LOCUS       BGC0001465             12220 bp    DNA     linear   CON 24-SEP-2021
DEFINITION  Marinomonas mediterranea MMB-1, complete sequence.
ACCESSION   BGC0001465
VERSION     BGC0001465
KEYWORDS    .
SOURCE      Marinomonas mediterranea MMB-1
  ORGANISM  Marinomonas mediterranea MMB-1
            Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
            Oceanospirillaceae; Marinomonas.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CP002583.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4087977
            Source DNA and organism available from Antonio Sanchez-Amat
            (antonio@um.es)
            Contacts: Antonio Sanchez-Amat (antonio@um.es)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-LANL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. it is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 01:51:09
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 4521274
            Orig. end    :: 4533494
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..1254)
                     /locus_tag="MARME_RS20525"
                     /old_locus_tag="Marme_4085"
     CDS             complement(1..1254)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175:pyridine nucleotide-disulfide oxidoreductase
                     (Score: 107.9; E-value: 7.7e-33)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019604.2"
                     /locus_tag="MARME_RS20525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Marme_4085"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_013663187.1"
                     /transl_table=11
                     /translation="MKQRCVIVGGGHAGAQVSTSLRKLGWEGKITVFTNEYSFPYHRPP
                     LSKSFLLGNTTEHELLIRPEIAYAKDDIDVLINQEVRDIYPERHSLVMQDGSNIHYDKL
                     VLCMGSKMRRLDVLGSDLRGIFYIKTIRDIRMLSEYLEGGQKNIVMVGGGYVSLETAAV
                     LRKMGHLVTILVRSNRILNGSTSAPVSDFLLEQHTRNGVNIVTQKSVSHFVEDSDSAEH
                     KMRQVICTDGSRYGADLVVIGVGSDADSELARKAGLDVTDGIVVDQYGRTSQEDIFAAG
                     DCTSQLQSNGIAMQIASVPNALEQAKSVASTICGKPKSSNAVQWFWSDQYENKLQMAGL
                     NHGHDQTVLREKSHDQFSLWYLRDGRVIASECINSPADFMLSKRMIAAKTCVPSHVLAD
                     VSCSLNEYAKPVKRMSEA"
     subregion       1..12220
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12220
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1266..1586)
                     /locus_tag="MARME_RS20530"
                     /old_locus_tag="Marme_4086"
     CDS             complement(1266..1586)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020581804.1"
                     /locus_tag="MARME_RS20530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Marme_4086"
                     /product="2Fe-2S iron-sulfur cluster-binding protein"
                     /protein_id="WP_013663188.1"
                     /transl_table=11
                     /translation="MPDITFIQHDGSRQTVFAKAGVTIMQAAMENMVEGLEAECGGSGS
                     CATCHCYLSLGWHQKVQAPDSNEEQMLEMVIEPKEGSRLSCQVKVTDAHDGLIVHLPEC
                     QY"
     gene            complement(1609..2187)
                     /locus_tag="MARME_RS20535"
                     /old_locus_tag="Marme_4087"
     CDS             complement(1609..2187)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_023401489.1"
                     /locus_tag="MARME_RS20535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Marme_4087"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_013663189.1"
                     /transl_table=11
                     /translation="MTDSMNTLVTPLQRSDAPQLEPVFRGMEQNLGFLPNGILTMGKNP
                     DLAVAFGGLFKCIDAFKHIPTELKWAIAMISSSAAGCMYCKSHFSHIATRTHVNRNKVM
                     AAFEFQTSDFYNEAERAALAFAFANSTSPAHLDKEHFDELARYYSEEAAIEIAAIIAIC
                     GFLNRWNAAMDSQIEAAPRATLDEIEKQN"
     gene            2449..3579
                     /locus_tag="MARME_RS20540"
                     /old_locus_tag="Marme_4088"
     CDS             2449..3579
                     /NRPS_PKS="Domain: PP-binding (11-73). E-value: 8.4e-11.
