LOCUS       BGC0001453              7234 bp    DNA     linear   BCT 02-MAY-2018
DEFINITION  Streptomyces argillaceus genomic DNA containing Desferrioxamine
            biosynthesis gene cluster region, strain ATCC 12956.
ACCESSION   BGC0001453
VERSION     BGC0001453
KEYWORDS    .
SOURCE      Streptomyces argillaceus
  ORGANISM  Streptomyces argillaceus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 01:46:01
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7234
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1050
                     /gene_functions="transport (smcogs) SMCOG1033:iron compound
                     ABC transporter, periplasmic (Score: 95.2; E-value:
                     5.5e-29)"
                     /gene_kind="transport"
                     /locus_tag="desaE"
                     /product="ABC_transporter_substrate-binding_protein"
                     /transl_table=1
                     /translation="MSNARATHLTRRGILAAGGALGLGAVLAACGDDAPGSGDAKSTEN
                     AAAKSGPWTFKDDRGTTVKLDAIPANIVAFTGVAAALHDYGVQVKGVFGPTKTTDGKAD
                     VQAGDMDVSKVEILGNVWDEFNVEKYAALAPDVLVSTMFDNAGTLWYVPEASKDKIAKL
                     APSVAVSVYDRQLTAPLERMWELAESLGADMTAAKVTDAKKRFETAATRLRAAAKAKPD
                     IKVMAGSASDQLFYVSGTNLSIDLEYFKSLGVNFVEPPESAKAVGGGWYESLSWENVDK
                     YQADIIMMDDRSSTIQPADITKPTWKQLPAVKAGQVIARSPEPILSYDKCVPLLETLAE
                     ALEKAKKVA"
     source          1..7234
                     /culture_collection="ATCC:12956"
                     /db_xref="taxon:41951"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces argillaceus"
                     /strain="ATCC 12956"
     misc_feature    <1..>7234
                     /note="genomic DNA containing Desferrioxamine biosynthesis
                     gene cluster region; gene boundaries, coding regions and
                     loci partiality not recorded"
     subregion       1..7234
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7234
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             1440..1997
                     /gene_functions="other (smcogs) SMCOG1200:vibriobactin
                     utilization protein ViuB (Score: 171; E-value: 4.4e-52)"
                     /gene_kind="other"
                     /locus_tag="desaF"
                     /product="siderophore-interacting_protein"
                     /transl_table=1
                     /translation="MRSYTLRELRRDPDEIDVDFVLHTPAGPASAWAGRACAGDRVLPL
                     GPAVADNRAIRFRPPDDTDLVLLWGDETALPAIASVLASPPAGRRVRAWLEVRDARSAR
                     HLATSADAEISWPADGTCLDVLRAAPLPPAERPYAWTAGESGSVKALCRHFVREWGIDR
                     RRVTFVGYWRQGMTEEQLRAAG"
     CDS             2172..3614
                     /NRPS_PKS="Domain: Aminotran_5 (139-265). E-value: 1.8e-09.
                     Score: 28.8. Matches aSDomain:
                     nrpspksdomains_desaA_Aminotran_5.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180:Decarboxylase, pyridoxal-dependent (Score: 391.1;
                     E-value: 1.1e-118)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="desaA"
                     /product="pyridoxal 5-phosfate
                     (PLP)-dependen_lysine_decarboxylase"
                     /transl_table=1
                     /translation="MRSHLLNDTNAERYRRSVTEGVERVAAKLAATDRPFTGVTVDALA
                     PRIEDIDLDRPLGDTTAVLDELEEVYLRDAVYFHHPRYLAHLNCPVVIPAVLGEAVLSA
                     VNSSLDTWDQSAGGTLIERKLVDWTAARIGLGPAADGVFTSGGSQSNLQALLLAREEAK
                     TGSLEKLRVFASDVSHFSVKKSAKLLGLGQDAVVSIPVDHDKRMQTVALARELQRCEEA
                     GLVPMAVVATAGTTDFGSIDPLPEIAELCERYGAWMHVDAAYGCGLLASVKYRGRIDGI
                     ERADSVTVDYHKSFFQPVSSSAVLVRDAATLRHATYHAEYLNPRRMVQERIPNQVDKSL
                     QTTRRFDALKLWMTLRTMGADGIGQLFDEVCDLAARGWELLAADPRFDVVVEPSLSTLV
                     FRYVPRAVTDPAEIDRANLHARKALFASGDAVVAGTKVSGRHYLKFTLLNPETTVDDMA
                     AVLELIAGHAEQYLGESLDRAS"
     aSDomain        2589..2966
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_desaA_Aminotran_5.1"
                     /evalue="1.80E-09"
                     /label="desaA_Aminotran_5.1"
                     /locus_tag="desaA"
                     /protein_end="265"
                     /protein_start="139"
                     /score="28.8"
                     /tool="antismash"
                     /translation="DGVFTSGGSQSNLQALLLAREEAKTGSLEKLRVFASDVSHFSVKK
                     SAKLLGLGQDAVVSIPVDHDKRMQTVALARELQRCEEAGLVPMAVVATAGTTDFGSIDP
                     LPEIAELCERYGAWMHVDAAYG"
     CDS             3598..4890
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 417.7;
                     E-value: 7.5e-127)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="desaB"
                     /product="FAD-dependent monooxygenase"
                     /transl_table=1
                     /translation="LTARPENPAATHDLVGIGLGPFNLGLACLTEPIDALNGVFLESKP
                     DFEWHAGMFLDGAHLQTPFMSDLVTLADPTSPYSFLNYLKEKGRLYPFYIRENFYPLRV
                     EYDDYCRWAAGKLSSVRFSTTVAEVTYDEGTELYAVRTTDGEEYRAPHLVLGTGTVPFV
                     PEACRGLEDGVLHTSQYMHRKAELRGKKSITVVGSGQSAAEIYHELLCEIDVHGYQLNW
                     VTRSPRFFPLEYTKLTLEMTSPDYIDYFRALPEETRYRLEKQQKGLFKGINSELIDAIF
                     DLLYQKNVESGGRGVPTRLLTNSSLTSARQEDGGYTLGFHQDEQDKDFEIRTEGLVLAT
                     GYHYEPPAFLDPIRDRLRFDAHGRFDVTRDYAIDVTGRGVFLQNAGVHTHSVTSPDLGM
                     GPYRNSCIIRELLGSEYYPVEKTIAFQEFGA"
     CDS             4887..5438
