LOCUS       BGC0001456              9777 bp    DNA     linear   BCT 02-MAY-2018
DEFINITION  Streptomyces argillaceus genomic DNA containing Isorenieratene
            biosynthesis gene cluster region, strain ATCC 12956.
ACCESSION   BGC0001456
VERSION     BGC0001456
KEYWORDS    .
SOURCE      Streptomyces argillaceus
  ORGANISM  Streptomyces argillaceus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:36:25
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1017)
                     /locus_tag="crtaV"
                     /transl_table=1
                     /translation="MSPDRPGGRERRFPLSLRRNPVSWERQRPTWREARPAVIARALKR
                     AQARPSGNWYVVGATLDVRDDRPLARTVAGREVVVWRDAGGRLVAGPGVCPHLGAPLRD
                     SPVRCGTLVCHWHGLALRGGPFAGWEPLPVHDDGVLVWVRLDDVGGEPPLAAPVVPVRP
                     ALSGAVSAVYTGVGTCEPEDVVANRLDPWHGAWFHPYSFVDLAVVEDGTGAAADGDGFT
                     VDVSFKLAGRLVVPVRAVFTAPEPRTVVMHITEGEGRGSVVETHATPLGPDDRGRPRTA
                     VVEAIVAASDRPGFAVARSVTPLLRPLMRVAAGRLWRDDLAYAERRWHLRSTGRFPG"
     source          1..9777
                     /culture_collection="ATCC:12956"
                     /db_xref="taxon:41951"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces argillaceus"
                     /strain="ATCC 12956"
     misc_feature    <1..>9777
                     /note="genomic DNA containing Isorenieratene biosynthesis
                     gene cluster region; gene boundaries, coding regions and
                     loci partiality not recorded"
     protocluster    1..9777
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[1013:7362]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1014..7362
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..9777
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..9777
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001456"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9777
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(1014..2045)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /locus_tag="crtaB"
                     /sec_met_domain="phytoene_synt (E-value: 1.6e-121,
                     bitscore: 393.7, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTARELDAAGIAEPALRAAYTRCRLLNARHGKTYFLATRLLPVER
                     RPAVHALYGFARWADDIVDSLETDVPPHRRASALAALQEGLERGLRGGGSDDPVVLALA
                     DTARRYGIPHGHFRDFMDAMRSDLSVTDYATYDELRAYMHGSAAVIGLQMLPVLGTVVP
                     REEAAPHAAALGVAFQLTNFLRDVGEDLDRGRVYLPADLLGSHGADRDLLRWSRRTGRR
                     DHRITEALRAFEDLTRGVYREAAPGLAMLDPVARPCIRTAFVLYGGILDSVAADGYAVV
                     HRRAVVPRRRRAAVALDGLVRVAAARAAARRKAPPGASRPPAGLPGAHGTPHAPEREHE
                     EVA"
     CDS             complement(2042..3586)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 497.6; E-value: 7.6e-151)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="crtaI"