                     Score: 34.1. Matches aSDomain:
                     nrpspksdomains_MARME_RS20540_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036:alpha/beta hydrolase fold protein (Score: 83.5;
                     E-value: 3.4e-25)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.2"
                     /locus_tag="MARME_RS20540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Marme_4088"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_013663190.1"
                     /sec_met_domain="PP-binding (E-value: 1.7e-11, bitscore:
                     34.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.1e-13, bitscore:
                     41.8, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4e-11, bitscore: 32.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEKLIHFINNDLLEGAADDLDQNTPLLELGILDSLSMVLLLAHI
                     DQQYGVKIPEHEINPEHFENVATLAALINQLSKDETAEAMPQQENVSELARLVKLQETY
                     NIESQMVEVGGGLTQHALRVKGNGPLWVMLPALGNPSTSWSPLLRSVQNRHNAVALDLA
                     GFGLTQSNKDNPSFKDHVNNTLQYLETIEEQEWVLIANSAGSMVAAEVARRFPEKVKAL
                     VITGFGLVEDVEGWWQGLKAMSKKPEEFLEAAYYNPPKLTPDLNNLLNEVLSRPAYHNF
                     LDTHAKERISHIFDGITVPTLFIAGNHDQIVPPEWSEKAAESMEDASVVRLSRCGHFSA
                     SERPEEFIWVVEDFLMKINQKQNMASQTNNQEASMA"
     aSDomain        2482..2667
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MARME_RS20540_PP-binding.1"
                     /evalue="8.40E-11"
                     /label="MARME_RS20540_PP-binding.1"
                     /locus_tag="MARME_RS20540"
                     /protein_end="73"
                     /protein_start="11"
                     /score="34.1"
                     /tool="antismash"
                     /translation="DLLEGAADDLDQNTPLLELGILDSLSMVLLLAHIDQQYGVKIPEH
                     EINPEHFENVATLAALI"
     gene            3576..4808
                     /locus_tag="MARME_RS20545"
                     /old_locus_tag="Marme_4089"
     CDS             3576..4808
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 249.6; E-value: 1.1e-75)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.2"
                     /locus_tag="MARME_RS20545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Marme_4089"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_013663191.1"
                     /sec_met_domain="Trp_halogenase (E-value: 2.7e-15,
                     bitscore: 45.6, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTNANYDVVIIGSGPAGSLCGIECRKKGLSVLCIEKDEFPRFHI
                     GESLTGNAGQIITDLGLYDKMEEAEFPNKLGVNVIGSLSKNEFFIPILAKTWQVRRSSF
                     DKMLKEKALEHGVEYQTGMVTDVLRDGEKVVGATYKTAAGSQNVNSKVLVDASGQTTFL
                     SRKGVAGKRKVEFFSQQIASFAHFENVERDLPPFSTNTTILYSKQYHWSWIIPISPTTD
                     SLGVVIPKDLYYKECNSPEAAIEWGMNNISPELKRRFKNAEQVEASQSMADFSYRIEPF
                     VGDGWLCIGDSHRFLDPIFSYGVSFGMKEGIRSAEAIATSIQTGDWKTPFYAFRDWSNK
                     GQQIAADLIRYFWIYPIFFGYQMQNPDLRDEVIRLLGGCCFDCEGWKAPSIFSNAIKEY
                     DRKQMETKIAS"
     gene            4872..5750
                     /locus_tag="MARME_RS20550"
                     /old_locus_tag="Marme_4090"
     CDS             4872..5750
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014035.2"
                     /locus_tag="MARME_RS20550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Marme_4090"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_013663192.1"
                     /transl_table=11
                     /translation="MNTRFVLIVASLWLAVLFGVMDNPTWLLQENWPIIFIAFASAAVA
                     NATAVGGGFIFLPLFSFAYSLSAAEALKLALATQAFGMSSGALGWSKKVIDFHFLKLGA
                     GAGVLGMFIGTFLFTPPGHLIHNIFGYASIVVSLALFIEMIYIRKTDKTVFDEPNHSLV
                     EFCIWALLGGLITAWTSIGIGEVVALWLLFRAKQSIVKSVATGVAVLAICSISGLLFHI
                     YEGGIVWEYLIFTAPGVLLGGRAGALLGKRMAGVKKQQEPHSHNDNKGFGLKLFVALVI
                     FADGIVVIFNQ"
     gene            5765..6907
                     /locus_tag="MARME_RS20555"
                     /old_locus_tag="Marme_4091"
     CDS             5765..6907
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 322.1; E-value:
                     8.4e-98)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.2"
                     /locus_tag="MARME_RS20555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Marme_4091"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_013663193.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 5.3e-19, bitscore:
                     58.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.3e-26, bitscore:
                     81.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.2e-35, bitscore:
                     112.5, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFEWTHEQAELFEHALRFGKELSAPLQEDNGFPRDNWNALGDFG
                     YFGLPIPEKYAKDGSGFDILTTIKIIEGLGQSCTDTGLLFAGAAHTFACSMPILEHGSE
                     TLKHQLLPDLATGRKIAANAISEASAGSDISNLATTAQKEGDYYVLNGGKSYVTNGSIA
                     DYYVVYATTNKKHGYLGQTAFVVPRNTPGISVGNDYHKLGLRSAPLNQVFFDNCTIHKD
                     YALGREGQGARIFAASMDWERCCLFAIFVGAMQRDLNQCIEYANTRMQGDKTISRFQAV
                     SHRIADMGVRLESARLMLYYAAWQKSQDVDNTKAVAMSKLAISEAFVQSGIDSIRVHGA
                     LGYLDEGRVNNSIKDALGSVLFSGTSDIQRELICNRLGLL"
     gene            6904..8433
                     /locus_tag="MARME_RS20560"
                     /old_locus_tag="Marme_4092"
     CDS             6904..8433
                     /NRPS_PKS="Domain: AMP-binding (16-417). E-value: 3e-94.
