BGC0001471: saalfelduracin biosynthetic gene cluster from Amycolatopsis saalfeldensis
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Location: 708,690 - 737,346 nt. (total: 28,657 nt).
This entry is originally from NCBI GenBank NZ_FOEF01000002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001471
Short description saalfelduracin biosynthetic gene cluster from Amycolatopsis saalfeldensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "As we are waiting on publication, we do not have a DOI/PMID for article associated with this cluster (Step 2). A related publication from our lab has been used to allow for MIBiG submission while this publication is finishing the review process."
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
NZ_FOEF01000002.1
708690 - 737346
via Heterologous expression
Compounds
  • saalfelduracin
Species Amycolatopsis saalfeldensis [taxonomy]
References
Chemical products information
saalfelduracin Evidence: NMR, Mass spectrometry
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C69H76N18O18S6
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BMY97_RS07420
  • WP_091614342.1
 708692 - 709702 (-) aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme
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    • BMY97_RS07425
    • WP_177231217.1
    		 709707 - 710135 (-) ester cyclase
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      • BMY97_RS07430
      • WP_177231218.1
      		 710179 - 711417 (-) acyl-CoA dehydrogenase family protein
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        • BMY97_RS07435
        • WP_177231219.1
        		 711434 - 712270 (-) SAM-dependent methyltransferase
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          • BMY97_RS07440
          • WP_091614353.1
          		 712267 - 712830 (-) DUF2867 domain-containing protein
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            • BMY97_RS07445
            • WP_177231220.1
            		 712874 - 713917 (-) alpha/beta hydrolase
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              • BMY97_RS07450
              • WP_091614358.1
              		 714479 - 714664 (+) thiocillin/thiostrepton family thiazolyl peptide
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                • BMY97_RS07455
                • WP_143086144.1
                		 714784 - 715575 (+) alpha/beta fold hydrolase
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                  • BMY97_RS07460
                  • WP_091614364.1
                  		 715572 - 718226 (+) lantibiotic dehydratase
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                    • BMY97_RS07465
                    • WP_091614367.1
                    		 718223 - 719224 (+) lantibiotic dehydratase C-terminal domain-containing protein
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                      • BMY97_RS07470
                      • WP_177231221.1
                      		 719230 - 720333 (+) lantibiotic dehydratase C-terminal domain-containing protein
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                        • BMY97_RS07475
                        • WP_091614372.1
                        		 720330 - 721949 (+) hypothetical protein
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                          • BMY97_RS07480
                          • WP_091614375.1
                          		 721946 - 723592 (+) hypothetical protein
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                            • BMY97_RS07485
                            • WP_177231222.1
                            		 723589 - 725517 (+) TOMM precursor leader peptide-binding protein
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                              • BMY97_RS07490
                              • WP_143086145.1
                              		 725495 - 726823 (+) cytochrome P450
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                                • BMY97_RS07495
                                • WP_091614382.1
                                		 726799 - 728094 (+) class I adenylate-forming enzyme family protein
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                                  • BMY97_RS07500
                                  • WP_091614385.1
                                  		 728091 - 729272 (+) cytochrome P450
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                                    • BMY97_RS46895
                                    • WP_091614387.1
                                    		 729260 - 731740 (+) lantibiotic dehydratase
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                                      • BMY97_RS46900
                                      • WP_177231223.1
                                      		 731737 - 732264 (+) pyridoxamine 5'-phosphate oxidase family protein
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                                        • BMY97_RS07515
                                        • WP_091614389.1
                                        		 732264 - 733454 (+) YcaO-like family protein
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                                          • BMY97_RS07520
                                          • WP_091614392.1
                                          		 733461 - 734825 (+) TfuA-like protein
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                                            • BMY97_RS07525
                                            • WP_091614395.1
                                            • tsrT
                                            		 734822 - 736543 (+) tryptophan 2-C-methyltransferase
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                                              • BMY97_RS07530
                                              • WP_091614398.1
                                              		 736540 - 737343 (+) SDR family NAD(P)-dependent oxidoreductase
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                                                Biosynthesis information
                                                Annotation changelog

                                                Entry version: 4

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Update chemical activity to schema version 2.11
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 3

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Updated coordinates from duplicate entry BGC0002023
                                                • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Migrated from v1.4
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2018-08-06
                                                Submitted
                                                • (ID: JW4IUWLB4KKWRZXPXDMX77W3)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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