BGC0001492 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001492 (Streptomyces sp. LC-6-2)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	70,308	abyssomicin M/abyssomicin N/abyssomicin O/abyssomicin P/abyssomicin Q/abyssomicin R/abyssomicin S/abyssomicin T/abyssomicin U/abyssomicin V/abyssomicin W/abyssomicin X	PKS	100%

BGC0001492 - Region 1 - T1PKS

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Location: 1 - 70,308 nt. (total: 70,308 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 70,309
Label		BGC0001492

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001492	0.98	Polyketide	abyssomicin M, abyssomicin N, abyssomicin O, abyssomicin P, abyssomicin Q, abyssomicin R, abyssomicin S, abyssomicin T, abyssomicin U, abyssomicin V, abyssomicin W, abyssomicin X	Streptomyces sp. LC-6-2
BGC0000041	0.39	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000844	0.34	Other	clavulanic acid	Streptomyces clavuligerus
BGC0001276	0.33	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002138	0.33	Polyketide	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670
BGC0001504	0.32	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0000160	0.31	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001735	0.31	Other	pentostatine, vidarabine	Streptomyces antibioticus
BGC0002266	0.30	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002211	0.30	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001492	1.00	Polyketide	abyssomicin M, abyssomicin N, abyssomicin O, abyssomicin P, abyssomicin Q, abyssomicin R, abyssomicin S, abyssomicin T, abyssomicin U, abyssomicin V, abyssomicin W, abyssomicin X	Streptomyces sp. LC-6-2
BGC0000041	0.71	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000844	0.67	Other	clavulanic acid	Streptomyces clavuligerus
BGC0001276	0.66	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002138	0.66	Polyketide	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670
BGC0001504	0.66	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0000160	0.64	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001735	0.64	Other	pentostatine, vidarabine	Streptomyces antibioticus
BGC0002266	0.64	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002211	0.63	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 69464:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - ccmal - ccmal) + (Me-mal - Me-redmal) + (mal)
Non-colinear ordering:: ARE67853.1 + ARE67852.1 + ARE67851.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ARE67853.1

PKS_AT (547..840): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 186.5
inactive: 94.0
Methoxymalonyl-CoA: 76.9
Methylmalonyl-CoA: 70.0
Isobutyryl-CoA: 42.5
Propionyl-CoA: 39.4
Ethylmalonyl-CoA: 38.8
2-Methylbutyryl-CoA: 25.2
Acetyl-CoA: 21.9
CHC-CoA: 19.7
fatty_acid: 16.1
Benzoyl-CoA: 15.9
trans-1,2-CPDA: 13.2
3-Methylbutyryl-CoA: 3.4

PKS_AT (1568..1859): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.0
Ethylmalonyl-CoA: 208.9
Methoxymalonyl-CoA: 175.7
2-Methylbutyryl-CoA: 142.1
trans-1,2-CPDA: 139.3
Propionyl-CoA: 109.6
CHC-CoA: 97.0
Malonyl-CoA: 85.4
Isobutyryl-CoA: 84.1
Benzoyl-CoA: 68.8
Acetyl-CoA: 45.6
3-Methylbutyryl-CoA: 44.7
inactive: 24.4
fatty_acid: 23.2

PKS_AT (3377..3660): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.0
inactive: 75.6
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 61.9
Isobutyryl-CoA: 32.1
Propionyl-CoA: 31.7
Ethylmalonyl-CoA: 31.5
trans-1,2-CPDA: 17.4
Acetyl-CoA: 17.2
Benzoyl-CoA: 16.0
2-Methylbutyryl-CoA: 9.8
fatty_acid: 8.5
3-Methylbutyryl-CoA: 6.1
CHC-CoA: 0.8

PKS_AT (5104..5396): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 164.2
Methoxymalonyl-CoA: 63.3
inactive: 62.5
Methylmalonyl-CoA: 58.9
Ethylmalonyl-CoA: 33.2
Propionyl-CoA: 22.7
Isobutyryl-CoA: 18.7
CHC-CoA: 15.0
Acetyl-CoA: 14.5
fatty_acid: 13.8
trans-1,2-CPDA: 11.8
3-Methylbutyryl-CoA: 11.8
Benzoyl-CoA: 11.7
2-Methylbutyryl-CoA: 10.7

ARE67852.1

PKS_AT (636..936): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.5
Ethylmalonyl-CoA: 189.7
Methoxymalonyl-CoA: 159.8
2-Methylbutyryl-CoA: 136.3
trans-1,2-CPDA: 126.9
Propionyl-CoA: 108.4
CHC-CoA: 99.9
Malonyl-CoA: 85.0
Isobutyryl-CoA: 75.1
Benzoyl-CoA: 57.2
3-Methylbutyryl-CoA: 47.3
Acetyl-CoA: 44.2
fatty_acid: 34.3
inactive: 13.7

PKS_AT (1965..2275): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.7
Ethylmalonyl-CoA: 171.8
Methoxymalonyl-CoA: 169.8
trans-1,2-CPDA: 117.1
2-Methylbutyryl-CoA: 113.5
Malonyl-CoA: 102.9
Propionyl-CoA: 95.8
CHC-CoA: 74.9
Isobutyryl-CoA: 67.5
Benzoyl-CoA: 47.4
3-Methylbutyryl-CoA: 41.5
Acetyl-CoA: 39.7
inactive: 25.9
fatty_acid: 18.2

ARE67851.1

PKS_AT (570..874): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Propionyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 158.6
inactive: 69.8
Methoxymalonyl-CoA: 67.3
Methylmalonyl-CoA: 57.6
Propionyl-CoA: 56.8
Ethylmalonyl-CoA: 34.5
2-Methylbutyryl-CoA: 32.4
CHC-CoA: 29.7
trans-1,2-CPDA: 15.0
Acetyl-CoA: 13.5
fatty_acid: 11.0
Isobutyryl-CoA: 9.9
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0