LOCUS       BGC0001478              5420 bp    DNA     linear   BCT 10-APR-2018
DEFINITION  Streptomyces sp. ID38640 desferrioxamine biosynthesis gene cluster,
            complete sequence.
ACCESSION   BGC0001478
VERSION     BGC0001478
KEYWORDS    .
SOURCE      Streptomyces sp. ID38640
  ORGANISM  Streptomyces sp. ID38640
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:39:05
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5420
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..5420
                     /db_xref="taxon:1265399"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. ID38640"
     protocluster    1..5420
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[100:1918]"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      101..1918
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
     cand_cluster    1..5420
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="NI-siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..5420
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001478"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..5420
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NI-siderophore"
                     /region_number="1"
                     /rules="IucA_IucC"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(101..1918)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /note="IucA/IucC family protein"
                     /product="DesA"
                     /protein_id="AVV61969.1"
                     /sec_met_domain="IucA_IucC (E-value: 7.2e-81, bitscore:
                     259.4, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPSDGTPPLSARDAVAHLTPDLWARANRLLIRKGLAEFAHERL
                     LTPKRLPQDGHYAIRSDDGATEYRFAARRRALDHWQIDADSITRHRDDSELPLDALAFF
                     IELRDSLGLGETILPVYLEEISSTLSGTAYKLAAGRPGAAELAKSHFQAIETGMTEGHP
                     CFVANNGRLGFGIHEYHAYAPETAAPLRLIWLAARRDHATFTAGAGLDYDALIRDELPE
                     ETRTRFAATLTSLGLDPADYYFFPTHPWQWWNKLSVTFAAEVAQQHLVCLGPGDDDYLA
                     QQSIRTFFNTTDPTKHYVKTALSVLNMGFMRGLSASYMEATPAINDWLARLIDADDTFR
                     AARFSIIRERAAIGYHHRQYEAATAKGSPYRKMLAALWRESPVPTLEPGQRLATMASLL
                     HTDDDGGSLAAALIEESGLEPAVWLRRYLDAYLTPVVHAFYAYDLVFMPHGENAILVVE
                     DGAVARVIFKDIAEEIAVMDPDAVLPPTVERIRADVPEDKKLLSVFTDVFDCFFRFLSS
                     TLDDHGILDEDTFWRTVAACVTDYQAANPHLADKFDRYDLFTDEFALSCLNRLQLRNNQ
                     EMVDLQDPAGALQLIGTLRNPLAPYAPAS"
     misc_feature    complement(101..5365)
                     /note="desferrioxamine biosynthesis gene cluster"
     CDS             complement(1915..2484)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     130.7; E-value: 1.6e-39)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative siderophore biosynthesis protein"
                     /product="DesB"
                     /protein_id="AVV61970.1"
                     /transl_table=11
                     /translation="MNTPLFTRTDAALGEFSLRPVDPYGDAELLHRWVTHPKAAFWLMQ
                     DCDLAAVEKEFARIAADPFHDAFLGLRNGTPAFLMERYDPAHRELVGIHAAEPGDVGMH
                     FLSAPTDTPVHGFTLAVITTVMEMLFDDPATRRVVVEPDARNTAVHALNKAVGFEILRT
                     VSLPSKDAYLSTCTRDQFLATRGDHR"
     CDS             complement(2481..3800)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 420.6;
