LOCUS       BGC0001444             14045 bp    DNA     linear   BCT 05-JUN-2014
DEFINITION  Streptomyces sp. NTK 937 contig00001, whole genome shotgun sequence.
ACCESSION   BGC0001444
VERSION     BGC0001444
KEYWORDS    .
SOURCE      Streptomyces sp. NTK 937
  ORGANISM  Streptomyces sp. NTK 937
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Fiedler H.P. collection (Universitat
            Tubingen, Germany). Source DNA available from Salas J.A. group
            (University of Oviedo, Spain).
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 01:39:20
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 5309240
            Orig. end    :: 5323285
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..14045
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..14045
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(9..2127)
                     /locus_tag="DT87_23835"
                     /note="hypothetical protein; disrupted; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
     gene            3282..4652
                     /locus_tag="DT87_23840"
     CDS             3282..4652
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 328.6; E-value:
                     1.3e-99)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_014045655.1"
                     /locus_tag="DT87_23840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KDQ70105.1"
                     /transl_table=11
                     /translation="MYQSPRHYFEKRLRLPSDPMTAAARLASSGLHADYMVYENRGTWS
                     YAGGAAAEITLDRTGARLRQPDEVLLPWDGRPLHQVQSLLDAVRVTGWRAYGWAAFELS
                     YAKGGDLAHIGDQRLLHLVVPHTEVRIEGGEAYLRSVDEAGLAAALDVLTAEHTERHSV
                     PDPVDVRQAGADAYRRAVGIAVDAINDQRLQKVIFSRVVPVERELDFVGTYLAGRRGNS
                     PARSFLLDLGGIEATGFSPEIVVQVDPDGKVVSQPLAGTRALTGDRAEDERLREELLAD
                     PKEIYEHAISVKIACDELIGVCAPGTVGVEEFMAVKERGTVQHLASRVGGRLAAGRRAW
                     DAFDAVFPAVTASGVPKAAAYDSIRSNESEARGLYSGAVLTVDHQGAMDAALVLRSVYR
                     QDGRTWLRAGAGIVAHSRPERELEETCEKLGSVGRFLVPAAEPVGAGAAPMAEGARP"
     gene            4649..5704
                     /locus_tag="DT87_23845"
     CDS             4649..5704
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PKS-like: ksIII"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 97.8; E-value: 1.1e-29)"
                     /gene_kind="biosynthetic"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_007032080.1"
                     /locus_tag="DT87_23845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-oxoacyl-ACP synthase"
                     /protein_id="KDQ70106.1"
                     /sec_met_domain="ksIII (E-value: 1.3e-81, bitscore: 263.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTDGIFLAGVATCLPEPYTTRRAVAEGAYDEADREESGIESVPV
                     AGETPGPDLAVRAARTALARSGHRPEDFGALLHSGVHFQGPDGWSAPHYVLRHTLDRPV
                     TAVEVRQGCLGMLSALEMAACRLTAVPEHPAVLLTSGDNFSTPLVDRWRASKLFLLGDA
                     GAAAVVSRRGGFARVLSVGSVSTPSMEELHRGGEPMFPPGPTVGRTLNLEERREYWRRE
                     WARGVPPPMGNFGDTVAAAARQSLAEAGATMADIARVCHLGFSELPLRACFLDPLDIDE
                     KRGIWEFTRTTGHLGAADPIAGPQHLWRTGQVGAGDLVMIIGASPGMEAGCAVVEITRS
                     FGGADEEDGHA"
     gene            5697..7370
                     /locus_tag="DT87_23850"
     CDS             5697..7370
                     /NRPS_PKS="Domain: AMP-binding (32-445). E-value: 6.4e-84.
                     Score: 273.7. Matches aSDomain:
                     nrpspksdomains_DT87_23850_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 451;
                     E-value: 7.2e-137)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_007032081.1"
                     /locus_tag="DT87_23850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Triostin synthetase I"
                     /protein_id="KDQ70107.1"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-93, bitscore:
                     303.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEGCTPWPGERARRYREAGHWRGENLADLLSTTAAAHADRTALV
                     LGGRRLTFAELDRRVARTAAGFVERGIAAGDRVVVQLPNVPEFVIVCFALFRMGAKPVF
                     SLVSHRANEIRHLCGISGAVAYVVPGEYQGFDHTRLALDLVEEYAALRKVFVLDGRAVA
                     GAAAAPAGVLVALDDVDAEPLPLPAPDPSDVAFFLLSGGTTALPKLIPRTHDDYAYQVR
                     AAAALLELDQDAVYLAVLPAEFNFTWGCPGVVGTLLSGGTVVLADAPIADECFETVARE
                     GVTFTSLVPTLAQLWVEAAEWSEADLSSLRLVQIGGARTHGSLAERIGPVLGCRLQQVF
                     GMAEGLLTLSRPTDSEERVLATQGRPLSPDDEVRIVGPGGDDLPPGGTGELLTRGPYTL
                     QGYYKAPEHNARAFTADGFYRTGDLARLTDDGDLVIEGRIKDVINRGGDKVSAPEVEEH
                     LLAHPAVAEAAVVPVPDPFLGERIGAYVVPDGPPPGLRELKEALHADGLADYKLPDWLA
                     IVEALPLTGLGKVDKKTLAADAAARIHAADTAAPDAATVR"
     aSDomain        5793..7031
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DT87_23850_AMP-binding.1"
                     /evalue="6.40E-84"
                     /label="DT87_23850_AMP-binding.1"
                     /locus_tag="DT87_23850"
                     /protein_end="445"
                     /protein_start="32"
                     /score="273.7"
                     /tool="antismash"
                     /translation="TTAAAHADRTALVLGGRRLTFAELDRRVARTAAGFVERGIAAGDR
                     VVVQLPNVPEFVIVCFALFRMGAKPVFSLVSHRANEIRHLCGISGAVAYVVPGEYQGFD
                     HTRLALDLVEEYAALRKVFVLDGRAVAGAAAAPAGVLVALDDVDAEPLPLPAPDPSDVA
                     FFLLSGGTTALPKLIPRTHDDYAYQVRAAAALLELDQDAVYLAVLPAEFNFTWGCPGVV
                     GTLLSGGTVVLADAPIADECFETVAREGVTFTSLVPTLAQLWVEAAEWSEADLSSLRLV
                     QIGGARTHGSLAERIGPVLGCRLQQVFGMAEGLLTLSRPTDSEERVLATQGRPLSPDDE
                     VRIVGPGGDDLPPGGTGELLTRGPYTLQGYYKAPEHNARAFTADGFYRTGDLARLTDDG
                     DLVIEGRIKDVINR"
     CDS_motif       6846..6935
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DT87_23850_0001"
                     /evalue="2.90E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="DT87_23850"
                     /protein_end="413"
                     /protein_start="383"
                     /score="16.5"
                     /tool="antismash"
                     /translation="PPGGTGELLTRGPYTLQGYYKAPEHNARAF"
     gene            7367..7744
                     /locus_tag="DT87_23855"
     CDS             7367..7744
                     /NRPS_PKS="Domain: PP-binding (47-111). E-value: 8.9e-13.