                     /sec_met_domain="DAO (E-value: 3.4e-19, bitscore: 58.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MRTVPGRTDHVVVVGAGLSGLSAALHLLGAGRRVTIVERDALPGG
                     RAGLLTRGGYRIDTGPTVLTMPDLADEAFAAVGENLRDSVDLIPLHPAYRALFADGSRI
                     DVHTDADAMEAEVERFAGPGEAAGYRRLRHWLEQLYRAQMRRFIDTNFDSPLQLLTPDL
                     ARLAALGGFGRLDARIGRHLRDERLRRVFSFQALYAGVPPARALAAYAVIAYMDTVAGV
                     YFPRGGMHAVPRAMADAAARAGADLRFGQDVVRLERSGNRVTAVVTADERIACDAVVLT
                     PELPVAYRLLGRTPRRPLRITHAPSAVVLHAGTDRTWPELAHHTLSFGAAWHRTFDELT
                     RTGELMSDPSLLITRPTATDPSLAPPGRHLHYVLAPCPNTDIGPDAAAWGELAPRYRAS
                     VLRELERRGFDGIAAAVEDETLVTPADWHAQGHAAGTPFSAAHTFAQTGPFRPRNLVRG
                     TDNVVLAGCGTTPGVGVPTVLLSGKLAAARVTGRTAAAPPSRRGRSALVTPEGTPS"
     CDS             complement(3583..4974)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 245.5; E-value:
                     1.1e-74)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="crtaE"
                     /transl_table=1
                     /translation="MRPSTARHDSAADTPSGASRAPRPGPTVTRPGHADRGPSPDSRPE
                     GAMPARFPLDVSDLSALDDDVPGAVGRLLDHLLAERAEQAAALDPVFARDLAERVRRFT
                     LDGGKRMRPRFVWWALRACGGGAGEAESALRVGAALELIQTCALIHDDVMDGSAFRRGR
                     PALHADVTAQYAGTVPSARGPRFGEAAAILAGDLALAWADDVVAATEAPAATARTVREV
                     WSAMRTEMVAGQYLDVQGQATSSRSLARAIRAACLKSALYSVERPLALGAALAGADSAR
                     TGALCSAGRCVGIAFQLRDDLLDAFGGDRRTGKPVGGDIRAGRPTYLMAVARARAEANR
                     DRGALAVLRRSVGRTDLPDSGLAEVRDVLVAVGARDTVEAKIERLVAQGMRHLDSVVLD
                     PVAGRRLTGLFHATAGTSPAAPAAPPASASAGPWDGPAAPDHDVPPPPDGGMTVPLLLT
                     EGAPR"
     CDS             5310..5930
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 104.9;
                     E-value: 6.2e-32)"
                     /gene_kind="regulatory"
                     /locus_tag="crtaQ"
                     /transl_table=1
                     /translation="MTAQQVTERTLPATAGPAQDFFTDDELAAGFIRGDEACLAAAYHR
                     WGLLVHTLARRSLGDAREAEDVTQTVFLAAWRGRSGFRPERGPLSAWLVGITRRKIADA
                     LSARTRRADLVAAAGARLSVTADDRHAQPDAVLDRVVLTHELARLPAPQRRVLTLAFYC
                     DLTQSQIAELTGWPLGTVKSHARRGLHRLGTRVREEDPQARVG"
     CDS             6172..7362
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /locus_tag="crtaY"
                     /sec_met_domain="Lycopene_cycl (E-value: 5.8e-109,
                     bitscore: 353.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MRDADVAIVGAGAAGLSLAYRLARADPARRPSVLLFEPPPGPLRP
                     PSRTWCFWEPGPGPYDAVLTAAWQRLRVHTPEGRTVEDGIAPLRYKMIRSDDFEAFVGR
                     ELARRDHVRRVEATVETVDGTADGAEIRARTADGRPLTVRARWVFDSRPLGSLPAARTT
                     LLQHFHGWFVRTARPVFDPASVDLMDFRVPQPPHGLAFGYVLPTSPREALVEYTEFSGA
