Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001439.1:
Cluster 1Polyketide / Saccharide140065

BGC0001439, cervimycin biosynthetic gene cluster from Streptomyces sp. CS113. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: antibiotic HKI 10311129
SMILES string: Copy to clipboard
Molecular formula: C56H75NO22
Exact molecular mass: 1113.4765 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Tetracycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
None
Polyketide synthase / ketosynthase-encoding genes:

Saccharide subclass:
hybrid/tailoring
Glycosyltransferases:
B9W62_31960:
Specificity: Unknown
Evidence for specificity: Unknown
B9W62_31975:
Specificity: Unknown
Evidence for specificity: Unknown
B9W62_31995:
Specificity: Unknown
Evidence for specificity: Unknown
B9W62_32000:
Specificity: Unknown
Evidence for specificity: Unknown
B9W62_32015:
Specificity: Unknown
Evidence for specificity: Unknown

Gene cluster description

cervimycin (BGC0001439). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank KZ195574, positions 7078663-7118727. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Monica G. Malmierca (University of Oviedo)

Literature references

1. Herold K et al. (2004) Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety. Org Biomol Chem 2(17):2411-4. doi: 10.1039/B409221J. Epub 2004 Aug 4.
2. Herold K et al. (2005) Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance. Chemistry 11(19):5523-30. doi: 10.1002/chem.200500320.
3. Krugel H et al. (2010) Cervimycin C resistance in Bacillus subtilis is due to a promoter up-mutation and increased mRNA stability of the constitutive ABC-transporter gene bmrA. FEMS Microbiol Lett 313(2):155-63. doi:
4. Bretschneider T et al. (2011) A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat Chem Biol 8(2):154-61. doi: 10.1038/nchembio.746.
5. Ghosh S et al. (2017) The cave microbiome as a source for drug discovery: Reality or pipe dream? Biochem Pharmacol 134:18-34. doi: 10.1016/j.bcp.2016.11.018. Epub