                     Score: 40.5. Matches aSDomain:
                     nrpspksdomains_DT87_23855_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:isochorismatase (Score: 56.3; E-value: 4.6e-17)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_014045652.1"
                     /locus_tag="DT87_23855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KDQ70108.1"
                     /sec_met_domain="PP-binding (E-value: 1.5e-13, bitscore:
                     40.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPAAPGPAHAAAPAHPRPVEAEGHRTTMHTTAQDSGGRTPAQV
                     SAALREDVAAMIGTDPGTIGQDANLVHLGLGSLEMMRLVNRWRREGVKVSFRELAAEPT
                     LGAWQRHLDAVAAAGPEGDRA"
     aSDomain        7508..7699
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DT87_23855_PP-binding.1"
                     /evalue="8.90E-13"
                     /label="DT87_23855_PP-binding.1"
                     /locus_tag="DT87_23855"
                     /protein_end="111"
                     /protein_start="47"
                     /score="40.5"
                     /tool="antismash"
                     /translation="ALREDVAAMIGTDPGTIGQDANLVHLGLGSLEMMRLVNRWRREGV
                     KVSFRELAAEPTLGAWQRH"
     gene            7741..9300
                     /locus_tag="DT87_23860"
     CDS             7741..9300
                     /codon_start=1
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_014045651.1"
                     /locus_tag="DT87_23860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase"
                     /protein_id="KDQ70109.1"
                     /transl_table=11
                     /translation="MSGPAGPDPEGLPARPPALLIRGGHLCTADAEARVHPTGSVLVVD
                     DRIAAVGPDGDVAEAVARLTPGQRAGLRTLDARSMLVMPGFVNNHWHDLFAVRLPFKGA
                     LRTPQDQADEPGFMALGGDIAKVSGGFEGFRRLTDALEPEEARAVARYALWTQLRSGTT
                     TLGDVGSVNRPEALADAALDLGIRCSVSAWVGDIHCGPGTTSPERTRDTDTELERTRRL
                     LDRCAADRTGRLRAWPTAPYLTNISDELGRGLAALSAEYGVPFATHVGALRHEADAVRA
                     HFGTTPLRRLDRLGLLNDRLMAVHCAFADAEERRMLLDAGVHISHSPAKYGPNGESALT
                     ETGLIPELRRSGLDVSLSTDGGVFPVMGMAEEMRAAWQMYNEMAADHTTLPASEALAMA
                     TRIAARGLGWEHEVGSLEAGKQADLVLVPVDDWRYLLNPRPLEAYLALGGTRDVHTVLV
                     AGRVLLENGRTPHLDEDALRDAYLRALRSFSARALGVAEKDLTALFDDNPRPPARASTV
                     PA"
     gene            9368..10600
                     /locus_tag="DT87_23865"
     CDS             9368..10600
                     /codon_start=1
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_012999100.1"
                     /locus_tag="DT87_23865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phospho-2-dehydro-3-deoxyheptonate aldolase"
                     /protein_id="KDQ70110.1"
                     /transl_table=11
                     /translation="MPDNTALLLAEDEGAALSLAELRRWRALPARQQPDWLDHPELDPT
                     RELLAARPALVTGDEVATLRLLLAEVAQGRCQVVQAGDCAEDPAECAAGPVSRKADLLD
                     RLATVMSSRSGVPVLRVGRIAGQFAKPRSRPTEHVGERELPVYRGHMVNAPAPDARARR
                     PAPSRMAVCYDAAATAVDTLRLRRTGDPAAPDSRVWTSHEALVLDYELPLTRRDHAGRL
                     LLTSTHWPWIGERTRQADGAHVRLLAAVDNPVACKVGPSAAVDDLLRLCGLLDPGRTPG
                     RLTLIARMGAEAVTARLPALVSAVRAAGHPVSWLSDPMHGNTVSTPGGLKTRRVDTIVA
                     EVVRFQEAVSAAGGVAGGLHLETTPHAVTECVADAIGQDRLDGAYTTLCDPRLNPGQAH
                     AVVSAWRGQDL"
     gene            10630..11400
                     /locus_tag="DT87_23870"
     CDS             10630..11400
                     /NRPS_PKS="Domain: PKS_KR (6-162). E-value: 8.7e-17. Score:
