LOCUS       BGC0001496              9037 bp    DNA     linear   BCT 06-FEB-2014
DEFINITION  Actinokineospora spheciospongiae strain EG49 contig1268_1, whole
            genome shotgun sequence.
ACCESSION   BGC0001496
VERSION     BGC0001496
KEYWORDS    .
SOURCE      Actinokineospora spheciospongiae
  ORGANISM  Actinokineospora spheciospongiae
            Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
            Actinokineospora.
COMMENT     Bacteria and source DNA available from: Department of Botany II,
            Julius-von-Sachs Institute for Biological Sciences, University of
            Wuerzburg, Julius-von-Sachs Platz 3, D-97082 Wuerzburg, Germany.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 02:06:30
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9037
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..384)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /locus_tag="UO65_3799"
                     /product="hypothetical protein"
                     /protein_id="EWC60869.1"
                     /sec_met_domain="PF13471 (E-value: 2.1e-27, bitscore: 85.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGIRARLAVGVARVLITLPPRRLARAVAFLHRGARPASAELTQR
                     ARDTVCATSARCTGQGCLPRSVAVVVYCRLHGRAPDWCTGFALDPFTAHAWVEVDGAPV
                     GEPPKVAEYIISQAVRLRSPAAA"
     protocluster    1..9037
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[0:2086]"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..2086
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     cand_cluster    1..9037
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..9037
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001496"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9037
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..384)
                     /locus_tag="UO65_3799"
     gene            complement(381..647)
                     /locus_tag="UO65_3800"
     CDS             complement(381..647)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="UO65_3800"
                     /product="hypothetical protein"
                     /protein_id="EWC60870.1"
                     /sec_met_domain="PF05402 (E-value: 4.7e-11, bitscore: 32.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.7e-17,
                     bitscore: 52.9, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRLRPGVTIHESGDQAILLGTGRDAAYWRLNGTAKQMVTLLLD
                     GRDVEAVVTATTALVAADAAVVRRDVENLVTALVDAKLAEDVG"
     gene            complement(644..2086)
                     /locus_tag="UO65_3801"
     CDS             complement(644..2086)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 94.8; E-value: 8.4e-29)"
                     /gene_kind="biosynthetic"
                     /locus_tag="UO65_3801"
                     /product="putative asparagine synthetase"
                     /protein_id="EWC60871.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.5e-33, bitscore:
                     105.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDSPAVLRAMTGAAPDLTSVALSLAKAMPIQPFAHRTMWSGITA
                     VGIGRWLRLPPGGVPSTHRWWSPTGGPALPVAEAAAGVRDALRDVLRAQSRSAGLVTAD