                     Score: 307.7. Matches aSDomain:
                     nrpspksdomains_MARME_RS20560_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     293.1; E-value: 5.1e-89)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="MARME_RS20560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Marme_4092"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_013663194.1"
                     /sec_met_domain="AMP-binding (E-value: 2.4e-108, bitscore:
                     351.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLNYIFSAGMIAGEDNLAVSDTTESLTYKELNNITNQLVRTFQ
                     LLGVKEGDRVGLWLEKSCRGIACMLAISRLNASYVPIDPMNPLARVSTIIKDCQMSAIV
                     ISQGKLAKFIDSEHRELPLLIPDNLSLDDLNIHSDTNLSHVANWSDVRSQSSEHVDLDV
                     TYSETDLAYILYTSGSTGVPKGVCINHLNACAFINWSIEEVEPRPEDRFSNHAPWHFDL
                     SVFDIYVALGSGASVYLISEMVSYVPAQLVDFIEKNQISIWYSVPTALSLMMDAEPQLE
                     TRCSSLHTVIFAGEPFAIKKLKELRKRFPHKALYNFYGPTETNVSTYYKVPNEVPDKLP
                     IGHVCSGDSLSLLDDNGTKVAIGEQGFITIKGPSVFSGYWGKTARTEDAYNTGDIGYFN
                     DKGELMYVGRNDHMIKVKGYRIHLGEIETTIEKHPAIEECCVLLGEDKALHAYLVQQDD
                     SALSLIKIKLHCSAHLPKYMLPDFVHFLPMLPRNGNGKVARKDLAALEVSA"
     aSDomain        6952..8154
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MARME_RS20560_AMP-binding.1"
                     /evalue="3.00E-94"
                     /label="MARME_RS20560_AMP-binding.1"
                     /locus_tag="MARME_RS20560"
                     /protein_end="417"
                     /protein_start="16"
                     /score="307.7"
                     /tool="antismash"
                     /translation="DNLAVSDTTESLTYKELNNITNQLVRTFQLLGVKEGDRVGLWLEK
                     SCRGIACMLAISRLNASYVPIDPMNPLARVSTIIKDCQMSAIVISQGKLAKFIDSEHRE
                     LPLLIPDNLSLDDLNIHSDTNLSHVANWSDVRSQSSEHVDLDVTYSETDLAYILYTSGS
                     TGVPKGVCINHLNACAFINWSIEEVEPRPEDRFSNHAPWHFDLSVFDIYVALGSGASVY
                     LISEMVSYVPAQLVDFIEKNQISIWYSVPTALSLMMDAEPQLETRCSSLHTVIFAGEPF
                     AIKKLKELRKRFPHKALYNFYGPTETNVSTYYKVPNEVPDKLPIGHVCSGDSLSLLDDN
                     GTKVAIGEQGFITIKGPSVFSGYWGKTARTEDAYNTGDIGYFNDKGELMYVGRNDHMIK
                     VK"
     CDS_motif       7414..7473
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MARME_RS20560_0001"
                     /evalue="4.00E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="MARME_RS20560"
                     /protein_end="190"
                     /protein_start="170"
                     /score="31.6"
                     /tool="antismash"
                     /translation="AYILYTSGSTGVPKGVCINH"
     CDS_motif       8119..8184
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MARME_RS20560_0002"
                     /evalue="1.30E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="MARME_RS20560"
                     /protein_end="427"
                     /protein_start="405"
                     /score="30.2"
                     /tool="antismash"
                     /translation="YVGRNDHMIKVKGYRIHLGEIE"
     gene            8513..10063
                     /locus_tag="MARME_RS20565"
                     /old_locus_tag="Marme_4093"
     CDS             8513..10063
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) PBDE:
                     FMO-like"
                     /gene_functions="other (smcogs) SMCOG1092:hypothetical
                     protein (Score: 291.1; E-value: 3.1e-88)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012946.2"
                     /locus_tag="MARME_RS20565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Marme_4093"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_013663195.1"