                     53.4. Matches aSDomain: nrpspksdomains_DT87_23870_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     250.5; E-value: 2.8e-76)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_018486864.1"
                     /locus_tag="DT87_23870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2,3-dihydroxybenzoate-2,3-dehydrogenase"
                     /protein_id="KDQ70111.1"
                     /sec_met_domain="adh_short (E-value: 3.2e-39, bitscore:
                     124.0, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 3.2e-33, bitscore:
                     104.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDTIAVVTGAAGGIGAAVAEALAVRGASVALLDRDADRLAVVAK
                     ELTSAGHRATAFPADVTSGQDVEAVIEAVEERLGPVDRLVNAAGVLRTGPAHEFADEDW
                     EATFAVNTTGVFHVSRAVVRRMRTRRRGALVTIASNAAGSARTEMAAYAASKAAASMFT
                     KCLGLENAAYGIRCNVVAPGSTDTPMLTALWDDASAADASIAGVPEAYRVGIPLAKLAR
                     PKDVADAVLFLLSDQASHITMHHLTVDGGATLGA"
     CDS_motif       10648..10716
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DT87_23870_0001"
                     /evalue="1.30E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="DT87_23870"
                     /protein_end="29"
                     /protein_start="6"
                     /score="21.1"
                     /tool="antismash"
                     /translation="VVTGAAGGIGAAVAEALAVRGAS"
     aSDomain        10648..11115
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DT87_23870_PKS_KR.1"
                     /evalue="8.70E-17"
                     /label="DT87_23870_PKS_KR.1"
                     /locus_tag="DT87_23870"
                     /protein_end="162"
                     /protein_start="6"
                     /score="53.4"
                     /tool="antismash"
                     /translation="VVTGAAGGIGAAVAEALAVRGASVALLDRDADRLAVVAKELTSAG
                     HRATAFPADVTSGQDVEAVIEAVEERLGPVDRLVNAAGVLRTGPAHEFADEDWEATFAV
                     NTTGVFHVSRAVVRRMRTRRRGALVTIASNAAGSARTEMAAYAASKAAASMF"
     gene            11425..12075
                     /locus_tag="DT87_23875"
     CDS             11425..12075
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:isochorismatase (Score: 295.2; E-value: 5.9e-90)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_006135771.1"
                     /locus_tag="DT87_23875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isochorismatase"
                     /protein_id="KDQ70112.1"
                     /transl_table=11
                     /translation="MAIPTIEPYPMPTQGDLPANTASWSVDPSRAVLLVHDMQYYFLRP
                     FPAGASPVDALLGNAVRLRQTCARLGVPVAYTAQPGDMTEEQRGLLKDFWGPGMSAGPR
                     DRAVVDELAPGPDDTVFTKWRPSAFFRTGLLDLLRDTGRDQLIVCGVYAHVGILMTTGE
                     ACAHDIQTFVVGDAVADFTPADHRMTLEYVATRCGMTVTTKTVLRQLEEASGT"
     gene            12072..14045
                     /locus_tag="DT87_23880"
     CDS             12072..14045
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 310.6; E-value:
                     4e-94)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_014138975.1"
                     /locus_tag="DT87_23880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="anthranilate synthase"
                     /protein_id="KDQ70113.1"
                     /transl_table=11
                     /translation="MNPGAPEAFAGGPDPLLRRILDGEPPPFALVHRPRTTGPDRLELM
                     VGTLSRPGSLAGLPLPQGPGTSRHDVLAVLPYRLLAERGYTCPDDGTPLLALTIEEQRL
                     LSRREFLRHVPDLPLRMAEHGFDLDDDAYARTAGRIIRDEIGRGTGANFVFRRTYRADL
                     ADWGVTAALAFFRRLLRRESGAYWTFLIHTGDRCLVGATPEQHVALSGGAVTMNPISGT
                     YRYPESGADPEGVLDFLRDTKESDELFMVLDEELKMMGRVCHRGGRVRGPYLKEMERLA