                     PLTRTAYEAALDRYTHGVLGLGAFEVTATETGVIPMTDARFARRTAPSVFRIGAAGGAT
                     RPSTGYTFAAVQRQTRGVAAALAAGRRPLPPAPHSARSRAMDAVLLRALDSGRVDGAEV
                     FSSLFSRVPAERLLRFLDGRTRLHEDLSVGARTPVLPMLRSVLDLSRLPRAPFPRP"
     CDS             7418..8152
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 75; E-value: 1.1e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="crtaT"
                     /transl_table=1
                     /translation="MTLLLRDADLAAAFDHAARSYDTLVAANPGYHAHLRRSARRLGLP
                     HGGAGLRVLDLGCGTGASTAALAAVFPEARITAVDASGGMLEQAARKRWRQEVSFVHAP
                     AERLAEAGVEGPFDAVFAAYLFRNATDPDAVLAAVREALGPRGRLAVHEYTLSGRAAHR
                     AVWTAVCRGFVQPVATVLGDGELYRHLWHSVVRFDTAEAFTERVRAAGFEQVRALPLPG
                     WQTGITHTVVARRPGSDTAVGR"
     CDS             8149..9777
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 35.9; E-value: 7.3e-11)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="crtaU"
                     /sec_met_domain="DAO (E-value: 9.7e-14, bitscore: 40.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTAARRSEAARRGRDRMARTIRPRPGAPALTGDHRPTTAVVGGGI
                     AGLAAATALAERGVRVTLHEREPALGGRLAGWPTALADGSTVTMSRGFHAFFRQYYNLR
                     GLLRRTDPGLRRLRGLPDYPLRHSSGTHDSFRHVPRTPPWSALGFVALSPTFGLRDLAR
                     MNPVAALPLLDVRVPDVYTRLDDISAHDFLESVRFPEAAHHLAFEVFSRSFFADPRGLS
                     AAEMVLMFHIYFLGSAEGLLFDVPDEPFPAALWDPLAGYLEGHGAELRTGTSVEAVEPT
                     GDGGFVVAAAGEERRYDTVVLALDTAGLRSVAAGSPRLADAAWRERVAGLRNAPPFLVS
                     RLWLDRPVAADRPGFLGTSGYGSLDNVSVLERWEGEAARWAARTGGSVVELHAYALPET
                     PSRDVEQRRLLEQLHRVYPETRAARVVDARHEWRADCPLFPVGGHGERPTVRTTDPGLV
                     VAGDLVRTDLPVALMERAATSGFLAANALLERWGVAGQTLWTVPDRGRGALLRGLARAG
                     EGRRGEVARAVPTARRLSKDNIFQL"
ORIGIN
        1 tcagccgggg aagcggcccg tggaacgcag gtgccagcgg cgttccgcgt aggccaggtc
       61 gtcgcgccac aggcgtccgg cggccacccg catgagcggt cgcagcagcg gcgtcaccga
      121 acgggccacg gcgaatcccg gccggtccga ggccgccacg atcgcctcga cgaccgcggt
      181 ccgcggccgg ccccggtcgt cggggcccag cggcgtcgcg tgcgtctcga cgaccgaccc
      241 gcggccctcg ccctccgtga tgtgcatgac caccgtgcgc ggttcgggcg ccgtgaacac
      301 cgcccggacc ggcacgacca gtcgtccggc gagcttgaag gagacgtcca ccgtgaaacc
      361 gtccccgtcc gccgccgcgc cggtgccgtc ctcgaccacg gccaggtcga cgaacgagta
      421 cgggtggaac caggccccgt gccacgggtc cagccggttg gcgacgacgt cctccggctc
      481 gcatgtaccg acgcccgtgt agaccgcgga cacggcgccc gacagggccg gccggaccgg
      541 caccaccggc gccgccagcg gcggctcgcc gcccacgtcg tccagccgta cccacaccag
      601 cacaccgtcg tcgtgcacgg gcagcggttc ccagcccgcg aacggaccgc cccgcagcgc
      661 gagcccgtgc cagtggcaga ccagggtgcc gcagcgcacc ggactgtccc gcagcggtgc
      721 gcccaggtgg gggcagacac cgggtccggc gaccagccgg cccccggcgt cgcgccagac
