LOCUS       BGC0001499             14029 bp    DNA     linear   BCT 01-MAY-2018
DEFINITION  Pantoea ananatis strain 15320 aerobactin biosynthetic gene cluster,
            complete sequence.
ACCESSION   BGC0001499
VERSION     BGC0001499
KEYWORDS    .
SOURCE      Pantoea ananatis
  ORGANISM  Pantoea ananatis
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Erwiniaceae; Pantoea.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:41:37
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14029
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..14029
                     /db_xref="taxon:553"
                     /mol_type="genomic DNA"
                     /organism="Pantoea ananatis"
                     /strain="15320"
     misc_feature    1..14029
                     /note="aerobactin biosynthetic gene cluster"
     protocluster    1..14029
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3611:8017]"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3612..8017
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
     cand_cluster    1..14029
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="NI-siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..14029
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001499"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..14029
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NI-siderophore"
                     /region_number="1"
                     /rules="IucA_IucC"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(2268..3479)
                     /gene="mdtG"
     CDS             complement(2268..3479)
                     /codon_start=1
                     /gene="mdtG"
                     /product="multidrug resistance protein MdtG"
                     /protein_id="AWD37847.1"
                     /transl_table=11
                     /translation="MTSLELTATPQKALPNWPLALSAGLLGVGQNGLLVAIPMLVAQTS
                     LSLSVWAGLLTLGSMLFLPSSPWWGKQIARLGSKPVVLWSLAGYGASFLLLAMGCALLS
                     TRAVSAPIGLGILIIARVIYGLMVSAMVPACQVWALNRAGEGKRMTALATISSGLSCGR
                     LFGPLCAAGMLVIHPMAPLVLLVVAPLLALAMLLPLRGTEPQPAVARRNARLRIDCLPY
                     LLCALLLAATVSLMQLGLSPALARQFTGDTAAISHQVAWLLSVAAIASLGAQFMVLRPQ
                     LLTPLALLLSAGLLMSLGLAMMLSTPLWLFYTGCALLSFGAALGTPAYQLLLNDRLADG
                     AGAGWIATSHTLGYGLCALLVPLVSQSQGATALIAAAFSAALLFVAMSGVIWRARRRST
                     LSAH"
     gene            3612..5336
                     /gene="iucA"
     CDS             3612..5336
                     /codon_start=1
                     /gene="iucA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /product="aerobactin biosynthesis protein IucA"
                     /protein_id="AWD37848.1"
                     /sec_met_domain="IucA_IucC (E-value: 1.1e-67, bitscore:
                     216.8, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQSTHNGSWDVAAQCFLNSLIRETKDWRLSQGEPAELVIPLAEE
                     KALHFKVAYFSPTQHHRFAFPARLVTHRGSETVTFATVARLIVDKLQHQQQLPAPGCEA