                     /sec_met_domain="FMO-like (E-value: 3e-80, bitscore: 259.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRIAIIGAGLSGIAAIKQLTDEGHHVVCYEKAESFGGVFAAKK
                     IYEDLHLTISNYFMAYSDFLPTEQSLKFWSKQEYVQYLKRYLAHFDIEKHIVYNHKVVN
                     AEQNGDKWTVKVQSGSGEETESEFDMVVVCSGHFQEPKTPDLEGLSDFMGDIIHSNDYR
                     DKMAFKGKRVMCVGLGESSADITSEISEVAEKCILSLRRYPAVAPRYMAFQEDPYFTID
                     TSWLTSRIVNKLPFSYHRGITKNIFHKYVNSRNLHLRIRGEWLHKSGPSIHQAVTKNER
                     LFKPIAEGKVLPNIGGIERFEGNTVIFKDGTHEEIDAIVFCTGYKLSFPFLQHKIECMR
                     DLYKQIFIPSVGSSLAFVGFVRPQQGGIPVIAEMQSRYLAQLASGVKSLPSLEKQKEVI
                     MEDANHWETEYHITPHVASLVNYCHYMDSMARLVGCMPKTPSLLKDPLLRVKLLHNPQF
                     AAQYRLEGPHPMSESSRDFLVNFPNISTWPRIIHFECALAMQKLLSFLSMDNLRELKK"
     gene            10117..10746
                     /locus_tag="MARME_RS20570"
                     /old_locus_tag="Marme_4094"
     CDS             10117..10746
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) PBDE:
                     DUF98"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014054.2"
                     /locus_tag="MARME_RS20570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Marme_4094"
                     /product="chorismate pyruvate-lyase family protein"
                     /protein_id="WP_013663196.1"
                     /sec_met_domain="DUF98 (E-value: 3.5e-14, bitscore: 42.6,
                     seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVISSEKQSNQNKELNLDQYNEHSLSVLQRLILESDGTLTQLVG
                     NLVGESIIAEKLFEGPTPDSRSQTSSLQQDERYLQKRIVSLKGQKSGFCYLYANSIVYH
                     DNLNVNFSRALLDSKITIGRAWERYRVETYKELDAWGFESAGTLGRHFNLSSEALLLFR
                     TYSVYSGGKKIFLITEKFPMAWFQKPNQTYPANSQPHAQERYDEIL"
     gene            10733..12220
                     /locus_tag="MARME_RS20575"
                     /old_locus_tag="Marme_4095"
     CDS             10733..12220
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) PBDE:
                     p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 169.9; E-value: 1.5e-51)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012296.2"
                     /locus_tag="MARME_RS20575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Marme_4095"
                     /product="cytochrome P450"
                     /protein_id="WP_013663197.1"
                     /sec_met_domain="p450 (E-value: 1.5e-68, bitscore: 221.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYYEEDANVTDSPNRNAAPKLIPTIKLGSQDNHDMMWNEDFHLT
                     ITNMAKKYGAIYALETGKTTLIALNDHNAVREALVNQSDVFNIRADLEILQVAPQKHFL
                     ELEAGELWSLHRKTFATAMRDYFRDRWDTMDQWLVTEIDDIEAAWKSQGDQAVFDPNRD
                     ISIKLASFLHRVMFDRRFGEFEESVFDEKSLSWLPAGFINSTRYELMPEHNKESYYAHY
                     GDVIEKFASNLNGLDAYVSMNVLKEKECYNKGQYRHLTDFLLNACDDIPNDVKQQVGAT
                     EKEIIIGSLTQVAGAGGGVGAFALRWMLLYLASFPEKQKQVHAELDQVIGQNETPQQSH
                     KGDLHYTQAFIAEVLRHCSITSMPASNYAASKDTFIDGYFVAKGTPLIVNNYGMTRDEA
                     LWENPDEFIPERFLEADGTFSKKQQAKSFPFGIGQRRCLGELFGKFLINTLFTHLAHRF
                     EFSLPNNEPINLRAISGVFLVPEKVDIKAKSRSLSDS"
ORIGIN
        1 tcaagcttca ctcatccgtt taacgggttt ggcatactca ttcagagaac agcttacatc
       61 ggctaacacg tgagaaggca cacaggtctt cgcggcgatc attcttttag atagcataaa
      121 gtctgctggg gaattaatgc attctgaagc aatgactcta ccgtcgcgta aataccatag
      181 actaaattga tcgtggcttt tctcgcgtaa aacggtttga tcatggccat gattcaggcc
      241 agccatttgt agtttgttct catattggtc agaccagaac cattgcactg cattcgagct
      301 tttcggctta ccacagattg tcgatgcaac acttttcgct tgttctagtg cattcggtac
      361 agaggcaatt tgcatagcaa tgccgttgct ttgcaattga gaagtacaat ctcctgcagc