      781 gaccacctcc cgtccggcga ccgtgcgcgc gaggggacgg tcgtcacgga cgtccagggt
      841 ggcgcccacg acgtaccagt tgccggacgg gcgtgcctgc gcacgcttca gcgcccgcgc
      901 gatcacggcg ggccgcgcct cgcgccacgt cgggcgctgc cgctcccagg acaccgggtt
      961 cctgcgcagt gacagcggga accgccgttc gcgcccgccc ggacggtcgg ggctcatgcg
     1021 acctcctcgt gctcacgttc cggcgcgtgc ggtgtgccgt gcgcgccggg cagaccggcg
     1081 ggcggccgcg acgcaccggg cggagccttc cgccgggccg cggcacgggc ggccgccacg
     1141 cggaccagac cgtcgagggc caccgcggca cgccgtcggc ggggcaccac ggcacggcgg
     1201 tggacgaccg cgtacccgtc ggcggcgacg gagtccagga tcccgccgta cagcacgaac
     1261 gcggtgcgga tgcacggacg ggccaccggg tcgagcatgg cgagacccgg tgccgcctcg
     1321 cggtacaccc cccgcgtcag gtcctcgaac gccctgagcg cctcggtgat ccggtggtcc
     1381 cgtcgcccgg tgcggcggga ccaccggagc aggtcccggt cggcgccgtg gctccccagc
     1441 aggtcggcgg gcaggtagac gcggccccgg tcgaggtcct cgcccacgtc gcgcaggaag
     1501 ttggtcagct ggaaggcgac gccgagggcc gccgcgtgcg gggccgcctc ctcgcgcggg
     1561 acgacggttc ccagcaccgg cagcatctgc agcccgatca cggccgccga gccgtgcatg
     1621 tacgcgcgca gctcgtcgta ggtggcgtag tcggtgaccg agaggtcgct gcgcatggcg
     1681 tccatgaagt cgcggaagtg cccgtggggg atgccgtacc ggcgggcggt gtcggcgagg
     1741 gcgaggacga ccgggtcgtc gctgccgccg ccgcgcagac cccgctccag cccctcctgg
     1801 agggcggcga gcgcggacgc gcggcggtgc ggcgggacgt cggtctccag cgagtcgacg
     1861 atgtcgtcgg cccagcgcgc gaaaccgtac agcgcgtgca cggccggacg ccgttccacc
     1921 ggcagcagcc gggtggccag gaagtacgtc tttccgtgcc gggcgttgag caggcggcag
     1981 cgcgtgtagg cggcgcgcag ggccggctcg gcgatgcccg ccgcgtccag ttcgcgggcg
     2041 gtcatgacgg ggttccttcc ggggtgacga gcgcggaacg cccgcgccgg gagggcgggg
     2101 ccgcggccgt gcggccggtg acgcgggccg cggcgagctt gcccgacagc aggacggtcg
     2161 gcacgccgac gcccggagtg gtcccgcagc ccgcgagcac gacgttgtcg gtgccgcgga
     2221 cgaggttgcg cgggcggaac gggccggtct gggcgaaggt gtgggcggcc gagaagggcg
     2281 tgcccgccgc gtgcccctgg gcgtgccagt cggccggcgt gaccagggtc tcgtcctcga
     2341 cggccgcggc gatcccgtcg aacccgcgcc gctccagttc ccgcagcacg ctggcgcggt
     2401 agcgcggtgc cagctcgccc caggcggcgg cgtccggtcc gatgtccgtg ttcgggcagg
     2461 gggccagcac gtagtgcagg tggcggccgg gcggggcgag ggacgggtcg gtggcggtgg
     2521 gccgggtgat cagcagcgac gggtcgctca tcagctcacc cgtacgggtg agttcgtcga
     2581 aggtgcggtg ccaggcggcg ccgaaggaga gcgtgtggtg cgcgagctcg ggccacgtcc
     2641 ggtcggtccc cgcgtgcagc acgacggccg acggcgcgtg ggtgatccgc agggggcggc
     2701 ggggcgtccg gccgagcagc cggtaggcga ccggcagctc cggggtgagg accacggcgt
     2761 cgcaggcgat gcgctcgtcc gcggtgacga cggcggtgac ccggttgccg gagcgctcca
     2821 gccggacgac gtcctgcccg aaccgcaggt ccgcgccggc ccgcgcggcg gcgtcggcca
     2881 tggcgcgcgg caccgcgtgc atgccgccgc gcgggaagta cacgccggcg acggtgtcca
     2941 tgtaggcgat gaccgcgtac gcggcgaggg cgcgggccgg cgggacgccc gcgtacagcg