                     HTEYVIEGSSGRGVRDLLRETMFAPTVTGSPLESACRVIGTYEPHGRGYYSGVAALIGR
                     DADGGTVLDSSILIRTADIDRTGSLSLGVGATLVRHSSPRAEVAETHAKAAGLLSALRA
                     APDTGPTAGAGTGAPARGPGLRDHPDVRAALAGRNATLADFWLADPDGRAEPVDRLAGR
                     RLLVVDGEDTFTSMARHCLAALGLDVTVRRFDEPYTLDGQDFVIVGPGPGDPARHTDPK
                     IAHLRDLTGRLLRSRTPFLAVCLGHQVLSSLLGLDLVRRPEPNQGSQQKIDFFGRPELV
                     GFYNTFAARSPGAPLSCPYRGGAVRVCHDPGGGEVHALRGPGYASVQFHPASVLTRNGT
                     ALLRDLLLGTVRDGFPPEARGA"
ORIGIN
        1 tcaccccttc acggcgcata cggccgcgtc ccgtggccgg ggacccggat cgggcccctg
       61 ggcggacccg gccggtaccg ggcggtggtg cggccggcgg tgcagccggt ggagctccgc
      121 cagcgtacgg gcgagggagc gggccgtggc gtcgtgcccg tcggcgtcgg cctggtggaa
      181 cgccgcgacc agcccgatcc gctcggcgtc ggaccacggc agggccccgg ccgcgcgcac
      241 ggggcgcccg tcggtcaggg cgcggacggt ggcacgggcc cgcagcagcc acgcggtgag
      301 cgcccggtcg accgtcgcgc ggcgttcggc gccgtcgctc tcgtcctccg cgcgttcggc
      361 ggcgaacagg cggatgacgg gcggcatccg gtagcggagc cgccccgcgc gatccgaccc
      421 gctcacctcc agcagccggg cgtcgacgag gccttcgagg acgtcctcgg ccgtggactc
      481 gtcggtctcc agcacgacgg ccgtcagcca ggcgggtatc tccggggtcc gcagcagcga
      541 cagccggcac agggccgtcc tggcctcgcc cggcagccgc agatagcccc ggcggagcga
      601 ggaccggacg tccaggtcgc ccaggcgcag ctcgtccagc ggccgccggt gcccgtcggc
      661 cagcctgcgc gccatctcgg tcagcgtcca gtggggtttg gcggccaggc gcccggccac
      721 cacgcgcacg gcgagcggca gcagcccgca ccgctcgacc agccagtcgg ccacggcggg
      781 ctccgccgcg acccggccgg agccggccac ccggctcaac agggcgagcg cctcgggccg
      841 ttcgaagacg tccagctcca gctgccgggc gccctccagg gccgtgaagc gcgaccgggc
      901 cgtcacgacc acccggctgc acgcggcccc cggaagcagc ggccgcacct gctgttcgtc
      961 atgggcgttg tccaggacga ccagcacacg gcgctcggcg agcacgctgc ggtagagctg
     1021 ggtgcgctcg tccaccgtca ggggcagcgg ggtgcccggc tcgcacagcg actggaggaa
     1081 ccattcgagt acgtcgtgcg ggtccttgga gcggcccggt ggcccggcca ggtccgcgta
     1141 caactggccg tcggggaagg agtccaggcg cagccgcccg gcctggacgg cgagggcgct
     1201 cttgcccgcc ccggcggccc cggtcaccac gaccggtgcc gcgcccgcct gttggccggt
     1261 caacaggtca cacagctcgt cgagttgggc cttccggccg gtgaagtcgg cgacgtgagg
     1321 gggcagcatg gccggacgca ccggccgccg ccgcccgacg ggtgcctccg ggggccggtc
     1381 ggcgggggcg gtgagcccgg ggtccccgga caggatggac tggaagacgt cgttgagcgc
     1441 cgaactgggg tcgataccca gctcctccgc gaggatcacc cgcccgcgcc ggtactcggc
     1501 cagggcgtcg gcctgccgcc ccgcccggta gagcgcggtc atcaactggg cgcgcagccg
     1561 ctcccgtacg gggtgcgcct ccaccaggcc caccagctcg gagacgagcg cgtcatggcg
     1621 tccgagcgcg agatcggcgg cgatgcggcc ctccagcgcc gccatacgcg cctcttcgag
     1681 ccgggggagt tcgatccggg ccaggtgctc ggtcacgccg ccgagggcgg ggccgcgcca
     1741 gagcgcgagc gcggtggcca ggtgtgcgga ggccgccgag tggcggcgcg ccttcaaggc
     1801 gtcgtagccg agaccggcca gccggtcgaa ctcggcgtgg tccagggtcg cgtcggtcag
     1861 cacgagccgg tagcccggcc ggtggcgcag gatagcggca ccgggggaga gcagtttgcg
     1921 cagccgtgag acataggtgt agagctgctg atcgaccgtg gcggggggcg tcggccccca
     1981 ggtcacctcc cgcaggcgcg cgtcggagac gacccggccg cccgccagga gcagcgcggc
     2041 caggaccgtc ttgggcttct ccgccaccgg cgtgaggccc cggcccgcct gacgtatgcc
     2101 gaccggtccg agaacgcgga tctccacccg tacccctttt gtgtcatcac ggtccagaac
     2161 ggcggacacg gcccaggcgt caaggcgccg aggggaagcg gcgggagcct cgtgccgcag
     2221 ggtgagggcg ccggcctccc acgacggcgg gagcggcgcg aaggacgctc cccgccggtg
     2281 gcccggcacg ggtcacggca gccgggaacc ggccgcgcac accgcccggc agccccgccg
     2341 gccccgcccg gggcgcggag gacgacatcg cccggagcca ggcgggcacg cggaggaggc
     2401 gctcgggcca ggcggacgcc gcaggcgcgt acggacgtgc gggggccggg aacggccggg