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     145.7; E-value: 4.4e-44)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="desaC"
                     /product="N-acetyltransferase"
                     /transl_table=1
                     /translation="MNTTAAVGRLTFRPLDPPKDAELLHSWVTHPKAAFWMMQDATPAD
                     VERAYAEIAADEHHHALLGLHDGTPAFLMEHYDPRHRELVGLYEPRPGDVGMHFLVAPT
                     DRPVHGFTRAVITAVVARLFQDPAVERVVVEPDVSNKAVHALNEAVGFVPEREIDKPEK
                     KALLSFCTRERFAAATGVDA"
     CDS             5435..7234
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /locus_tag="desaD"
                     /product="NTP-dependent siderophore synthetase"
                     /sec_met_domain="IucA_IucC (E-value: 7.8e-82, bitscore:
                     263.1, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="VSLADAVAHLSPERWEEANRLLVRKALAEFAHERLITPEPVSGPT
                     GGQDGRNEQYVVRSDDGLTSYRFTAVRRALDHWQVDADSITRTRDGAALPLAALDFLIE
                     LRGTLGLSDEILPVYLEEISSTLSGTCYKLTKPRLTAAELLEGGFQAIESGMTEGHPCF
                     VANNGRLGFGVHEYLAYAPETASPVRLVWLAAHRSRAAFTAGAGIDYASFVRQELGEET
                     VERFDGVLRGRGLDPADYLLIPVHPWQWWNKLSVTFAAEVARQNLVCLGEGDDEYLAQQ
                     SIRTFFNATHPEKHYVKTALSVLNMGFMRGLSAAYMEATPAINDWLDRLIDSDPVLKST
                     GLSIIRERAAVGYRHLEYEAATDRYSPYRKMLAALWRESPVPSLRDGESLTTMAALVHV
                     DHEGRSVAGALVERSGLDPAEWLRHYLRAYYTPLLHSFYAYDLAFMPHGENTILVLKDG
                     VVQRAVYKDIAEEIVVMDPDAVLPPEVRRVRAEVPEDMKLLSIFTDVFDCFFRFLAAGL
                     AAEGILAEDGFWRTVAEVSREYQEAHPELDDRFRQYDLFAPEFALSCLNRLQLRNNRQM
                     VDLSDPSGALQLIGTLKNPLAGL"
ORIGIN
        1 atgtccaacg ccagagccac tcacctcacc cgtcgcggca tcctcgccgc cggtggcgcc
       61 ctcggtctcg gcgccgtgct cgcagcctgc ggggacgacg ccccggggag cggtgacgcg
      121 aagtcgacgg agaacgccgc cgccaagtcc ggcccctgga cgttcaagga cgaccgcggg
      181 accaccgtga agctcgacgc gatcccggcg aacatcgtcg cgttcaccgg cgtcgcggcc
      241 gccctccacg actacggcgt ccaggtcaag ggcgtcttcg gcccgacgaa gaccaccgac
      301 ggcaaggcgg acgtccaggc cggcgacatg gacgtcagca aggtcgagat cctcggcaac
      361 gtctgggacg agttcaacgt cgagaagtac gcggccctcg cgcccgacgt gctcgtctcg
      421 acgatgttcg acaacgccgg caccctctgg tacgtccccg aggcctccaa ggacaagatc
      481 gccaagctgg ccccgagcgt cgccgtctcc gtctacgacc ggcagctcac cgctcccctg
      541 gagcgcatgt gggaactggc cgagtccctc ggcgcggaca tgaccgccgc caaggtcacc
      601 gacgccaaga agcgcttcga gaccgccgcc acccggctgc gcgccgccgc caaggccaag
      661 cccgacatca aggtcatggc cggttccgcg agcgaccagc tgttctacgt ctccggcacg
      721 aacctctcca tcgacctgga gtacttcaag tccctcggcg tgaacttcgt cgagccgccg
      781 gagagcgcca aggccgtggg cggcggctgg tacgagtcgc tgagctggga gaacgtcgac