                     LSGGLDSTSICYALDDLGRRFRAFRTSSTSPWNDETGRARAAAADLGVELVEFPPLSET
                     STAFTLDARADPVELAEGPVVWSASRGYLDVLAPAVAATGSRVHFTGLGGDELFDVVPG
                     VYRSVWAERGLGALGVLRRHQLSGKFPLRPFASGVADRRSYAAHLRSVVAAVAAGRAAR
                     RADSYSWFPPPVLPGWLTAEGRALVVGALEEAAAGDPEPLGADPTAHQVVESISYQGQI
                     LRQFGVVFAGTGITWQAPFTDRRVVEAALRAPVSARLDAREDKRLLAEAVAPFMPRALF
                     AKRDRGDFTADIYAEHRRRRHDLVAGFATARLADLGLVDPHRLLPHLDSPALADVGLLE
                     LERVVGAERWLRAIDNETRSTG"
     gene            complement(2564..2683)
                     /locus_tag="UO65_3802"
     CDS             complement(2564..2683)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lassopeptides)
                     predicted lassopeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="UO65_3802"
                     /product="hypothetical protein"
                     /protein_id="EWC60872.1"
                     /transl_table=11
                     /translation="MLSVYIAPVFEKIGGFREVTNGYPFWDNRDIFGGYTFIG"
     CDS_motif       complement(2621..2683)
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MLSVYIAPVFEKIGGFREVTN"
                     /locus_tag="UO65_3802_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(2564..2620)
                     /prepeptide="core"
                     /locus_tag="UO65_3802_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="-6.60"
                     /molecular_weight="2107.3"
                     /monoisotopic_mass="2106.0"
                     /core_sequence="GYPFWDNRDIFGGYTFIG"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MLSVYIAPVFEKIGGFREVTN"
                     /leader_location="[2620:2683](-)"
     gene            2904..4664
                     /locus_tag="UO65_3803"
     CDS             2904..4664
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 315.5; E-value:
                     1.2e-95)"
                     /gene_kind="transport"
                     /locus_tag="UO65_3803"
                     /note="FIG00511811"
                     /product="hypothetical protein"
                     /protein_id="EWC60873.1"
                     /transl_table=11
                     /translation="MGAITRPRPAKVLWGLVRQQRGTLLPAAGLSVLGAVAALAQPVVV
                     NAIITAVQHGDPGAALAVGACALFLAVGVIMSVQQYLLQRMGEGVVLSARRSLVSALLR
                     LPIAEFDRRRSGDLVSRVSSDTTVLRLALARGVLAGVGGTVTVIGALGALVYIDALLFG
                     LTVLVALVFAAITAVLAKGVRRASQEVQAQVGVLTAAVDRAVRGIRTIRAGNSTDRQEE
                     LLQRHATASWHAGLRLARASSVIEPMSVLTTQAMLIIVLGVGGYRVAAGQLAMPDLVSF
                     LMFVFLLVAPLGQIFAAVGTLGSSLGALDRIQEIRDLPSEDEVRRRAAVVPTAPADGGG
                     ARHALSFHDVRFGYDTGGGGDPALDGVSFDIERGARVALVGPSGAGKSTALNLVVGFYP
                     PESGTITVGGVDAATLTAAQLRAGVAYVEQDAPALAGTLRENLTLTAPGATDVECWEAL
                     SAVNLTGLVQRSSRGLDSEVGESGVALSGGERQRLAIARALLSRPEVLLLDESTSNLDG
                     HNEMLARQAVQRASAGCTLLVVAHRLSTVVDSDLILVFDGGRIVARGTHEGLLTRSGLY
                     RELATHQLIA"
     gene            4793..5506
                     /locus_tag="UO65_3804"
     CDS             4793..5506