     3001 cctggaagga gaagacccgg cgcagccgtt cgtcgcgcag gtggcggccg atgcgcgcgt
     3061 cgagccggcc gaagccgccc agcgcggcga gccgggccag gtcgggcgtc agcagctgga
     3121 ggggcgagtc gaagttggtg tcgatgaacc gccgcatctg cgcccggtag agctgctcca
     3181 gccagtggcg cagcctgcgg taccccgcgg cctccccggg ccccgcgaag cgctcgacct
     3241 ccgcttccat cgcgtccgcg tcggtgtgca cgtcgatgcg gctgccgtcg gcgaacagcg
     3301 cccggtaggc ggggtgcagg gggatcaggt cgacgctgtc gcgcaggttc tcgccgaccg
     3361 ccgcgaaggc ctcgtcggcc aggtcgggca tggtcaggac ggtcggaccg gtgtcgatgc
     3421 ggtagccgcc gcgcgtcagg agccccgcgc gtccgcccgg cagcgcgtcg cgttcgacga
     3481 tcgtgacgcg gcggccggcg cccagcaggt ggagcgcggc cgacaggccg gagagtccgg
     3541 cgccgaccac gacgacatgg tcggtgcgtc cgggaacggt cctcatcgtg gggccccttc
     3601 ggtgagcagc agcgggacgg tcatgccccc gtcaggggga gggggtacgt cgtggtccgg
     3661 ggcggccggg ccgtcccacg gaccggccga agcggacgcg ggaggtgcgg cgggcgcggc
     3721 cggggacgtg ccggcggtgg cgtggaacag ccccgtcaga cgccgcccgg ccacgggatc
     3781 gagcacgacc gagtcgaggt ggcgcattcc ctgggccacc agccgctcga tcttcgcctc
     3841 gacggtgtcg cgcgccccga cggcgacgag gacgtcgcgg acctcggcga gaccgctgtc
     3901 gggcaggtcc gtccgtccga cggaccggcg cagcaccgcg agggcgccgc ggtcgcggtt
     3961 cgcctccgcg cgggcccggg ccacggccat gaggtaggtg ggccggcccg cccggatgtc
     4021 accgccgacc ggtttgccgg tccggcggtc gccgccgaac gcgtcgagga ggtcgtcgcg
     4081 cagctggaag gcgatgccca cgcagcggcc cgccgagcac agcgccccgg tccgcgcgga
     4141 gtcggcgccc gccagggcgg cgcccagggc cagcggacgc tccaccgagt acagggcgct
     4201 cttgaggcac gcggcgcgga tcgcccgcgc gagggaacgc gaggacgtgg cctgcccctg
     4261 cacgtccagg tactggccgg ccaccatctc ggtgcgcatc gcgctccaca cctcgcgcac
     4321 cgtccgggcg gtggccgcgg gtgcctcggt cgccgcgacg acgtcgtccg cccacgccag
     4381 ggccaggtcc ccggcgagga tcgcggcggc ctcgccgaac cgggggcccc gggcggaggg
     4441 cacggtgccg gcgtactggg cggtgacgtc cgcgtgcagg gcgggccggc cgcggcggaa
     4501 cgccgagccg tccatcacgt cgtcgtggat cagcgcgcac gtctggatca gttcgagcgc
     4561 ggcgccgacg cgcagcgcgc tctccgcctc gcccgcccct ccgccgcagg cgcgcagtgc
     4621 ccaccacacg aaccggggcc gcatccgttt gccgccgtcc agggtgaagc gcctgacgcg
     4681 ttcggcgagg tcccgcgcga acacggggtc cagcgcggcg gcctgctccg cgcgctctgc
     4741 caggagatgg tcgaggagac gtcccacggc tccgggtacg tcgtcgtcga gggcggacag
     4801 gtcgctgacg tccagcggga aacgggcggg catggcgcct tccggtcggc tgtcggggga
     4861 ggggccgcga tcggcgtgcc ccggccgggt caccgtcgga cccggccggg gcgcgcggga
     4921 agcgccggac ggcgtgtccg ccgcggagtc gtgtctcgcg gtgctggggc gcatgccggt
     4981 tgctcccgtc gtgatcgcag tgggccctga cttcaagtca ttccgcgtcg gggacggtca
     5041 tggatgcgcc agacgagcga ctcgcggacc gattccgttc cgcttccgtt ccgccccaaa
     5101 ggggccggag gagggcgggc cggcggaagc gcgcacgaaa acgacgcaaa gacgctgcga
     5161 gttgttgcga ggatgcatcg ctccgcatgg tgaaggaaca aaggtcgctc cgggcgaccc
     5221 cgggtccccg gcctccgcgg gtgcggacgg ccggcaccgg ccggacccgg acgagaagcg
