BGC0001469: marthiapeptide A biosynthetic gene cluster from Brevibacillus sp. Leaf182
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Location: 252,909 - 282,961 nt. (total: 30,053 nt).
This entry is originally from NCBI GenBank LMPN02000037.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001469
Short description marthiapeptide A biosynthetic gene cluster from Brevibacillus sp. Leaf182
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Reference of the current paper describing the biosynthetic gene cluster will be added as soon as published. "
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: LMPN02000037.1
Compounds
  • marthiapeptide A
Species Brevibacillus sp. Leaf182 [taxonomy]
References
Chemical products information
marthiapeptide A
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C30H31N7O3S4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ASG16_028310
  • RAT94085.1
  • marD
 252909 - 253166 (-) transcriptional regulator
  • Regulation
Sequence-based prediction
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  • ASG16_028315
  • RAT94086.1
 253520 - 253990 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • ASG16_028320
  • RAT94087.1
  • marF
 254099 - 254710 (-) DUF 4304 domain-containing protein
  • Unknown
Sequence-based prediction
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  • ASG16_028325
  • RAT94088.1
  • marG
 254767 - 255186 (-) DUF 2809 domain-containing protein
  • Unknown
Sequence-based prediction
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  • ASG16_028330
  • RAT94089.1
  • marH
 255445 - 256374 (-) acetamidase
  • Unknown
Sequence-based prediction
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  • ASG16_028335
 256672 - 256761 (-) iron chaperone
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  • ASG16_028340
  • RAT94090.1
  • marB
 257040 - 274781 (-) NRPS
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_028345
  • RAT94091.1
  • marA
 274798 - 278088 (-) NRPS
  • Scaffold biosynthesis
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  • ASG16_028350
  • RAT94092.1
  • marC
 278596 - 279609 (-) dehydrogenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • ASG16_028355
  • RAT94093.1
  • cysE__marJ
 279647 - 280219 (-) serine O-acetyl-transferase
  • Unknown
Sequence-based prediction
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  • ASG16_028360
  • RAT94094.1
  • marK
 280585 - 281148 (+) PadR family transcriptional regulator
  • Regulation
Sequence-based prediction
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  • ASG16_028365
  • RAT94095.1
  • marL
 281524 - 282960 (-) sensor histidine kinase
  • Unknown
Sequence-based prediction
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NRP-specific information
Subclass N/A
Cyclic? yes
Release type
  • Macrolactamization
Thioesterase genes
  • marB (Unknown)
NRP-synthases
Gene Modules
marA
Module 1
Specificity: isoleucine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Modification domains: Epimerization
marB
Module 2
Specificity: serine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Modification domains: Epimerization
Module 3
Specificity: cysteine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Heterocyclization
Modification domains: Heterocyclization
Module 4
Specificity: cysteine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Heterocyclization
Modification domains: Heterocyclization
Module 5
Specificity: cysteine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Heterocyclization
Modification domains: Heterocyclization
Module 6
Specificity: cysteine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Heterocyclization
Modification domains: Heterocyclization
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: CUIZDUBUBVAF27VHF4OZXTI3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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