold biosynthesis
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  • B9W62_31935
  • OWA01598.1
 7081238 - 7081495 (+) actinorhodin polyketide synthase
  • Scaffold biosynthesis
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  • B9W62_31940
  • OWA01599.1
 7081532 - 7083370 (+) asparagine synthase (glutamine-hydrolyzing)
  • Tailoring
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  • B9W62_31945
  • OWA01600.1
 7083467 - 7084774 (-) lipopolysaccharide biosynthesis protein RfbH
  • Tailoring
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  • B9W62_31950
  • OWA01601.1
 7084934 - 7085968 (+) hypothetical protein
  • Scaffold biosynthesis
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  • B9W62_31955
  • OWA01602.1
 7085993 - 7086754 (-) short-chain dehydrogenase
  • Scaffold biosynthesis
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  • B9W62_31960
  • OWA01603.1
 7086936 - 7088270 (+) hypothetical protein
  • Tailoring
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  • B9W62_31965
  • OWA01604.1
 7088267 - 7089406 (+) hypothetical protein
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    • B9W62_31970
    • OWA01605.1
    		 7089399 - 7090454 (+) hypothetical protein
    • Scaffold biosynthesis
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    • B9W62_31975
    • OWA01606.1
    		 7090582 - 7091799 (-) hypothetical protein
    • Tailoring
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    • B9W62_31980
    • OWA01607.1
    		 7091903 - 7092910 (-) hypothetical protein
    • Tailoring
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    • B9W62_31985
    • OWA01608.1
    		 7093093 - 7093698 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
    • Tailoring
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    • B9W62_31990
    • OWA01609.1
    		 7093705 - 7097025 (+) hypothetical protein
    • Regulation
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    • B9W62_31995
    • OWA01610.1
    		 7097050 - 7098246 (-) hypothetical protein
    • Tailoring
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    • B9W62_32000
    • OWA01611.1
    		 7098251 - 7099414 (-) glycosyl transferase
    • Tailoring
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    • B9W62_32005
    		 7099755 - 7100162 (-) hypothetical protein
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      • B9W62_32010
      • OWA01612.1
      		 7099906 - 7102008 (+) hypothetical protein
      • Transport
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      • B9W62_32015
      • OWA01613.1
      		 7102191 - 7103339 (-) hypothetical protein
      • Tailoring
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      • B9W62_32020
      • OWA01614.1
      		 7103489 - 7104388 (+) glucose-1-phosphate thymidylyltransferase
      • Tailoring
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      • B9W62_32025
      • OWA01615.1
      		 7104398 - 7105210 (-) hypothetical protein
      • Regulation
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      • B9W62_32030
      • OWA01684.1
      		 7105443 - 7106213 (-) hypothetical protein
      • Regulation
      • Other in vivo study
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      • B9W62_32035
      • OWA01685.1
      		 7106365 - 7107336 (-) oxidoreductase
      • Tailoring
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      • B9W62_32040
      • OWA01616.1
      		 7107405 - 7108850 (-) NDP-hexose 2,3-dehydratase
      • Tailoring
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      • B9W62_32045
      • OWA01617.1
      		 7108882 - 7109847 (-) dTDP-glucose 4,6-dehydratase
      • Tailoring
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      • B9W62_32050
      • OWA01618.1
      		 7109889 - 7110920 (-) polyketide synthase
      • Scaffold biosynthesis
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      • B9W62_32055
      • OWA01619.1
      		 7110949 - 7111896 (-) aromatase
      • Scaffold biosynthesis
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      • B9W62_32060
      • OWA01620.1
      		 7112090 - 7112530 (+) hydroxylacyl-CoA dehydrogenase
      • Scaffold biosynthesis
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      • B9W62_32065
      • OWA01621.1
      		 7112593 - 7113366 (-) cyclase
      • Scaffold biosynthesis
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      • B9W62_32070
      • OWA01622.1
      		 7113376 - 7115031 (-) oxygenase
      • Scaffold biosynthesis
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      • B9W62_32075
      • OWA01623.1
      		 7115170 - 7116792 (+) acyl--CoA ligase
      • Tailoring
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      • B9W62_32080
      • OWA01624.1
      		 7116845 - 7117147 (+) oxygenase
      • Scaffold biosynthesis
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      • B9W62_32085
      • OWA01625.1
      		 7117155 - 7118726 (+) methylmalonyl-CoA carboxyltransferase
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        Biosynthesis information
        Annotation changelog

        Entry version: 4

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Remove negative ketide_length
        • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Migrated from v1.4
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2019-10-16
        Updated compound(s) information (NPAtlas curation)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2018-08-06
        Submitted
        • (ID: IZJNS6CU5DLATL4TXZ3XDCFK)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        Detailed domain annotation
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