     5281 gacgaccgcc cgcacgagga gcagccacca tgacggcaca gcaggtcacc gagcggaccc
     5341 ttccggcgac ggcgggtccc gcccaggact tcttcaccga cgacgaactg gcggcgggct
     5401 tcatcagggg tgacgaagcc tgtctggccg ccgcctacca ccgctgggga ctcctggtcc
     5461 acacgctggc acgccgcagt ctgggcgacg cccgggaggc ggaggacgtg acgcagacgg
     5521 tgttcctggc cgcctggcgc ggccgctccg ggttccggcc cgagcgcggc ccgctgtcgg
     5581 cgtggctggt cggcatcacc cggcgcaaga tcgccgacgc cctgtcggcg cggacccggc
     5641 gggccgacct cgtcgcggcg gcgggagcgc ggctgtccgt caccgccgac gaccggcacg
     5701 cccagcccga cgccgtgctc gaccgcgtcg tgctcaccca cgaactggcg aggctgcccg
     5761 ctccgcagcg ccgcgtcctc accctcgcct tctactgcga cctgacccag agccagatcg
     5821 ccgagctgac gggctggccc ctgggcaccg tcaagagcca cgcgcgccgc gggctgcacc
     5881 ggctcggcac gcgcgtacgg gaggaggacc cgcaggcccg cgtcggctga tgcgacgcac
     5941 gatcgatgcg accccgctga ccgtcccgga agaggccgca cgaccgggtg atcgccgcgc
     6001 ggccaccggc gatccgcccg ccgcaccgca cccgccggtc cgtccgcggt gcgccgcacg
     6061 gccgacggtc cggcccggcc tgcatccgcc cggccgtccg gaggggaatg ctgggcacag
     6121 gacccggaca cggggccggg ccggacggac aggacaggga gggcgcgaca cgtgcgggac
     6181 gcggacgtcg ccatcgtggg cgccggagct gccggactgt ccctcgcgta ccggctggca
     6241 cgcgccgacc cggcccgccg gccgtcggtg ctcctgttcg aacccccgcc cggcccgctg
     6301 cggccgccga gccgcacctg gtgcttctgg gagccggggc ccggccccta cgacgccgtc
     6361 ctgaccgccg cgtggcagcg cctgcgggtc cacacccccg aggggcgcac cgtcgaggac
     6421 ggcatcgcgc cgctgcgcta caagatgatc cgctccgacg acttcgaggc gttcgtcggg
     6481 cgcgaactgg cgcgccgcga ccacgtgcgc cgcgtcgagg cgaccgtcga gacggtggac
     6541 gggaccgccg acggagcgga gatccgggcc cgcaccgccg acggccgccc gctgaccgtg
     6601 cgcgcccgct gggtcttcga ctcccggccg ctcgggagcc tgccggcggc ccgcaccacc
     6661 ctgttgcagc acttccacgg ctggttcgtc cgcaccgcgc ggccggtgtt cgaccccgcg
     6721 tccgtcgacc tcatggattt ccgggtcccc cagcccccgc acgggctggc gttcggctac
     6781 gtcctgccca cgagcccccg cgaggccctc gtggagtaca cggagttctc cggcgcgccc
     6841 ctgacccgga cggcctacga ggccgcgctg gaccggtaca cccacggcgt gctggggctc
     6901 ggggcgttcg aggtgaccgc gacggagacc ggtgtgatcc cgatgacgga cgcgcggttc
     6961 gcgcgccgga ccgcgccctc ggtcttccgg atcggcgcgg cgggcggcgc cacccgtccg
     7021 tcgaccggtt acaccttcgc cgccgtccag cgccagacgc ggggcgtcgc ggcagcgctg
     7081 gccgccggcc gccggccgct gccccccgcc ccccactcgg cccgctcccg cgccatggac
     7141 gcggtgctgc tgcgcgccct ggacagtgga cgcgtcgacg gcgccgaggt cttctcgagt
     7201 ctcttctccc gggtcccggc ggagcggctg ctgcgcttcc tggacggccg gacccgcctc
     7261 cacgaggacc tctcggtcgg cgcgcgcacc cccgtgctgc ccatgctccg ttccgtcctg
     7321 gacctgtccc gcctgccccg cgcccccttc ccccgcccct gaccgccgga ccggcgacgt
     7381 ccgcgcgacg gcccgcccac gcccttgagg agaccccatg accctgctgc tgcgcgacgc
     7441 ggacctggcc gccgcgttcg accatgccgc ccgcagctac gacaccctgg tggccgccaa