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 146.2; E-value:
                     2.1e-44)"
                     /gene_kind="transport"
                     /locus_tag="UO65_3804"
                     /product="ABC transporter, ATP-binding protein"
                     /protein_id="EWC60874.1"
                     /transl_table=11
                     /translation="MLTIDRLTKRRGSALILSDVTFQARPGRVTGFLGPNGAGKSSTLR
                     ILLGLDRPTSGTALVDGVPFERLPDPLRTVGAVLDGSGAHRARTGRAHLSWVAAAAGIP
                     RRRVDEVLAEVDLTGAARKRVGSYSLGMGRRLGLAAALLGDPAALVLDEPVNGLDPEGI
                     RWMRRFLRERAEAGHTVLLSSHLMGELAEVVDDVVIINGGRVVEQGTLAEVTGAHRTLE
                     DAFFALTTGARGDAR"
     gene            5503..6264
                     /locus_tag="UO65_3805"
     CDS             5503..6264
                     /codon_start=1
                     /locus_tag="UO65_3805"
                     /product="ABC transporter integral membrane protein"
                     /protein_id="EWC60875.1"
                     /transl_table=11
                     /translation="MSAYSGELRKLTSLPSVWAAFAIGIAVPAVVGVLSAVSTSSAIAN
                     GSKPEAGPDLGYQELAFGVAGAIVLGVVAASSEYFTEGESAGSGRQITTSLTAVPSRTR
                     FLLAKVAALTTAVVLMSAIATGITLSCVQAVVGDHAHALDGAAATRVPGVVLYWVLTAL
                     LAFGITLLTRNGVVPLAVLVLNTSVVTVTFLLSKVTPLAVYFPDLAGMRMFLTEVRVPV
                     ELSPLTGGVVMAVWVVLLLACGFTAFTRRDA"
     gene            6261..7034
                     /locus_tag="UO65_3806"
     CDS             6261..7034
                     /codon_start=1
                     /locus_tag="UO65_3806"
                     /product="putative integral membrane protein"
                     /protein_id="EWC60876.1"
                     /transl_table=11
                     /translation="MMTTVAPTRARGSEFTRSSRAEVLKLLSLPATLLTAAGSLLVSAV
                     LAVAFATAGRQGSTGTASALDIGLAPIGYTQAGFIILGVLAATSEYTGGQVQTSLTVVP
                     RRVLLHLSKVVALVLIAVPTALVVVLGGLVVADLVLGDAAVVPPFGDFAVGVGGAAAYL
                     ALTAVLSSSVATVIRRTIPAVAGLLVYYFIAGPLLRDRTAFAAYLPDTAGYGMWFHSGA
                     GRFGSLSALVGTGFVVAWVVLAVAVAAVSFRARDA"
     gene            complement(7078..7854)
                     /locus_tag="UO65_3807"
     CDS             complement(7078..7854)
                     /codon_start=1
                     /locus_tag="UO65_3807"
                     /product="regulatory protein"
                     /protein_id="EWC60877.1"
                     /transl_table=11
                     /translation="MLHQGEDIERGASGSTAGQDGVEEALAKAAALITFAARNHQYHRD
                     GAERLPTPHARRHAARLLVSTTTTSLRCTAPPPGAEFAELVDLVAALPGRGVRVELLCT
                     VKHLAEPVRGTLLSTMDNGVAVRVRASARPSPHLLIADGADAVLASGTEAVLVRAPAVL
                     AGLSAFFASTWAEATDLGEHARLSDRSLGALGARVLCALVAGHTDDAAARELSMSVRTY
                     RRHVADIMRELDVTSRFAAGARAAALGLFPTERCAP"
     gene            complement(7888..8190)
                     /locus_tag="UO65_3808"
     CDS             complement(7888..8190)
                     /codon_start=1
                     /locus_tag="UO65_3808"
                     /product="hypothetical protein"