     2461 cggaacacct gggcacccga ggggcgaccg caccgcgtcc gcgcggccgg cccgccgccc
     2521 accggacgtg cgcgcgggaa cgcgccctgc cctgtgcgcg tgtgcggaaa cggcgtggtg
     2581 tggcacagcc cgactctcca gacgaagcga ccgcgccggt gcaacggcgc ccctcatggc
     2641 acggtgccac ggaaatgtcg cagatgccca cagggatcga tgcggtcgat cgtgcacatc
     2701 cccgccggcc cccctgcccg attccacgga gtgatcccga aggtacaccc tgcgatcacg
     2761 acgcaacagg ccgctttcgc acgcttctcc atgcgttttg cacaccgata ggcctgtttc
     2821 ggacatcagt tgacgtccca tcagcagacg gccccgtgtg ttcgccgcgg cgtccggacg
     2881 gctcatcgac ctgcgcggta tagccgcgat atggcttcgc tccgcgccgg tatagaaacc
     2941 gtccgcaaga tgtgggccga gcggacagcc gggtggacac cccgctgcgt cagtcaatgc
     3001 ctacggggga gcgccatgag cggcgggcta atcggaggac cggccgtacc cgccggtggc
     3061 acggcccgtc ggacacgggc accccgggga cgaatccccg ggccacggcg tccggggcgt
     3121 ccgcgatgtt ccccgtcccg ctcctgatct gcgacgtgtc gccgtccccg tcgccggcac
     3181 tcccgcgcga cccccgggct cccgcacgcc cgtgtgcggc ccccgcggtg aactccccgc
     3241 tccgctctcc cctttcggct gtcgagaaga ggacgttcgc gatgtaccag tcgcccaggc
     3301 actacttcga gaagaggctg aggctgccct cggaccccat gaccgccgcc gcccgcctgg
     3361 cctcctcggg cctgcacgcg gactacatgg tctacgagaa ccggggcacc tggtcctacg
     3421 ccggcggagc ggcggccgag atcaccctgg accgcaccgg cgccaggctg cggcagccgg
     3481 acgaggtgct gctgccctgg gacggccgcc ccctgcacca ggtgcagagc ctcctcgacg
     3541 ccgtacgggt caccggctgg cgggcctacg gctgggcggc gttcgagctg tcgtacgcca
     3601 agggcgggga cctcgcgcac atcggtgacc agcggctgct gcacctggtc gtcccgcaca
     3661 ccgaggtcag gatcgagggc ggcgaggcgt atctgcgctc cgtggacgag gccggcctcg
     3721 cggccgcgct ggacgtgctg accgcggagc acaccgagcg gcactccgtg cccgatccgg
     3781 tggacgtacg gcaggccggg gcggacgcct accggcgggc ggtcggcatc gcggtcgacg
     3841 cgatcaacga ccagcggctc cagaaggtga tcttctcgcg ggtggtcccc gtcgaacgcg
     3901 agctggactt cgtgggcacc tacctggcgg gccgccgggg caacagcccg gctcggtcgt
     3961 tcctgctcga cctcgggggc atcgaggcga ccggcttcag cccggagatc gtcgtccagg
     4021 tcgatccgga cgggaaggtg gtcagccagc cgctggccgg cacccgggcg ctgaccggcg
     4081 accgggccga ggacgagcgg ctgcgcgagg aactcctcgc ggacccgaag gagatctacg
     4141 agcacgcgat ctccgtgaag atcgcctgcg acgaactgat cggggtgtgc gcccccggca
     4201 ccgtgggcgt cgaggagttc atggccgtca aggagcgcgg cacggtgcag cacctcgcct
     4261 cacgcgtggg cgggcggctg gccgccggcc gccgcgcctg ggacgccttc gacgcggtgt
     4321 tccccgccgt caccgcctcc ggtgtgccca aggccgccgc atacgacagc atccgcagca
     4381 acgagtccga ggcccggggg ctgtacagcg gggccgtgct gacggtcgat caccaagggg
     4441 cgatggacgc ggcgttggtg ctgcgcagtg tctaccggca ggacggccgc acctggctgc
     4501 gcgccggtgc gggcatcgtg gcgcactccc ggcccgaacg ggaactggag gagacctgcg
     4561 agaagctggg cagcgtcggg cgcttcctgg tgccggccgc cgaacccgtg ggcgccggtg
     4621 ccgccccgat ggcggaaggg gcccgcccgt gaagaccgac ggcatcttcc tcgccggagt
     4681 cgcgacctgc ctgccggagc cgtacaccac gcggcgcgcc gtcgcggagg gggcgtacga
     4741 cgaggcggac cgggaggagt ccgggatcga gtccgtgccc gtcgcgggcg agacccccgg
     4801 gcccgatctg gcggtgcgcg ccgcccggac cgcgctggcc cgctccggac accggcccga
     4861 ggacttcggc gccctgctgc acagcggcgt ccacttccag ggccccgacg gctggtcggc
     4921 cccgcactac gtgctccggc acaccctcga ccgcccggtg accgccgtcg aggtccggca
     4981 gggctgcctg ggcatgctct ccgccctgga gatggccgcc tgccgcctca cggccgtgcc
     5041 cgagcacccg gcggtcctgc tgacctccgg ggacaacttc tccaccccgc tggtggaccg
     5101 ctggcgcgcc tcgaagctct tcctgctggg cgacgccggg gccgcggccg tggtgtcccg
     5161 ccggggcggc ttcgcccggg tgctctccgt gggctcggtc tccaccccgt cgatggagga
     5221 gctgcaccgc ggcggggagc ccatgttccc gcccggcccc accgtgggac gcaccctcaa
     5281 cctggaggag cgcagagagt actggcgccg cgagtgggcc cggggggtcc cgccgcccat
