BGC0001443: matlystatin A biosynthetic gene cluster from Actinomadura atramentaria DSM 43919
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Location: 32,199 - 56,356 nt. (total: 24,158 nt).
This entry is originally from NCBI GenBank NZ_KB907224.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001443
Short description matlystatin A biosynthetic gene cluster from Actinomadura atramentaria DSM 43919
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: NZ_KB907224.1
Compounds
  • matlystatin A
Species Actinomadura atramentaria DSM 43919 [taxonomy]
References
Chemical products information
matlystatin A
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C22H40N4O5
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • G339_RS40700
  • WP_019634547.1
  • meaB
 32199 - 33410 (-) methylmalonyl Co-A mutase-associated GTPase MeaB
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  • G339_RS0128875
  • WP_019634548.1
 33407 - 33814 (-) cobalamin B12-binding domain-containing protein
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  • G339_RS0128880
  • WP_019634549.1
 33811 - 34746 (-) alpha/beta fold hydrolase
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  • G339_RS37205
  • WP_019634550.1
 34743 - 39389 (-) type I polyketide synthase
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  • G339_RS35690
  • WP_157408076.1
 39435 - 41045 (-) MFS transporter
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  • G339_RS0128895
  • WP_019634552.1
 41092 - 41691 (-) helix-turn-helix domain-containing protein
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  • G339_RS0128900
  • WP_019634553.1
  • ccrA
 41744 - 43087 (-) crotonyl-CoA carboxylase/reductase
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  • G339_RS0128905
  • WP_026341873.1
 43092 - 44906 (-) condensation domain-containing protein
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  • G339_RS0128910
  • WP_019634554.1
 44903 - 46468 (-) AMP-binding protein
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  • G339_RS0128915
  • WP_019634555.1
 46465 - 46716 (-) phosphopantetheine-binding protein
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  • G339_RS0128920
  • WP_019634556.1
 46713 - 47975 (-) condensation domain-containing protein
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  • G339_RS35695
  • WP_019634557.1
 47975 - 49615 (-) acyl-CoA/acyl-ACP dehydrogenase
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  • G339_RS35700
  • WP_240489931.1
 49602 - 50246 (-) FMN-binding negative transcriptional regulator
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  • G339_RS0128935
  • mce
 50317 - >50731 (-) methylmalonyl-CoA epimerase
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  • G339_RS0128940
  • WP_019634560.1
 50733 - 52031 (-) lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein
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  • G339_RS0128945
  • WP_019634561.1
  • asnB
 52028 - 53884 (-) asparagine synthase (glutamine-hydrolyzing)
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  • G339_RS35705
  • WP_019634562.1
 53923 - 55368 (-) methylmalonyl-CoA mutase family protein
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  • G339_RS0128955
  • WP_169514798.1
 55370 - 56188 (-) diiron oxygenase
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
G339_RS37205 Synthase subclass:
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Feeding study
Genes: G339_RS37205
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
G339_RS0128920
Module 1
Condensation domain type: LCL
G339_RS0128905
Module 2
Condensation domain type: LCL
G339_RS37205
Module 2
Specificity: isoleucine
Evidence for specificity:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: 4ACA66D6INRVNJRPWB3JQW5E, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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