     7501 tcccggctac cacgcccatc tgcggcgctc cgcgcgccgc ctcggcctgc cgcacggcgg
     7561 agccggtctg cgcgtcctcg acctgggctg cggcaccggc gcctccaccg ccgccctggc
     7621 cgccgtgttc cccgaggccc ggatcaccgc ggtggacgcc tccggcggca tgctggaaca
     7681 agccgcccgc aaacggtggc ggcaggaggt gagcttcgtg cacgccccgg cggaacgcct
     7741 ggcggaggca ggggtcgaag gccccttcga cgcggtcttc gccgcctacc tcttccgcaa
     7801 cgccaccgac ccggacgcgg tgctcgccgc ggtgcgcgag gcgctcgggc cgcggggccg
     7861 gctcgccgtc cacgagtaca ccctcagcgg ccgggccgcc caccgcgccg tgtggacggc
     7921 ggtgtgccgg ggcttcgtcc agcccgtcgc caccgtcctc ggcgacggcg agctgtaccg
     7981 ccacctctgg cacagcgtcg tccggttcga cacggcggag gccttcaccg agagggtccg
     8041 cgccgccggc ttcgagcagg tgcgggcgct gcccctgccc ggctggcaga ccggcatcac
     8101 ccacaccgtc gtcgcccgcc ggccgggctc cgacacggcg gtcgggcgat gacggcggcc
     8161 cgccggtccg aggcggcccg ccgcggcagg gaccgcatgg cccgcacgat ccgcccccgg
     8221 ccgggcgcgc ccgcgctcac cggtgaccac cggccgacca ccgccgtggt gggcggcggc
     8281 atcgccggcc tggcggcggc gacggccctg gccgaacggg gcgtgcgcgt cacgctccac
     8341 gaacgcgaac ccgccctcgg cggacgcctg gccgggtggc cgaccgccct ggccgacggc
     8401 agcaccgtca cgatgagccg cggcttccac gccttcttcc gccagtacta caacctgcgc
     8461 ggactgctgc ggcgcaccga tccggggctg cgccgcctca ggggactgcc cgactacccg
     8521 ctgcgccaca gcagcggcac gcacgacagc ttccggcacg ttccgcgcac cccgccgtgg
     8581 agcgcgctgg gcttcgtcgc gctgagcccc accttcggcc tgcgcgacct cgcccgcatg
     8641 aacccggtcg ccgcgctgcc cctgctggac gtgcgggtac ccgacgtgta cacgcgcctg
     8701 gacgacatca gcgcccacga cttcctggag tcggtccgct tccccgaggc cgcgcaccac
     8761 ctcgcgttcg aggtgttctc ccgcagcttc ttcgccgacc cccgcggcct gtcggcggcg
     8821 gagatggtgc tgatgttcca catctacttc ctcggctccg ccgagggcct gctcttcgac
     8881 gtgcccgacg agcccttccc cgccgcgctc tgggaccccc tggccggcta cctggagggc
     8941 cacggcgccg aactgcgcac cggtacgtcc gtcgaggccg tcgaacccac cggggacggc
     9001 ggcttcgtcg tggccgccgc gggcgaggag cggcggtacg acaccgtggt cctcgccctg
     9061 gacaccgccg gcctgcgttc cgtcgccgcc ggttccccgc ggctggccga cgccgcatgg
     9121 cgcgaacgcg tggccgggct ccgcaacgcc ccgcccttcc tggtctcgcg cctgtggctg
     9181 gaccgtcccg tcgccgccga ccggcccggc ttcctcggca ccagcggcta cggctccctc
     9241 gacaacgtca gcgtgctgga acgctgggag ggcgaggcgg cgcgctgggc cgcccgcacc
     9301 gggggctccg tcgtggaact gcacgcgtac gccctgccgg agacgccctc ccgcgacgtc
     9361 gaacagcgcc gcctgctgga gcagctgcac cgggtgtacc cggagacgcg cgcggcgcgg
     9421 gtcgtcgacg cccgtcacga gtggcgggcc gactgccccc tgttccccgt cgggggccac
     9481 ggtgagcggc cgaccgtgcg caccaccgac cccgggctgg tcgtcgccgg cgacctggtc
     9541 cgcacggacc tgccggtggc cctcatggag cgggcggcca cgagcggctt cctcgccgcc
     9601 aacgcccttc tggaacgctg gggagtcgcg ggccagaccc tgtggaccgt gcccgaccgc
     9661 gggcggggtg cgctgctgcg cgggctcgca cgtgcgggtg agggccggcg gggagaggtt
     9721 gcgcgcgccg tgccgactgc gagacggttg tcgaaagaca acattttcca gttgtag
//