     5341 gggcaacttc ggtgacacgg tcgccgccgc cgcccggcag tccctcgccg aggccggagc
     5401 caccatggcg gacatcgccc gcgtctgcca cctcggattc tccgaactcc ccctgcgcgc
     5461 atgcttcctg gacccgctgg acatcgacga gaagcggggc atctgggagt tcacccgcac
     5521 gaccggccac ctgggcgccg ccgacccgat cgccggtccc caacacctgt ggcggaccgg
     5581 gcaggtgggc gccggcgacc tggtgatgat catcggcgcc tcacccggca tggaggcggg
     5641 ctgcgccgtc gtcgagatca cccgctcctt cggcggtgcg gacgaggagg acggccatgc
     5701 ttgagggatg caccccctgg cccggggaac gcgcgcggcg ctaccgggag gcgggccact
     5761 ggcggggcga gaacctcgcg gacctgctgt ccaccaccgc cgcggcgcac gccgaccgca
     5821 ccgcgctcgt gctcggaggg cgccgtctca ccttcgccga gctcgaccgg cgggtggcca
     5881 ggacggccgc cgggttcgtg gagcggggca tcgcggcggg ggaccgggtc gtcgtacagc
     5941 tgccgaacgt gcccgagttc gtcatcgtct gcttcgccct gttccgcatg ggcgccaagc
     6001 cggtgttctc gctggtctcc caccgggcca acgagatccg gcacctgtgc gggatctccg
     6061 gcgccgtggc ctacgtggtg ccgggcgagt accagggctt cgaccacacg cggctggccc
     6121 tggacctggt ggaggagtac gccgccctgc ggaaggtctt cgtcctcgac gggcgggccg
     6181 tcgccggggc cgcggccgcc ccggcggggg tgctcgtcgc gctggacgac gtggacgccg
     6241 agccgctgcc gcttcccgcg cccgacccgt ccgacgtcgc gttcttcctg ctgtccgggg
     6301 gcaccacggc gctgcccaag ctgatcccca ggacccacga cgactacgcc taccaggtca
     6361 gggcggccgc cgccctgctc gaactggacc aggacgccgt ctacctggcg gtgctcccgg
     6421 cggagttcaa cttcacctgg gggtgccccg gtgtggtggg gaccctgctc tccggcggca
     6481 ccgtggtcct ggcggacgcg cccatcgccg acgagtgctt cgagaccgtg gcgcgggagg
     6541 gcgtcacctt cacctcgctg gtgccgaccc tggcccagct gtgggtggag gcggccgagt
     6601 ggagcgaggc cgacctgtcg agcctgcggc tcgtccagat cggcggcgcc cggacgcacg
     6661 gttcgctcgc cgaacggatc ggccccgtcc tgggctgccg gctgcaacag gtcttcggga
     6721 tggcggaggg cctgctcacc ctctcccggc ccaccgactc cgaggagcgg gtcctggcca
     6781 cccagggccg gccgctctcg cccgacgacg aggtgcgcat cgtcggcccc ggcggtgacg
     6841 acctgccgcc gggcggtacc ggcgaactcc tgacccgggg cccctacacc ctccagggct
     6901 actacaaggc gccggaacac aacgcccgcg cgttcaccgc ggacggcttc taccgcaccg
     6961 gcgacctcgc ccgcctgacc gacgacggcg acctcgtcat cgagggccgt atcaaggacg
     7021 tgatcaaccg gggcggggac aaggtctccg cgccggaggt ggaggaacac ctgctggccc
     7081 atccggcggt ggcggaggcc gccgtcgtgc cggtgcccga cccgttcctg ggcgagcgga
     7141 tcggcgccta cgtggtcccc gacggcccgc cgcccggact gcgggagctg aaggaggcac
     7201 tgcacgcgga cggcctggcc gactacaagc tccccgactg gctggcgatc gtcgaggcgc
     7261 tcccgctgac cggcctcggc aaggtcgaca agaagaccct cgcggccgac gcggcggcca
     7321 ggatccacgc ggcggacacc gcggcgcccg acgcggcgac cgtccgatga cctcccccgc
     7381 cgccccggga ccggcccacg ccgccgctcc cgcccacccc cgtcccgtcg aagccgaagg
     7441 acacaggacc acgatgcaca ccacagcaca ggacagcgga gggcggaccc cggcgcaggt
     7501 gtccgccgca ctgcgcgagg acgtcgcggc catgatcggc accgaccccg ggaccatcgg
     7561 acaggacgcc aacctcgtcc acctcggact cggttcgctg gagatgatgc gcctggtcaa
     7621 ccggtggcgc cgggaaggag tgaaggtctc cttccgcgag ctggcggccg agcccaccct
     7681 cggcgcctgg cagcggcacc tcgacgccgt cgcggcggcc gggcccgagg gggaccgggc
     7741 gtgagcgggc ccgcggggcc ggaccccgag ggcctgcccg cccgcccgcc ggccctcctc
     7801 atccgcggcg gccacctctg cacggcggac gccgaggccc gggtgcaccc cacggggtcc
     7861 gtgctcgtcg tggacgaccg gatcgccgcc gtgggccccg acggtgacgt ggcggaggcc
     7921 gtcgcccgcc tcacccccgg tcagcgggcc ggactgcgca cactcgacgc ccggtccatg
     7981 ctcgtcatgc ccggcttcgt gaacaaccac tggcacgacc tgttcgccgt ccggctcccc
     8041 ttcaagggcg cccttcgcac cccccaggac caggccgacg agcccggctt catggccctg
     8101 ggaggggaca tcgccaaggt ctccggcggc ttcgagggat tccgccggct gaccgacgcc
     8161 ctggagcccg aggaggcacg ggccgtcgcc cggtacgccc tgtggaccca gctgcgctcc
     8221 ggcaccacca cgctcggcga cgtcggatcc gtcaaccggc ccgaggcgct ggccgacgcg