                     E-value: 1e-127)"
                     /gene_kind="biosynthetic-additional"
                     /note="lysine/ornithine N-monooxygenase"
                     /product="DesC"
                     /protein_id="AVV61971.1"
                     /transl_table=11
                     /translation="MSAPYDFIAIGLGPFNLGLACLTEPIDGLDGLFLDNKASFDWHPG
                     MMLDSSHLQVPFLADLVTLADPTSPFSFLNYLKESGRLYSFYIRENFYPLRAEFNDYCR
                     WAAGKLASVRFAHQVTTVEYDEREELYVVHAEQLPTGEHHTFRARRLVLGTGTPPHIPE
                     SCQGLGGDLLHNAGYLDAKAALQTKDSITLIGSGQSAAEIYFDLLQDIDSHGYHLTWAT
                     RSPRFFPLEYTKLTLEMTSPEYVDYFHALPPATRDHLNATQKHLYKGIDSALINDIFDL
                     LYQKNLGGPVPTRLLTNTALQQASYDEASGTYTLGLRQEEQGTDFALDTQGLILATGYR
                     YRVPDFLSAVRDRIVWDDAGRYDVARNYSIDTTGQGIFVQNAELHTHGFVTPDLGMAAY
                     RNACIIRELLGREYYPVEKAIAFQEFAAPAGSHHPMELPV"
     CDS             complement(3836..5365)
                     /NRPS_PKS="Domain: Beta_elim_lyase (197-356). E-value:
                     3.6e-07. Score: 21.5. Matches aSDomain:
                     nrpspksdomains_AVV61972.1_Beta_elim_lyase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180:Decarboxylase, pyridoxal-dependent (Score: 370.9;
                     E-value: 1.4e-112)"
                     /gene_kind="biosynthetic-additional"
                     /note="pyridoxal-dependent decarboxylase"
                     /product="DesD"
                     /protein_id="AVV61972.1"
                     /transl_table=11
                     /translation="MSLLAHSAEDPADNRAYLLNNGTARRYQSAVTESVTRISAKIAGT
                     TRPFTGITVDGLTPTVSGVDLDAPLHDAAAALDELEEVYLRDAVYFHHPRYLAHLNCPV
                     VIPALVGEAVLSAVNSSLDTWDQSAGGTLIERRLIDWTADRIGLGEAADGIFTSGGSQS
                     NLQAMLLARDEACRRELTREGANDARLTDVLPRLRILTSECSHFSIRKSATLLGMGAEA
                     VITVPSDENKRMRTDELAAELARCERDGLIPMAVVATAGTTDFGSIDPLPEIAGLCAGY
                     GAWMHVDAAYGCGLLVSRRRDLLSGIERADSVTVDYHKSFFQPVSSSAILVRDRATLKH
                     VTYHADYLNPRRMVEQRIPNQVDKSIQTTRRFDALKLWLTLRIMGAQAVGELFDEVVDR
                     AADAWKLLHDDPRFDVVVEPQLSTLVFRYVPTTDQDPELSDRVNLHAREALFASGEAIV
                     ASTVVDGRHYLKFTLLNPETTLEDIATVLDLIADHAGSFLAEQPRPALSAR"
     aSDomain        complement(4298..4774)
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AVV61972.1_Beta_elim_lyase.1"
                     /evalue="3.60E-07"
                     /label="AVV61972.1_Beta_elim_lyase.1"
                     /locus_tag="AVV61972.1"
                     /protein_end="356"
                     /protein_start="197"
                     /score="21.5"
                     /tool="antismash"
                     /translation="RILTSECSHFSIRKSATLLGMGAEAVITVPSDENKRMRTDELAAE
                     LARCERDGLIPMAVVATAGTTDFGSIDPLPEIAGLCAGYGAWMHVDAAYGCGLLVSRRR
                     DLLSGIERADSVTVDYHKSFFQPVSSSAILVRDRATLKHVTYHADYLNPRRMVEQ"
ORIGIN
        1 cgcgaaggac tgagccggcc gtcggtctga gccgatgtga cgcatgagga agggcgggac
       61 cccggggtgg ggtcccgccc ttctgcgtat gggggagggg tcaggaggcc ggcgcgtagg
      121 gggcgagcgg gttgcggagg gtgccgatga gctggagggc gcccgcgggg tcctggaggt
      181 cgaccatctc ctggttgttg cgcagctgga ggcggttgag gcaggagagc gcgaactcgt
