LOCUS       BGC0001498             14521 bp    DNA     linear   BCT 23-JAN-2014
DEFINITION  Xenorhabdus szentirmaii DSM 16338 WGS project CBXF000000000 data,
            contig XENSZ_2115_Contig_30, whole genome shotgun sequence.
ACCESSION   BGC0001498
VERSION     BGC0001498
KEYWORDS    .
SOURCE      Xenorhabdus szentirmaii DSM 16338
  ORGANISM  Xenorhabdus szentirmaii DSM 16338
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Morganellaceae; Xenorhabdus.
COMMENT     Annotation results relative to BLAST similarities, COG
            assignations, enzymatic function prediction (PRIAM software),
            TMHMM, PsortB and SignalP predictions, and synteny conservation
            (Syntonizer software) are available in the MicroScope annotation
            platform
            http://www.genoscope.cns.fr/agc/microscope.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 15:41:24
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 16054
            Orig. end    :: 30575
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..14521
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..14521
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1443..3662)
                     /gene="iutA"
                     /locus_tag="XSR1_300018"
     CDS             complement(1443..3662)
                     /codon_start=1
                     /gene="iutA"
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 226.4; E-value: 1.7e-68)"
                     /gene_kind="transport"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XSR1_300018"
                     /product="Ferric aerobactin receptor"
                     /protein_id="CDL83400.1"
                     /transl_table=11
                     /translation="MIKHSSFGIILPCLSVISTPSVFAAAESKEDTIVVSSSRTHRSIP
                     QMAQTSWVIESHDIEQQVNGGKEFKDILAQLIPGMDVSSQGRTNHGMNIRGRSIAVMID
                     GVRLNSSRSDSRQLDSIDPFNIERIEVISGATSLYGGGSTGGLINIVTKKGQEGGQVDL
                     QFGAKSGLINSSDHDENIAAAVSGGNENIKGRLSVSYQRYGGWFDGKHNQVLIDNTQTG
                     LQYSDRLDVMGTGTLNIDEHQQLQLTTQYYKSKADGKHGINLGKDFSAVLGKGSAHNAS
                     GLDSDRVPGTTRHLISLQYSNTDFLGQDLVTQLFYRDESFAFYPFPTLGNKKGTKKKEV
                     ISISASEQKTDFYGGKFTLNSQPVKNLSLTYGFDADHEKFSANQQFFDLKTAQEHSGMK
                     LKNAYNVGRYPGYSITNLAPFLQANYDINSIFTVSSGLRYQYTKNKIDDFIPYNQQQAI
                     ATSKILSADAVPGGTTSYNNYLFNAGILANLPERQQVWFNFSQGFELPDVGKYYGSGNY
                     GKSVNGHIPLVKSINVNDSKLKGIKVNSYELGWRYNGDNLRTQIAAYYSLSDISINIIK
                     KDMRIEISPDKRRIYGIEGAVDYLFDNSDWTAGTTFNILKSETQKKDKWEKLSIETASP
                     SKMTAYVNWAPDDWEFRLQSQQTFDVSDNKGKKLDGYNTIDFLGTYHLPVGKISFSIEN
                     LLDKDYTSVWGQRASVLYSPAYGAAELYNYKGRGRTFGLSYSATF"
     gene            complement(3700..5004)
                     /gene="iucD"
                     /locus_tag="XSR1_300019"
     CDS             complement(3700..5004)
                     /EC_number="1.14.13.59"
                     /codon_start=1
                     /gene="iucD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 390.9;
                     E-value: 1e-118)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XSR1_300019"
                     /product="L-lysine 6-monooxygenase"
                     /protein_id="CDL83401.1"
                     /transl_table=11
                     /translation="MSQPYDFIGIGIGPFNLSIAALSSGIPGFNTLFLERASRFSWHEG
                     ILLPECHMQTSFLKDLVSAVDPTSPYSFLNYLVKRKKFYRFLTTEQRTVSREEFADYLS
                     WAANNLDSLQFGEEVIHVTFDDQKKLFQVTTQNNQYLARHVCMGIGKRFKLPECVKIQN
                     NQCFHAGEMMLRTPDLTDKRVTVVGGGQSGADLFLNIFRGEWGTPKQLNWVSRRNNYNA
                     LDEAAFSNEYFTPEYVESFYSLEPEIKKRMLEEQKMTSDGITSHSLLSIYQAMYHRFEV
                     LRETPWVKLLPSRALLDVKEQGESYQLVTQHLLDNGKEYIDSDTVIFATGYQPSESKFL
