BGC0001460: decaplanin biosynthetic gene cluster from Amycolatopsis decaplanina DSM 44594
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Location: 276,857 - 343,203 nt. (total: 66,347 nt).
This entry is originally from NCBI GenBank AOHO01000074.1.

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core biosynthetic genes
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transport-related genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001460
Short description decaplanin biosynthetic gene cluster from Amycolatopsis decaplanina DSM 44594
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "nmayil@imtech.res.in"
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AOHO01000074.1
276857 - 343203
via
Compounds
  • decaplanin
Species Amycolatopsis decaplanina DSM 44594 [taxonomy]
References
Chemical products information
decaplanin Evidence:
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C72H86Cl1N9O28
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • H074_31612
  • EME52961.1
 276857 - 277933 (-) phospho-2-dehydro-3-deoxyheptonate aldolase
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    • H074_31617
    • EME52962.1
    		 278126 - 278923 (-) enoyl-CoA hydratase
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      • H074_31622
      • EME52963.1
      		 278920 - 280146 (-) enoyl-CoA hydratase
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        • H074_31627
        • EME52964.1
        		 280143 - 280805 (-) enoyl-CoA hydratase
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          • H074_31632
          • EME52965.1
          		 280799 - 281824 (-) chalcone and stilbene synthases-like protein
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            • H074_31637
            • EME52966.1
            		 282005 - 282622 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
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              • H074_31642
              • EME52967.1
              		 282646 - 283755 (-) glutamine--scyllo-inositol transaminase
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                • H074_31647
                • EME52968.1
                		 283752 - 284723 (-) NAD-dependent epimerase/dehydratase
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                  • H074_31652
                  • EME52969.1
                  		 284725 - 286155 (-) 2,3-dehydratase
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                    • H074_31657
                    • EME52970.1
                    		 286506 - 287855 (-) sodium/hydrogen exchanger
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                      • H074_31662
                      • EME52971.1
                      		 287887 - 288966 (-) FMN-dependent alpha-hydroxy acid dehydrogenase
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                        • H074_31667
                        • EME52972.1
                        		 288963 - 290015 (-) 4-hydroxyphenylpyruvate dioxygenase
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                          • H074_31672
                          • EME52973.1
                          		 290125 - 291315 (-) cytochrome P450
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                            • H074_31677
                            • EME52974.1
                            		 291330 - 293066 (-) non-ribosomal peptide synthetase
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                              • H074_31682
                              • EME52975.1
                              		 293063 - 293893 (-) alpha/beta hydrolase fold containing protein
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                                • H074_31687
                                • EME52976.1
                                		 294143 - 295429 (+) GntR family transcriptional regulator
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                                  • H074_31692
                                  • EME52977.1
                                  		 295410 - 296282 (-) hypothetical protein
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                                    • H074_31697
                                    • EME52978.1
                                    		 296292 - 297125 (-) LmbE family protein
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                                      • H074_31702
                                      • EME52979.1
                                      		 297127 - 298353 (-) NDP-hexose C-3 methyl transferase
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                                        • H074_31707
                                        • EME52980.1
                                        		 298400 - 299632 (-) glycosyl transferase family protein
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                                          • H074_31712
                                          • EME52981.1
                                          		 299665 - 300885 (-) glycosyl transferase family protein
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                                            • H074_31717
                                            • EME52982.1
                                            		 300906 - 302096 (-) glycosyl transferase family protein
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                                              • H074_31722
                                              • EME52983.1
                                              		 302146 - 303621 (-) tryptophan halogenase
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                                                • H074_31727
                                                • EME52984.1
                                                		 303666 - 304886 (-) cytochrome P450 FAS1
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                                                  • H074_31732
                                                  • EME52985.1
                                                  		 305014 - 306210 (-) cytochrome P450 FAS1
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                                                    • H074_31737
                                                    • EME52986.1
                                                    		 306426 - 307601 (-) linalool 8-monooxygenase
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                                                      • H074_31742
                                                      • EME52987.1
                                                      		 307710 - 307919 (-) MbtH-like protein
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                                                        • H074_31747
                                                        • EME52988.1
                                                        		 307916 - 313414 (-) amino acid adenylation protein
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                                                          • H074_31752
                                                          • EME52989.1
                                                          		 313513 - 325683 (-) amino acid adenylation protein
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                                                            • H074_31757
                                                            • EME52990.1
                                                            		 325994 - 335443 (-) amino acid adenylation protein
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                                                              • H074_31762
                                                              • EME52991.1
                                                              		 335446 - 337398 (-) ABC transporter
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                                                                • H074_31767
                                                                • EME52992.1
                                                                		 337515 - 338345 (-) prephenate dehydrogenase
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                                                                  • H074_31772
                                                                  • EME52993.1
                                                                  		 338528 - 339502 (-) streptomycin biosynthesis operon regulator
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                                                                    • H074_31777
                                                                    • EME52994.1
                                                                    		 340693 - 341301 (-) D-Ala-D-Ala dipeptidase
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                                                                      • H074_31782
                                                                      • EME52995.1
                                                                      • vanB
                                                                      		 341298 - 342338 (-) D-alanine--D-lactate ligase
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                                                                        • H074_31787
                                                                        • EME52996.1
                                                                        		 342340 - 343203 (-) D-isomer specific 2-hydroxyacid dehydrogenase
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                                                                          Biosynthesis information

                                                                          Biosynthetic modules

                                                                          Name
                                                                          Unk01
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          H074_31677
                                                                          Substrates
                                                                          tyrosine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk02
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          H074_31747
                                                                          Substrates
                                                                          3,5-dihydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk03
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          H074_31752
                                                                          Substrates
                                                                          4-hydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk04
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          H074_31752
                                                                          Substrates
                                                                          4-hydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk05
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          H074_31752
                                                                          Substrates
                                                                          R-beta-hydroxytyrosine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk06
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          H074_31757
                                                                          Substrates
                                                                          leucine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk07
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          H074_31757
                                                                          Substrates
                                                                          R-beta-hydroxytyrosine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk08
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          H074_31757
                                                                          Substrates
                                                                          asparagine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Annotation changelog

                                                                          Entry version: 4

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-10-07
                                                                          Update chemical activity to schema version 2.11
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 3

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-09-15
                                                                          Added NRP substrate specificities
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 2

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2019-10-16
                                                                          Migrated from v1.4
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2019-10-16
                                                                          Updated compound(s) information (MIBiG Annotathon)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 1

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2018-08-06
                                                                          Submitted
                                                                          • (ID: UZDMKOBVVEVI67YDKBV3PKAC)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          Detailed domain annotation
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