      841 aagtaccagg ccgacatcat catgatggac gaccgttcct cgacgatcca gccggccgac
      901 atcaccaagc cgacgtggaa gcagctcccc gcggtgaagg ccgggcaggt catcgcccgc
      961 tcgcccgagc cgatcctgtc gtacgacaag tgcgtgccgc tgctggagac cctcgccgag
     1021 gcgctcgaga aggcgaagaa ggtcgcctga cgaggcggcc cggggcccgc gcccacgcgg
     1081 tcgaaccgct cgggcacggg cccgcccccg aaggaaggcc ggctgcccct cccccgttcc
     1141 aggagcccgc gtgaccacgg ccgtcgccgc cccgttccgt ttcttcgcgc tgcacgtcgt
     1201 acggacgagg cggctcggtc cgtccctggt ccgggtgagt ttcgccgggg aggacctgcg
     1261 gcacttcctc tccgacggcc gggaccagtc cctgtcgctg ttcctgccgc atccggggca
     1321 ggacgcgccg gtcgtccccg tcgaactcgg atgggggtcc cccccgctcg agcgcagccg
     1381 agagtggggg agggtggtgg cagggctggc gcgaactgcc ggacggcgta cgggcggtga
     1441 tgcgttcgta cacgctgcgg gagctgcgca gggaccccga cgagatcgac gtcgacttcg
     1501 tgctgcacac cccggccggg cccgcctccg cgtgggccgg ccgggcgtgc gccggtgacc
     1561 gggtgctgcc gctcggcccc gcggtcgccg acaaccgggc gatccggttc cggccgccgg
     1621 acgacaccga cctggtgctg ctgtggggcg acgagacggc cctgccggcg atcgcgtccg
     1681 ttctcgcgtc gccgcccgcc ggacggcgcg tccgggcgtg gctggaggtg cgcgacgccc
     1741 ggagcgcgcg gcacctggcg acctcggcgg acgccgagat ctcctggccg gccgacggga
     1801 cctgtctcga cgtcctgcgc gcggcaccgc tcccgcccgc cgagcggccg tacgcctgga
     1861 ccgcgggcga gtcggggtcg gtgaaggcgc tgtgccggca cttcgtgcgg gagtggggca
     1921 tcgacagacg ccgggtcacc ttcgtcgggt actggcgtca gggcatgacg gaggaacagc
     1981 tgcgcgcggc cggctgatca accacccttc cgggcaagga agttgaccgg caaagcaaac
     2041 gtgacgaccg tcaccggggg atggcgtttc gttcacgtca cttaggttag gctaacctaa
     2101 gaaaaaatcg aggctccgct tccgcgtccg ccccgcggcg gacccgtccc catccccgga
     2161 ggacccccac gatgcgctcg cacctgctca atgacacgaa cgcggagcgg taccgccgct
     2221 ccgtgaccga aggagtcgag cgggtggccg ccaaactcgc cgccaccgac cgtccgttca
     2281 ccggcgtcac ggtcgacgcc ctcgcccccc gcatcgagga catcgacctc gaccggccgc
     2341 tgggcgacac cacggcggtg ctggacgagc tggaggaggt ctacctccgc gacgcggtct
     2401 acttccacca cccccgctac ctcgcccacc tcaactgccc ggtcgtcatc ccggccgtgc
     2461 tcggcgaggc ggtcctgtcc gccgtcaact cctccctgga cacctgggac cagtcggcgg
     2521 gcggcaccct catcgagcgg aagctggtcg actggacggc cgcccgcatc ggcctcggcc
     2581 ccgccgccga cggtgtgttc acctccggcg gcagccagtc caacctccag gcgctgctcc
     2641 tcgcccgcga ggaggccaag accggctccc tggagaaact gcgcgtcttc gcctccgacg
     2701 tcagccactt cagcgtgaag aagtcggcga aactgctggg cctgggccag gacgcggtgg
     2761 tctccattcc cgtcgaccac gacaagcgca tgcagaccgt cgccctcgcc cgggaactcc
     2821 agcgctgcga ggaggccggc ctcgtcccca tggccgtcgt cgccaccgcc ggcaccaccg
     2881 acttcggctc catcgacccg ctgcccgaga tcgccgagct gtgcgagcgg tacggcgcct
