Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001446.1:
Cluster 1Polyketide115813

BGC0001446, asparasone biosynthetic gene cluster from Aspergillus flavus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: asparasone A
PubChem ID: 10808295
SMILES string: Copy to clipboard
Molecular formula: C18H14O8
Average molecular mass: 358.302 Da
Molecular activity: Other

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
Iterative PKS subtype:
Non-reducing
Number of iterations:
8
Other
Thioesterase type:
Unknown
Release / cyclization type:
Unknown

Modular polyketide synthases:
No gene ID (EED57518.1)
Module 1
AT specificity: None
Evidence for specificity: None
Scaffold-modifying domain: None
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

asparasone (BGC0001446). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank EQ963472, positions 2642293-2658105. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Jeff Cary (USDA Souther Regional Research Center)

Literature references

1. Cary JW et al. (2014) Functional characterization of a veA-dependent polyketide synthase gene in Aspergillus flavus necessary for the synthesis of asparasone, a sclerotium-specific pigment. Fungal Genet Biol 64:25-35. doi: 10.1016/j.fgb.2014.01.001. Epub 2014
2. Malysheva SV et al. (2014 TI) Identification of novel metabolites from Aspergillus flavus by high resolution and multiple stage mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 31(1):111-20.