      421 aaagatatct tcttgactgg tgcggccata ttggtcgacg acaatgccat cagttacatc
      481 taaccccgct ttccgtgcca gttcactatc ggcatcagat ccaacgccga taacaacaag
      541 gtccgcgcca taacgagatc catccgtaca aatcacttgg cgcatcttat gttctgcact
      601 gtcgctgtct tctacaaaat gactcacact tttctgagtc actatattga cgccattgcg
      661 agtatgctgt tctaggagaa aatctgagac aggggcagaa gttgagccat ttagtattcg
      721 gttactacga accaaaatag tcactaagtg ccccattttt cttaatacgg cggctgtttc
      781 caaagacaca tatccaccac ctaccatcac aatgtttttc tgcccaccct caaggtattc
      841 actcaacata cgaatatcgc gtatcgtctt gatgtaaaaa atacctcgca gatccgatcc
      901 aagcacatcc aaacgtcgca ttttactccc catgcacagc acgagtttat cgtagtgaat
      961 attagaacca tcctgcataa ccagactatg acgctcaggg taaatatccc taacctcttg
     1021 attaataaga acatctatat catctttcgc gtatgctatt tctgggcgaa ttagtagctc
     1081 atgctccgtc gtgttaccaa gtaaaaaact cttcgacagc ggtgggcggt gatatgggaa
     1141 actatattcg tttgtgaaca cagtaatttt tccttcccaa ccgagctttc ttaaactggt
     1201 actcacctga gcacccgcat gccctccacc aacaatcaca cagcgctgct tcataactca
     1261 ctcctttaat actgacattc aggcaaatga acgataagtc catcatgtgc gtcggtcact
     1321 ttcacctgac aacttaaacg gctgccttct ttcggctcaa taaccatttc gagcatttgc
     1381 tcttcattac tgtctggagc ctgtactttt tgatgccaac ccaaactcag gtaacaatgg
     1441 caggttgcac aactgccgga accgccacac tcagcttcga gcccttccac catattttcc
     1501 atcgcggcct gcataatagt aaccccagct ttcgcaaaaa cagtctgacg gctaccatca
     1561 tgttggataa aggtaatatc tggcataatt cactccttaa acgggcattt agttctgttt
     1621 ttcaatctca tctaacgtcg ctctaggagc ggcttctatc tgactatcca tagcagcatt
     1681 ccagcgattt agaaaaccgc aaattgcgat aattgcagcg atttctatag ccgcctcttc
     1741 gctgtaatat cgggcgagtt cgtcaaagtg ctctttgtcg aggtgcgctg gcgacgtgct
     1801 attagcaaac gcaaatgcca gtgcagcccg ttccgcttcg ttgtaaaaat cacttgtttg
     1861 aaattcaaag gccgccatta ctttatttcg attgacgtgt gttcgggtcg caatatgaga
     1921 gaaatgactt ttgcaataca tgcagcccgc agctgagcta ctgatcattg caatcgccca
     1981 tttgagctct gtcggaatat gtttgaatgc atcgatacat ttgaacaaac caccaaacgc
     2041 taccgctaaa tctgggtttt ttcccattgt taatatgcca ttcggtaaaa agcccaaatt
     2101 ttgttccatt ccgcgaaata caggctctaa ttgaggagca tcactccttt gcagcggggt
     2161 tactaaggtg ttcattgaat cggtcatttc atcctcccta ttcctttgat cagtgttaat
     2221 acaataggaa gttttatttt ttgaaccata gctcatgcag cctatgcaca ttttttacta
     2281 gtcctattta acccctttcc caaaaaactc tagctctact ggtgtggagt gatagcccaa
     2341 ttgagccatt gagagtacgt cacaaacttc ttaatttaga gatcagtgct gtcgcgaagt
     2401 agtacagcga aagcatgaaa attcgctcac gataattagg acgtcaccat gattgaaaaa
     2461 ttaattcact ttataaacaa tgatttacta gaaggtgctg cagatgacct tgatcagaac
     2521 acccctctac tggaactggg gattctagat tcattgtcta tggttttgct tctagcacac
     2581 atagatcaac agtacggagt gaagattcca gaacatgaaa tcaatccaga gcattttgaa
     2641 aatgtcgcta cactcgccgc gctcattaac cagttaagca aagacgaaac cgcagaggct
     2701 atgcctcagc aagagaacgt gtcagagctg gctcgcctag ttaagttaca agaaacctac
     2761 aacatagaaa gtcagatggt tgaggtcggt ggtgggctca cgcagcacgc tcttcgcgtc
     2821 aaaggaaacg gtcctttatg ggtcatgttg ccagcccttg gcaacccttc tacctcatgg
     2881 tcaccgttgt tacgttccgt tcagaatcga cacaatgcag tcgcgctgga tctggctgga
     2941 ttcggtttaa cacaaagcaa taaagacaac ccttcgttta aagatcatgt aaacaacacc
     3001 cttcaatatc ttgaaacgat tgaagagcaa gagtgggtat tgattgcaaa ttcggctggg
     3061 agcatggtcg ccgccgaggt tgctcgccgg ttcccagaaa aagttaaagc cttggtcatc
     3121 acaggctttg gccttgttga agatgttgaa ggttggtggc aaggactcaa agccatgtct
     3181 aaaaagcctg aggagttttt ggaagcggct tactataacc cgccgaaact cacaccagac
     3241 ttaaacaact tactaaacga agtcttatct cgccccgcct accataattt cctagacact
     3301 cacgcaaaag agcgcataag ccatatcttt gatggcatta cggttccaac gctttttatt