                     EPLMQRLHMTQNGGYQIAPDFTLGWDGPDSHCLFAVNAGMQSHGIAEPQMSLMAWRSAH
                     ILNRALGKNHFDLSHSPGVIKWRSESTTQPFFSAF"
     gene            complement(5001..6764)
                     /gene="iucC"
                     /locus_tag="XSR1_300020"
     CDS             complement(5001..6764)
                     /codon_start=1
                     /gene="iucC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XSR1_300020"
                     /product="Aerobactin siderophore biosynthesis protein iucC"
                     /protein_id="CDL83402.1"
                     /sec_met_domain="IucA_IucC (E-value: 1.3e-76, bitscore:
                     246.9, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLNHTNWSHAGWEYVNRRMIAKILAELEYERSLNATSAGDHWHI
                     KLGNVGYTFSAKRGIWGWLFIEPNSLKTDNHEPLDADYSLLQLAKVLEMNDAQIAEHME
                     DLYATLRGDLQLLSMRRNMSAQDLIDLNPDQLQCLLSAHPKFIFNKGRRGWGLEALHRY
                     APEYQGQFRLHWIAAKRDIFVWSMDSSCSLNTLLDSAMDQSERQRFNKRWEELALNDDW
                     LPVPIHPWQWQQKIALHFLPQLASEELVELGEFGDEYLAQQSLRTLTNVSRKTSFDIKL
                     PLTIYNTSCYRGIPGKYISAGPAASHWLQQQFAQDPVLLSSGAQILGEPAAGYMAHPTY
                     AMLAEAPYRYQEMLGVIWRESPSPYLQNGEQAILMATLMESDQQGIPLIAAYVERSGLC
                     MENWLERMFQTVIIPFYHLMCRYGVSLIAHGQNITLVMKENVPHRILLKDFQGDMRLVD
                     QDFPEAASLPQIVKDVTVRLSADYLIHDLQTGNFVTVLRFISPLLEKYGVDELQFYQIL
                     TKILQQYQAQNPEMNNRFELFDLFKPQIIRVVLNPVKLTYSEHDGGNRMLPKYRQDLTN
                     PLYIAKKESEL"
     gene            complement(6761..7762)
                     /gene="iucB"
                     /locus_tag="XSR1_300021"
     CDS             complement(6761..7762)
                     /codon_start=1
                     /gene="iucB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     287.3; E-value: 3.5e-87)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XSR1_300021"
                     /product="Aerobactin siderophore biosynthesis protein iucB"
                     /protein_id="CDL83404.1"
                     /transl_table=11
                     /translation="MPQANLVHSLGGFRCEILEKELPISLGLDGSAILHFLNPTPDGWL
                     AQALDQLLIMAPQISGVSLPYHEWNNEPQALALFNLAQGDYLARESFYQLPVWLVGSPR
                     PSIDQVNTSDQVNTSDQMHYETERQLWLPVRPSRPEGEVYRRYDPEIKHWLSFRLPDLS
                     QDVEQFTHWMNTPRVNAFWEMAGPQEQQKKYLQRQLEANYCYPLLGCFDDQPFGYFEVY
                     WAPEDRIGRHYRWQPFDRGLHMLVGEEQWRGAQYIRSWLRGLTHYLYLDEPKTTRIVAE
                     PRFDNQRLFRHLPTAGYKTIKEFDFPHKRSRLIMNQRHDFFGREMLRGEGVS"
     gene            complement(7749..9521)
                     /gene="iucA"
                     /locus_tag="XSR1_300022"
     CDS             complement(7749..9521)
                     /codon_start=1
                     /gene="iucA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XSR1_300022"
                     /product="Aerobactin siderophore biosynthesis protein iucA"
                     /protein_id="CDL83405.1"
                     /sec_met_domain="IucA_IucC (E-value: 7.3e-65, bitscore:
                     208.4, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSKSCHLKTDIAAQCFINALIRETQDWEIFSPTNQLQYPQLHIP
                     LSDTQSVRIALRYVSPTHHHQYLFPPHLYQNDNTEYRILDMKEFVSLLLEKLKIHGTLS
                     DVTIERFYQRVMESHDNTWQAINIRLDWPMLRDKPLNFAEAEQGLLAGHAFHPAPKSHE
                     PFDAAQARRYLPDFAARFPLRWFAVNSSYICGDSLELTLKQRLQRFTAESAPHLLSYFS
                     DETWLVPMHPWQAEYLLNQDWTQALVQKGHLHDLGEAGTRWLPTSSSRSLYSETNHDMI
                     KYSLSVRLTNSIRTLSVKEVNRGMRLARLAKTPRWQELQARYPTMRVMQEDGWAGLRDI
                     DGTIREESLMAFRANLLFGRPDVQTNVLVTLTQPAPDGGDSLLASSIRRLSTRLNLSLK
                     QSAHCWLDAYCQHILLPLFSAEANYGLVLLAHQQNILVEMEQDLPIGLLYRDCQGSGFT
                     QSAASWLGEIGEAEAENRFTDSQLLRYFPYYLLVNSTLAVTAAMGAAGFDREENLMGKV
                     RDALIQLRTTAQNTLCLDYVLDSPHWNCKGNFFCYLHDHNENTIVDPAIIYFDFANPLV
                     VTHDLQGLTNNAAS"
     gene            9650..10864
                     /locus_tag="XSR1_300023"
     CDS             9650..10864
                     /codon_start=1
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XSR1_300023"
                     /note="Evidence 4 : Homologs of previously reported genes
                     of unknown function"
                     /product="conserved membrane hypothetical protein"
                     /protein_id="CDL83406.1"
                     /transl_table=11
                     /translation="MQVQHHHFFDRNRSSSNWSLAFCAGLLGIGQNGLLVALPTLVDMT
                     HLSLSIWAGLLTLGSMLFLIGSPFWGKQTEIRGGKYVVLAALSGYLLSFIILALAVWGL
                     FSEKISVPIGLFLLIAARVIYGLTVSGMVPACQTWALQRAGAERRMSALATISSGLSCG
                     RLLGPLCAVAVLKLHPLAPLWLMAIAPLIAILIISREYNDPPLSAQESQQQSRLRMSML
                     PYLLCAMLLAASVSLMQLGLAPHLSLLFEQQTTVISNHVAILLSLSAVATLLAQFLMIR
                     PQKFTPLQLMLLAGVFMVIGLIFMTTQQISLFYLGCMLASFGAAMATPGYQLLLNEQLS
                     TGKGAGLISTSHTMGYGMSALAVPVIALWFGESQLITASLVFAALFSAIAVGLWNRQNL
                     PSKDK"
     gene            10884..11822
                     /locus_tag="XSR1_300024"
     CDS             10884..11822
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1200:vibriobactin
                     utilization protein ViuB (Score: 212; E-value: 1.4e-64)"
                     /gene_kind="other"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XSR1_300024"
                     /product="FAD-binding 9 siderophore-interacting
                     domain-containing protein"
                     /protein_id="CDL83407.1"
                     /transl_table=11
                     /translation="MSSTYGVFDLYLKERIVVSPSILRCVFQGNDVDQMQRHAPDQRIK
                     LLLPQPDSVKLNFGDENDWYRGYQSIPKEQRPLMRTYTIRELRTEKKEMDVEFVLHDHH
                     SPVSNWLSQVQSGDLLQVVAPRREQQNGMEGSGKKGNGIEGCEWKPSPQVRQSLLIADE
                     TALPAALGILEQLAEDDAPPYVQAFFEVPVTEDCVNLDHFTFADIFWLPRDGQEKYEHG
                     ERLVEAVRQHVVIPESANIQMQSTIEEASSEDKLWERAENENNPNSFYAWVAAESSTVK
                     KLRHYLILERHLDRSTINFMAYWSKSSPRGR"
     gene            11825..12622
                     /gene="fhuC"
                     /locus_tag="XSR1_300025"
     CDS             11825..12622
                     /EC_number="3.6.3.34"
                     /codon_start=1
                     /gene="fhuC"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 204.1; E-value:
                     4.1e-62)"
                     /gene_kind="transport"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XSR1_300025"
                     /product="Iron(3+)-hydroxamate import ATP-binding protein
                     FhuC"
                     /protein_id="CDL83408.1"
                     /transl_table=11
                     /translation="MIERISSSTSTFVLQQVSFEVPNRRLLNNLSVTFASGLVTGLIGH
                     NGSGKSTLLKILGRHQFPGEGTIQLREKPLTQWNNKAFAREVAYLPQQLPPAEGMTVRE
                     LVAVGRYPWHGALGRFSSEDRQRVEEAIKLVGLSSMAHRLVDSLSGGERQRAWLAMTVA
                     QNSRCLLLDEPTSALDVAHQVEVLALIQRLSRECGLTVIVVLHDINMAARYCDRLVALR
                     GGELIAQGIPEQLMQEPVLEQIYGIPMGILPHPAGGAPVSFVY"
     gene            12622..13533
                     /gene="fhuD"
                     /locus_tag="XSR1_300026"
     CDS             12622..13533
                     /codon_start=1
                     /gene="fhuD"
                     /gene_functions="transport (smcogs) SMCOG1033:iron compound
                     ABC transporter, periplasmic (Score: 138.2; E-value:
                     4.6e-42)"
                     /gene_kind="transport"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /locus_tag="XSR1_300026"
                     /product="Iron(3+)-hydroxamate-binding protein fhuD"
                     /protein_id="CDL83409.1"
                     /transl_table=11
                     /translation="MNKFNLNLTRRHFMTTLALSPLWLPSLARSVTSPHTAHLNQQRIA
                     VLEWLPVELLMALGVMPLAVADVHKYHLWVQQPELTAQVVDLGSRTEPNMELLQQLSPS
                     LILYSQNYGPSIEKMSSIAPTMGFSFNSSRRTPLAQAFYSLKMLAERLDLHDQYTLHLR
                     RYHQQMERNQQRLRLWDDVPILLFTLLDNDHAMVFGQGGLFQDVLDQLGLRNAWQGKTN
                     AWGSQIIGLEQLATIQEARAVFFSHGNEALFARVKKTPLWQALPFVRRYPVIMQPAVWF
                     YGATLSAMRFSDLLATALEKQG"
ORIGIN
        1 gtacaaagaa aaaagtgttt ttgctttttt tgaaactttt attattggaa tgatttttgg
       61 cgggattggt tggtatttca cccgtaaaat taaaatacag cctagtacac aagatggatt
      121 tcttattatt gtactatttt ggttattgtt ttcattactg agcgccttgc ctttcgtcct
      181 cgataaaagc ctgaatgtca atctggtgga tgcaatgttt gaaggcgtat cgggaataac
      241 gaccacgggt gcaacagtac tgaatgatgt ttctgccctg cccaaatccg ttctctatta
      301 tcgcgctcag ctcaatttca taggcggttt gggggtggtc gtccttgcgg ttgctatttt
      361 accgttgctg gggattgggg gagcaaaact gtatcaatca gaaatgccgg ggccttttaa
      421 agaagaacga ttgacaccac gtcttgctga cagcgcgaaa agcttatggg gcgtttacct
      481 gatgctggga gtcgggtgca ttttcagttt ctgggctgct gggatgtcgt ggtttgatgc
      541 gatttgccat ggtatttcta ccgtgtccct aggtgggttt tcaacccgga atgaaagcct
      601 gggttattat gacagtgcag cgattgaaat ggtcggtggc attttttcga tactgtcagc
      661 cgttaacttt acactttatt tcgtcgcact gacacgcagg agctggaagc cgctgctaaa
      721 aaatgcagaa ctgcagtttt tcttgctggt tttggcgata atcgttggca tcatttggct
      781 ggaattatac cgctcaggta tgtacggcgt gaaagaggcc tttgttcacg gttttttcat
      841 gaccagctca atgatgaccg acaacggttt ggcgacttcg gattacgccc aatggccacc
      901 ccatactatt ttaatgctgc tggcagtcag tttttttggc ggctgtgtcg gttcaacttg
      961 tggcggcatc aaggcacttc gctttatgat cctggcaaaa cagagtgtca gtgaaattaa
     1021 tcaacttgtt catccaaacg caatttcaac gattaaaatt ggtcaatcgg cagtacagga
     1081 aagggtattg cgctcagtct gggggttttt ctttctgtat atctttttca gttgcttctt
     1141 tatatgggca ctgaatttgc ttggttatga tctggtgaca tcatttgcca cagtggctgc
     1201 ctgcatcaat aacatgggga ttggatatgg ggaaacggca caaggctttg gggagcttga
     1261 tgcggctgca aaatggatga tgtgtgcggc catgttattg ggacgattgg aaatttatcc
     1321 aatattgatt ttgtgttcaa aagcattctg gcgtttttga actgataatg aactgaaatg
     1381 ataatggata atcgaatacg gtgggttttc cagtatccga ttatccacct tggttagccg
     1441 tattagaaag tcgctgaata actcaggcca aatgttcttc cacgcccttt gtagttatat
     1501 aactcagcgg caccataggc cgggctataa aggacagaag cccgttgtcc ccaaactgag
     1561 gtgtaatctt tatccagtaa gttttcgata ctgaaactga tcttcccgac aggcaagtgg
     1621 taagtcccca gaaaatcgat ggtattgtac ccatctaact ttttaccttt attatcagag
     1681 acatcgaagg tttgttggga ttgcagccgg aattcccagt catcgggtgc ccaattgaca
     1741 taagcggtca ttttagaggg gctagcagtc tcaattgaca gtttttccca cttatctttt
     1801 ttctgcgttt ctgatttgag aatgttgaac gttgtgcctg ctgtccagtc actgttgtca
     1861 aagagataat ctaccgcacc ttctataccg taaatcctgc gtttatcggg gcttatctca
     1921 attctcatgt ctttctttat gatattgatc gagatatcag acaatgaata ataagccgct
     1981 atttgtgtac gcaggttatc gccgttatag cgccatccca attcatacga attgacctta
     2041 atgcctttca atttagagtc attgacattg atgcttttta ccaaaggtat gtgtccattg
     2101 acacttttac catagttgcc tgaaccataa tattttccga catcgggtaa ctcgaagcct
     2161 tgggaaaaat taaaccagac ctgttggcgt tcgggcaggt tggcgagtat gccggcatta
     2221 aacaagtaat tattgtaact tgttgtgcct cccggaacag catccgcgga gagtattttg
     2281 ctggtggcaa tagcttgctg ttgattatac ggaataaagt catcaatctt atttttcgta
     2341 tattgataac gcaatccgct actgacggtg aatatggaat tgatatcgta gttggcctgc
     2401 aagaaaggcg ccaggtttgt gatgctatat cccggatagc gacccacatt ataggcattc
     2461 ttgagtttca tgccgctatg ttcttgcgct gtcttcaaat cgaaaaattg ctgattggcg
     2521 ctgaattttt catggtcagc gtcaaagccg taggttaacg agagattttt aaccggttgg
     2581 ctatttaggg tgaatttacc gccataaaaa tctgtttttt gttccgatgc actaatactg
     2641 ataacttctt tctttttggt tcctttcttg ttaccgagag tcggaaatgg atagaaagca
     2701 aaagattcat cccgataaaa gagttgggtg actaaatctt gccccaaaaa atcggtgttg
     2761 gagtattgca gactgatgag atgacgtgta gtgcccggaa cacggtctga atccagccca
     2821 ctggcattat gggcgctccc tttgcccaat acggctgaaa aatccttgcc aagatttatg
     2881 ccatgttttc catccgcttt actcttgtaa tattgcgttg tcagctgtaa ttgctgatgt
     2941 tcatcaatgt tcagggtgcc ggttcccata acatcaaggc gatcggaata ttgcaggccg
     3001 gtttgggtat tatcgataag gacttgatta tgcttgccat caaaccaacc gccataacgt
     3061 tgataggaga cagaaaggcg tccttttata ttttcatttc cgccactgac tgcggcggca
     3121 atattctcat catgatctga gctgtttatc aagccgcttt tagcaccgaa ttgcagatca
     3181 acttgcccgc cttcctgtcc ttttttggtg acaatattaa tcaatcctcc cgtactcccg
     3241 ccaccataga gcgaggttgc accagaaatc acttcaatac gttcaatatt gaaaggatcg
     3301 atggaatcca gctgtcggct gtcggaacgg gaggagttca aacgcacacc atcaatcatg
     3361 acggcaatgg aacgcccgcg tatattcatt ccgtgattag tccgtccctg actgctgaca
     3421 tccatgcctg gaattaattg tgccagtatg tctttaaatt ccttgccgcc attgacttgt
     3481 tgttctatat cgtgactctc aatcacccaa gaggtttgtg ccatttgggg aatgctgcga
     3541 tgggtacgac tggaagaaac aacaatggtg tcttcctttg actccgcagc agcaaagaca
     3601 gatggagtcg aaatcacaga caagcagggg aggataatcc caaaagaact atgctttatc
     3661 attgcctacc ttcatgttgg tcaaataaat taataacagt tagaacgcag aaaaaaaagg
     3721 ttgcgttgtt gattcactac gccacttgat tacgccggga gagtgtgaca gatcaaagtg
     3781 gtttttacct agtgcccgat tcaaaatatg tgctgaacgc catgccatca aactcatttg
     3841 tggctctgca attccatggc tttgcatacc tgcattcaca gcaaacaggc aatgactatc
     3901 aggaccatcc caacctaaag taaagtcggg ggcaatttgg tagccgccat tttgagtcat
     3961 gtgcaggcgt tgcattaacg gttcaaggaa tttggactct gatggctgat aacccgtcgc
     4021 aaaaataacg gtatcactgt cgatatactc tttcccgtta tccaacagat gttgagtcac
     4081 cagttgataa ctttccccct gttcttttac gtccagcaaa gcccggctgg gtaacaactt
     4141 aacccaaggc gtttcacgca gcacttcaaa tcgatggtac attgcctgat agatggaaag
     4201 taatgaatga cttgtaatcc catcagaggt catcttttgt tcttccagca tgcgtttttt
     4261 gatttcaggc tcaaggctat aaaagctctc gacatactcc ggtgtgaagt attcgttgga
     4321 gaatgcagct tcatccagag cattataatt attgcgtcgt gaaacccagt taagttgttt
     4381 gggggtgccc cattcaccgc gaaaaatatt gaggaacagg tcggcaccac tttgcccgcc
     4441 accgacaaca gtcacacgct tatccgttaa atcaggagta cgcagcatca tttctcctgc
     4501 atgaaaacac tgattattct gtatttttac gcattccggc agtttaaatc gtttgccgat
     4561 gcccatgcaa acatgacgcg ctaaatattg attattttgt gttgtcacct gaaataattt
     4621 tttttggtca tcgaaagtga catgtatgac ttcttcgcca aattgcaggg aatccaaatt
     4681 atttgcggcc cacgaaaggt aatcagcaaa ctcttcgcgg gaaactgtgc gttgttctgt
     4741 ggtcaggaag cggtaaaact ttttccgttt aaccaaataa ttaagaaaac tatacgggct
     4801 tgtggggtct acagcactca ccagatcttt taagaaactg gtttgcatgt ggcattcagg
     4861 caggagtatt ccttcatgcc aggaaaaacg ggacgcccgt tctaaaaata gggtattaaa
     4921 accagggata ccactactaa gagcagcaat actaagatta aatggtccta taccaatacc
     4981 gatgaaatca tagggctggc tcatagttca gattcctttt tggcaatata aagagggtta
     5041 gtaagatctt ggcggtattt tggcagcata cgatttccgc catcatgttc ggaataagtc
     5101 agttttacag ggttcaggac aacccgaata atttgtggtt tgaacagatc aaataattca
     5161 aagcgattat tcatctctgg gttctgtgct tgatattgtt gtaatatttt tgtcagaatt
     5221 tgataaaact gaagctcatc gacgccatat ttttccaata aaggtgaaat gaagcgcaat
     5281 accgtgacaa aatttccggt ctgtaaatcg tgaatgagat agtcagcaga caaacgcaca
     5341 gtgacatctt taacgatttg gggcaaagaa gccgcttcag gaaaatcttg gtcgactagg
     5401 cgcatatcgc cttgaaaatc cttcagtaaa attcggtgag gcacattttc tttcatcact
     5461 aatgtgatgt tctggccgtg ggcaattaat gacacaccat agcgacacat cagatggtaa
     5521 aaagggatga tgacggtctg gaacatacgc tccagccagt tttccatgca caagccagaa
     5581 cgttcaacat aggctgctat cagcggtata ccttgttgat cactttccat taatgtcgcc
     5641 atcaaaatgg cttgttcacc attctgcaga taaggtgacg ggctctcacg ccagataacc
     5701 ccaagcattt cctgataacg gtaaggtgct tcagccagca tcgcataggt tggatgtgcc
     5761 atgtaacccg ctgccggttc accaaggatc tgcgcaccgc tggataataa aacgggatct
     5821 tgtgcaaatt gttgttgtaa ccagtgtgag gcagcagggc cagcactgat gtatttcccg
     5881 ggaatgccgc gataacagga tgtattgtag atagtcaggg gtagcttgat atcaaacgat
     5941 gttttgcggc tgacatttgt caatgtacgc aatgattgtt gggcaagata ttcatctcca
     6001 aactcaccca gttcgaccag ttcctcagag gcgagttgtg gcagaaaatg aagcgcaatt
     6061 ttttgctgcc attgccacgg gtgaatagga acggggagcc aatcatcatt aagcgccagc
     6121 tcctcccagc gtttattgaa acgttggcgt tcactctgat ccatcgcact atccagcaat
     6181 gtatttaaag agcaggaact atccatgctc catacgaaaa tatcgcgctt ggcggctatc
     6241 cagtgcaacc tgaattgccc ctgatattca ggagcataac gatgcaacgc ctccaatccc
     6301 cagccccggc ggcctttatt gaaaataaat ttgggatggg cagacagcaa acattgaagc
     6361 tggtcggggt taagatcaat taagtcctga gcactcatat tgcggcgcat tgacaataat
     6421 tgcagatcac cccgcaatgt tgcgtacaaa tcttccatgt gctctgctat ttgagcatca
     6481 ttcatctcca gtactttggc gagttggagt aatgagtaat cggcatctag cggctcatga
     6541 ttatccgttt tcagtgagtt gggttcgatg aatagccatc cccagatacc gcgttttgcg
     6601 gagaaggtat aacccacatt acccagttta atgtgccaat gatcgcctgc tgatgttgca
     6661 ttcagtgagc gctcatattc tagttcagcc aagattttgg ctatcattcg gcggttgacg
     6721 tattcccagc cagcatgtga ccaatttgtg tgattgagct tcatgacacc ccctctccac
     6781 ggagcatttc tctgccaaaa aagtcatggc gctgattcat gatgagccgt gagcgtttat
     6841 gtggaaaatc aaattctttg atggtcttat aacccgcagt tggcagatgg cggaataagc
     6901 gttggttatc gaaacggggt tcggcgacaa tacgtgtggt tttgggttca tccagatata
     6961 aataatgtgt cagacctcgt agccaactgc gtatatattg cgctccccgc cactgctcct
     7021 caccgacaag catatgcagt ccgcgatcaa acggttgcca acggtagtgg cggccaatgc
     7081 gatcttctgg tgcccaatag acttcaaaat aaccgaatgg ctgatcatca aagcagccca
     7141 gaaggggata acagtaattg gcttcaagct ggcgttgtaa atattttttt tgttgttctt
     7201 gaggcccggc catttcccaa aatgcattga cgcgtggcgt attcatccaa tgggtaaatt
     7261 gttcaacgtc ctgtgataaa tcaggcaaac ggaagcttag ccaatgtttg atttccggat
     7321 cataacgacg ataaacttcg ccttctggtc gtgatggacg cactggcagc cataattggc
     7381 gttcggtttc gtagtgcatc tgatcgcttg tattcacctg atcgcttgta tttacctgat
     7441 cgattgaggg acgaggtgaa cccactaacc acacaggaag ttgatagaaa ctttctcttg
     7501 ccaaataatc gccttgagcc aaattgaaca gcgccaacgc ttgtggctcg ttattccatt
     7561 catgataagg caggctgacc ccgctaattt gcggggccat gatcagtaat tgatccaaag
     7621 cctgggccag ccagccatct ggggttggat tcaggaaatg caaaatagca cttccatcca
     7681 aaccgagact gatgggcaac tctttttcta atatctcgca gcggaagcca ccaagagaat
     7741 gtactaaatt agcttgcggc attattggtg agtccttgca gatcgtgggt aacgacaagt
     7801 gggttagcaa agtcaaaata aataattgcg ggatcgacaa tcgtattttc attgtgatcg
     7861 tgcaggtagc agaagaaatt acctttacaa ttccagtggg gactatcgag tacataatcc
     7921 agacacagcg tgttttgtgc ggttgtccgt aactggataa gtgcatcacg tactttaccc
     7981 atcaggtttt cttcccgatc aaaaccggct gctcccattg ccgcagtgac tgccaaggtg
     8041 gagttgacca gcaaataata agggaaatag cgcagtaatt ggctgtctgt gaagcggttt
     8101 tctgcttcgg cctcaccaat ttccccgagc catgaagctg cactttgagt aaaaccacta
     8161 ccttggcaat cccggtatag caacccgata ggtaaatctt gttccatttc cacaagaata
     8221 ttttgctgat gtgctaacag gactaagcca taatttgcct ctgcactgaa cagcggcagt
     8281 aaaatatgtt ggcagtaagc atccagccaa caatgggcag attgttttaa tgatagattg
     8341 aggcgggtgc tcaggcggcg tattgacgat gccaataagc tatctccccc gtcaggggca
     8401 ggctgtgtaa gagtaaccag tacgttggtt tgcacatcag gacggccaaa cagtaaatta
     8461 gcgcggaatg ccatcaggct ctcttcacgg atagttccgt caatatcgcg caaaccggcc
     8521 caaccatctt cctgcatgac acgcattgtc ggatagcgtg cttgtaactc ttgccagcga
     8581 ggtgtttttg ccaaccgagc caaacgcatt cctcgattaa cttcttttac tgatagtgtc
     8641 ctgattgaat tggtcaggcg aacacttaaa gagtatttga tcatgtcatg attggtttcg
     8701 ctgtacagag agcgtgacga actggtcgga agccatcggg ttccggcttc gcctaaatca
     8761 tgtaaatgcc ctttttgtac cagtgcctga gtccaatcct ggtttaacag gtattctgcc
     8821 tgccatggat gcatcggaac taaccaagtc tcatcagaaa agtaagacag cagatgcggg
     8881 gcactttcgg cagtgaaacg ttgtaaacgc tgttttaatg tcagttccag gctatcaccg
     8941 caaatataag aagaatttac ggcgaaccaa cgcagtggaa aacgtgcagc aaaatcaggt
     9001 aaatagcgcc tggcttgtgc ggcatcaaaa ggctcatgag attttggggc agggtgaaaa
     9061 gcatgtcctg ctaacagccc ttgttctgct tcggcaaaat ttaaaggttt gtcgcgcagc
     9121 attggccaat ccaatcggat attgattgcc tgccaagtat tatcgtggct ttccattacc
     9181 cgttggtaaa atcgttctat cgttacatct gataatgttc cgtgtatttt cagtttttcc
     9241 agcaataaac tgacgaattc tttcatatcc agaatgcgat actcagtatt gtcattctga
     9301 tacagatgtg gcggaaacaa gtattgatgg tgatgagtgg gagaaacata acgtaacgca
     9361 atacgaacgg attgcgtatc ggaaagcgga atatgtaatt gtgggtattg taattgattg
     9421 gtaggtgaaa aaatttccca atcttgagtt tcacggatta aggcattgat aaaacattgt
     9481 gcagcaatat cagtttttag atgacaagat tttgaataca ttggatttaa tctaaacgct
     9541 attgataatt gttatcaata tgatattcat ttgatttgtt aagtaaagtg ttttgtgttt
     9601 atatttacaa ctaacgagtt atttttgata ttgataacac aagaataata tgcaggttca
     9661 acaccatcat ttttttgacc ggaatcgttc atcttcaaat tggtctctgg cattttgcgc
     9721 gggattattg ggtattggac aaaatggttt gctcgtcgca ctgcctacgc ttgtagacat
     9781 gacacacctt tctctctcta tttgggccgg gttattgaca ctgggttcca tgctatttct
     9841 gataggctcc ccattttggg ggaaacaaac agaaattcgt ggcggaaaat atgtcgtcct
     9901 ggccgcatta tcagggtatt tactgagttt tattatattg gccctggcgg tatgggggct
     9961 ttttagtgag aaaatctctg ttccgattgg gttgtttttg cttattgcag cccgggttat
    10021 ttatggattg actgtatccg gcatggtacc tgcgtgccag acctgggcgc tgcaacgtgc
    10081 gggggcggaa cgcagaatgt ctgcactggc caccattagc tcaggtttaa gttgtggccg
    10141 cttattgggg cctttatgtg cagttgcggt attaaaattg catcccttgg cacctttgtg
    10201 gctgatggcg attgctccgc ttattgccat attgattatt tccagagaat acaatgatcc
    10261 gcctttgtca gcacaggaaa gtcagcaaca aagccggctg cggatgagta tgcttcccta
    10321 cctgttgtgt gcaatgctct tggctgcttc agtcagtttg atgcaattgg gactggcccc
    10381 tcacttatcg cttttattcg aacagcaaac taccgtgatt agcaatcatg tagcaattct
    10441 gctgagcctg tcagccgtcg caacattatt ggcccagttt ttgatgatcc gtccccaaaa
    10501 attcactcca ttacaattga tgttgttggc gggtgttttt atggtgattg gattgatatt
    10561 catgaccact caacaaatct ctctgtttta tttgggatgc atgctggctt catttggcgc
    10621 tgcaatggcg actcccggat atcagctttt actgaatgaa caactttcca cgggcaaagg
    10681 tgccggattg atttccacca gccatacaat gggttatggc atgagtgcgt tggccgtgcc
    10741 tgttattgct ttatggtttg gtgaatctca attgattacg gcatcgttgg ttttcgctgc
    10801 attattcagc gccatcgcag tagggctatg gaatcgtcag aatttgccat ccaaagataa
    10861 atagatttca aggagaagtt tcgatgtctt caacttacgg cgtttttgat ttgtacttaa
    10921 aagaacggat tgttgtatca ccatcaatat tacgttgtgt ttttcaaggc aatgacgtgg
    10981 atcaaatgca acgacatgct cccgatcaac gtataaaatt actgcttccg caaccagaca
    11041 gcgttaaatt gaatttcggt gatgaaaacg attggtaccg tgggtatcag tctataccta
    11101 aagaacaacg cccgctcatg agaacttata ccatcaggga attgcggact gaaaagaaag
    11161 agatggatgt ggaatttgtg ttacatgacc accacagccc ggtgtcgaat tggttgtcgc
    11221 aagttcaatc aggcgatctt ttacaagttg ttgctcccag aagagaacag caaaatggta
    11281 tggaaggaag tggtaaaaaa ggaaatggca tcgaagggtg tgaatggaag ccttccccac
    11341 aagtacgcca atcacttttg atcgctgatg aaaccgcttt gccggcagcg ttgggtattc
    11401 ttgaacagtt agcggaagat gatgctcccc cttatgtaca ggcatttttt gaagtgcctg
    11461 tgacagagga ttgtgtcaat ctggaccatt tcacatttgc tgatattttc tggcttccga
