Gene cluster description
Homologous known gene clusters
General MIBiG information on this cluster
|Complete gene cluster sequence?||complete|
|Evidence for cluster-compound connection:||Knock-out studies, Enzymatic assays|
|Contact for this cluster:||Leonard Kaysser (University of Tuebingen)|
1. Wolf F et al. (2017) Biosynthesis of the beta-Lactone Proteasome Inhibitors Belactosin and Cystargolide. Angew Chem Int Ed Engl 56(23):6665-6668. doi: 10.1002/anie.201612076.
2. Asai A et al. (2004) A new structural class of proteasome inhibitors identified by microbial screening using yeast-based assay. Biochem Pharmacol 67(2):227-34.
3. Asai A et al. (2000) Belactosin A, a novel antitumor antibiotic acting on cyclin/CDK mediated cell cycle regulation, produced by Streptomyces sp. J Antibiot (Tokyo) 53(1):81-3.