      241 cggtgaacag gtcgtagcgg tcgaacttgt cggcgaggtg ggggttggct gcctggtagt
      301 cggtgacaca ggcggcgacc gtgcgccaga aggtgtcctc gtcgaggatg ccgtggtcgt
      361 cgagggtgct gctgaggaag cggaagaagc agtcgaagac gtcggtgaag acggacagga
      421 gtttcttgtc ctcggggacg tcggcgcgga tgcgctcgac cgtgggcggc aggaccgcgt
      481 ccgggtccat gacggcgatc tcctcggcga tgtccttgaa gatcacgcgg gccacggcgc
      541 cgtcctcgac gaccaggatg gcgttctcgc cgtgcggcat gaagaccagg tcgtaggcgt
      601 agaaggcgtg cacgaccggc gtcagatagg cgtccaggta gcggcggagc cagacggcgg
      661 gctccaggcc ggactcctcg atgagggcgg ccgcaaggga gccgccgtcg tcgtcggtgt
      721 ggaggagcga ggccatggtg gccaggcgct ggcccggttc gagggtgggg acggggctct
      781 cgcgccacag cgcggcgagc attttccggt acggggagcc cttggcggtg gcggcctcgt
      841 actggcggtg gtggtacccg atggcggcgc gctcacggat gatcgagaag cgggcggccc
      901 ggaaggtgtc gtcggcgtcg atgaggcggg ccagccagtc gttgatggcc ggggtggcct
      961 ccatgtagga cgcggacagg ccgcgcatga agcccatgtt gaggaccgag agcgccgttt
     1021 tgacgtagtg cttggtgggg tcggtcgtgt tgaagaaggt gcggatggac tgctgggcca
     1081 ggtagtcgtc gtcgccgggg cccaggcaca ccaggtgctg ctgggcgact tcggcggcga
     1141 aggtgacgga gagcttgttc caccactgcc aggggtgggt ggggaagaag tagtagtcgg
     1201 ccgggtcgag gccgaggctg gtgagggtgg cggcgaagcg ggtgcgggtc tcctcgggga
     1261 gttcgtcgcg gatgagggcg tcgtagtcga ggccggcgcc ggcggtgaag gtggcgtggt
     1321 cgcggcgggc ggcgagccag atcagccgga gcggggcagc ggtctcgggg gcgtaggcgt
     1381 ggtactcgtg gatgccgaag ccgagccggc cgttgttggc gacgaagcag gggtggccct
     1441 cggtcatacc ggtctcgatg gcctggaagt gcgacttcgc gagctcggcg gcgccgggcc
     1501 ggccggcggc gagtttgtag gcggtgccgg agagggtgga gctgatctcc tccaggtaga
     1561 ccgggaggat cgtctcgccg aggcccaggg agtcccggag ttcgatgaag aacgccaggg
     1621 cgtccagggg gagttcgctg tcgtcgcggt gccgggtgat gctgtcggcg tcgatctgcc
     1681 agtggtccag ggctcgtctg cgggcggcga agcggtactc cgtggcgccg tcgtcgctgc
     1741 gtatggcgta gtggccgtcc tgggggaggc gcttgggggt gagcagccgc tcatgggcga
     1801 actcggcgag gcccttgcgg atcagcagcc ggttggcgcg ggcccacagg tcgggggtga
     1861 ggtgggcgac ggcgtcccgg gcggagaggg gcggggtgcc gtcggagggg gcggtcatcg
     1921 gtggtctcct cgggtggcca ggaactggtc gcgggtgcag gtgctgaggt aggcgtcttt
     1981 ggaggggagc gagacggtgc gcaggatctc gaagccgacg gccttgttga gggcgtggac
     2041 ggcggtgttg cgcgcgtcgg gctcgacgac gacgcggcgg gtggccgggt cgtcgaagag
     2101 catctccatg acggtggtga tcacggcgag ggtgaagccg tgtacggggg tgtcggtggg
     2161 cgccgacagg aagtgcatac cgacgtcgcc cggttcggcg gcgtggatgc cgacgagttc
     2221 gcggtgggcg gggtcgtagc gctccatgag gaaggccggg gtgccgttgc gcaggccgag
     2281 gaaggcgtcg tggaaggggt cggcggctat gcgcgcgaat tccttctcga cggcggcgag
     2341 gtcgcagtcc tgcatcagcc agaaggcggc tttggggtgg gtgacccagc ggtgcagcag
     2401 ttcggcgtcg ccgtacgggt cgaccgggcg gagcgagaac tccccgaggg cggcgtcggt
     2461 gcgggtgaag aggggggtgt tcataccggg agctccatgg ggtggtgcga accggccggg
     2521 gcggcgaact cctggaaggc gatggccttt tcgaccgggt agtactcgcg gccgagcagc
     2581 tcgcggatga tgcacgcgtt gcggtaggcg gccatgccga ggtcgggggt gacgaagccg
     2641 tgggtgtgca gctcggcgtt ctgcacgaag atgccctggc cggtggtgtc gatgctgtag
     2701 ttgcgcgcca cgtcgtagcg gccggcgtcg tcccagacga tgcggtcgcg gacggcggag
     2761 aggaagtccg gtacgcggta gcggtagccg gtggcgagga tcaggccctg ggtgtcgagg