                     FYQRVMESHAHTAEATAARHDWRGLREKALNFAEAEQALLVGHAFHPAPKSHEPFTQQQ
                     AERYLPDFAPHFPLRWFAVDKDHLAGDSLQLTLQQRLTRFAAENAPQLLHALTDRQWLF
                     PLHPWQADYLLQQTWCQQLVEKGLVTDLGEAGAPWLPTSSSRSLYSATSRDMIKFSLSV
                     RLTNSVRTLSVKEVKRGMRLARLAQTDRWQDMQARFPAFRVMQEDGWAGLRDAQGTIME
                     ESLFALRENLIVDRPQSQTNVLVSLTQSAPDGGDSLLSAAVKRLSQRLHISEKQAAHAW
                     VDAYCQQVLKPLFTAEADYGLVLLAHQQNILVEMEQDLPVGLIYRDCQGSAFMPHAAGW
                     LDMIGEAQAENVFSREQLLRYFPYYLLVNSTFAVTAALGAAGMDSETHLMARVRDALSA
                     LRNEVTHKGCLDYVLESPHWNVKGNFFCYLHDHNENTIVDPSVIYFDFINPLLSQER"
     gene            5337..6284
                     /gene="iucB"
     CDS             5337..6284
                     /codon_start=1
                     /gene="iucB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     315.2; E-value: 1.1e-95)"
                     /gene_kind="biosynthetic-additional"
                     /product="aerobactin biosynthesis protein IucB"
                     /protein_id="AWD37849.1"
                     /transl_table=11
                     /translation="MSQATIVHSGHGLRCEKSGKTLNLGWGQDNSAVLHFAGPLPEGWL
                     RDALDQMFIAAPQLSAVVLPFAEWREEPQALALFAALKSDIVHRETFWQLPLWLSAPRQ
                     QASGEMIFDAEREIYFPQRPARPDGEVYRRYDPRVRRTLSFRVADPARDAEAFTRWMND
                     PRVDYFWEQSGSLATQTAYLERQLGSSYAFPLIGCFDDEPFSYFEIYWAAEDRIGRHYS
                     WQPYDRGLHLLVGEPQWRGPHFVQSWLRGISHYLLLDNPQTQRLVLEPRADNQRLFRHL
                     EPAGYTTVKEFDFPHKRSRLVMTQRARFFSEVGL"
     gene            6284..8017
                     /gene="iucC"
     CDS             6284..8017
                     /codon_start=1
                     /gene="iucC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /product="aerobactin biosynthesis protein IucC"
                     /protein_id="AWD37850.1"
                     /sec_met_domain="IucA_IucC (E-value: 5e-79, bitscore:
                     254.0, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSHAWETVNRQLVAKMLAELEYEQVFQAQPQGDNRYCISLPGAE
                     WQFTAERGIWGWLWIDAQSLRCADEPVLAQTLLCQLQPVLSMSDATVAEHMQDLYATLR
                     GDLQLMQARQGMSADALIDMDADRLQCLLSGHPKFAFNKGRRGWGQEALARYAPEYMNT
                     FRLHWLAVKRDHMVWRCDSELDIQQLLQAAMDSAEYTRFTEAWQAQGLDDSWLPLPVHP
                     WQWQQKIALDFVADLATGNMLSLGEFGDRWLAQQSLRTLTNASRQGGLDIKLPLTIYNT
                     SCYRGIPGKYIAAGPLASRWLQNVFATDTTLQQSGAVILGEPAAGYVSHRGYGALPEAP
                     YRYQEMLGVIWRENPSRWLHADETPILMATLMECDENNQPLIGAYIARSGLSAEAWLSQ
                     MFRVAVVPLYHLLCRYGVALIAHGQNITLAMKDGVPQRVLLKDFQGDMRLVKDDFPEMD
                     SLPQDVRDVTARLSADYLIHDLQTGHFVTVLRFISPLMARLGVPERRFYQLLAAVLSDY
                     MQDHPQLSARFALFSLFKPQIIRVVLNPVKLTWPDQDGGSRMLPNYLENLQNPLWLVTK
                     D"
     gene            8021..9355
                     /gene="iucD"
     CDS             8021..9355
                     /codon_start=1
                     /gene="iucD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 402.5;