     3361 gccggtaatc acgatcaaat cgttccccct gaatggagtg aaaaagccgc tgaaagcatg
     3421 gaagacgcgt cggtagtccg tctgtctcga tgcggtcact tctcagcctc agaacgtcct
     3481 gaagaattta tctgggtcgt tgaggacttc ttaatgaaga tcaatcaaaa gcaaaacatg
     3541 gcaagtcaaa cgaacaatca agaagcgagc atggcatgaa tactaacgca aattacgatg
     3601 tggttatcat tggtagtggt ccagcaggca gtttgtgcgg catcgaatgt cgaaaaaaag
     3661 gtttatccgt tctttgtatc gagaaggacg aattcccccg ctttcacatc ggagagtcat
     3721 taaccgggaa tgcaggccaa atcattactg acctcggcct atacgacaaa atggaagaag
     3781 ctgagtttcc caataaattg ggggttaacg ttatcggcag cttatctaaa aacgagtttt
     3841 tcattccgat tctggccaag acttggcaag tacgccgaag cagtttcgac aagatgctca
     3901 aagaaaaagc attagagcac ggtgtagaat atcaaacagg gatggtaact gatgtactta
     3961 gagacggtga gaaagtcgtc ggtgctacct ataaaaccgc cgcgggcagc caaaacgtca
     4021 actcaaaagt gctggtcgat gccagtggcc aaaccacgtt tctctctcgt aagggcgtag
     4081 cgggtaaacg taaggtggag ttcttctctc aacagatcgc atcattcgcg cactttgaaa
     4141 atgtcgaaag agatttacct ccgttctcca ctaacacaac gattctgtat tccaaacagt
     4201 accactggtc ttggattatt ccgatttccc ccactaccga cagccttggt gttgttattc
     4261 caaaagacct ttattacaaa gaatgcaatt ctccagaagc cgcaatcgag tggggaatga
     4321 acaacatcag tccagaactg aaacgtcgct tcaaaaatgc agaacaagta gaagcctctc
     4381 agtctatggc cgacttctcc tatcgcatcg agcctttcgt tggtgatggc tggctatgca
     4441 ttggcgattc tcatcgcttc cttgatccaa ttttctccta cggtgtgtca tttggcatga
     4501 aagaagggat ccgttccgct gaggcgatcg cgacgtccat tcaaacgggt gactggaaaa
     4561 ctccatttta tgcgttccgt gattggagta acaaaggcca gcagattgca gcagacctga
     4621 ttcgttattt ctggatttat cctattttct tcggttatca gatgcaaaac cccgacttgc
     4681 gagacgaagt tattcgctta cttggtggtt gctgcttcga ttgcgaaggc tggaaagcac
     4741 ccagcatttt cagcaatgca atcaaagaat atgaccgcaa acaaatggaa acgaagatag
     4801 cgtcgtaacg ctcggcacga cgacagcgct tgaaccactg tcgtcgtatt tttcaaagtc
     4861 ggagaataaa cgtgaatact cggtttgtac taattgtcgc atcgctatgg ctggcagtgt
     4921 tatttggggt aatggacaac ccaacttggt tgcttcaaga aaactggcct atcattttta
     4981 tcgctttcgc cagtgccgca gtcgcaaacg caaccgcggt gggtggcggt tttatctttc
     5041 tgcctttgtt ttcgtttgca tacagtttaa gtgccgccga ggcattaaag ctggcactcg
     5101 caacgcaggc atttggtatg tcgtcaggtg cattaggctg gtctaaaaaa gtcatcgact
     5161 tccattttct gaaactgggc gccggagcag gtgtgctcgg catgtttata ggcaccttcc
     5221 tatttacgcc tccaggccat ctaatccata acattttcgg atacgcctcc attgtggtga
     5281 gtctggcttt gtttatcgag atgatctaca tccgtaaaac agataaaacg gtctttgacg
     5341 agccgaacca cagtctagtg gagttctgta tttgggcctt actcggcggc cttattaccg
     5401 cttggacatc catcggcatt ggcgaagtgg tcgccctatg gctgctattt agggcaaaac
     5461 aaagcatcgt gaaaagcgtt gctacaggcg tcgcagtact ggcgatttgc tccatcagcg
     5521 gtcttctatt tcacatttac gaaggcggca ttgtttggga ataccttatc ttcactgctc
     5581 cgggtgtgct gttaggcggt cgtgctggcg cgctgcttgg taaaagaatg gcaggcgtta
     5641 aaaagcagca agagcctcac agtcataatg acaacaaagg atttgggcta aagctgtttg
     5701 tcgcattagt catctttgcg gatggcattg tggtgatttt caaccaatag tgaaggagac
     5761 aaacatgaat ttcgaatgga cacacgaaca agcagaactt tttgagcacg ctttacgctt
     5821 cggtaaagag ctgagcgccc ccttacaaga ggataacggc ttccctcgcg acaactggaa
     5881 cgcacttggt gacttcggct acttcggtct tcccatccca gaaaagtatg ctaaagatgg
     5941 ttcggggttt gacatactca ccacaatcaa aatcatagaa gggttggggc aaagctgcac
     6001 tgatacagga cttttgtttg ctggcgctgc acacactttc gcttgcagca tgcctatatt
     6061 agagcacgga agcgaaacct taaaacacca acttttaccc gatcttgcta ctggcagaaa
     6121 gatcgcagcc aatgctattt cagaagcatc cgcgggctcc gatatatcaa accttgcgac
     6181 aacagcccaa aaagaaggtg actactatgt cctcaacggc ggtaagtcgt acgtcacaaa
     6241 cggcagtatt gcggactatt acgtggtata tgcgacaacg aataaaaagc atggctacct
