Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001443.1:
Cluster 1NRP124158

BGC0001443, matlystatins biosynthetic gene cluster from Actinomadura atramentaria. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Matlystatin A
PubChem ID: 10054339
SMILES string: Copy to clipboard
Molecular formula: C27H47N5O8S
Average molecular mass: 601.76 Da
Molecular activity: Inhibitor
Molecular target: typeIV collagenase

Class-specific details

Biosynthetic class(es):
NRP
None (linear)
Thioesterase type:
Unknown
Release / cyclization type:
None

Nonribosomal peptide synthetases:
matH (WP_019634556.1)
Module 1
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL
matK (WP_026341873.1)
Module 2
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL
matO (WP_019634550.1)
Module 2
A specificity: Isoleucine
Evidence for specificity: Sequence-based prediction
C domain subtype: N/A

Gene cluster description

matlystatins (BGC0001443). Gene Cluster 1. Biosynthetic class = NRP. GenBank NZ_KB907224, positions 32199-56356. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Leonard Kaysser (University of Tuebingen)

Literature references

1. Haruyama H et al. (1994) Matlystatins, new inhibitors of type IV collagenases from Actinomadura atramentaria. III. Structure elucidation of matlystatins A to F. J Antibiot (Tokyo) 47(12):1473-80.
2. Tamaki K et al. (1994) Matlystatins, new inhibitors of type IV collagenases from Actinomadura atramentaria. IV. Synthesis and structure-activity relationships of matlystatin B and its stereoisomers. J Antibiot (Tokyo) 47(12):1481-92.