BGC0001442 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001442 (Streptomyces sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	32,297	actinonin	NRPS:Type I	100%

BGC0001442 - Region 1 - NRPS

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Location: 1 - 32,297 nt. (total: 32,297 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 32,298
Label		BGC0001442

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001442	1.00	NRP	actinonin	Streptomyces sp. strain ATCC 14903
BGC0000885	0.32	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000343	0.31	NRP	enterobactin	Pseudomonas sp. J465
BGC0001637	0.30	NRP	kleboxymycin	Klebsiella oxytoca
BGC0002491	0.29	NRP	myxochelin B, myxochelin A, pseudochelin A	Pseudoalteromonas piscicida
BGC0002474	0.28	NRP	agrobactin	Agrobacterium tumefaciens
BGC0001627	0.28	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0000846	0.28	Other	tabtoxin	Pseudomonas syringae
BGC0002071	0.28	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000446	0.27	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001442	1.00	NRP	actinonin	Streptomyces sp. strain ATCC 14903
BGC0000885	0.65	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000343	0.65	NRP	enterobactin	Pseudomonas sp. J465
BGC0001637	0.63	NRP	kleboxymycin	Klebsiella oxytoca
BGC0002491	0.63	NRP	myxochelin B, myxochelin A, pseudochelin A	Pseudoalteromonas piscicida
BGC0002474	0.62	NRP	agrobactin	Agrobacterium tumefaciens
BGC0001627	0.62	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0000846	0.61	Other	tabtoxin	Pseudomonas syringae
BGC0002071	0.61	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000446	0.61	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 32297:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Pro)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

actE

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AMP-binding (567..968): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFVAHVVK
Nearest Stachelhaus code(s):: Pro DVQFVAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

actH

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AMP-binding (10..412): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVFK
Nearest Stachelhaus code(s):: Thr DFWNIGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)