BGC0001439

BGC0001439: antibiotic HKI 10311129 biosynthetic gene cluster from Streptomyces sp. CS113

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Location: 7,078,663 - 7,118,727 nt. (total: 40,065 nt).
This entry is originally from NCBI GenBank KZ195574.1.

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

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Gene details

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General

Compounds

Genes

Polyketide

Saccharide

History

NRPS/PKS domains

KnownClusterBlast

General information about the BGC

MIBiG accession	BGC0001439
Short description	antibiotic HKI 10311129 biosynthetic gene cluster from Streptomyces sp. CS113
Status	Minimal annotation: no A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s) Completeness: complete Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)	Polyketide (Tetracycline) Saccharide (hybrid/tailoring)
Loci	NCBI GenBank: KZ195574.1
Compounds	antibiotic HKI 10311129 antibiotic A2121-1 cervimycin D cervimycin C cervimycin A
Species	Streptomyces sp. CS113 [taxonomy]
References	Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety. Herold K et al., Org Biomol Chem (2004) PMID:15326518 Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance. Herold K et al., Chemistry (2005) PMID:15940739 Cervimycin C resistance in Bacillus subtilis is due to a promoter up-mutation and increased mRNA stability of the constitutive ABC-transporter gene bmrA. Krügel H et al., FEMS Microbiol Lett (2010) PMID:21077936 A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Bretschneider T et al., Nat Chem Biol (2011) PMID:22179067 The cave microbiome as a source for drug discovery: Reality or pipe dream?. Ghosh S et al., Biochem Pharmacol (2017) PMID:27867014

Chemical products information

antibiotic HKI 10311129

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C₅₆H₇₅N₁O₂₂

antibiotic A2121-1

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C₅₉H₇₇N₁O₂₅

cervimycin D

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C₆₀H₇₉N₁O₂₅

Chemical database entries
NPAtlas

cervimycin C

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C₆₁H₈₁N₁O₂₅

Chemical database entries
NPAtlas

cervimycin A

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C₆₂H₈₂O₂₅

Chemical database entries
NPAtlas

List of genes involved in compound(s) production

Identifiers	Position	Product	Functions	Evidence	Extra
B9W62_31925 OWA01596.1	7078664 - 7079944 (+)	beta-ACP synthase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31930 OWA01597.1	7079941 - 7081158 (+)	ketosynthase chain-length factor	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31935 OWA01598.1	7081238 - 7081495 (+)	actinorhodin polyketide synthase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31940 OWA01599.1	7081532 - 7083370 (+)	asparagine synthase (glutamine-hydrolyzing)	Tailoring (Unknown)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31945 OWA01600.1	7083467 - 7084774 (-)	lipopolysaccharide biosynthesis protein RfbH	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31950 OWA01601.1	7084934 - 7085968 (+)	hypothetical protein	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31955 OWA01602.1	7085993 - 7086754 (-)	short-chain dehydrogenase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31960 OWA01603.1	7086936 - 7088270 (+)	hypothetical protein	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31965 OWA01604.1	7088267 - 7089406 (+)	hypothetical protein	Unknown	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31970 OWA01605.1	7089399 - 7090454 (+)	hypothetical protein	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31975 OWA01606.1	7090582 - 7091799 (-)	hypothetical protein	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31980 OWA01607.1	7091903 - 7092910 (-)	hypothetical protein	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31985 OWA01608.1	7093093 - 7093698 (+)	dTDP-4-dehydrorhamnose 3,5-epimerase	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31990 OWA01609.1	7093705 - 7097025 (+)	hypothetical protein	Regulation	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_31995 OWA01610.1	7097050 - 7098246 (-)	hypothetical protein	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32000 OWA01611.1	7098251 - 7099414 (-)	glycosyl transferase	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32005	7099755 - 7100162 (-)	hypothetical protein			copy AA seq copy Nt seq
B9W62_32010 OWA01612.1	7099906 - 7102008 (+)	hypothetical protein	Transport	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32015 OWA01613.1	7102191 - 7103339 (-)	hypothetical protein	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32020 OWA01614.1	7103489 - 7104388 (+)	glucose-1-phosphate thymidylyltransferase	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32025 OWA01615.1	7104398 - 7105210 (-)	hypothetical protein	Regulation	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32030 OWA01684.1	7105443 - 7106213 (-)	hypothetical protein	Regulation	Other in vivo study	copy AA seq copy Nt seq
B9W62_32035 OWA01685.1	7106365 - 7107336 (-)	oxidoreductase	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32040 OWA01616.1	7107405 - 7108850 (-)	NDP-hexose 2,3-dehydratase	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32045 OWA01617.1	7108882 - 7109847 (-)	dTDP-glucose 4,6-dehydratase	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32050 OWA01618.1	7109889 - 7110920 (-)	polyketide synthase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32055 OWA01619.1	7110949 - 7111896 (-)	aromatase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32060 OWA01620.1	7112090 - 7112530 (+)	hydroxylacyl-CoA dehydrogenase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32065 OWA01621.1	7112593 - 7113366 (-)	cyclase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32070 OWA01622.1	7113376 - 7115031 (-)	oxygenase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32075 OWA01623.1	7115170 - 7116792 (+)	acyl--CoA ligase	Tailoring (Unknown)	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32080 OWA01624.1	7116845 - 7117147 (+)	oxygenase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
B9W62_32085 OWA01625.1	7117155 - 7118726 (+)	methylmalonyl-CoA carboxyltransferase	Unknown	Sequence-based prediction	copy AA seq copy Nt seq

Polyketide-specific information

Subclass	Tetracycline
Cyclic?	yes

Saccharide-specific information

Subclass	hybrid/tailoring
Glycosyltransferases	B9W62_31960 Evidence: Sequence-based prediction
	B9W62_31975 Evidence: Sequence-based prediction
	B9W62_31995 Evidence: Sequence-based prediction
	B9W62_32000 Evidence: Sequence-based prediction
	B9W62_32015 Evidence: Sequence-based prediction

Annotation changelog

MIBiG version	Submitter	Notes
1.4	Hidden contributor (ID: IZJNS6CU5DLATL4TXZ3XDCFK, no GDPR consent given).	Submitted
2.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Migrated from v1.4 Updated compound(s) information (NPAtlas curation)
3.0	Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).	Remove negative ketide_length
3.1	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Update chemical activity to schema version 2.11

Detailed domain annotation

Selected features only

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