BGC0001445: leporin B biosynthetic gene cluster from Aspergillus flavus NRRL3357
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Location: 704,693 - 736,312 nt. (total: 31,620 nt).
This entry is originally from NCBI GenBank EQ963479.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001445
Short description leporin B biosynthetic gene cluster from Aspergillus flavus NRRL3357
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: EQ963479.1
Compounds
  • leporin B
Species Aspergillus flavus NRRL3357 [taxonomy]
References
Chemical products information
leporin B
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C22H25N1O3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFLA_066840
  • EED49862.1
 704693 - 716533 (-) hybrid PKS/NRPS enzyme, putative
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  • AFLA_066850
  • EED49863.1
 716818 - 717296 (+) conserved hypothetical protein
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  • AFLA_066860
  • EED49864.1
 717626 - 719404 (-) conserved hypothetical protein
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  • AFLA_066870
  • EED49865.1
 719479 - 719901 (-) conserved hypothetical protein
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  • AFLA_066880
  • EED49866.1
 720534 - 722044 (+) monocarboxylate transporter, putative
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  • AFLA_066890
  • EED49867.1
 722643 - 724554 (-) cytochrome P450, putative
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  • AFLA_066900
  • EED49868.1
 726830 - 729366 (+) conserved hypothetical protein
  • Regulation
Heterologous expression
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  • AFLA_066910
  • EED49869.1
 730081 - 731221 (-) conserved hypothetical protein
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  • AFLA_066920
  • EED49870.1
 731458 - 732722 (+) alcohol dehydrogenase, putative
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  • AFLA_066930
  • EED49871.1
 732934 - 734586 (-) cytochrome P450, putative
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  • AFLA_066940
  • EED49872.1
 734919 - 736312 (+) O-methyltransferase, putative
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
AFLA_066840 Synthase subclass: Iterative type I
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 5
Module 1
Genes: AFLA_066840
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass N/A
Cyclic? yes
NRP-synthases
Gene Modules
AFLA_066840
Module 2
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: YBVE4IRPJQLTEDBWA2WPXAKO, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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