BGC0001445: leporin B biosynthetic gene cluster from Aspergillus flavus NRRL3357
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Location: 704,693 - 736,312 nt. (total: 31,620 nt).
This entry is originally from NCBI GenBank EQ963479.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001445
Short description leporin B biosynthetic gene cluster from Aspergillus flavus NRRL3357
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
EQ963479.1
704693 - 736312
via Knock-out studies
Compounds
  • leporin B
Species Aspergillus flavus NRRL3357 [taxonomy]
References
Chemical products information
leporin B Evidence: NMR, Mass spectrometry
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C22H25N1O3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFLA_066840
  • EED49862.1
 704693 - 716533 (-) hybrid PKS/NRPS enzyme, putative
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    • AFLA_066850
    • EED49863.1
    		 716818 - 717296 (+) conserved hypothetical protein
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      • AFLA_066860
      • EED49864.1
      		 717626 - 719404 (-) conserved hypothetical protein
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        • AFLA_066870
        • EED49865.1
        		 719479 - 719901 (-) conserved hypothetical protein
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          • AFLA_066880
          • EED49866.1
          		 720534 - 722044 (+) monocarboxylate transporter, putative
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            • AFLA_066890
            • EED49867.1
            		 722643 - 724554 (-) cytochrome P450, putative
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              • AFLA_066900
              • EED49868.1
              		 726830 - 729366 (+) conserved hypothetical protein
              • Regulation
              • Heterologous expression
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              • AFLA_066910
              • EED49869.1
              		 730081 - 731221 (-) conserved hypothetical protein
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                • AFLA_066920
                • EED49870.1
                		 731458 - 732722 (+) alcohol dehydrogenase, putative
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                  • AFLA_066930
                  • EED49871.1
                  		 732934 - 734586 (-) cytochrome P450, putative
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                    • AFLA_066940
                    • EED49872.1
                    		 734919 - 736312 (+) O-methyltransferase, putative
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      1
                      Type
                      pks-modular
                      Genes
                      AFLA_066840
                      Substrates
                      Integrated Monomers
                      Domains
                      acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, methyltransferase
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Removed gene names of 'No gene ID'
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2018-08-06
                      Submitted
                      • (ID: YBVE4IRPJQLTEDBWA2WPXAKO)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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