     6301 aggccaaacc gcgttcgtag tacctcgaaa tacaccagga atttctgtcg gcaacgatta
     6361 ccacaaactg ggattgcgct cggcacctct taatcaggtt ttcttcgaca attgtacgat
     6421 acacaaggat tacgcacttg gcagagaagg acaaggagca aggatcttcg cggcttctat
     6481 ggattgggag cgctgctgcc tgtttgccat ttttgtcggt gctatgcaaa gggacctcaa
     6541 ccagtgcatc gagtacgcaa atacgcgtat gcaaggcgat aagacaatta gccgatttca
     6601 agccgtttct caccgaattg cggatatggg cgttcgtctg gaatctgctc gtttaatgct
     6661 ctattacgca gcatggcaaa aatcgcaaga cgtcgacaac accaaagccg ttgcgatgag
     6721 caaattggcc atcagtgaag cctttgttca atccggtata gacagtatta gggtacacgg
     6781 tgcattaggc tacctagatg aagggcgagt gaataacagt attaaagacg ctttaggatc
     6841 tgttctattt tctggcacct ccgatattca acgagagtta atctgcaata ggctggggct
     6901 actatgaaac gactcaatta tattttttct gctggcatga tagcaggaga ggacaacctc
     6961 gctgtctccg atacaactga atctttgact tataaagagt tgaataacat cactaaccag
     7021 ctcgttcgca cctttcagct gcttggtgtt aaagaaggtg atcgagtcgg tttatggcta
     7081 gaaaaatcct gccgagggat cgcttgtatg ttggctatca gtcgcttaaa cgcaagctat
     7141 gtgcctattg atccgatgaa cccgcttgct cgagtcagta cgattatcaa ggactgccaa
     7201 atgtcggcaa tcgtaatatc acaaggaaaa ttagcaaagt ttattgattc cgaacaccgt
     7261 gaattgcctt tgctcattcc tgacaaccta agtctagacg acttaaatat tcactctgat
     7321 accaatttga gtcatgttgc caattggtca gacgtacgct ctcaatcaag cgagcatgtt
     7381 gatcttgatg tgacttacag cgaaacagat cttgcgtaca ttttatatac ctcaggttct
     7441 acaggtgtgc ctaaaggagt ctgtattaat cacctaaacg cctgcgcctt cattaattgg
     7501 agtattgagg aagtcgagcc tcgtccagaa gaccggttct caaatcatgc cccttggcac
     7561 tttgacctgt ctgttttcga tatctatgtt gcacttggtt ctggtgccag cgtctatctt
     7621 atctcggaga tggtgagtta cgtaccggct caactcgtcg attttattga gaaaaaccag
     7681 atcagtatct ggtactccgt gccgaccgcg ctgtccttga tgatggatgc agaaccgcag
     7741 ctcgaaacac gctgcagttc gttacacacc gttatctttg ccggtgaacc tttcgcaatc
     7801 aaaaagctaa aagaactgcg aaaacgattc ccacacaaag cactttataa cttctacggc
     7861 ccgacagaaa ccaatgtaag cacctactac aaagtaccca acgaggtacc tgacaagtta
     7921 ccgattgggc acgtatgtag cggcgacagc ctctctttac ttgatgacaa cggcacaaag
     7981 gtcgctatcg gagagcaggg ctttattacg ataaagggcc ccagtgtctt ctccggttat
     8041 tggggtaaaa ctgcgcgaac agaagacgct tataacacag gagacattgg ttatttcaat
     8101 gataaaggcg agctgatgta tgtaggacga aacgaccata tgataaaggt caaaggctat
     8161 cgcattcacc ttggggaaat cgaaacgaca atagaaaagc acccagccat tgaggaatgt
     8221 tgtgtgctac ttggtgagga taaagcactc catgcctatt tggtgcagca agatgacagt
     8281 gcgctttctc tcatcaaaat aaagctccat tgctccgccc acttacctaa atacatgctg
     8341 ccagactttg tgcactttct acctatgctt cctcgcaacg gcaacggaaa agtcgcgcgc
     8401 aaagacctcg ccgcactaga agtcagtgct taaagtccaa atgagctaag tcgacacggc
     8461 ctaccttaac caacgacaga gtaggctgat aataaaaagg gagattatca ctatgaagaa
     8521 acgtatcgca attattggcg cgggcctgtc tggaatcgcc gcaattaaac agcttacaga
     8581 tgaaggccat catgttgtct gctatgaaaa agcagaaagc ttcggtggcg tgttcgcagc
     8641 taaaaaaatc tacgaagatc tgcatctaac catttccaat tattttatgg cctactccga
     8701 cttcctaccc acagagcaaa gtctgaaatt ttggtcgaaa caggaatatg tgcaatacct
     8761 aaagcgttac ctcgctcact tcgacattga aaagcacatt gtctacaacc ataaggtcgt
     8821 aaacgcggag cagaatgggg acaaatggac agtcaaagtt caatcgggct caggagaaga
     8881 aacagagtct gaatttgata tggttgttgt ctgctctggc cacttccaag aacctaaaac
     8941 acccgattta gaaggcttgt cggactttat gggggacatc attcactcta acgattatcg
     9001 tgacaaaatg gcgtttaaag gcaaacgcgt catgtgcgtt ggccttggag aaagttctgc
     9061 tgatattaca tccgaaatat cagaagtagc agaaaagtgt attctgtcac tgcgccgata
     9121 tcctgccgtc gcgccgcgct atatggcctt tcaggaagac ccctatttca cgatcgatac
     9181 ctcttggttg acctccagaa ttgtgaacaa actccccttc tcataccacc ggggaatcac
     9241 aaaaaacatt tttcacaaat acgtgaacag ccgaaatcta cacttaagaa ttcgtggtga
