Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001471.1:
Cluster 1RiPP124763

BGC0001471, saalfelduracin biosynthetic gene cluster from Amycolatopsis saalfeldensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: saalfelduracin
SMILES string: Copy to clipboard
Molecular formula: C69H76N18O18S6
Exact molecular mass: 1637.3996 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Thiopeptide (cyclic)
Peptides in this cluster:
WP_091614358.1
RiPP core peptide sequence(s): ASSSSCTTCICTCSCSS
Leader peptide length: 61
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage:

Gene cluster description

saalfelduracin (BGC0001471). Gene Cluster 1. Biosynthetic class = RiPP. GenBank NZ_FOEF01000002, positions 708692-733454. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?unknown
Evidence for cluster-compound connection:Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Comments:As we are waiting on publication, we do not have a DOI/PMID for article associated with this cluster (Step 2). A related publication from our lab has been used to allow for MIBiG submission while this publication is finishing the review process.
Contact for this cluster:Christopher Schwalen (University of Illinois at Urbana-Champaign)

Literature references

1. Schwalen CJ et al. (2018) Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics. J Am Chem Soc 140(30):9494-9501. doi: 10.1021/jacs.8b03896. Epub 2018
2. Mahanta N et al. (2018) Enzymatic reconstitution of ribosomal peptide backbone thioamidation. Proc Natl Acad Sci U S A 115(12):3030-3035. doi: