Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001470.1:
Cluster 1Polyketide195175

BGC0001470, macrobrevin biosynthetic gene cluster from Brevibacillus sp. Leaf182. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: macrobrevin
SMILES string: Copy to clipboard
Molecular formula: C42H66O6
Exact molecular mass: 689.4762 Da ([M+Na]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Trans-AT type I
Starter unit:
Acetyl-CoA
RAT98531.1
Thioesterase type:
Unknown
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
breB (RAT98530.1)
Module 1
KR stereochemistry: Unknown
Scaffold-modifying domain: None

breC (RAT98529.1)
Module 1
Scaffold-modifying domain: Methylation
Module 2
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 3
KR stereochemistry: Unknown
Scaffold-modifying domain: None

breD (RAT98528.1)
Module 3
Scaffold-modifying domain: Methylation
Module 4
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 5
Scaffold-modifying domain: None
Module is non-elongating
Evidence for non-elongation: Unknown

breE (RAT98527.1)
Module 5
Scaffold-modifying domain: None
Module 6
Scaffold-modifying domain: Methylation
Module 7
KR stereochemistry: Unknown
Scaffold-modifying domain: Methylation
Module 8
Scaffold-modifying domain: None

breF (RAT98526.1)
Module 10
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 9
KR stereochemistry: Unknown
Scaffold-modifying domain: None

breG (RAT98525.1)
Module 10
Scaffold-modifying domain: Methylation
Module 11
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 12
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 13
Scaffold-modifying domain: None

breM (RAT98519.1)
Module 13
Scaffold-modifying domain: None
Module 14
KR stereochemistry: Unknown
Scaffold-modifying domain: None

breN (RAT98518.1)
Module 14
Scaffold-modifying domain: Methylation
Module 15
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 16
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 17
Scaffold-modifying domain: None
Module is non-elongating
Evidence for non-elongation: Unknown

breO (RAT98517.1)
Module 17
Scaffold-modifying domain: None
Module 18
KR stereochemistry: Unknown
Scaffold-modifying domain: Methylation
Module 19
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 20
Scaffold-modifying domain: None
Module is non-elongating
Evidence for non-elongation: Unknown

Gene cluster description

macrobrevin (BGC0001470). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank LMPN02000017, positions 318348-223174. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Eric J. N. Helfrich (ETH Zurich)

Literature references

1. Bai Y et al. (2015) Functional overlap of the Arabidopsis leaf and root microbiota. Nature 528(7582):364-9. doi: 10.1038/nature16192. Epub 2015 Dec 2.