Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001474.1:
Cluster 1RiPP128372

BGC0001474, thiopeptin biosynthetic gene cluster from Streptomyces tateyamensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: thiopeptin
SMILES string: Copy to clipboard
Molecular formula: C71H84N18O18S6
Exact molecular mass: 1668.45 Da (None)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Thiopeptide (cyclic)
Peptides in this cluster:
PYC80213.1
RiPP core peptide sequence(s): VASASCTTCICTCSCSS
Leader peptide length: 43
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage:

Gene cluster description

thiopeptin (BGC0001474). Gene Cluster 1. Biosynthetic class = RiPP. GenBank PYBW01000040, positions 24523-52894. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Christopher Schwalen (University of Illinois at Urbana-Champaign)

Literature references

1. Schwalen CJ et al. (2018) Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics. J Am Chem Soc 140(30):9494-9501. doi: 10.1021/jacs.8b03896. Epub 2018
2. Miyairi N et al. (1972) Thiopeptin, a new feed additive antibiotic: microbiological and chemical studies. Antimicrob Agents Chemother 1(3):192-6.