                     E-value: 3.2e-122)"
                     /gene_kind="biosynthetic-additional"
                     /product="aerobactin biosynthesis protein IucD"
                     /protein_id="AWD37851.1"
                     /transl_table=11
                     /translation="MTNTVDFIGVGIGPFNLSIAALAHEAEGFTSQFLDSRPDFAWHPG
                     MLVPDCHMQTSFLKDLVSAVAPTSPFSFVNYLVKRKKFYRFMTTELRTVSRDEFSDYLR
                     WAAEGMNNLRFNHTVERIDFDEANKRFVIHSNGGESYARNICLGIGKQPYLPPCVNRIS
                     ATCFHASEMSLRKPDLRGKRVAVIGGGQSGADLFLNAFRGEWGEPAEVNWVSRRNNFNA
                     LDEAAFANEYFTPEYVSSFVGLNEAARQKMLAEQKMTSDGITADSLLTIYRELYHRFEV
                     QRQPRNAHLLPSRSVIELNSHHQGWQLQLQHQLDQGYDLIECDVVIFATGYRPALPELL
                     SPLMSRLTMKDECTFSVREDFTLEWNGPKENNIFAVNASMQTHGIAEPQLSLMAWRSAR
                     ILNRALGRDLFDLSTPPALIQWRSVSREKPQHGAASTKNYTESLG"
     gene            9383..11578
                     /gene="iutA"
     CDS             9383..11578
                     /codon_start=1
                     /gene="iutA"
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 200.3; E-value: 1.3e-60)"
                     /gene_kind="transport"
                     /product="aerobactin siderophore receptor IutA"
                     /protein_id="AWD37852.1"
                     /transl_table=11
                     /translation="MKTKNKNIWLLNPLLLAMMAPAVAQQTSENDMVVSASRTHRTVAE
                     MAQTTWVIEGAELEQQVQGGKEFKDALAQLVPGLDVSSQGRTNYGMNMRGRAIVVLVDG
                     VRLNSSRTDSRQLDSIDPFNIDHIEVISGSTSLYGGGSTGGLINIVTKKGQPGTQFEFE
                     TGTKTGFNNSKDHDERVAGAISGGNDRASGRLSVAYQKFGGWYDGNGDSVLLDNTQTGL
                     QYSDRLDVMGTGTLEIDDHQQLQLVTQYYKSQGDDDYGLYLGRNFSAVTGNGNAYTSKG
                     LNSDRIPGTERHLVSLQYSNTDFLGQELVGQVYYRDESLAFYPFPTVSGGRVTSLSSSK
                     QDTDQYGGKLAITSKPLDNLQLTYGVDADHERFSSNQMFFDLAQSAASGGLNNQSIYTT
                     GRYPGYGITNLAAFLQSSYDINDTFTLSGGVRYQYTENKVDDFVGYAQQQAIANGTARS
                     ADAIPGGSTDYDNVLYNAGILMHITERQQAWFNFSQGVELPDPGKYYGNGTYRLQNGNY
                     QLLNSVNVDQSKLQGIKVDSYELGWRYTGNDLRTQLAAYYSLSDKSISVNRSDMTINVD
                     DDKRRIYGVEGAVDYFIPDTNWSTGVNFNLVKSETKKDGGWKKWDVIYASPSKATAYVG
                     WSPDPWSLRLQSTQSFDLTDNGGNKIDGYTTVDFIGSYQLPVGKLSFSVENLLDRDYTT
                     VWGQRAPLFYSPTYGSPSLYQYKGRGRTFGLNYSVLF"
ORIGIN
        1 cactggagca gtggagcctg ttggacaagg tggtgcgaga gggcagtttt gccagagcgg
       61 cgagtctgac caaccgcagt cagtcatccg tcagctataa ccttgctatg ttgcagcagc
      121 gcatagggat tacgctgtta catgcagagg ggcgcaaggc ggtgctgacg ccggcaggcg
      181 agttgctgct ggcgcaggtg cgcccgctac tgaaagcttt tcattcactg gaggcgtttg
      241 cgggatcaat acgcagcggc gtcagaacaa agctggatgt ggtggttgac agcatctttc
      301 cgcgtcgaca actgttttcc gtccttaagg cgtttcagca atgccatcct catactcaga
      361 tcaacctgac cgaggtgctg gaaaccaaca ccgattacgc cgaggccgac gtgatggtgg
      421 tgacccagcg ccaggatatg gccgggcggg gagagtggtt gatgaatgtg gatttcgtcg
      481 ccgtggcgca ctgcgaccat cccttgcatc agcatggcgg catcctggat gaagaacggt