                     /protein_id="EWC60878.1"
                     /transl_table=11
                     /translation="MFTLPRSWRESACAGFPQAAHRGSPDHPIQVMAQHFPLVAVRGSF
                     DCTRVPEGIWWKRIRSCGGRETGSTADVVATGGTGHRSSCAKNRRNSGSGGAPES"
     gene            8258..9037
                     /locus_tag="UO65_3809"
     CDS             8258..9037
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048:sensor
                     histidine kinase (Score: 129; E-value: 4.1e-39)"
                     /gene_kind="regulatory"
                     /locus_tag="UO65_3809"
                     /product="two-component system sensor kinase"
                     /protein_id="EWC60879.1"
                     /transl_table=11
                     /translation="MLSAVLLAVGAQGPGAVVIPPAVAVLAVGVTAWTVVRARRRRAEY
                     EARLTAWAAERAADRERIRIAGELHDIVSHGLGVIIMRAAAARRVPGESEQALVDVERL
                     GRDAVAELRRMLTVLRAGDRNSVPLRPVRSLSDLPGIVDAARAAGHTARLSVDDLGEVS
                     PGVQAAVCAIVQEAIANTSRHAGPTGLLVHLARDGGCVVVVVRDDGPRTEWYPTRGAGH
                     GLVGLRERVDALGGTLDAAPAATGFSLTARLPDGAAR"
ORIGIN
        1 tcaggcagcg gcaggcgacc gcagtcggac agcctggctg atgatgtact cggcgacctt
       61 gggcggttcg ccgaccggcg cgccgtccac ctccacccag gcgtgcgcgg tgaacgggtc
      121 cagtgcgaaa ccggtgcacc agtccggtgc gcgcccgtgc aggcgacagt acacgaccac
      181 ggccaccgag cgcggcaggc agccctggcc ggtgcaccgc gcgctcgtcg cgcagacggt
      241 gtcccgcgcc cgctgggtga gttccgcgga cgccgggcgc gcaccgcggt gcaggaacgc
      301 caccgcccgc gccagccgcc ggggcgggag cgtgatcagc acccgggcga cgcccacggc
      361 gagccgggcc cggatgccgg tcatccgacg tcctccgcga gcttcgcgtc caccagtgcc
      421 gtcaccaggt tctccacgtc gcggcggacc acggcggcgt cggccgccac cagcgcggtg
      481 gtggccgtga cgacggcctc gacgtcgcgg ccgtcgagca ggagggtgac catctgcttg
      541 gcggtcccgt tgaggcgcca gtaggcggcg tcgcggccgg tgccgagcag gatcgcttgg
      601 tcgccggact cgtggatggt cacgccgggg cgcaggcgca gtgtcatccg gtgctcctcg
      661 tctcgttgtc gatggcccgc agccaccgct cggcgccgac gaccctctcc agctccagca
      721 gacccacgtc cgccagcgcg ggggagtcca ggtgcggcag caggcggtgc gggtcgacca
      781 gcccgaggtc tgcgaggcgg gccgtggcga agcccgccac caggtcgtgc ctgcgcctgc
      841 ggtgctcggc gtagatgtcg gcggtgaaat caccgcggtc ccgcttggcg aacaacgcgc
      901 gcggcatgaa cggggccacc gcctcggcca gcagccgctt gtcctcccgg gcgtccaagc
      961 gcgccgacac cggcgcccgc agcgccgctt cgaccacccg gcggtcggtg aacggggcct
     1021 gccaggtgat gccggtgccc gcgaacacca cgccgaactg ccgcaggatc tgcccctggt
     1081 agctgatcga ctcgaccacc tggtgcgcgg tcgggtccgc gccgagcggc tcggggtccc
     1141 cggccgccgc ctcctcgagc gcgcccacca ccagcgcgcg cccctcggcg gtcagccagc
     1201 cgggcagcac cggcggcggg aaccacgagt aggagtccgc ccgccgcgcg gctcggcccg
     1261 cggccaccgc ggccaccacc gaccgcaggt gcgcggcgta ggaacgccgg tcggcgaccc
     1321 cggaggcgaa cgggcgcaac gggaacttgc cggacagctg gtgcctgcgc aggaccccga
     1381 gcgcgcccag tccgcgctca gcccacaccg atcggtacac accgggcacg acgtcgaaga
     1441 gttcgtcacc gccgagaccg gtgaagtgca cccgcgaccc cgtcgcggcc accgccgggg
     1501 ccagcacgtc caggtaaccg cgggaagccg accacaccac cgggccctcg gccagctcca
     1561 ccgggtcggc gcgggcgtcc agcgtgaacg ccgtgctggt ctccgacagc ggtgggaact
     1621 cgaccagttc gacccccaga tcggcggcgg ctgccctggc ccgcccggtc tcgtcgttcc
     1681 acgggctcgt cgaggaggtg cggaaggcgc ggaaccgcct gccgaggtcg tcgagcgcat
     1741 agcagatgct cgtcgagtcc aggcctcccg acaggtccgc ggtcaccagg cccgccgacc
     1801 gcgactgcgc gcgcaggacg tcccgcagcg cgtcgcgcac accggccgcg gcttccgcga
     1861 ccgggagcgc gggcccaccg gtgggtgacc accagcggtg cgtgctcggg accccgccgg
     1921 gtggcagccg cagccaccgc ccgatcccca ccgcggtgat ccccgaccac attgtgcggt
     1981 gcgcgaacgg ctggatcggc atcgccttcg ccagcgacag cgccaccgag gtcaggtcgg
     2041 gcgcggcacc ggtcatggcg cgcagcacgg cgggtgagtc cgacacgagt ggcaggttgt
     2101 tgtccagcgc ccagaagaat cgacaggaac ctgacaggtt tccctggaaa cgggtgccgc
     2161 ccggcccttg gccgataaaa tgggcgtggg cagaaatatg tccggcgacg gaattccacg
     2221 agtggtgatc aatgggattc ccggtcaacc ggtcgatgtc gagcgcggtc gccggggggg
     2281 tggtggaaac aattcgggca ccgggcgggg acgcgatctc gtgccactgc gcgtccggtg
     2341 tcgagatgat ccacgggcgc ccggacgggt accgcaggac ctggtcgccg acgatgtcgc
     2401 ctgcccgctc cccggcggcg gcggagagtg ggtcgtccgg gagcacgacg aagggcacga
     2461 ctgcctccgc gatcttggtt gcctggtcag acccgctttt gccgcggtgt gcggcggtgg
     2521 tgccggtggg gcgggttccg gaccccgccc caccggcggg tgctcagccg atgaaggtgt
     2581 agccaccgaa gatgtcgcgg ttgtcccaga acgggtagcc gttggtgacc tcgcggaagc
     2641 cgccgatctt ctcgaagacc ggtgcgatgt agacggacag cacgatgtac ctcccagtgt
     2701 gttccagcgt gttggtggaa aggaagacaa aaaggtcatc ctgagcggcg aaaatcacgc
     2761 tctcccccgc tcggcagccc catgccgtct ccccgaaatc aacgtagcac gcactcgacg
     2821 gaatcggcaa gaaatctgta tggtgaccac cgcggccgca gattgtccgg ccgggcgacc
     2881 aatgaaaacg ggggtttggt gccatgggtg cgatcacacg tccacgcccg gcgaaggtgt
     2941 tgtgggggtt ggtgcggcag cagcgcggga cactgctccc cgcggccggg ctcagcgtgc
     3001 tcggcgcggt cgcggccctc gcgcaaccgg tggtggtgaa cgccatcatc accgcggtcc
     3061 agcacggcga ccccggtgcc gcgctcgcgg tgggcgcctg cgcgctgttc ctcgcggtcg
     3121 gggtgatcat gtcggtgcag cagtacctgt tgcagcgaat gggagagggg gtcgtgctct
     3181 ccgcccggcg atcgctggtg tcggcgctgc tgcggctgcc gatcgccgag ttcgaccgga
     3241 ggcgctccgg cgacctggtt tcccgggtca gcagcgacac cacagtcctg cgcctcgcgc
     3301 tggcccgcgg ggtgctggcg ggagtcggcg gtacggtcac ggtgatcggc gcgctgggag
     3361 cgctggtcta catcgacgcg ctgctgttcg gtctcaccgt gctggtcgcg ctggtgttcg
     3421 cggcgatcac cgcggttctg gccaagggcg tgcggcgcgc cagccaggag gtccaggccc
     3481 aggtgggggt gctcaccgcc gcggtcgacc gggccgtgcg gggaatccgg accatccggg
     3541 cggggaactc gaccgaccgc caggaggaac tgctccagcg gcacgcgacc gcgtcctggc
     3601 acgcggggct ccggctggcg cgggcgtcct cggtcatcga gccgatgtcg gtgctgacca
     3661 cgcaggccat gctgatcatc gtgctcgggg tcggcggcta ccgggtggcc gccgggcaac
     3721 tggcgatgcc cgacctggtg tcgttcctga tgttcgtctt cctgctcgtc gcaccgctgg
     3781 gccagatctt cgccgccgtc ggcaccctgg gctcgtcgct gggtgccctc gaccgcatcc
     3841 aggagatccg cgacctgccg tccgaggacg aggtgcggcg gcgggcggcg gtcgtcccca
     3901 ccgcgcccgc cgacggcggt ggcgcgcggc acgcgctgtc cttccacgac gtccgcttcg
     3961 gctacgacac gggtggaggt ggcgacccgg ccctggacgg cgtgtccttc gacatcgaac
     4021 ggggggcgcg cgtcgcgctc gtgggtccgt ccggagcggg caagagcacc gcgctcaacc
     4081 tcgtcgtcgg cttctacccg ccggagtcgg ggaccatcac cgtcggcggt gtggacgcgg
     4141 ccacgttgac cgccgcgcag ctgcgcgcgg gtgtggccta cgtcgagcag gacgcgcccg
     4201 ccctcgcggg aaccctgcgg gagaacctga ccctcaccgc gcccggggcc accgacgtcg
     4261 agtgctggga ggcgctgtcc gcggtcaacc tcaccggcct ggtccagcgc tccagccggg
     4321 gtctggacag cgaagtcggg gaatccggcg tcgccctctc gggcggggag cgccagcggc
     4381 tcgccatcgc gcgcgcactg ctgtcccgac ccgaggtgct gctgctcgac gagtcgacgt
     4441 ccaacttgga cgggcacaac gagatgctgg ccaggcaggc ggtccagcgc gcctcggcgg
     4501 ggtgcacgct gctcgtcgtc gcgcaccggc tgtccaccgt cgtcgactcc gacctcatcc
     4561 tggtcttcga cggcggccgg atcgtcgccc ggggcaccca cgagggcctg ctcacccgca
     4621 gcgggctcta ccgcgagctc gccacccacc agctcatcgc gtgaacagcc gcgtcagacc
     4681 caggtctgat gcgcgggctc gacgaagatc aggcccgggg ccgatgtgcc cgccccggcc
     4741 caccggttga ctggacctcg acaaaccagt gctccgacgg ggtgaacgcc acatgttgac
     4801 gatcgacagg ctcacgaagc ggcgggggtc ggcgctgatc ctctccgacg tcaccttcca
     4861 agcccggccc ggccgcgtca ccggcttcct cggccccaac ggcgccggga agtcctcgac
     4921 gctgcgaatc ctgctcggcc tcgaccgccc gacctccggc accgccctgg tcgacggggt
     4981 cccgttcgag cggctgcccg acccgctgcg cacggtcggc gccgtgctcg acgggtccgg
     5041 cgcccaccgc gcgcgcaccg ggcgggcgca cctgagctgg gtggccgccg cggcgggcat
     5101 cccacggcgg cgggtggacg aggtgctcgc cgaggtcgac ctgaccggtg ccgcccgcaa
     5161 gcgcgtgggc agctactcgc tgggcatggg caggcggctg ggcctggccg ccgcgctgct
     5221 cggcgatccc gccgcgctgg tgctcgacga gccggtcaac ggcttggacc ccgagggcat
     5281 ccgctggatg cgccggttcc tgcgcgagcg cgccgaggcc gggcacacgg tcctgctgtc
     5341 gagccacctc atgggcgaac tggccgaggt ggtcgacgac gtcgtgatca tcaatggcgg
     5401 gcgggtcgtc gagcagggca ccctggccga ggtcaccggc gcgcaccgca ccctcgagga
     5461 cgcgttcttc gcgctcacca ccggggcgcg gggggacgcg cggtgagcgc ctactcggga
     5521 gagctgcgca agctgacctc gctgccgtcg gtctgggccg cgttcgccat cggcatcgcc
     5581 gtgcccgcgg tcgtcggtgt cctgtccgcg gtttcgacga gctcggcgat cgcgaacggg
     5641 tccaagcccg aggccggacc cgacctcggc taccaggaac tcgcgttcgg ggtcgcgggc
     5701 gccatcgtcc tcggcgtggt cgcggccagc agcgagtact tcaccgaggg ggagagcgcg
     5761 ggctccggac ggcagatcac caccagcctc accgcggtac cgtcccggac gcggttcctc
     5821 ctggccaagg tcgccgcgct gaccaccgcg gtcgtgctga tgtcggccat cgccaccggg
     5881 atcaccctct cctgcgtgca ggcggtggtc ggcgaccacg cgcacgcgct cgacggggcc
     5941 gccgcgaccc gggtgcccgg cgtcgtcctc tactgggtgc tgaccgcgtt gctcgccttc
     6001 ggcatcacgc tgctgacccg caacggagtc gtcccgctgg cggtgctggt cctcaacacc
     6061 tccgtcgtca cggtcacgtt cctgctctcc aaggtcaccc cgctcgcggt ctacttcccc
     6121 gatctggcag gcatgcgcat gttcctcacc gaggtcaggg tgccggtgga gttgtccccg
     6181 ctcaccggcg gtgtggtgat ggcggtgtgg gtcgtcctgc tgctcgcctg cgggttcacc
     6241 gccttcacga ggagggacgc gtgatgacga cggtcgcacc cacccgggcc cgcgggagcg
     6301 agttcacccg gtccagccgc gccgaggtgc tcaagctgct cagcctgccc gccaccctgc
     6361 tcaccgccgc gggctcgctg ctcgtctcgg cggtcctcgc ggttgccttc gccacggcgg
     6421 ggaggcaggg cagcacgggc accgcctcgg cgctcgacat cggactggcc ccgatcggct
     6481 acacccaggc cgggttcatc atcctcgggg tgctggcggc gacgtcggag tacaccggcg
     6541 gtcaggtcca gacctccctc accgtcgtgc cccgccgcgt gctcctgcac ctgtccaagg
     6601 tggtggcgct ggtgctgatc gcggtaccca ccgccctggt ggtggtcctc ggtggcctgg
     6661 tggtggccga tctggtgctg ggtgatgcgg cggtggtgcc gccgttcggc gacttcgcgg
     6721 tcggtgtggg tggcgccgcc gcctacctgg cgctgaccgc tgtgctgtcg tcgtcggtgg
     6781 ccacggtcat ccgccgcacg atccccgcgg tggccgggct gctcgtgtac tacttcatcg
     6841 ccggaccgct gctgcgcgac cggacggcgt tcgcggcgta cctgcccgac accgccgggt
     6901 acggcatgtg gttccacagt ggagcggggc gcttcggctc gctgagcgct ctggtcggaa
     6961 cgggtttcgt ggtcgcgtgg gtggtgctgg ccgtcgctgt ggccgccgtc tcgttccgag
     7021 cgcgggatgc ctgagcgcga gcaccaccgc cgggagtgcc cgcgcccccg cgcccggtca
     7081 gggcgcgcag cgctcggtcg ggaacaggcc gagcgccgcg gcgcgggccc cggcggcgaa
     7141 ccgggaggtc acgtccagct cgcgcatgat gtccgcgacg tgcctgcggt aggtgcgcac
     7201 cgacatgctc agctcgcggg ccgcggcgtc gtcggtgtga ccggcgacga gagcgcacag
     7261 cacccgtgcg ccgagcgcgc ccaggctgcg gtcgctcagc cgcgcgtgct cgccgaggtc
     7321 ggtcgcctcg gcccaggtgc tggcgaagaa ggcgctcagc cccgccagca cggcgggagc
     7381 gcgcaccagc accgcctccg tgccggacgc gagcaccgca tccgccccgt ccgcgatgag
     7441 caggtgcggg ctcggtcgcg ccgaggcccg cacccgcacc gcgactccat tgtccattgt
     7501 ggacaaaagg gtgccccgga cgggctcggc caagtgcttc accgtgcaca gcagctcgac
     7561 ccggaccccg cgcccgggca gcgcggccac gaggtcgacg agttcggcga actccgcacc
     7621 cggtggcggg gcggtgcacc gcaacgatgt cgtcgtggtg gagaccagca ggcgtgcggc
     7681 gtgcctgcgg gcgtgcggcg tgggcaaccg ctcggctccg tcgcggtggt actggtggtt
     7741 gcgcgcggcg aaggtgatca gggcggccgc cttcgccagt gcctcctcca ccccgtcctg
     7801 gcccgcggtg gacccggagg ccccgcgctc gatgtcttcc ccctggtgca gcactcatcc
     7861 cccacgtgtg tgtcctgcgg tgacctctca actctccggt gcaccaccag atccgctgtt
     7921 ccgccggttc ttcgcgcagc tggacctgtg accggtgccc ccggtcgcga cgacgtcggc
     7981 ggtgctcccg gtctccctgc ccccgcagga cctgatccgc ttccaccaga taccctctgg
     8041 gacgcgcgta cagtcgaagc taccacggac cgcaacgagc ggaaagtgtt gtgccatcac
     8101 ctgaatgggg tgatcgggac tccctcggtg cgcggcttgt gggaatcccg cgcatgcgga
     8161 ttcccgccac gagcgcggta gtgtgaacac gatgacaaca ggcgatcgac ccgttcggcg
     8221 gtcacgcgcg tggctcgtct gcgcggccgc gctgctcgtg ctctcggcgg tgctcctggc
     8281 ggtgggcgcc caggggccgg gggcggtggt gatcccgccc gcggtggccg tgctggccgt
     8341 cggggtgacc gcctggacgg tggtccgcgc ccgccgccgc agggcggagt acgaggcccg
     8401 gctcaccgcg tgggcggcgg agcgggcggc cgaccgggag cggattcgga tcgccgggga
     8461 actgcacgac atcgtctccc acggcctggg ggtgatcatc atgcgcgccg cggccgcccg
     8521 ccgggtgccc ggggagtccg agcaggcact ggtggacgtg gagcggttgg gccgggacgc
     8581 ggtcgcggag ctgcggcgga tgctgaccgt gctgcgcgcg ggcgaccgga actccgtgcc
     8641 gctgcgcccg gtgcggagcc tgtccgacct ccccggcatc gtcgacgccg cccgcgcggc
     8701 gggccacacc gcccggttgt ccgtcgacga cctcggcgag gtctccccgg gcgtccaggc
     8761 ggcggtctgc gcgatcgtcc aggaagccat cgccaacacc tcccgccacg cgggaccgac
     8821 cggcctcctg gtccacctgg ctcgcgacgg cggctgcgtc gtggtggtcg tgcgggacga
     8881 cggcccgcgc accgagtggt accccacccg cggcgcaggc cacggcctgg tgggcctgcg
     8941 cgagcgggtc gacgccttgg gcggcacgct cgacgccgcc cccgccgcca ccggcttctc
     9001 gctcaccgcg cgcctccccg acggggccgc ccgatga
//