     2941 ggatgcacgt cgacgccgcc tacggctgcg ggctgctcgc ctcggtgaag taccgcggcc
     3001 gcatcgacgg catcgaacgc gccgactccg tcaccgtgga ctaccacaag tccttcttcc
     3061 agccggtgag ttcctcggcc gtcctggtcc gggacgcggc cacgctgcgc cacgccacct
     3121 accacgccga gtacctgaac ccccgccgca tggtgcagga acgcatcccc aaccaggtcg
     3181 acaagtccct ccagaccacc cgccgcttcg acgcgctgaa actgtggatg acgctgcgca
     3241 cgatgggcgc cgacggcatc ggccagctgt tcgacgaggt ctgcgacctc gcggcccggg
     3301 gctgggaact gctcgccgcc gacccgcgct tcgacgtcgt cgtcgagccg tcgctgtcca
     3361 ccctggtctt ccgctacgtc ccgcgggccg tcaccgaccc ggccgagatc gaccgcgcca
     3421 acctccacgc ccgcaaggcc ctgttcgcct ccggcgacgc ggtggtggcg ggcaccaagg
     3481 tgagcggccg ccactacctg aagttcaccc tgctgaatcc cgagacgacg gtcgacgaca
     3541 tggccgccgt cctcgaactg atcgccggcc acgccgagca gtacctggga gagtcccttg
     3601 accgcgcgtc ctgaaaaccc cgccgccacg cacgacctcg tcgggatcgg gctcggcccc
     3661 ttcaatctcg gcctcgcctg cctgaccgag cccatcgacg cgctgaacgg cgtcttcctg
     3721 gagtccaagc ccgacttcga gtggcacgcg ggcatgttcc tcgacggcgc ccacctgcag
     3781 acgccgttca tgtcggacct ggtcaccctc gccgacccga cctcgccgta ctccttcctc
     3841 aactacctga aggagaaggg ccggctgtac ccgttctaca tccgcgagaa cttctacccg
     3901 ctgcgcgtgg agtacgacga ctactgccgc tgggccgccg gcaagctgag cagcgtgcgc
     3961 ttctcgacga cggtcgccga ggtgacgtac gacgagggca ccgagctgta cgccgtgcgg
     4021 accacggacg gcgaggagta ccgcgccccc cacctggtcc tgggaaccgg caccgtgccg
     4081 ttcgtccccg aggcgtgccg cggcctggag gacggcgtcc tgcacacctc gcagtacatg
     4141 caccgcaagg cggagctgcg ggggaagaag tcgatcaccg tggtcggcag cgggcagagc
     4201 gccgccgaga tctaccacga gctgctctgc gagatcgacg tccacggcta ccagctcaac
     4261 tgggtcaccc gctccccgcg gttcttcccg ctggagtaca ccaagctgac cctggagatg
     4321 acctccccgg actacatcga ctacttccgc gcgctgcccg aggagacccg ctaccggctg
     4381 gagaagcagc agaagggcct gttcaagggc atcaactcgg agctgatcga cgcgatcttc
     4441 gatctgctgt accagaagaa cgtcgagagc ggcggccgcg gcgttcccac ccggctgctc
     4501 accaactcct cgctgacctc cgcgcggcag gaggacggcg gctacacgct cggcttccac
     4561 caggacgaac aggacaagga cttcgagatc cgcaccgagg gcctggtgct ggccaccggc
     4621 taccactacg agccgccggc cttcctcgac ccgatccgcg accggctccg cttcgacgcg
     4681 cacggccgtt tcgacgtgac ccgcgactac gcgatcgacg tcaccggccg gggcgtcttc
     4741 ctgcagaacg ccggcgtcca cacgcacagc gtcaccagcc ccgacctcgg catgggcccc
     4801 taccgaaaca gctgcatcat ccgcgagctg ctcggcagcg agtactaccc ggtcgagaag
     4861 accatcgcgt tccaggagtt cggagcatga acacgaccgc ggccgtcggc cgtctcacct
     4921 tccgcccgct cgaccccccg aaggacgccg agctgctgca ctcctgggtg acgcacccca
     4981 aggcggcctt ctggatgatg caggacgcca caccggccga cgtcgagcgc gcctacgcgg
     5041 agatcgccgc cgacgagcac caccacgccc tgctcgggct gcacgacggc acaccggcct