      541 tggcacagta tccgctgatt cgcattgccg accgggaaca tttcaccgtg caggatgaga
      601 gcagcaatgg cgattactgg tcgttttcga ctattgaggc ggcggtagag gcggtggtgc
      661 accaggtggg ttatggctgg atccccttcg agcgcatcga acatgaactg gcgcagggaa
      721 cactaaaaat attgccctta cagcacggcg ttcgtcgtgc caccccgctg cacttactga
      781 ttaagaaaga tatcctgacg ctggatccac aaattgttac cctgctcgat ctgctgaaaa
      841 acgccacccg ttcgtgacag agggatcgcg atgaggaacg cgtcttcagg ggctatttgt
      901 caccgttcaa cgcaaggagc agggcatcca gcgaatctgg cgcgtgcgga tatccgtttt
      961 ttaccttgtg aacgtcccag gacattgcat cctcaaggca gaaatcgcct gcacactgca
     1021 acgcgaggtc ttcatctaac agcccaatcg gtagccagat cagggggcgg ccgcgcaaca
     1081 ggttcggcac cgtcgagcca cagtgcctgc aaaagtcatt acggtatccc tgcgggcgac
     1141 gccaactgct gatatcggct tcaccggcca gccagctaaa ctgatcggca tgaaccagcg
     1201 tggccaggtt atggccggta ccggtctgac ggcggcaaag cgaacagtga cagcggtaaa
     1261 aatggctggg ttgttgagcc agcttaaaaa cgaccgttcc gcataaacaa cgtccagaaa
     1321 tcatccttgt ttccctgaat gcgccaaccc taaggcgatg tttagtgtgc ccgctttttg
     1381 gcccagtaag ccataaagtt aatcgcgtcg cgatcgacgc cgcgctcccc tatcaggtgg
     1441 cggcgtaata gcttcaccac ggtcgattcg gccgctaccc aaccgtaaaa ttccgtgttg
     1501 cggccctgag cacggtccca cagcaattcg ccttctgcct cttcctgcac gtcctgctgg
     1561 cggccgccat cgggaacgtt aacccgggat tttattgcct caaccaggca ttccccgtgt
     1621 gaagcaaatg caggttttcg cggcaaccag acgatgtcgg caaaggtata ggcgtgcaga
     1681 tcgacgcaat cttccgcatc cgggacttca aaaaaggcct gaacccgagg cggattttcc
     1741 tgtctggaca gtctttccag aatgcctttc gccgcgggta atgcggtttc atcggcaatc
     1801 agtaacgcat tacgcagcgc atccggtggc gtccattcat atccgccgct gtcagattca
     1861 caggccgcat tgggcgcaac gatcaccagg ccgtcacccg gttcagcatt gattgcccag
     1921 gccgatgccg ggccttccgt accgtggctg acaaactcaa tcgtcaactc ctggcgctca
     1981 ggatcgagat gacgcagcgt ataggtgcgc aacagcggac gcttctcttt tggcagcgac
     2041 agaatggtct ggtaccactc gccatcattg ggaagcgcag gcatgctgcc atcttccgcc
     2101 ggcagcaaaa ttttgatccg ctgatcgggc gcgtcagact tcatctgcgc cacgtcaggc
     2161 ccgttgaaca ccaggctcag cattgaggga gaaagatgat gcttgcgtgc cagttttacg
     2221 tcaaacaggc ggtagctatg ggcttcagcc atcgtcgttc cttttggtta atgagccgat
     2281 aaggttgagc ggcgacgtgc acgccagatc acacctgaca tcgccacgaa cagcagggca
     2341 gcgctgaatg cggcagcgat cagcgccgtt gcgccctgtg actgcgacac caggggaacc
     2401 agcagcgcgc acaatccgta gcctaaggta tggctggtgg ctatccagcc ggcaccggca
     2461 ccgtctgcca gcctgtcatt tagcagcagc tgataagccg gcgtacccag tgcagcacca
     2521 aacgaaagca gggcacagcc ggtgtaaaac agccagagcg gtgtgctcag catcatcgcc
     2581 agacccagag acatcaacag ccctgcgctc agcaacagcg caagcggcgt cagtaactgg
     2641 ggtcgcagta ccataaactg ggcgcccagt gaggcgatgg ccgccacact cagcagccag
     2701 gcaacctgat ggctgattgc ggcggtatca ccggtaaact gtctggccag tgccggggat
     2761 aagcccaact gcatcaggct caccgtggcc gccagcagca gagcgcacag cagatagggc
     2821 agacaatcaa tgcgcaggcg ggcattcctg cgcgccaccg caggctgtgg ctcggtaccg
     2881 cgcaacggca acaacatagc cagcgccagc aacggcgcaa cgaccagtaa caccagcggt