     9301 atggctgcat aaatccggcc cttccatcca tcaggcggtt accaaaaatg agcgcctgtt
     9361 taagcctatc gccgaaggaa aagtattacc aaatatcggt ggtatagaac gctttgaagg
     9421 caacacggtt atttttaaag atggtacaca cgaagaaatt gatgccatcg tattttgcac
     9481 aggttataaa ctttctttcc ctttccttca gcataaaatt gagtgcatga gggacttata
     9541 caagcaaatc tttataccga gtgtaggcag tagccttgcg ttcgtgggtt ttgtcagacc
     9601 tcaacaaggt ggtattcccg ttatagcgga aatgcaaagc cgctatcttg cacagctcgc
     9661 cagtggagtt aaatctcttc cttcacttga gaaacaaaaa gaagtcatca tggaagatgc
     9721 caatcactgg gaaactgaat atcacattac accgcatgtg gcgtcgctgg ttaattattg
     9781 ccattacatg gactcaatgg ctcgtctagt tggctgtatg ccgaagacac cgtctcttct
     9841 aaaagacccg ctgctaagag tgaaattact gcacaacccg cagtttgccg cccagtatcg
     9901 actggaaggc ccacacccca tgtcggaaag ctctcgcgac ttcctagtga actttccaaa
     9961 catcagcact tggcctcgaa tcattcactt cgagtgcgca ttagcgatgc aaaaactact
    10021 tagttttttg agcatggaca atttaagaga gttaaaaaag tagcctgctg atgtgccttt
    10081 ttaggcagcg agttttcgac aaaaggactt agtaccatga tagtcatatc aagcgaaaaa
    10141 caaagcaacc aaaacaaaga actcaattta gaccaataca atgaacacag cctttcggtg
    10201 cttcagcgac tgattttaga aagcgacggc accttaacac agctggtagg caatctcgtc
    10261 ggtgaatcta ttattgcaga aaagctgttt gaaggcccaa ctcctgatag ccgatcgcag
    10321 acctccagcc ttcagcaaga cgagcgatat ctgcagaaga ggatagtctc acttaagggt
    10381 caaaaatccg gcttttgcta tttatacgct aactctattg tttatcacga caacctcaat
    10441 gtgaactttt ctagagcctt gctcgattcg aaaataacaa tcggcagagc atgggaaaga
    10501 tacagagtag aaacctataa agaacttgac gcatggggat ttgaaagcgc aggcacgcta
    10561 gggaggcatt tcaaccttag tagcgaagcc ttattactgt tccgcactta ctcggtgtac
    10621 tcaggtggaa agaaaatttt cctcattact gaaaaatttc caatggcctg gtttcaaaag
    10681 cctaatcaga cctacccagc caactctcaa ccccacgcac aggaaagata cgatgagata
    10741 ctatgaagaa gacgccaacg taacagactc gcccaatagg aatgccgctc ccaagttgat
    10801 tcctacaatc aagcttggat cacaagacaa tcatgacatg atgtggaacg aagatttcca
    10861 tctcaccatc accaacatgg caaaaaaata cggggctata tacgccttgg aaacaggcaa
    10921 aacaacacta atcgcgttaa atgatcacaa cgctgttcgt gaagcattgg tcaatcaaag
    10981 cgatgtattt aacattcgag cggatcttga gattcttcag gttgcgccac aaaagcactt
    11041 cttagaatta gaagcaggag agctgtggag cctgcataga aaaacctttg caacggcaat
    11101 gcgcgactac ttccgcgatc gttgggatac gatggatcag tggctggtca cagaaataga
    11161 tgacatcgag gccgcttgga aaagccaagg tgatcaagcc gtatttgatc caaatcgcga
    11221 catttcaatc aagctggcca gcttcttaca cagagtcatg tttgaccgtc gcttcggtga
    11281 attcgaggag agtgtcttcg atgaaaaaag tctgagttgg ttgccagcag gctttatcaa
    11341 cagtacgcga tatgagctca tgcctgaaca caacaaagaa agctactacg ctcattatgg
    11401 agacgtaata gaaaagtttg cctcaaacct taacggactc gacgcgtatg tttccatgaa
    11461 tgtccttaag gagaaagagt gctacaacaa aggtcaatat cgccacttaa cggatttctt
    11521 actaaacgcc tgcgacgaca ttcctaacga cgttaaacaa caagtaggcg caaccgaaaa
    11581 ggaaatcata atcggctctc ttactcaggt cgcaggagct ggaggcggtg taggcgcgtt
    11641 tgctttgcgt tggatgctat tatatctcgc gagcttccct gaaaagcaaa aacaagtaca
    11701 cgcagagctt gatcaagtta tcggccaaaa tgaaacgcca cagcaaagtc acaaaggcga
    11761 cctgcactac acgcaagctt ttattgctga agtacttcgt cactgttcaa tcacgtccat
    11821 gccagcctct aactacgctg ctagcaaaga cacctttatt gacggctact tcgttgcaaa
    11881 aggaacccct ttaatagtga acaactacgg aatgacccga gacgaagccc tatgggaaaa
    11941 ccctgatgag ttcatccctg agcgtttctt agaagcagat ggcaccttta gcaaaaagca
    12001 gcaagcaaag tcattcccat tcggaatagg tcagcgccgt tgcttaggtg agcttttcgg
    12061 taagttcctc attaacaccc tgttcactca tttagcgcat agatttgagt tctcccttcc
    12121 taacaatgaa ccgattaatc tacgtgctat atcgggtgta tttctggtgc cagaaaaggt
    12181 cgatataaaa gcgaaaagtc gcagtcttag cgactcataa
//
