BGC0001467: hapalosin biosynthetic gene cluster from Fischerella sp. PCC 9431
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 6,215,740 - 6,241,521 nt. (total: 25,782 nt).
This entry is originally from NCBI GenBank NZ_KE650771.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001467
Short description hapalosin biosynthetic gene cluster from Fischerella sp. PCC 9431
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "More accurate coordinates for FIS9431_RS32925 seem to be complement(6221211..6225791)"
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Other)
Loci NCBI GenBank: NZ_KE650771.1
Compounds
  • hapalosin
Species Fischerella sp. PCC 9431 [taxonomy]
References
Chemical products information
hapalosin
Copy SMILES
C28H43N1O6
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • FIS9431_RS0128775
  • WP_035122279.1
 6215740 - 6221196 (-) type I polyketide synthase
copy AA seq
copy Nt seq
  • FIS9431_RS32925
 6221211 - >6225689 (-) non-ribosomal peptide synthetase
copy AA seq
copy Nt seq
  • FIS9431_RS0128785
  • WP_081656241.1
 6225936 - 6232982 (-) non-ribosomal peptide synthetase
copy AA seq
copy Nt seq
  • FIS9431_RS37445
  • WP_035121546.1
 6232979 - 6238924 (-) type I polyketide synthase
copy AA seq
copy Nt seq
  • FIS9431_RS0128795
  • WP_026723805.1
 6239395 - 6241521 (-) AMP-dependent synthetase
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Hexanoyl-ACP
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
FIS9431_RS0128775
+
FIS9431_RS37445 		Synthase subclass: Modular type I
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: FIS9431_RS37445
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: FIS9431_RS0128775
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP), Thioesterase
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Hydrolysis
Thioesterase genes
  • FIS9431_RS0128775 (Type I)
NRP-synthases
Gene Modules
FIS9431_RS0128795
Module 0
Condensation domain type: Starter
FIS9431_RS0128785
Module 2
Specificity: 2S-hydroxyisovaleric acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
FIS9431_RS32925
Module 3
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Methylation
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: B54ZPFB4PBVBWY2K6JZNBOD5, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fix missing gene identifier
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.