     2941 gccatcggat gaataactaa cattccggca gcgcacagcg ggccaaacag cctgccgcag
     3001 ctcagaccgg aactgatggt cgccagcgcc gtcatgcgct tgccttcacc ggcacggttt
     3061 agcgcccaga cctggcacgc cggaaccatc gccgatacca tcaggccata aatcacccgg
     3121 gcaataatta atatacctaa tccaatcgga gcactgaccg cccgcgtgga aagaagtgcg
     3181 cagcccatag cgagtagcaa aaaacttgca ccataaccgg ccagtgacca cagcacgacc
     3241 ggtttgctgc cgagacgcgc aatctgtttt ccccaccacg gcgatgaggg caaaaacagc
     3301 atagagccga gcgttaacaa tcccgcccag accgaaagac ttaaactggt ctgcgcaacc
     3361 agcatcggga tagccaccag caaaccattc tgtccgacgc ccagcagtcc ggcgcttaat
     3421 gctaaaggcc agttaggtaa ggctttttgt ggcgtagcgg tcagttcaag agatgtcaca
     3481 atgttgctaa cccgtatctt tgttgtatgt atttgtaaaa tttattccgc caattctaac
     3541 aattgtcgtt gataatgaga actgttatcg gcagaattcg cattatcata acgcctggaa
     3601 attgtttgat aatgattcaa tcgacgcaca atggatcctg ggatgtggcc gcacagtgct
     3661 tcctgaattc cctgatccgt gaaaccaagg actggcgact cagccagggt gaacccgccg
     3721 aattagtgat tccgttggcg gaagaaaagg ccctacactt taaggtggct tacttttctc
     3781 ctacccagca tcatcggttt gccttcccgg cccggctggt cactcaccgt ggcagcgaga
     3841 cggtgacgtt cgccaccgtt gccagactga ttgtcgataa actgcaacat cagcaacagc
     3901 tgcccgctcc cggctgtgag gcgttttacc agcgcgtgat ggaaagccat gcgcataccg
     3961 ctgaggcaac ggctgcccgc cacgactggc gaggcctgcg tgagaaagcc ctgaactttg
     4021 ccgaagcaga gcaggccctg ctggtcgggc acgccttcca tccggcaccc aaatcacatg
     4081 aaccttttac gcagcagcag gccgaacgtt acctgcctga ttttgcgcca cattttccgt
     4141 tacgctggtt tgcggtggat aaagaccatc tggcgggtga cagcctgcag ctgacgttgc
     4201 agcagcgcct gacgcgcttt gcggcagaaa acgcgccgca gttactgcat gcgctaaccg
     4261 atcggcaatg gctgttcccg ctccatccct ggcaggcgga ctatctgctc cagcagacct
     4321 ggtgtcagca actggtggaa aaaggcctgg ttactgacct gggtgaagcc ggtgcgccct
     4381 ggctgcccac ctcctcatcg cgttcgctgt acagcgcgac cagccgcgac atgatcaagt
     4441 tttccctgag cgtgcggctg acaaactccg tccgcaccct gtcggtcaaa gaggtcaaac
     4501 gcggcatgcg gttggcgcgt ctggcgcaga ccgaccgctg gcaggacatg caggcacgct
     4561 tcccggcgtt tcgcgtgatg caggaagatg gctgggccgg actgcgcgat gcgcagggca
     4621 cgattatgga agagagcctg ttcgcactgc gtgaaaacct gattgtcgac aggccgcaga
     4681 gccagaccaa cgtgctggtt tccctgacgc agtccgcgcc ggacggcggc gactcactgc
     4741 tgtctgccgc agtgaagcgc ctgagccagc gcctgcacat cagcgaaaaa caggctgcgc
     4801 atgcctgggt cgacgcctac tgtcagcagg tgctgaagcc cctgtttacc gccgaagccg
     4861 attacggcct ggtgctgtta gcccatcagc aaaatatcct ggtggaaatg gagcaggacc
     4921 tgccggttgg cctgatttat cgcgactgcc agggcagcgc ctttatgcct cacgccgcag
     4981 gctggctgga catgattggc gaagcgcagg cggaaaacgt ctttagtcgc gagcagctgc
     5041 tgcgctactt cccctattac ctgttagtga attctacctt tgccgtcacg gcggcactgg
     5101 gcgcggcggg catggacagt gaaacccatt tgatggcgcg ggtacgcgat gcgttaagtg
     5161 cgctacgtaa cgaggtcacg cacaagggct gcctggatta cgtgctggaa agcccgcact
     5221 ggaacgtcaa gggcaacttc ttctgttacc tgcacgatca caatgaaaac accatcgtcg
     5281 atccgtcggt gatctacttc gacttcatca acccactgct gtctcaggag cgctaaatgt
