BGC0001467: hapalosin A biosynthetic gene cluster from Fischerella sp. PCC 9431
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Location: 6,215,740 - 6,241,521 nt. (total: 25,782 nt).
This entry is originally from NCBI GenBank NZ_KE650771.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001467
Short description hapalosin A biosynthetic gene cluster from Fischerella sp. PCC 9431
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "More accurate coordinates for FIS9431_RS32925 seem to be complement(6221211..6225791)"
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
NZ_KE650771.1
6215740 - 6241521
via Heterologous expression
Compounds
  • hapalosin A
  • hapalosin C
  • hapalosin D
  • hapalosin E
  • hapalosin F
  • hapalosin G
Species Fischerella sp. PCC 9431 [taxonomy]
References
Chemical products information
hapalosin A [synonyms: hapalosin] Evidence: MS/MS [1], [2], [3]
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C28H43N1O6
Chemical database entries
PubCHEM
CyanoMetDB CyanoMetDB_1323
ChemSpider
NPAtlas
hapalosin C Evidence: MS/MS [1], [4]
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C28H41N1O6
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_2235
hapalosin D Evidence: MS/MS [1]
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C27H41N1O6
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_2236
hapalosin E Evidence: MS/MS [1]
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C27H41N1O6
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_2237
hapalosin F Evidence: MS/MS [1]
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C26H39N1O6
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_2238
hapalosin G Evidence: MS/MS [1]
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C26H39N1O6
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_2239
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • FIS9431_RS0128775
  • WP_035122279.1
 6215740 - 6221196 (-) type I polyketide synthase
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    • FIS9431_RS32925
    		 6221211 - >6225689 (-) amino acid adenylation domain-containing protein
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      • FIS9431_RS0128785
      • WP_081656241.1
      		 6225936 - 6232982 (-) non-ribosomal peptide synthetase
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        • FIS9431_RS37445
        • WP_035121546.1
        		 6232979 - 6238924 (-) SDR family NAD(P)-dependent oxidoreductase
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          • FIS9431_RS0128795
          • WP_026723805.1
          		 6239395 - 6241521 (-) AMP-binding protein
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            Biosynthesis information

            Biosynthetic modules

            Name
            2
            Type
            nrps-type1
            Genes
            FIS9431_RS0128785
            Substrates
            2S-hydroxyisovaleric acid (evidence: Structure-based inference)
            Integrated Monomers
            Domains
            condensation (LCL), adenylation
            Name
            3
            Type
            nrps-type1
            Genes
            FIS9431_RS32925
            Substrates
            phenylalanine (evidence: Structure-based inference [3], [4])
            Integrated Monomers
            Domains
            condensation (LCL), adenylation, methyltransferase
            Name
            1
            Type
            pks-modular
            Genes
            FIS9431_RS37445
            Substrates
            Integrated Monomers
            Domains
            acyltransferase, ketosynthase, acyltransferase, ketoreductase, methyltransferase, carrier (ACP)
            Name
            4
            Type
            pks-modular
            Genes
            FIS9431_RS0128775
            Substrates
            Integrated Monomers
            Domains
            acyltransferase, ketosynthase, acyltransferase, ketoreductase, thioesterase, carrier (ACP)
            Annotation changelog

            Entry version: next

            Date
            Changes
            Submitters
            Reviewers
            2024-06-03
            MIBiG v4 annotathon
            • (ID: 2VKI7Z3FJAYQZQOV7NBR4NJN)
            • (ID: B54ZPFB4PBVBWY2K6JZNBOD5)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 4

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Fix missing gene identifier
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Corrected NRP module activity
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Updated NRP substrate specificities
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2019-10-16
            Updated compound(s) information (NPAtlas curation)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2018-08-06
            Submitted
            • (ID: B54ZPFB4PBVBWY2K6JZNBOD5)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            Detailed domain annotation
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