BGC0001460: decaplanin biosynthetic gene cluster from Amycolatopsis decaplanina DSM 44594
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Location: 276,857 - 343,203 nt. (total: 66,347 nt).
This entry is originally from NCBI GenBank AOHO01000074.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001460
Short description decaplanin biosynthetic gene cluster from Amycolatopsis decaplanina DSM 44594
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "nmayil@imtech.res.in"
Biosynthetic class(es)
  • NRP (Glycopeptide)
Loci NCBI GenBank: AOHO01000074.1
Compounds
  • decaplanin
Species Amycolatopsis decaplanina DSM 44594 [taxonomy]
References
Chemical products information
decaplanin
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C72H86Cl1N9O28
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • H074_31612
  • EME52961.1
276857 - 277933 (-) phospho-2-dehydro-3-deoxyheptonate aldolase
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  • H074_31617
  • EME52962.1
278126 - 278923 (-) enoyl-CoA hydratase
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  • H074_31622
  • EME52963.1
278920 - 280146 (-) enoyl-CoA hydratase
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  • H074_31627
  • EME52964.1
280143 - 280805 (-) enoyl-CoA hydratase
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  • H074_31632
  • EME52965.1
280799 - 281824 (-) chalcone and stilbene synthases-like protein
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  • H074_31637
  • EME52966.1
282005 - 282622 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
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  • H074_31642
  • EME52967.1
282646 - 283755 (-) glutamine--scyllo-inositol transaminase
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  • H074_31647
  • EME52968.1
283752 - 284723 (-) NAD-dependent epimerase/dehydratase
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  • H074_31652
  • EME52969.1
284725 - 286155 (-) 2,3-dehydratase
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  • H074_31657
  • EME52970.1
286506 - 287855 (-) sodium/hydrogen exchanger
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  • H074_31662
  • EME52971.1
287887 - 288966 (-) FMN-dependent alpha-hydroxy acid dehydrogenase
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  • H074_31667
  • EME52972.1
288963 - 290015 (-) 4-hydroxyphenylpyruvate dioxygenase
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  • H074_31672
  • EME52973.1
290125 - 291315 (-) cytochrome P450
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  • H074_31677
  • EME52974.1
291330 - 293066 (-) non-ribosomal peptide synthetase
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  • H074_31682
  • EME52975.1
293063 - 293893 (-) alpha/beta hydrolase fold containing protein
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  • H074_31687
  • EME52976.1
294143 - 295429 (+) GntR family transcriptional regulator
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  • H074_31692
  • EME52977.1
295410 - 296282 (-) hypothetical protein
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  • H074_31697
  • EME52978.1
296292 - 297125 (-) LmbE family protein
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  • H074_31702
  • EME52979.1
297127 - 298353 (-) NDP-hexose C-3 methyl transferase
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  • H074_31707
  • EME52980.1
298400 - 299632 (-) glycosyl transferase family protein
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  • H074_31712
  • EME52981.1
299665 - 300885 (-) glycosyl transferase family protein
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  • H074_31717
  • EME52982.1
300906 - 302096 (-) glycosyl transferase family protein
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  • H074_31722
  • EME52983.1
302146 - 303621 (-) tryptophan halogenase
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  • H074_31727
  • EME52984.1
303666 - 304886 (-) cytochrome P450 FAS1
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  • H074_31732
  • EME52985.1
305014 - 306210 (-) cytochrome P450 FAS1
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  • H074_31737
  • EME52986.1
306426 - 307601 (-) linalool 8-monooxygenase
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  • H074_31742
  • EME52987.1
307710 - 307919 (-) MbtH-like protein
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  • H074_31747
  • EME52988.1
307916 - 313414 (-) amino acid adenylation protein
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  • H074_31752
  • EME52989.1
313513 - 325683 (-) amino acid adenylation protein
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  • H074_31757
  • EME52990.1
325994 - 335443 (-) amino acid adenylation protein
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  • H074_31762
  • EME52991.1
335446 - 337398 (-) ABC transporter
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  • H074_31767
  • EME52992.1
337515 - 338345 (-) prephenate dehydrogenase
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  • H074_31772
  • EME52993.1
338528 - 339502 (-) streptomycin biosynthesis operon regulator
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  • H074_31777
  • EME52994.1
340693 - 341301 (-) D-Ala-D-Ala dipeptidase
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  • H074_31782
  • EME52995.1
  • vanB
341298 - 342338 (-) D-alanine--D-lactate ligase
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  • H074_31787
  • EME52996.1
342340 - 343203 (-) D-isomer specific 2-hydroxyacid dehydrogenase
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NRP-specific information
Subclass Glycopeptide
Cyclic? no
NRP-synthases
Gene Modules
H074_31677
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
H074_31747
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
H074_31752
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
H074_31757
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: asparagine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: UZDMKOBVVEVI67YDKBV3PKAC, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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