     8281 gcgctggacc tcggcatccg ctgttcggtg agcgcctggg tcggggacat ccactgcgga
     8341 ccgggcacca cgtcccccga gcgcacccgc gacaccgaca ccgaactgga gcggaccaga
     8401 aggctgctgg accggtgcgc ggcggaccgg accggccggc tgcgcgcctg gcccacggcc
     8461 ccctacctca ccaacatcag cgacgagctc ggacgcggcc tcgccgcact ctcggccgag
     8521 tacggcgtcc ccttcgccac ccacgtcggg gccctgcgcc acgaggcgga cgcggtgcgc
     8581 gcgcacttcg gcaccacgcc cctgcgcagg ctggaccggc tcgggctcct caacgaccgg
     8641 ctcatggcgg tgcactgcgc gttcgccgat gccgaggagc ggcggatgct cctcgacgcg
     8701 ggcgtccaca tcagccactc gcccgcgaag tacgggccca acggcgagtc cgcgctgacc
     8761 gagaccggcc tcatccccga gctcagacgg tccggcctgg acgtgtcgct gtccacggac
     8821 gggggcgtgt tccccgtcat gggcatggcc gaggagatgc gggcggcctg gcagatgtac
     8881 aacgagatgg cggccgacca caccaccctg cccgcgagcg aggccctggc catggccacc
     8941 cggatcgcgg cgcgcggcct cggctgggag cacgaggtcg gcagcctgga ggcgggcaaa
     9001 caggccgacc tggtcctcgt cccggtcgac gactggcgct atctgctcaa cccccgcccg
     9061 ctggaggcct acctggccct gggcggcacc cgggacgtgc acaccgtgct ggtggcgggc
     9121 cgggtcctgc tggagaacgg ccgcaccccc cacctcgacg aggacgctct gcgcgacgcc
     9181 tacctgcggg ccctgcgctc cttctccgcc cgtgccctcg gcgtcgccga gaaggacctg
     9241 accgcgctgt tcgacgacaa cccccggccg ccggcgcgcg cgagcaccgt cccggcctga
     9301 cgacccgccc gcccgcgtcc cgcgcacgct ccttcattcc cgtgtcccgt acggaggtgg
     9361 cgccaccatg cccgacaaca ccgccctgct gctcgccgag gacgaggggg ccgccctctc
     9421 cctggccgag ttacgccgat ggcgtgcgct gcccgcccgg cagcagcccg actggctcga
     9481 ccacccggaa ctcgacccca cacgtgaact cctcgccgcg cggcccgcgc tggtcacggg
     9541 tgacgaggtc gccacgctcc gcctcctgct ggccgaggtc gcccagggcc gctgccaggt
     9601 ggtccaggcg ggcgactgcg ccgaggaccc ggcggagtgc gcggccggac ccgtctcccg
     9661 caaggccgac ctgctcgacc ggctcgccac ggtgatgagt tcccgctccg gggtgccggt
     9721 gctgcgggtc ggccgcatcg ccggacagtt cgccaagccc cggtcccggc ccacggagca
     9781 cgtcggggaa cgcgaactgc ccgtctaccg gggacacatg gtcaacgccc cggcacccga
     9841 cgcccgcgcc cggcgccccg cgccctcccg gatggcggtg tgctacgacg ccgccgccac
     9901 ggccgtggac accctgcgcc tgcgccgcac cggcgacccg gccgcgccgg actcccgggt
     9961 ctggaccagc cacgaggcgc tcgtcctcga ctacgaactg ccgctgacgc gccgcgacca
    10021 cgccggccgg ctgttgctga cctccaccca ctggccgtgg atcggcgagc gcacccgaca
    10081 ggccgacggg gcgcacgtac gcctgctcgc cgccgtggac aaccccgtcg cctgcaaggt
    10141 cggaccgtcc gccgcggtgg acgacctgct gcgcctgtgc gggctgctcg accccggacg
    10201 gacgcccggc aggctcacgc tgatcgcccg gatgggcgcc gaggccgtca ccgcgcggct
    10261 gcccgccctg gtgtccgccg tacgggccgc ggggcatccg gtcagctggc tgtccgaccc
    10321 gatgcacggc aacaccgtca gcacgcccgg agggctgaag acacggcgcg tcgacacgat
    10381 cgtcgccgag gtcgtccgct tccaggaggc cgtctcggcg gccggcggcg tcgccggggg
    10441 cctccatctg gagacgaccc cgcacgccgt gaccgaatgc gtggcggacg ccatcggaca
    10501 ggaccggctg gacggcgcct acacgacgct ctgcgacccg cgcctcaacc cggggcaggc
    10561 ccacgccgtg gtctccgcgt ggcggggcca ggacctatga cgcacgacga cacgagcgga
    10621 ggacttccca tgaaggacac gatcgcggtg gtgaccggtg cggcgggagg catcggcgcg
    10681 gcggtggccg aggcgctcgc cgtacgcggg gcgtcggtcg ccctgctgga ccgggacgcc
    10741 gatcggctgg cggtggtggc caaggagctg acctcggccg ggcaccgggc gacggccttc
    10801 ccggccgacg tcacctcagg ccaggacgtc gaggcggtga tcgaggcggt cgaggagcgc
    10861 ctcggcccgg tcgaccggct cgtcaacgcc gccggggtgc tgcgcaccgg gcccgcgcac
    10921 gagttcgcgg acgaggactg ggaggcgacg ttcgccgtca acaccaccgg ggtgttccac
    10981 gtgtcccgcg ccgtcgtacg ccggatgcgg acgcggcggc gcggtgccct ggtcaccatc
    11041 gcctccaacg ccgccggctc cgcccgcacc gagatggccg cgtacgcggc gtcgaaggcc
    11101 gcggcgtcca tgttcaccaa gtgcctcggg ctggagaacg ccgcgtacgg catccgctgc