     2821 gcgaagtccg tgccctgctc ctcctggcgc aggcccaggg tgtaggtacc ggaggcctcg
     2881 tcgtaactgg cctgctgcag ggcggtgttg gtgaggagcc gggtggggac cggaccgccg
     2941 aggttcttct ggtagagcag gtcgaagatg tcgttgatca gcgccgagtc gatgcccttg
     3001 tagaggtgct tctgggtggc gttgaggtgg tcgcgggtgg ccggcgggag ggcgtggaag
     3061 tagtccacgt actccgggga ggtcatctcc agcgtgagct tggtgtattc gagggggaag
     3121 aagcgggggg agcgggtggc ccaggtcagg tggtagccgt ggctgtcgat gtcctggagg
     3181 aggtcgaagt agatctccgc cgcgctctgg ccgctgccga tgagggtgat gctgtccttg
     3241 gtctggaggg ccgccttggc gtcgaggtag ccggcgttgt gcagcagatc gccgccgagc
     3301 ccctggcagg actccgggat gtgcggcggg gtgccggtgc ccaggacgag cctgcgggcg
     3361 cggaaggtgt ggtgttcgcc ggtgggcagc tgctcggcgt ggacgacgta gagctcctcg
     3421 cgctcgtcgt actcgacggt ggtgacctgg tgggcgaagc ggacggaggc gagtttgccg
     3481 gctgcccagc ggcagtagtc gttgaactcg gcgcgcagcg gatagaagtt ctcgcggatg
     3541 tagaacgagt acagccgtcc cgactccttg aggtagttca ggaaggagaa gggggaggtg
     3601 gggtcggcga gggtgaccag gtcggccagg aacggcacct ggaggtggct gctgtccagc
     3661 atcatgccgg ggtgccagtc gaaggacgcc ttgttgtcca ggaacaggcc gtcgagtccg
     3721 tcgatcggct cggtcagaca ggccaggccc aggttgaacg ggccgaggcc gatggcgatg
     3781 aagtcgtaag gggcggacac ggagtctccg atgggggcgg tcggtggggg gagggtcagc
     3841 gtgcgctgag cgccggccgg ggctgctcgg cgaggaagct gccggcgtgg tcggcgatca
     3901 ggtcgaggac ggtggcgatg tcctcgagcg tggtctccgg gttgagcagg gtgaacttga
     3961 ggtagtggcg gccgtcgacg acggtgctcg cgacgatcgc ctcaccggag gcgaacaggg
     4021 cttccctggc gtgcagattg acccggtcgc tgagttcggg gtcctggtcg gtggtgggga
     4081 cgtaccggaa gaccagggtg ctcagctggg gctcgacgac gacatcgaag cgggggtcgt
     4141 catgcagcag tttccaggcg tccgcggccc ggtcgacgac ctcgtcgaag agttcaccga
     4201 cggcctgggc gcccatgatg cgcagggtga gccagagctt gagggcgtcg aagcggcggg
     4261 tggtctggat cgacttgtcg acctggttgg ggatgcgctg ctccaccatg cggcgggggt
     4321 tgagatagtc cgcgtggtag gtgacatgct tcagcgtggc gcggtcgcgg accaggatgg
     4381 cgctcgaact gactggctgg aagaaggact tgtggtagtc gacggtcacc gagtcggcgc
     4441 gttcgatacc ggacagcagg tcgcggcggc gggagaccag cagtccgcag ccgtaggcgg
     4501 cgtcgacatg catccaggcg ccgtatccgg cgcacaggcc ggcgatctcg gggagcgggt
     4561 cgatggagcc gaagtcggtg gtgccggcgg tggcgacgac ggccatgggt atcaggccgt
     4621 cgcgttcgca gcgcgccagt tcggcggcca gctcgtcggt gcgcatccgc ttgttctcgt
     4681 cgctggggac cgtgatgacg gcttccgcgc ccatgccgag cagggtggcc gacttgcgga
     4741 tgctgaagtg gctgcattcg gaggtgagga tgcgcagccg gggcagtacg tcggtgagcc
     4801 gggcgtcgtt tgcgccctcg cgggtcagct cccggcggca ggcctcgtca cgggcgagca
     4861 gcatggcctg gaggttggac tggctgccgc cgctggtgaa gatgccgtcg gccgcctcgc
     4921 ccagaccgat ccggtcggcc gtccagtcga tcagccggcg ttcgatgagc gtgccgcccg
     4981 cactctggtc ccaggtgtcc agggaggagt tgacggcgga gagcacggcc tcgcctacga
     5041 gggcggggat caccaccggg cagttgaggt gcgcgaggta gcgcgggtgg tggaagtaga
     5101 cggcgtcgcg gaggtagacc tcttcgagct cgtcgagtgc ggcggccgcg tcgtggagcg
     5161 gtgcgtcgag gtcgacgccg gagacggtgg gggtgagacc gtcgacggtg atgccggtga
     5221 acgggcgcgt ggtaccggct attttggcgc tgatccgggt aacgctctcg gtgaccgcgc
     5281 tctggtagcg cctggccgtg ccgttgttga gcagatacgc ccggttgtcg gccgggtcct
     5341 cggcagagtg cgcgaggaga ctcatgaagg tgtcctccct ggtgcggagt tgaccacgtc
     5401 ctgcgcaggg tggggtgtgc
//
