BGC0001467: hapalosin biosynthetic gene cluster from Fischerella sp. PCC 9431
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Location: 6,215,740 - 6,241,521 nt. (total: 25,782 nt).
This entry is originally from NCBI GenBank NZ_KE650771.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001467
Short description hapalosin biosynthetic gene cluster from Fischerella sp. PCC 9431
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "More accurate coordinates for FIS9431_RS32925 seem to be complement(6221211..6225791)"
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Other)
Loci NCBI GenBank: NZ_KE650771.1
Compounds
  • hapalosin
Species Fischerella sp. PCC 9431 [taxonomy]
References
Chemical products information
hapalosin
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C28H43N1O6
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • FIS9431_RS0128775
  • WP_035122279.1
6215740 - 6221196 (-) type I polyketide synthase
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  • FIS9431_RS32925
6221211 - >6225689 (-) non-ribosomal peptide synthetase
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  • FIS9431_RS0128785
  • WP_081656241.1
6225936 - 6232982 (-) non-ribosomal peptide synthetase
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  • FIS9431_RS37445
  • WP_035121546.1
6232979 - 6238924 (-) type I polyketide synthase
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  • FIS9431_RS0128795
  • WP_026723805.1
6239395 - 6241521 (-) AMP-dependent synthetase
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Polyketide-specific information
Subclass Other
Starter unit Hexanoyl-ACP
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
FIS9431_RS0128775
+
FIS9431_RS37445
Synthase subclass: Modular type I
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: FIS9431_RS37445
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: FIS9431_RS0128775
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP), Thioesterase
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Hydrolysis
Thioesterase genes
  • FIS9431_RS0128775 (Type I)
NRP-synthases
Gene Modules
FIS9431_RS0128795
Module 0
Condensation domain type: Starter
FIS9431_RS0128785
Module 2
Specificity: 2S-hydroxyisovaleric acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
FIS9431_RS32925
Module 3
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Methylation
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: B54ZPFB4PBVBWY2K6JZNBOD5, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fix missing gene identifier
  • Corrected NRP module activity
  • Updated NRP substrate specificities
Detailed domain annotation
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