BGC0001455: antimycin A1B biosynthetic gene cluster from Streptomyces argillaceus
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Location: 1 - 26,743 nt. (total: 26,743 nt).
This entry is originally from NCBI GenBank LT989885.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0001455
Short description antimycin A1B biosynthetic gene cluster from Streptomyces argillaceus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
LT989885.1
1 - 26743
via Correlation of genomic and metabolomic data
Compounds
  • antimycin A1B
Species Streptomyces argillaceus [taxonomy]
References
Chemical products information
antimycin A1B Evidence:
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C28H40N2O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • antaA
 1 - 519 (-) RNA_polymerase,_sigma-24_subunit
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    • antaB
    		 580 - 1971 (-) Putative acyltransferase
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      • antaC
      		 2369 - 11245 (+) NRPS
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        • antaD
        		 11238 - 15053 (+) Type I PKS
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          • antaE
          		 15124 - 16353 (+) crotonyl-CoA_reductase
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            • antaF
            		 16782 - 18266 (-) putative Acyl-CoA ligase
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              • antaG
              		 18266 - 18526 (-) acyl_carrier_protein
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                • antaH
                		 18633 - 19985 (+) phenylacetate-CoA oxigenase
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                  • antaI
                  		 19982 - 20293 (+) 1,2-phenylacetate-CoA epoxidase
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                    • antaJ
                    		 20274 - 21134 (+) phenylacetate-CoA oxigenase
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                      • antaK
                      		 21131 - 21643 (+) phenylacetate-CoA oxigenase
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                        • antaL
                        		 21652 - 22839 (+) phenylacetate-CoA oxigenase
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                          • antaM
                          		 22918 - 23709 (+) 3-oxoacyl-ACP reductase
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                            • antaN
                            		 23801 - 24649 (+) tryptophan 2,3-dioxygenase
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                              • antaO
                              		 24639 - 25487 (+) lipase
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                                • antaP
                                		 25484 - 26743 (+) kynureninase
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  antaC
                                  Substrates
                                  threonine (evidence: Structure-based inference [1])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  antaF
                                  Substrates
                                  anthanillic acid (evidence: Structure-based inference, Homology)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: next

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2023-10-05
                                  Specified compound from 'antimycin' to 'antimycin A1B', changed incorrect SMILES string, mol. formula, mol. mass. Specified BGC evidence according to linked paper. Specified locus start and end.
                                  • (ID: C62OJVVH7XOTOTFZSJT727YU)
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                                  2023-10-05
                                  Reviewed and approved changes.
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                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
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                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Updated bioactivity data
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                                  2022-09-15
                                  Added NRP substrate specificities
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                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
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                                  2019-10-16
                                  Updated reference publication(s) (MIBiG Annotathon)
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                                  2019-10-16
                                  Updated compound(s) information (NPAtlas curation)
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                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2018-08-06
                                  Submitted
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                                  Detailed domain annotation
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                                  Modifications to original record
                                  • antaA was added
                                  • antaB was added
                                  • antaC was added
                                  • antaD was added
                                  • antaE was added
                                  • antaF was added
                                  • antaG was added
                                  • antaH was added
                                  • antaI was added
                                  • antaJ was added
                                  • antaK was added
                                  • antaL was added
                                  • antaM was added
                                  • antaN was added
                                  • antaO was added
                                  • antaP was added