Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001441.1:
Cluster 1Other127983

BGC0001441, belactosin A / belactosin C biosynthetic gene cluster from Streptomyces sp. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: belactosin A
PubChem ID: 25053219
SMILES string: Copy to clipboard
Molecular formula: C17H27N3O6
Average molecular mass: 369.418 Da
Molecular activity: Inhibitor
Molecular target: 20S proteasome

Class-specific details

Biosynthetic class(es):
Other
Other biosynthetic class:
None

Gene cluster description

belactosin A / belactosin C (BGC0001441). Gene Cluster 1. Biosynthetic class = Other. GenBank KY249118. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays
MIxS-compliance:Unknown
Contact for this cluster:Leonard Kaysser (University of Tuebingen)

Literature references

1. Wolf F et al. (2017) Biosynthesis of the beta-Lactone Proteasome Inhibitors Belactosin and Cystargolide. Angew Chem Int Ed Engl 56(23):6665-6668. doi: 10.1002/anie.201612076.
2. Asai A et al. (2004) A new structural class of proteasome inhibitors identified by microbial screening using yeast-based assay. Biochem Pharmacol 67(2):227-34.
3. Asai A et al. (2000) Belactosin A, a novel antitumor antibiotic acting on cyclin/CDK mediated cell cycle regulation, produced by Streptomyces sp. J Antibiot (Tokyo) 53(1):81-3.