Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001440.1:
Cluster 1Other113771

BGC0001440, cystargolide A / cystargolide B biosynthetic gene cluster from Kitasatospora cystarginea. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: cystargolide A
PubChem ID: 122204527
SMILES string: Copy to clipboard
Molecular formula: C18H30N2O6
Average molecular mass: 370.446 Da
Molecular activity: Inhibitor
Molecular target: 20S proteasome

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
None

Gene cluster description

cystargolide A / cystargolide B (BGC0001440). Gene Cluster 1. Biosynthetic class = Other. GenBank KY249117. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays
MIxS-compliance:Unknown
Contact for this cluster:Leonard Kaysser (University of Tuebingen)

Literature references

1. Wolf F et al. (2017) Biosynthesis of the beta-Lactone Proteasome Inhibitors Belactosin and Cystargolide. Angew Chem Int Ed Engl 56(23):6665-6668. doi: 10.1002/anie.201612076.
2. Gill KA et al. (2015) Cystargolides, 20S Proteasome Inhibitors Isolated from Kitasatospora cystarginea. J Nat Prod 78(4):822-6. doi: 10.1021/np501060k. Epub 2015 Mar 13.