     5101 tcctgatgga gcactacgac ccccgccacc gcgagctggt cggcctgtac gagccgcggc
     5161 ccggcgacgt cggcatgcac ttcctggtcg cccccaccga ccggcccgtg cacggcttca
     5221 cccgcgcggt catcaccgcc gtcgtggccc gcctcttcca ggacccggcc gtcgaacggg
     5281 tggtggtcga gccggacgtc tccaacaagg ccgtgcacgc gctgaacgag gccgtcggct
     5341 tcgtccccga gcgcgagatc gacaagccgg agaagaaggc gctgctcagc ttctgcacgc
     5401 gggagcggtt cgccgccgcc acgggggtgg acgcgtgagc ctcgccgacg ccgtggccca
     5461 cctctccccc gaacgctggg aggaggccaa ccgcctgctg gtccgcaagg ccctcgcgga
     5521 gttcgcccac gagcggctga tcacccccga gcccgtgagc gggcccacgg gcgggcagga
     5581 cgggcggaac gagcagtacg tcgtccgcag cgacgacggc ctgacgtcct accgcttcac
     5641 cgccgtgcgc cgcgccctgg accactggca ggtcgacgcc gactcgatca cccgcacccg
     5701 ggacggcgcc gcactccccc tcgccgcact ggacttcctc atcgagctgc ggggcacgct
     5761 cggactgagc gacgagatcc tgccggtcta cctggaggag atctcctcca ccctctccgg
     5821 cacctgctac aaactcacca agccgcggct cacggccgcc gagctgctgg agggcggctt
     5881 ccaggccatc gagagcggca tgaccgaggg ccacccctgc ttcgtcgcca acaacgggcg
     5941 gctcggcttc ggcgtccacg agtacctggc gtacgcgccg gagaccgcga gcccggtccg
     6001 cctggtgtgg ctggcggcgc accggtcgcg ggcggcgttc acggcgggcg ccggcatcga
     6061 ctacgcgtcg ttcgtccggc aggagctggg cgaggagacc gtcgagcgct tcgacggcgt
     6121 actgcgcgga cggggcctcg acccggccga ctacctcctg atccccgtcc acccctggca
     6181 gtggtggaac aagctcagcg tcaccttcgc cgccgaggtc gcccgccaga acctggtgtg
     6241 cctcggcgag ggcgacgacg agtacctggc ccagcagtcc atccggacgt tcttcaacgc
     6301 gacccacccc gagaagcact acgtgaagac ggccctgtcc gtcctcaaca tgggcttcat
     6361 gcgcggcctg tcggcggcgt acatggaggc gaccccggcg atcaacgact ggctggaccg
     6421 gctgatcgac agcgacccgg tgctgaagtc gacgggcctg tcgatcatcc gggagcgggc
     6481 ggccgtcggc taccggcacc tggagtacga ggcggccacc gaccgctact cgccgtaccg
     6541 caagatgctg gccgcgctgt ggcgggagag ccccgtgccc tccctccgcg acggcgagtc
     6601 cctcaccacg atggccgccc tggtccacgt ggaccacgag ggcaggtcgg tggcaggcgc
     6661 actggtcgag cggtcgggcc tggaccccgc cgagtggctg cggcactacc tgcgggcgta
     6721 ctacacgccc ctcctgcact ccttctacgc ctacgacctg gccttcatgc cgcacggcga
     6781 gaacaccatc ctggtcctga aggacggtgt cgtgcagcgg gcggtctaca aggacatcgc
     6841 cgaggagatc gtcgtcatgg acccggacgc ggtgctgccg cccgaggtgc ggcgcgtccg
     6901 ggccgaggtc cccgaggaca tgaaactcct gtcgatcttc acggacgtct tcgactgctt
     6961 cttccgcttc ctcgccgccg gcctggccgc cgagggaatc ctggcggagg acggcttctg
     7021 gcgcacggtc gccgaggtct cccgcgagta ccaggaggcg caccccgaac tcgacgaccg
     7081 cttccggcag tacgacctgt tcgcccccga gttcgcgctg tcctgcctca accggctcca
     7141 gctgcggaac aaccggcaga tggtggacct gtcggacccg tcgggcgccc tccagctgat
     7201 cggcaccctg aagaaccccc tcgccggtct ctga
//
