BGC0001443: matlystatin A biosynthetic gene cluster from Actinomadura atramentaria DSM 43919
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Location: 14,743 - 59,389 nt. (total: 44,647 nt).
This entry is originally from NCBI GenBank NZ_KB907224.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001443
Short description matlystatin A biosynthetic gene cluster from Actinomadura atramentaria DSM 43919
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
NZ_KB907224.1
32199 - 56356
via Knock-out studies, Heterologous expression
Compounds
  • matlystatin A
Species Actinomadura atramentaria DSM 43919 [taxonomy]
References
Chemical products information
matlystatin A Evidence: NMR, Mass spectrometry
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C22H40N4O5
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • G339_RS40700
  • WP_019634547.1
  • meaB
 32199 - 33410 (-) methylmalonyl Co-A mutase-associated GTPase MeaB
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    • G339_RS0128875
    • WP_019634548.1
    		 33407 - 33814 (-) cobalamin B12-binding domain-containing protein
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      • G339_RS0128880
      • WP_019634549.1
      		 33811 - 34746 (-) alpha/beta fold hydrolase
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        • G339_RS37205
        • WP_019634550.1
        		 34743 - 39389 (-) type I polyketide synthase
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          • G339_RS35690
          • WP_157408076.1
          		 39435 - 41045 (-) MFS transporter
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            • G339_RS0128895
            • WP_019634552.1
            		 41092 - 41691 (-) helix-turn-helix domain-containing protein
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              • G339_RS0128900
              • WP_019634553.1
              • ccrA
              		 41744 - 43087 (-) crotonyl-CoA carboxylase/reductase
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                • G339_RS0128905
                • WP_026341873.1
                		 43092 - 44906 (-) condensation domain-containing protein
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                  • G339_RS0128910
                  • WP_019634554.1
                  		 44903 - 46468 (-) AMP-binding protein
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                    • G339_RS0128915
                    • WP_019634555.1
                    		 46465 - 46716 (-) phosphopantetheine-binding protein
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                      • G339_RS0128920
                      • WP_019634556.1
                      		 46713 - 47975 (-) condensation domain-containing protein
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                        • G339_RS35695
                        • WP_019634557.1
                        		 47975 - 49615 (-) acyl-CoA dehydrogenase family protein
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                          • G339_RS35700
                          • WP_019634558.1
                          		 49602 - 50300 (-) FMN-binding negative transcriptional regulator
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                            • G339_RS0128935
                            • mce
                            		 50317 - >50729 (-) methylmalonyl-CoA epimerase
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                              • G339_RS0128940
                              • WP_019634560.1
                              		 50733 - 52031 (-) SidA/IucD/PvdA family monooxygenase
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                                • G339_RS0128945
                                • WP_019634561.1
                                • asnB
                                		 52028 - 53884 (-) asparagine synthase (glutamine-hydrolyzing)
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                                  • G339_RS35705
                                  • WP_019634562.1
                                  		 53923 - 55368 (-) methylmalonyl-CoA mutase family protein
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                                    • G339_RS0128955
                                    • WP_276203781.1
                                    		 55370 - 56212 (-) diiron oxygenase
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      2
                                      Type
                                      nrps-type1
                                      Genes
                                      G339_RS37205
                                      Substrates
                                      isoleucine (evidence: Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      3
                                      Type
                                      pks-modular
                                      Genes
                                      G339_RS37205
                                      Substrates
                                      Integrated Monomers
                                      Domains
                                      acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                      Annotation changelog

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Corrected NRP module activity
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Updated bioactivity data
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Updated NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2019-10-16
                                      Updated compound(s) information (NPAtlas curation)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2018-08-06
                                      Submitted
                                      • (ID: 4ACA66D6INRVNJRPWB3JQW5E)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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