BGC0001462: avoparcin biosynthetic gene cluster from Amycolatopsis coloradensis
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Location: 95,249 - 164,623 nt. (total: 69,375 nt).
This entry is originally from NCBI GenBank MQUQ01000006.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001462
Short description avoparcin biosynthetic gene cluster from Amycolatopsis coloradensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "nkaur@imtech.res.in\nmayil@imtech.res.in"
Biosynthetic class(es)
  • NRP (Glycopeptide)
Loci NCBI GenBank: MQUQ01000006.1
Compounds
  • avoparcin
Species Amycolatopsis coloradensis [taxonomy]
References
Chemical products information
avoparcin
Copy SMILES
C83H92Cl1N9O31
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BS329_14000
  • OLZ52430.1
 95249 - 96415 (-) glycosyl transferase
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  • BS329_14005
  • OLZ52431.1
 96441 - 97238 (-) enoyl-CoA hydratase
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  • BS329_14010
  • OLZ52432.1
 97235 - 98533 (-) enoyl-CoA hydratase
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  • BS329_14015
  • OLZ52433.1
 98530 - 99192 (-) enoyl-CoA hydratase
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  • BS329_14020
  • OLZ52434.1
 99186 - 100286 (-) type III polyketide synthase
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  • BS329_14025
  • OLZ52435.1
 100500 - 101117 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
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  • BS329_14030
  • OLZ52436.1
 101141 - 102250 (-) daunorubicin biosynthesis sensory transduction protein DnrJ
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  • BS329_14035
  • OLZ52437.1
 102247 - 103224 (-) NAD-dependent epimerase/dehydratase
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  • BS329_14040
  • OLZ52647.1
 103226 - 104623 (-) NDP-hexose 2,3-dehydratase
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  • BS329_14045
  • OLZ52438.1
 105011 - 106360 (-) cation/H(+) antiporter
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  • BS329_14050
  • OLZ52439.1
 106550 - 107629 (-) alpha-hydroxy-acid oxidizing enzyme
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  • BS329_14055
  • OLZ52440.1
 107626 - 108687 (-) 4-hydroxyphenylpyruvate dioxygenase
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  • BS329_14060
  • OLZ52441.1
 108796 - 109986 (-) NikQ protein
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  • BS329_14065
  • OLZ52442.1
 110002 - 111738 (-) non-ribosomal peptide synthetase
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  • BS329_14070
  • OLZ52443.1
 111735 - 112565 (-) alpha/beta hydrolase
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  • BS329_14075
  • OLZ52444.1
 112785 - 114071 (+) GntR family transcriptional regulator
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  • BS329_14080
  • OLZ52445.1
 114120 - 114932 (-) PIG-L family deacetylase
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  • BS329_14085
  • OLZ52446.1
 114923 - 115741 (-) SAM-dependent methyltransferase
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  • BS329_14090
 116544 - 118160 (-) mannosyltransferase
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  • BS329_14095
  • OLZ52447.1
 118205 - 119401 (-) glycosyl transferase
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  • BS329_14100
  • OLZ52448.1
 119430 - 120656 (-) glycosyl transferase
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  • BS329_14105
  • OLZ52449.1
 120681 - 121850 (-) glycosyl transferase
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  • BS329_14110
  • OLZ52450.1
 121876 - 123351 (-) tryptophan halogenase
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  • BS329_14115
  • OLZ52451.1
 123414 - 124646 (-) cytochrome
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  • BS329_14120
  • OLZ52452.1
 124989 - 126026 (-) 3-deoxy-7-phosphoheptulonate synthase
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  • BS329_14125
  • OLZ52453.1
 126056 - 127252 (-) cytochrome
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  • BS329_14130
  • OLZ52454.1
 127397 - 128572 (-) cytochrome
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  • BS329_14135
  • OLZ52455.1
 128863 - 129072 (-) MbtH family protein
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  • BS329_14140
  • OLZ52456.1
 129069 - 134654 (-) non-ribosomal peptide synthetase
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  • BS329_14145
  • OLZ52457.1
 134674 - 146868 (-) non-ribosomal peptide synthetase
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  • BS329_14150
 147354 - 156423 (-) non-ribosomal peptide synthetase
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  • BS329_14155
  • OLZ52458.1
 156426 - 158384 (-) ABC transporter
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  • BS329_14160
  • OLZ52459.1
 158617 - 159684 (-) prephenate dehydrogenase
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  • BS329_14165
  • OLZ52648.1
 159711 - 160667 (-) streptomycin biosynthesis protein
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  • BS329_14170
  • OLZ52460.1
 161924 - 162538 (-) D-Ala-D-Ala dipeptidase VanX
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  • BS329_14175
  • OLZ52461.1
  • vanB
 162535 - 163578 (-) D-alanine--(R)-lactate ligase
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  • BS329_14180
  • OLZ52462.1
 163580 - 164623 (-) lactate dehydrogenase
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NRP-specific information
Subclass Glycopeptide
Cyclic? no
NRP-synthases
Gene Modules
BS329_14150
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
BS329_14065
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
BS329_14140
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
BS329_14145
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: UZDMKOBVVEVI67YDKBV3PKAC, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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