     5341 ctcaggcaac gattgttcac agcggccacg gcctgcgttg cgaaaagtca ggaaaaaccc
     5401 tgaatctggg gtggggacag gacaacagtg cggtgctgca ttttgccggt ccactgcccg
     5461 aaggctggct gcgtgacgcg ctggatcaga tgtttatcgc tgccccgcag ctttctgccg
     5521 tggtgctgcc cttcgcagag tggcgtgaag agcctcaggc gctggcgctg tttgcggccc
     5581 tgaaaagcga tatcgtccac cgcgagacgt tctggcaact gccgctgtgg ttgtctgcgc
     5641 ctcgtcagca ggcctccggc gagatgatat ttgatgccga acgtgagatc tattttcccc
     5701 agcgcccagc gcgacctgat ggcgaagtgt atcgccgtta cgatccgcgc gtacggcgaa
     5761 cgctgagctt ccgcgtggcc gatcctgccc gggatgccga agcgtttacc cgctggatga
     5821 acgatccgcg cgtggattac ttctgggagc agagcggatc gctggccact cagaccgcct
     5881 atcttgaacg ccagctcggc agcagctatg cctttccgct gattggctgt tttgatgacg
     5941 agcccttcag ctactttgaa atttactggg cggcggaaga tcgtatcggg cggcactaca
     6001 gctggcagcc gtacgatcgc ggtttgcatc tgctggtggg tgagccgcag tggcgcgggc
     6061 cgcactttgt gcagagctgg ctgcgcggca tcagccacta tctgctgctg gataatccgc
     6121 aaacccagcg cctggtgctg gaaccgcggg cggataatca gcgcctgttt cgtcaccttg
     6181 aacccgcggg ctataccacc gtgaaagagt tcgactttcc gcacaagcgc tctcgcctgg
     6241 tgatgaccca gcgcgcccgt ttcttcagcg aggtgggcct gtgatgaatt cgcatgcatg
     6301 ggaaaccgtt aaccgtcagc tggtggcaaa aatgctggcc gagctggagt acgagcaggt
     6361 ctttcaggcc cagccgcagg gcgacaaccg ttactgcatc agtctgccgg gtgccgaatg
     6421 gcagttcacc gccgagcggg gcatctgggg ctggttatgg attgatgcac aaagcctgcg
     6481 ctgtgcggat gagccggtac tggcccagac gctgctgtgc cagctacagc cggtgctgtc
     6541 gatgagtgat gccacggtgg cggaacatat gcaggatctc tatgccacgc tgcgcggcga
     6601 tcttcagctt atgcaggcac gccagggcat gagtgccgat gcgctgattg atatggatgc
     6661 cgaccgcctg cagtgcctgc tcagcgggca tcccaagttt gcctttaata aaggccgtcg
     6721 cggatgggga caagaggcgc tggcgcgcta cgcaccggag tacatgaata ccttccgcct
     6781 gcactggctg gcggtaaagc gtgatcatat ggtctggcgc tgcgacagcg agctggacat
     6841 ccagcagttg ttgcaggctg cgatggacag cgccgaatat acgcgtttca ccgaggcctg
     6901 gcaggcgcag gggctggacg acagctggct gcctttgccg gtgcatccct ggcagtggca
     6961 gcaaaaaatc gcgctcgatt ttgtcgcgga tctggccacg ggcaatatgc tgtcgctggg
     7021 tgaattcggc gatcgctggc tggcgcaaca gtcactgcgc accttgacca acgccagccg
     7081 tcagggcggg ctggatatca aactgccgct taccatttac aacacctcct gctatcgcgg
     7141 tattccgggc aaatatatcg cggcgggccc gctggcctcc cgctggttac aaaacgtctt
     7201 tgccaccgac acgacgctgc agcagagcgg ggcggtgatc ctgggcgagc cggccgccgg
     7261 ttatgtttcc catcgcggct acggcgcgtt gcccgaagcc ccctatcgct accaggaaat
     7321 gctgggcgtg atctggcgtg aaaatccgtc gcgctggctg cacgcggacg aaacgccaat
     7381 tctgatggcc acgctgatgg agtgcgatga aaacaaccag ccgcttatcg gcgcctacat
     7441 tgcccgctcg ggcctgagcg ccgaggcctg gttaagtcag atgttccgcg tggccgtggt
     7501 gccgctgtat cacctgctgt gccgttatgg cgtggcgttg atcgcacacg ggcaaaatat
     7561 tacgctggcg atgaaagacg gcgtacccca gcgcgtattg ctgaaagatt ttcagggcga
     7621 tatgcgtctg gtaaaggacg attttccgga gatggactct ctgcctcagg acgtccgcga
     7681 tgtgacggca cgcctgagtg ctgactattt gattcatgat ttgcagactg gccattttgt
