BGC0001470: macrobrevin biosynthetic gene cluster from Brevibacillus sp. Leaf182
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Location: 223,174 - 318,348 nt. (total: 95,175 nt).
This entry is originally from NCBI GenBank LMPN02000017.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001470
Short description macrobrevin biosynthetic gene cluster from Brevibacillus sp. Leaf182
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: LMPN02000017.1
Compounds
  • macrobrevin
Species Brevibacillus sp. Leaf182 [taxonomy]
References
Chemical products information
macrobrevin
Copy SMILES
C42H66O6
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ASG16_007415
  • RAT98517.1
  • breO
 223174 - 237495 (-) trans-acyltransferase polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007420
  • RAT98518.1
  • breN
 237539 - 247891 (-) trans-acyltransferase polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007425
  • RAT98519.1
  • breM
 247930 - 253734 (-) trans-acyltransferase polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007430
  • RAT98520.1
  • breL
 253757 - 254503 (-) enoyl-CoA hydratase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007435
  • RAT98521.1
  • breK
 254510 - 255274 (-) enoyl-CoA hydratase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007440
  • RAT98522.1
  • breJ
 255274 - 256524 (-) 3-hydroxy-3-methylglutaryl-ACP synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007445
  • RAT98523.1
  • breI
 256549 - 257787 (-) polyketide beta-ketoacyl:ACP synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007450
  • RAT98524.1
  • breH
 257765 - 258007 (-) acyl carrier protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007455
  • RAT98525.1
  • breG
 258004 - 271413 (-) trans-acyltransferase polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007460
  • RAT98526.1
  • breF
 271432 - 276963 (-) trans-acyltransferase polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007465
  • RAT98527.1
  • breE
 276988 - 292734 (-) trans-acyltransferase polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007470
  • RAT98528.1
  • breD
 292737 - 300644 (-) trans-acyltransferase polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007475
  • RAT98529.1
  • breC
 300685 - 310422 (-) trans-acyltransferase polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ASG16_007480
  • RAT98530.1
  • breB
 310472 - 315031 (-) trans-acyltransferase polyketide synthase
  • Scaffold biosynthesis
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  • ASG16_007485
  • RAT98531.1
  • breA
 315049 - 318348 (-) acyltransferase acyltransferase 2-Nitropropane dioxygenase (NPD)-like domain
  • Scaffold biosynthesis
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
breC
+
breG
+
breM
+
breE
+
breA
+
breN
+
breB
+
breO
+
breD
+
breF 		Synthase subclass: Trans-AT type I
Trans-acyltansferases: breA
Module 1
Genes: breB, breC
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 2
Genes: breC
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Genes: breC, breD
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 4
Genes: breD
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Genes: breD, breE
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 6
Genes: breE
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 7
Genes: breE
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP), Enoylreductase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 8
Genes: breE
Core domains: Ketosynthase
Module 9
Genes: breF
Core domains: Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 10
Genes: breF, breG
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 11
Genes: breG
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 12
Genes: breG
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 13
Genes: breG
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
Module 14
Genes: breM, breN
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 15
Genes: breN
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 16
Genes: breN
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 17
Genes: breN, breO
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 18
Genes: breO
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 19
Genes: breO
Core domains: Ketosynthase, Dehydratase, Ketoreductase
KR-domain stereochemistry: Unknown
Module 20
Genes: breO
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thioesterase
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: CUIZDUBUBVAF27VHF4OZXTI3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules
  • Corrected publication
  • Sorted modules by module number
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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