Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001473.1:
Cluster 1RiPP131851

BGC0001473, Sch 18640 biosynthetic gene cluster from Micromonospora arborensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Sch 18640
SMILES string: Copy to clipboard
Molecular formula: C72H87N19O17S6
Exact molecular mass: 1682.49 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Thiopeptide (cyclic)
Peptides in this cluster:
PYC67624.1
RiPP core peptide sequence(s): IASASCTTCICTCSCSS
Leader peptide length: 44
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage:

Gene cluster description

Sch 18640 (BGC0001473). Gene Cluster 1. Biosynthetic class = RiPP. GenBank PYBV01000027, positions 92736-124586. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Christopher Schwalen (University of Illinois at Urbana-Champaign)

Literature references

1. Schwalen CJ et al. (2018) Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics. J Am Chem Soc 140(30):9494-9501. doi: 10.1021/jacs.8b03896. Epub 2018
2. M. S. Puar, A. K. Ganguly, A. Afonso, R. Brambilla, P. Mangiaracina, O. Sarre, R. D. MacFarlane. (1981) Sch 18640. A new thiostrepton-type antibiotic. Journal of the American Chemical Society, vol. 103, no. 17, pp. 5231-5233