     7741 cacggtcctg cgttttattt cgccgttaat ggcgcgcctt ggcgttccgg aacgacgttt
     7801 ttaccaactg cttgccgcag tgttgagcga ctatatgcag gaccatccgc aactgtcggc
     7861 gcgttttgcg cttttctcac tcttcaagcc acaaatcatt cgtgtcgtgc tgaacccggt
     7921 aaaactcacc tggcccgatc aggacggcgg aagccgtatg ttgcccaatt acctggaaaa
     7981 tctgcaaaac ccgctgtggc tggttaccaa ggactgaatc atgacaaaca ctgttgattt
     8041 tattggcgtt ggcattggcc cgtttaacct gagtatcgcg gcgctggcac acgaagctga
     8101 aggctttacc agccagtttt tagacagtcg cccagatttt gcctggcatc ccggtatgct
     8161 ggtgcctgac tgccatatgc agacctcgtt tttaaaagat ctggtctccg cggtcgcgcc
     8221 caccagcccg ttcagctttg tgaactatct ggtgaagcgt aaaaagtttt accgctttat
     8281 gaccaccgag ttacgtaccg tctcgcgcga tgagttttcc gactatctgc gttgggctgc
     8341 cgagggcatg aacaacctgc gctttaatca cacggtggaa cgcatcgatt ttgatgaggc
     8401 caataaacgc tttgtgattc acagcaacgg cggggaaagc tatgcccgca acatctgtct
     8461 gggtattggc aagcagccct acctgccgcc ctgcgtaaac cgcatcagcg ccacctgttt
     8521 ccacgccagc gaaatgagcc tgcgtaaacc cgacctgcgc ggcaagcgtg tggcggtgat
     8581 tggcggcggt cagagtggtg ccgatctgtt cctcaacgcc ttccggggtg aatggggtga
     8641 accggctgag gtcaattggg tgtcgcgccg caacaatttt aacgccctgg atgaggccgc
     8701 ttttgccaac gagtacttca cgccagaata cgtttccagc tttgtcggtc tgaacgaggc
     8761 tgcccgacag aaaatgctgg ctgaacagaa gatgacctcg gacggcatca cggcagattc
     8821 cctgctgacg atttatcgcg agctgtatca tcgctttgaa gtgcagcgtc agccgcgcaa
     8881 tgcgcacctg ctgccgagcc gctcggtcat tgaactcaac agtcatcacc agggctggca
     8941 gcttcagttg cagcatcagc ttgaccaggg ctacgacctt atcgaatgcg atgtggtgat
     9001 tttcgccacc ggctaccggc ctgcgctgcc agaactgctc tcccccctga tgagccgcct
     9061 gactatgaaa gatgagtgca cgttcagcgt gcgtgaggac ttcacgcttg agtggaacgg
     9121 gccaaaagaa aataacatct ttgcggtgaa cgccagtatg caaacccacg gtatcgcgga
     9181 gcctcagctc agcctgatgg catggcgatc cgcccgtatt ctgaatcgcg cactggggcg
     9241 tgatttgttc gatctcagca cgccgcccgc cctgatccag tggcgcagcg tcagccggga
     9301 aaaaccgcag catggcgctg cgtccactaa aaactatacc gagtccttgg ggtaagcctt
     9361 aacctcgcac gcaggaacga taatgaagac taaaaacaag aatatctggc tgcttaatcc
     9421 gctgctgtta gccatgatgg cgcccgcggt cgcacagcaa accagtgaaa atgacatggt
     9481 ggtttcggcc agccgtacgc accgtacggt ggcagaaatg gctcaaacca cttgggtgat
     9541 tgagggggcc gaactggagc aacaagtcca gggcggcaaa gagtttaaag atgcgctggc
     9601 gcagctggtg ccgggcctcg acgtcagtag ccagggccga accaactacg gcatgaatat
     9661 gcgcggccgc gcgattgtgg tgctggtgga cggcgttcgc ctgaattctt cgcgcacaga
     9721 cagccgccag ctggattcga tcgatccctt taacatcgat cacatcgagg taatctcggg
     9781 atcgacctcg ctgtacggcg ggggcagcac cggtggcctg atcaatatcg tcaccaaaaa
     9841 aggccagccg ggcacccagt ttgagtttga aaccggcacc aaaaccgggt ttaacaacag
     9901 taaagatcac gatgagcgcg tggcgggcgc aatctcgggc ggcaatgacc gcgcctcggg
     9961 acggttgtcg gtggcctacc agaagtttgg cggctggtat gacggcaacg gcgattctgt
    10021 tctgctcgat aacacccaga cgggcctgca atactccgat cgtctggatg tgatgggcac