    11521 gggatggaca ggaaaaatat gagcatggtg aacggttggt agaggctgtt cgccaacatg
    11581 tcgttatccc tgaatcagca aacattcaga tgcaatccac tatcgaagag gcatcatctg
    11641 aggataaact gtgggaaaga gcagaaaatg aaaataatcc aaacagtttt tacgcttggg
    11701 tagcagcaga atcatcgaca gtaaaaaagc tgcgccatta tctaattctt gagcggcact
    11761 tagatcgcag cacaattaat tttatggcgt attggtctaa atcttcaccc agaggtcgtt
    11821 aggcttgatt gagcgtattt catcatcaac atctactttt gttttgcagc aagtcagctt
    11881 tgaggtgcca aaccggcgac tactcaacaa tctttctgtg acttttgctt ccggtttagt
    11941 gactggattg attggtcata atggttctgg aaagtcgaca ttgctcaaga tattgggacg
    12001 ccatcaattc cccggagaag gcacgataca gttgcgggaa aaacctctca cgcaatggaa
    12061 caataaggca ttcgcacgtg aagtggctta tttgccacaa cagttaccac cggcggaagg
    12121 gatgacggtg cgtgaactgg tggcagtggg gcgctacccc tggcatggag cactgggcag
    12181 attcagctct gaagatcgcc agcgtgttga agaagccatc aagctggtgg ggttaagttc
    12241 aatggcacat agattggttg atagtttgtc cggcggcgaa cgacagcgag catggctagc
    12301 gatgacagtg gcgcagaaca gccgttgttt gttgcttgat gaaccaactt cagcgttaga
    12361 tgtggctcat caagttgaag tcttggcgtt gattcaacgc ttgagccgtg agtgtgggct
    12421 gacagtcatt gttgttttgc atgatattaa tatggctgcg cgttattgtg atcgtttggt
    12481 tgcattgcgt ggaggcgagc tgattgccca ggggatacct gaacagctca tgcaggaacc
    12541 cgtcttggaa caaatatatg gaatacccat ggggatcttg ccgcatcctg ctggtggtgc
    12601 tccggtaagc tttgtctact gatgaataaa tttaacctta atctcacgcg tcgtcatttt
    12661 atgacgacgc tggcactttc gccattatgg ctgccatcat tggctcgttc tgtgacttct
    12721 ccacacaccg cacaccttaa tcagcaacgt attgccgtgc tggaatggtt gcctgtggaa
    12781 ctcctgatgg cattgggtgt gatgccttta gcggtagctg atgtccataa atatcatttg
    12841 tgggtacaac aacctgagct gacagctcag gttgttgatt tgggatcgcg tactgaaccc
    12901 aatatggaat tgttgcaaca attgtcaccc tctctcattc tctattcgca aaattatggc
    12961 ccttcaatag aaaaaatgtc ctcaattgcg cccacaatgg gatttagctt caactccagt
    13021 cgccgaacgc cgttggctca ggctttttat tcactgaaaa tgctggctga gcggcttgat
    13081 ctccatgacc aatacacttt gcatttacga cgctatcacc agcagatgga gcgaaaccag
    13141 caacgattgc gtctttggga cgatgtaccc attttgctgt ttacattgct tgataacgat
    13201 catgcgatgg ttttcggtca gggagggtta tttcaggatg ttctcgatca gttggggcta
    13261 cggaatgcat ggcagggaaa gacaaacgct tggggaagcc aaataattgg tctggaacag
    13321 ctggcgacca ttcaggaagc ccgggctgtt tttttcagtc atgggaatga agcactgttc
    13381 gctcgtgtga agaagacacc attgtggcaa gcattaccgt ttgtccgacg ttatccggtc
    13441 attatgcaac cggctgtgtg gttttatggt gccacattat cggctatgcg ttttagtgac
    13501 ttattggcaa cagcgttgga gaaacaggga tgagaagctt gtgggcagta cctttgttat
    13561 tgctatttcc agcattgatg ctgacgtttt ataacctgca acagcaatta cctgttttcc
    13621 aatggtggca atctttactt tctccagatg tggataatat ccgtcagatt gtaatgcatt
    13681 acagtatgtt accgcgtttg gtcatctctt tgctggtggg ggccgggttg ggattggcgg
    13741 gattgctgtt tcagcaagta ttgcgcaatc cattggcaga gcctgcaacg ctgggggtat
    13801 cagcgggagc gcaatgcggg gtgacagtgg cattattatt ggccatccca cccgaaagtt
    13861 tgttgatgca actcgccgcc ttggcaggct cggtgattgt tgcattggtg gtatttggtt
    13921 tgtcatgggg acggcggcta tccccaataa cgttaatcct tgctggctta gtgatgagct
    13981 tatattgcgg agccgtcaat tctcttttgg cactgttcaa ctatgaaaaa ttgcagggga
    14041 tctttgtttg ggccagtggt tctctggtcc agcatgagtg gcaggtgacg aagtggttga
    14101 tattggtctt gttgattgct ttgttattaa cgttattgct gttgcgcccg ttaacgttgc
    14161 ttgggttgga tgatggcgtg gcaaagaatt tgggattggg gctgaatagt gccagactgt
    14221 cagcattatc attggctgtt gtattgagtg cggtaatggt taatgcggtt ggggttattg
    14281 gttttattgg cttgtttgcc cccttgttgg cccgaatgtg cggagcaagg cgattagggc
    14341 agcaagtgat aatgtcccct ttgattggtg cgcttctttt gtggttgact gatcaggttg
    14401 tgcaatggct ggctactgtc tggcgcagta ttcccacagg ttctgcggtt gcgttattag
    14461 gtgcgccaat attgctatgg ctcctgccgc gtttgcgtac tggcggacaa aaattaccct
    14521 c
//
