BGC0001462: avoparcin biosynthetic gene cluster from Amycolatopsis coloradensis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 95,249 - 164,623 nt. (total: 69,375 nt).
This entry is originally from NCBI GenBank MQUQ01000006.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001462
Short description avoparcin biosynthetic gene cluster from Amycolatopsis coloradensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "nkaur@imtech.res.in\nmayil@imtech.res.in"
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MQUQ01000006.1
95249 - 164623
via
Compounds
  • avoparcin
Species Amycolatopsis coloradensis [taxonomy]
References
Chemical products information
avoparcin Evidence: Mass spectrometry
Copy SMILES
C83H92Cl1N9O31
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BS329_14000
  • OLZ52430.1
 95249 - 96415 (-) glycosyl transferase
    copy AA seq
    copy Nt seq
    • BS329_14005
    • OLZ52431.1
    		 96441 - 97238 (-) enoyl-CoA hydratase
      copy AA seq
      copy Nt seq
      • BS329_14010
      • OLZ52432.1
      		 97235 - 98533 (-) enoyl-CoA hydratase
        copy AA seq
        copy Nt seq
        • BS329_14015
        • OLZ52433.1
        		 98530 - 99192 (-) enoyl-CoA hydratase
          copy AA seq
          copy Nt seq
          • BS329_14020
          • OLZ52434.1
          		 99186 - 100286 (-) type III polyketide synthase
            copy AA seq
            copy Nt seq
            • BS329_14025
            • OLZ52435.1
            		 100500 - 101117 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
              copy AA seq
              copy Nt seq
              • BS329_14030
              • OLZ52436.1
              		 101141 - 102250 (-) daunorubicin biosynthesis sensory transduction protein DnrJ
                copy AA seq
                copy Nt seq
                • BS329_14035
                • OLZ52437.1
                		 102247 - 103224 (-) NAD-dependent epimerase/dehydratase
                  copy AA seq
                  copy Nt seq
                  • BS329_14040
                  • OLZ52647.1
                  		 103226 - 104623 (-) NDP-hexose 2,3-dehydratase
                    copy AA seq
                    copy Nt seq
                    • BS329_14045
                    • OLZ52438.1
                    		 105011 - 106360 (-) cation/H(+) antiporter
                      copy AA seq
                      copy Nt seq
                      • BS329_14050
                      • OLZ52439.1
                      		 106550 - 107629 (-) alpha-hydroxy-acid oxidizing enzyme
                        copy AA seq
                        copy Nt seq
                        • BS329_14055
                        • OLZ52440.1
                        		 107626 - 108687 (-) 4-hydroxyphenylpyruvate dioxygenase
                          copy AA seq
                          copy Nt seq
                          • BS329_14060
                          • OLZ52441.1
                          		 108796 - 109986 (-) NikQ protein
                            copy AA seq
                            copy Nt seq
                            • BS329_14065
                            • OLZ52442.1
                            		 110002 - 111738 (-) non-ribosomal peptide synthetase
                              copy AA seq
                              copy Nt seq
                              • BS329_14070
                              • OLZ52443.1
                              		 111735 - 112565 (-) alpha/beta hydrolase
                                copy AA seq
                                copy Nt seq
                                • BS329_14075
                                • OLZ52444.1
                                		 112785 - 114071 (+) GntR family transcriptional regulator
                                  copy AA seq
                                  copy Nt seq
                                  • BS329_14080
                                  • OLZ52445.1
                                  		 114120 - 114932 (-) PIG-L family deacetylase
                                    copy AA seq
                                    copy Nt seq
                                    • BS329_14085
                                    • OLZ52446.1
                                    		 114923 - 115741 (-) SAM-dependent methyltransferase
                                      copy AA seq
                                      copy Nt seq
                                      • BS329_14090
                                      		 116544 - 118160 (-) mannosyltransferase
                                        copy AA seq
                                        copy Nt seq
                                        • BS329_14095
                                        • OLZ52447.1
                                        		 118205 - 119401 (-) glycosyl transferase
                                          copy AA seq
                                          copy Nt seq
                                          • BS329_14100
                                          • OLZ52448.1
                                          		 119430 - 120656 (-) glycosyl transferase
                                            copy AA seq
                                            copy Nt seq
                                            • BS329_14105
                                            • OLZ52449.1
                                            		 120681 - 121850 (-) glycosyl transferase
                                              copy AA seq
                                              copy Nt seq
                                              • BS329_14110
                                              • OLZ52450.1
                                              		 121876 - 123351 (-) tryptophan halogenase
                                                copy AA seq
                                                copy Nt seq
                                                • BS329_14115
                                                • OLZ52451.1
                                                		 123414 - 124646 (-) cytochrome
                                                  copy AA seq
                                                  copy Nt seq
                                                  • BS329_14120
                                                  • OLZ52452.1
                                                  		 124989 - 126026 (-) 3-deoxy-7-phosphoheptulonate synthase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • BS329_14125
                                                    • OLZ52453.1
                                                    		 126056 - 127252 (-) cytochrome
                                                      copy AA seq
                                                      copy Nt seq
                                                      • BS329_14130
                                                      • OLZ52454.1
                                                      		 127397 - 128572 (-) cytochrome
                                                        copy AA seq
                                                        copy Nt seq
                                                        • BS329_14135
                                                        • OLZ52455.1
                                                        		 128863 - 129072 (-) MbtH family protein
                                                          copy AA seq
                                                          copy Nt seq
                                                          • BS329_14140
                                                          • OLZ52456.1
                                                          		 129069 - 134654 (-) non-ribosomal peptide synthetase
                                                            copy AA seq
                                                            copy Nt seq
                                                            • BS329_14145
                                                            • OLZ52457.1
                                                            		 134674 - 146868 (-) non-ribosomal peptide synthetase
                                                              copy AA seq
                                                              copy Nt seq
                                                              • BS329_14150
                                                              		 147354 - 156423 (-) non-ribosomal peptide synthetase
                                                                copy AA seq
                                                                copy Nt seq
                                                                • BS329_14155
                                                                • OLZ52458.1
                                                                		 156426 - 158384 (-) ABC transporter
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • BS329_14160
                                                                  • OLZ52459.1
                                                                  		 158617 - 159684 (-) prephenate dehydrogenase
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • BS329_14165
                                                                    • OLZ52648.1
                                                                    		 159711 - 160667 (-) streptomycin biosynthesis protein
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • BS329_14170
                                                                      • OLZ52460.1
                                                                      		 161924 - 162538 (-) D-Ala-D-Ala dipeptidase VanX
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • BS329_14175
                                                                        • OLZ52461.1
                                                                        • vanB
                                                                        		 162535 - 163578 (-) D-alanine--(R)-lactate ligase
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          • BS329_14180
                                                                          • OLZ52462.1
                                                                          		 163580 - 164623 (-) lactate dehydrogenase
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            Biosynthesis information

                                                                            Biosynthetic modules

                                                                            Name
                                                                            Unk01
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            BS329_14150
                                                                            Substrates
                                                                            4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                            Integrated Monomers
                                                                            Domains
                                                                            adenylation
                                                                            Name
                                                                            Unk02
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            BS329_14150
                                                                            Substrates
                                                                            R-beta-hydroxytyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                                            Integrated Monomers
                                                                            Domains
                                                                            adenylation
                                                                            Name
                                                                            Unk03
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            BS329_14065
                                                                            Substrates
                                                                            tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                                            Integrated Monomers
                                                                            Domains
                                                                            adenylation
                                                                            Name
                                                                            Unk04
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            BS329_14140
                                                                            Substrates
                                                                            3,5-dihydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                            Integrated Monomers
                                                                            Domains
                                                                            adenylation
                                                                            Name
                                                                            Unk05
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            BS329_14145
                                                                            Substrates
                                                                            4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                            Integrated Monomers
                                                                            Domains
                                                                            adenylation
                                                                            Name
                                                                            Unk06
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            BS329_14145
                                                                            Substrates
                                                                            4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                            Integrated Monomers
                                                                            Domains
                                                                            adenylation
                                                                            Name
                                                                            Unk07
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            BS329_14145
                                                                            Substrates
                                                                            tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                                            Integrated Monomers
                                                                            Domains
                                                                            adenylation
                                                                            Annotation changelog

                                                                            Entry version: 4

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-10-07
                                                                            Update chemical activity to schema version 2.11
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 3

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-09-15
                                                                            Added NRP substrate specificities
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 2

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2019-10-16
                                                                            Migrated from v1.4
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2019-10-16
                                                                            Updated compound(s) information (MIBiG Annotathon)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 1

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2018-08-06
                                                                            Submitted
                                                                            • (ID: UZDMKOBVVEVI67YDKBV3PKAC)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            Detailed domain annotation
                                                                            Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                            A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                            Selected features only
                                                                            Show module domains
                                                                            Similar known gene clusters from MIBiG 4.0
                                                                            Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                            Click on reference genes to show details of similarities to genes within the current region.
                                                                            Click on an accession to open that entry in the MiBIG database.