    11161 aacgtggtcg cccccggctc gaccgacacc cccatgctca ccgcgctgtg ggacgacgcg
    11221 tccgccgccg acgcctcgat cgcgggcgtc ccggaggcgt accgcgtcgg catcccgctg
    11281 gcgaaactgg cccgcccgaa ggacgtcgcc gacgcggtgc tgttcctgct gtccgaccag
    11341 gcctcgcaca tcaccatgca ccacctcacc gtcgacggcg gggccacgct cggcgcgtga
    11401 gcccgccccg gaaaggagcc ggttgtggcc atccccacga tcgagccgta cccgatgccc
    11461 acccagggcg atctgccggc caacacggcc tcgtggtccg tggatccgtc gcgcgcggtc
    11521 ctgctggtgc acgacatgca gtactacttc ctgcggccgt tccccgcggg cgcgtcgccc
    11581 gtggacgcac tgctcggcaa cgccgtccgg ctccggcaga cctgcgcccg gctgggcgtc
    11641 cccgtcgcct acaccgccca gccgggcgac atgaccgagg aacagcgcgg cctgctcaag
    11701 gacttctggg gaccgggcat gtccgccgga ccgcgcgacc gcgccgtcgt ggacgaactc
    11761 gcgccgggcc ccgacgacac ggtgttcacc aagtggcggc cgagcgcctt cttccgtacg
    11821 ggcctgctgg acctcctgcg ggacaccggg cgggaccagc tcatcgtgtg cggtgtgtac
    11881 gcccacgtcg gcatcctcat gacgaccggt gaggcctgcg cccacgacat ccagaccttc
    11941 gtcgtggggg acgccgtcgc cgacttcacc ccggccgacc accgcatgac cctggagtac
    12001 gtcgccaccc ggtgcggcat gaccgtgacc acgaagaccg tgctgcggca gctggaggag
    12061 gcgagcggca catgaacccc ggtgcccccg aggcgttcgc gggcggaccg gacccgctgc
    12121 tgcggcggat cctggacggc gaaccgccgc cgttcgccct ggtgcaccgg ccgcggacca
    12181 ccgggcccga ccggctcgaa ctgatggtgg gcacgctctc gcggcccggt tcgctcgccg
    12241 gactgcccct gccgcagggc cccggcacct cacggcacga cgtcctcgcc gtcctgccct
    12301 accggctgct ggccgaacgc ggctacacct gcccggacga cggcaccccc ctgctcgccc
    12361 tcacgatcga ggagcaacgc ctcctgtccc gccgggagtt cctccggcac gtcccggacc
    12421 tgcccctgcg gatggccgag cacggcttcg acctcgacga cgacgcgtac gcccggacgg
    12481 cgggccggat catccgggac gagatcggac gggggaccgg cgccaacttc gtcttccggc
    12541 gcacctaccg ggcggacctg gcggactggg gcgtgaccgc ggccctggcg ttcttccggc
    12601 gcctcctgcg gcgggagtcc ggcgcctact ggacgttcct gatccacacg ggcgaccgct
    12661 gcctcgtcgg cgccaccccg gaacagcatg tggcgctgtc cggcggggcc gtgacgatga
    12721 acccgatcag cggcacctac cgctatccgg agagcggcgc cgaccccgag ggggtgctgg
    12781 acttcctccg ggacaccaag gagtcggacg aactgttcat ggtcctcgac gaggaactga
    12841 agatgatggg ccgggtgtgc caccgcgggg gccgggtccg cggcccgtac ctcaaggaga
    12901 tggagcgcct cgcgcacacc gagtacgtca tcgaggggtc cagcggccgg ggcgtgcgcg
    12961 acctcctccg cgagacgatg ttcgcgccga ccgtgaccgg gagcccgctg gagagcgcct
    13021 gccgggtcat cggcacgtac gaaccccacg gacgcggcta ctacagcggg gtggccgccc
    13081 tcatcggccg ggacgccgac ggcggtaccg tcctggactc ctcgatcctc atccgcaccg
    13141 ccgacatcga ccggacgggg agcctctccc tcggcgtcgg cgccaccctc gtccggcact
    13201 cctccccacg ggccgaggtg gccgagaccc acgcgaaggc cgccggactg ctctccgccc
    13261 tgcgcgccgc acccgacacc gggcccacgg cgggagccgg caccggggcc ccggcgcgcg
    13321 gaccgggact gcgggaccac ccggacgtgc gggccgcgct ggcgggccgc aacgccaccc
    13381 tggccgactt ctggctggcg gaccccgacg gccgggccga gcccgtggac cggctggccg
    13441 gacggcggct gctcgtcgtg gacggcgagg acaccttcac ctccatggcc cggcactgcc
    13501 tcgccgcgct gggcctggac gtgacggtgc gccgcttcga cgagccgtac acgctcgacg
    13561 gccaggactt cgtgatcgtg gggcccggcc ccggggaccc ggcccggcac accgacccca
    13621 agatcgccca cctgcgtgac ctcaccgggc gcctgctgcg ctcccggacg ccgttcctcg
    13681 cggtgtgcct gggccaccag gtgctcagct cgctgctggg actggacctc gtgcgcagac
    13741 cggagcccaa ccagggctcc cagcagaaga tcgacttctt cggacggccg gaactcgtcg
    13801 gcttctacaa cacgttcgcc gcgcgctcgc ccggtgcccc gctgtcctgc ccgtaccggg
    13861 gcggggcggt ccgggtctgc cacgatccgg gcggcggcga ggtgcacgcg ctgcgcggtc
    13921 ccggatacgc ctccgtgcag ttccacccgg cgtccgtcct gacgcgcaac gggaccgccc
    13981 tcctgcgtga cctcctgctc ggcacggtgc gggacggctt cccgccggag gcccggggcg
    14041 cgtga
//
