BGC0001449: ucs1025a biosynthetic gene cluster from Thermothelomyces thermophilus
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Location: 1,175,000 - 1,217,500 nt. (total: 42,501 nt).
This entry is originally from NCBI GenBank CP003004.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001449
Short description ucs1025a biosynthetic gene cluster from Thermothelomyces thermophilus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Genetic and biochemical analysis revealed a a new strategy used by nature to construct heterocyclic alkaloid-like ring systems using assembly line logic."
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
  • Alkaloid (Pyrrolizidine)
Loci NCBI GenBank: CP003004.1
Compounds
  • ucs1025a
Species Thermothelomyces thermophilus [taxonomy]
References
Chemical products information
ucs1025a [synonyms: ucs 1025a, ucs-1025a]
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C20H25N1O5
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MYCTH_2303693
  • AEO57479.1
 1175898 - 1176863 (-) hypothetical protein
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  • MYCTH_2303695
  • AEO57480.1
 1179001 - 1180827 (+) hypothetical protein
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  • MYCTH_68164
  • AEO57481.1
 1181825 - 1194022 (-) PKS-NRPSs
  • Scaffold biosynthesis
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  • MYCTH_50128
  • AEO57482.1
 1195042 - 1195934 (+) methyltransferase-like protein
  • Unknown
Sequence-based prediction
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  • MYCTH_115957
  • AEO57483.1
 1197173 - 1198357 (+) 2OG-Fe(II) oxygenase-like protein
  • Precursor biosynthesis
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  • MYCTH_2303701
  • AEO57484.1
 1198891 - 1199634 (-) pyrroline-5-carboxylate reductase
  • Precursor biosynthesis
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  • MYCTH_2303702
  • AEO57485.1
 1200562 - 1201868 (+) Diels-Alderase
  • Tailoring (Unknown)
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  • MYCTH_2138881
  • AEO57486.1
 1202910 - 1204496 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • MYCTH_2303707
  • AEO57487.1
 1204928 - 1206041 (-) short chain dehydrogenase/reductase (SDR)
  • Unknown
Sequence-based prediction
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  • MYCTH_81364
  • AEO57488.1
 1206613 - 1208349 (+) p450
  • Tailoring (Carboxylation)
Activity assay
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  • MYCTH_2303709
  • AEO57489.1
 1209400 - 1210866 (-) hydrolase
  • Unknown
Sequence-based prediction
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  • MYCTH_50920
  • AEO57490.1
 1211983 - 1213963 (+) general substrate transporter
  • Transport
Sequence-based prediction
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  • MYCTH_48716
  • AEO57491.1
 1215630 - 1217022 (+) enoylreductase
  • Scaffold biosynthesis
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Claisen condensation
Polyketide-synthases
Genes Properties Modules
MYCTH_68164
+
MYCTH_68164 		Synthase subclass: Iterative type I
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 6
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: MYCTH_68164
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Inactive
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Reductive release
NRP-synthases
Gene Modules
MYCTH_68164
Module 2
Specificity: 3S-methylproline
Evidence for specificity:
  • Feeding study
Condensation domain type: Starter
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: LETUUHCEOV6XPKOFSNBTL3D3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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