Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001445.1:
Cluster 1NRP / Polyketide131620

BGC0001445, leporin biosynthetic gene cluster from Aspergillus flavus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Leporin B
SMILES string: Copy to clipboard
Molecular formula: C22H25NO3
Exact molecular mass: 351.1834 Da (M+)
Molecular activity: Siderophore, Other

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (cyclic)
Thioesterase type:
Unknown
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
No gene ID (EED49862.1)
Module 2
A specificity: None
Evidence for specificity: None
C domain subtype: LCL
Module is iterated
Evidence for iteration: Unknown
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
Iterative PKS subtype:
Partially reducing
5
Thioesterase type:
Unknown
Release / cyclization type:
Unknown

Modular polyketide synthases:
No gene ID (EED49862.1)
Module 1
AT specificity: None
Evidence for specificity: None
KR stereochemistry: Unknown
Scaffold-modifying domain: Methylation
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

leporin (BGC0001445). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank EQ963479, positions 704693-736312. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Jeff Cary (USDA-ARS-SRRC)

Literature references

1. Cary JW et al. (2015) An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS-NRPS is necessary for synthesis of the 2-pyridones, leporins. Fungal Genet Biol 81:88-97. doi: 10.1016/j.fgb.2015.05.010. Epub 2015