BGC0001459: decaplanin biosynthetic gene cluster from Amycolatopsis regifaucium
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Location: 259,653 - 327,583 nt. (total: 67,931 nt).
This entry is originally from NCBI GenBank LOBU02000007.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001459
Short description decaplanin biosynthetic gene cluster from Amycolatopsis regifaucium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "nkaur@imtech.res.in\nmayil@imtech.res.in"
Biosynthetic class(es)
  • NRPS (Type I)
Loci
LOBU02000007.1
259653 - 327583
via
Compounds
  • decaplanin
Species Amycolatopsis regifaucium [taxonomy]
References
Chemical products information
decaplanin Evidence: Mass spectrometry
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C72H86Cl1N9O28
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATP06_0208065
  • OKA09416.1
 259653 - 260612 (+) lactate dehydrogenase
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    • ATP06_0208070
    • OKA09417.1
    • vanB
    		 260605 - 261645 (+) D-alanine--(R)-lactate ligase
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      • ATP06_0208075
      • OKA09418.1
      		 261642 - 262250 (+) D-Ala-D-Ala dipeptidase VanX
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        • ATP06_0208080
        • OKA09661.1
        		 262657 - 263163 (+) peptidase M15
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          • ATP06_0208085
          • OKA09419.1
          		 263491 - 263865 (-) hypothetical protein
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            • ATP06_0208090
            • OKA09420.1
            		 264663 - 265628 (+) streptomycin biosynthesis protein
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              • ATP06_0208095
              • OKA09421.1
              		 265760 - 266584 (+) prephenate dehydrogenase
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                • ATP06_0208100
                • OKA09422.1
                		 266720 - 268672 (+) ABC transporter
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                  • ATP06_0208105
                  • OKA09423.1
                  		 268675 - 278142 (+) non-ribosomal peptide synthetase
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                    • ATP06_0208110
                    • OKA09424.1
                    		 278627 - 290818 (+) non-ribosomal peptide synthetase
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                      • ATP06_0208115
                      • OKA09425.1
                      		 290859 - 296435 (+) non-ribosomal peptide synthetase
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                        • ATP06_0208120
                        • OKA09426.1
                        		 296432 - 296641 (+) MbtH family protein
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                          • ATP06_0208125
                          • OKA09427.1
                          		 296807 - 297982 (+) cytochrome
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                            • ATP06_0208130
                            • OKA09428.1
                            		 298105 - 299301 (+) cytochrome
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                              • ATP06_0208135
                              • OKA09429.1
                              		 299428 - 300648 (+) cytochrome
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                                • ATP06_0208140
                                • OKA09430.1
                                		 300710 - 302185 (+) tryptophan halogenase
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                                  • ATP06_0208145
                                  • OKA09431.1
                                  		 302243 - 303433 (+) glycosyl transferase
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                                    • ATP06_0208150
                                    • OKA09432.1
                                    		 303430 - 304674 (+) glycosyl transferase
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                                      • ATP06_0208155
                                      • OKA09433.1
                                      		 304707 - 305939 (+) glycosyl transferase
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                                        • ATP06_0208160
                                        • OKA09434.1
                                        		 305985 - 307211 (+) SAM-dependent methyltransferase
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                                          • ATP06_0208165
                                          • OKA09662.1
                                          		 307222 - 308046 (+) PIG-L family deacetylase
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                                            • ATP06_0208170
                                            • OKA09663.1
                                            		 308086 - 308907 (+) SAM-dependent methyltransferase
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                                              • ATP06_0208175
                                              • OKA09435.1
                                              		 308993 - 310279 (-) GntR family transcriptional regulator
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                                                • ATP06_0208180
                                                • OKA09436.1
                                                		 310528 - 311358 (+) alpha/beta hydrolase
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                                                  • ATP06_0208185
                                                  • OKA09664.1
                                                  		 311370 - 313118 (+) non-ribosomal peptide synthetase
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                                                    • ATP06_0208190
                                                    • OKA09437.1
                                                    		 313133 - 314323 (+) NikQ protein
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                                                      • ATP06_0208195
                                                      • OKA09438.1
                                                      		 314458 - 315501 (+) 4-hydroxyphenylpyruvate dioxygenase
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                                                        • ATP06_0208200
                                                        • OKA09439.1
                                                        		 315498 - 316577 (+) alpha-hydroxy-acid oxidizing enzyme
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                                                          • ATP06_0208205
                                                          • OKA09440.1
                                                          		 316626 - 317975 (+) cation/H(+) antiporter
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                                                            • ATP06_0208210
                                                            • OKA09441.1
                                                            		 318207 - 319619 (+) NDP-hexose 2,3-dehydratase
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                                                              • ATP06_0208215
                                                              • OKA09442.1
                                                              		 319621 - 320589 (+) NAD-dependent epimerase/dehydratase
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                                                                • ATP06_0208220
                                                                • OKA09443.1
                                                                		 320586 - 321695 (+) daunorubicin biosynthesis sensory transduction protein DnrJ
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                                                                  • ATP06_0208225
                                                                  		 321719 - 322318 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
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                                                                    • ATP06_0208230
                                                                    • OKA09444.1
                                                                    		 322493 - 323593 (+) type III polyketide synthase
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                                                                      • ATP06_0208235
                                                                      • OKA09445.1
                                                                      		 323587 - 324249 (+) enoyl-CoA hydratase
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                                                                        • ATP06_0208240
                                                                        • OKA09446.1
                                                                        		 324267 - 325550 (+) enoyl-CoA hydratase
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                                                                          • ATP06_0208245
                                                                          • OKA09447.1
                                                                          		 325547 - 326350 (+) enoyl-CoA hydratase
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                                                                            • ATP06_0208250
                                                                            • OKA09448.1
                                                                            		 326504 - 327583 (+) 3-deoxy-7-phosphoheptulonate synthase
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                                                                              Biosynthesis information

                                                                              Biosynthetic modules

                                                                              Name
                                                                              Unk01
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              ATP06_0208105
                                                                              Substrates
                                                                              leucine (evidence: Structure-based inference, Sequence-based prediction)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk02
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              ATP06_0208105
                                                                              Substrates
                                                                              R-beta-hydroxytyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk03
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              ATP06_0208105
                                                                              Substrates
                                                                              asparagine (evidence: Structure-based inference, Sequence-based prediction)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk04
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              ATP06_0208110
                                                                              Substrates
                                                                              4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk05
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              ATP06_0208110
                                                                              Substrates
                                                                              4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk06
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              ATP06_0208110
                                                                              Substrates
                                                                              R-beta-hydroxytyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk07
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              ATP06_0208115
                                                                              Substrates
                                                                              3,5-dihydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Name
                                                                              Unk08
                                                                              Type
                                                                              nrps-type1
                                                                              Genes
                                                                              ATP06_0208185
                                                                              Substrates
                                                                              tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                                              Integrated Monomers
                                                                              Domains
                                                                              adenylation
                                                                              Annotation changelog

                                                                              Entry version: 4

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2022-10-07
                                                                              Update chemical activity to schema version 2.11
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 3

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2022-09-15
                                                                              Added NRP substrate specificities
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 2

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2019-10-16
                                                                              Migrated from v1.4
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              2019-10-16
                                                                              Updated compound(s) information (MIBiG Annotathon)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 1

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2018-08-06
                                                                              Submitted
                                                                              • (ID: O6YNIU5QQ6ENKKRTK6AUSAXS)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              Detailed domain annotation
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