    10081 cggcacgctt gagattgacg atcaccagca gttgcagctg gtgacgcaat actacaagag
    10141 ccagggcgat gacgattatg gcctctatct tggccgaaac ttttcggcgg taaccggtaa
    10201 cggtaacgcc tacaccagta aaggactgaa ctcagaccgt attcccggca ccgagcgcca
    10261 cctggtcagt ctgcagtact ctaataccga tttcctgggt caggagctgg tgggtcaggt
    10321 ctactaccgt gatgaatctc tggcgtttta tcccttccca acggtgtccg gcgggcgggt
    10381 gaccagcctc tcttcctcta aacaggatac tgatcagtac ggcggcaagc tggcaatcac
    10441 cagtaaaccg ctcgacaacc tgcagctgac ctacggtgtt gatgccgatc atgaacgttt
    10501 tagttccaat cagatgttct ttgatctggc acagtcggcc gcctcgggtg gcctgaacaa
    10561 ccagagcatt tacaccaccg gacgctatcc gggttatggc attactaacc tggcggcttt
    10621 cctgcagtcc agctacgaca tcaacgatac cttcaccttg agtggcggcg tacgttatca
    10681 gtacaccgaa aacaaggtgg acgactttgt cggctatgcc cagcagcagg cgattgctaa
    10741 tggcacggcg cgttcggccg atgcgattcc aggcggctca acggattacg acaacgtcct
    10801 gtacaacgcc ggtatcctga tgcatatcac cgagcggcag caggcatggt tcaacttctc
    10861 gcaaggcgtt gaactgccgg atccgggcaa gtattacggc aacggcacct atcgtctgca
    10921 aaacggcaac tatcagttgt tgaacagcgt taatgtcgat cagtcgaagc ttcagggcat
    10981 caaagtcgat tcttacgagc tgggctggcg ttacaccggt aatgacctgc gcacgcagtt
    11041 agcagcctac tattcgctgt cagacaaatc gatttcggtc aaccgcagcg atatgaccat
    11101 taacgtggac gatgacaagc gccgtattta tggcgtggaa ggtgcggtgg attactttat
    11161 ccccgatacc aactggagca ccggcgtcaa cttcaacctg gtcaagtctg aaaccaaaaa
    11221 agatggcggc tggaagaagt gggatgtcat ttatgccagt ccatcgaaag ccaccgccta
    11281 tgttggctgg tcgccggatc cctggagcct gcgcctgcaa agcacgcagt cgtttgacct
    11341 gaccgataac ggcggcaaca aaattgacgg ttataccacc gttgatttta tcggcagcta
    11401 ccagttgccg gtgggcaagc tgagctttag cgtcgagaac ctgctggatc gcgactacac
    11461 cacggtgtgg ggacagcgtg cgccgctgtt ctacagcccg acctatggct cgccgtcgct
    11521 gtatcagtac aaaggccggg gtcgcacctt tgggctgaac tattcggtac tgttttaagt
    11581 cttcattctt gcccggtgtg acgccgggca agcctcactc aatctcactt tttcctcctg
    11641 tcgccgctaa acacgctgtg ccgttacata atgtaaacaa tacctaaacg aatacgctca
    11701 gttttgtcag gtacatgccg atagtcttta tgtacgtaca tttaatgcac aaagcatttt
    11761 cgttttaacg accaggcgga acaaaaaatg accattacac agcgactttt cctgaccttc
    11821 tccctccttg ccgcctcact ggctgttctg gctatggtgg cgatcacggt ggtaacagga
    11881 tttcaatcac gcttcgatta cgtgcagaga aatacaattc cttctattac cgatcttaat
    11941 aagcttgtcg atagcagcaa tgccctgaca ctgctgcttt atcgccatca aagtgcgacc
    12001 gatcaacgca agcaggccca gtttgagaaa gatatcgctg gcgtgattgc ggatctgaaa
    12061 aagcaaaacc agtattactt tgatcacgac ctttccagtg ctgaagacaa ggccctgagc
    12121 gaaaaagcat ttgcggagat aaaagaagcg gaagccaggc tgccgacctt ttttgccggg
    12181 tcacgggcac aaaatgatgc tatcgcgttg ggcgcgatcc agggagacag tggcgtgggt
    12241 cagtctgttc gcgatctgat agcggggtta aagcgacagc tgcagctgaa tgtggacatt
    12301 ggcaaaacct acagccagca aaacaatcag gtttatcaac aaaccttgtg gggcatgtcc
    12361 ggcggttcgc tgctaattat cctgctgctt ggcgcgtttt cggtgaaaac catcttcagc
    12421 atccgtcgtc agctcaacgc gattcgtgcc accatggaaa gcgccagcga acgcctcgat
    12481 ctgacgctgc gcgcagatga gtcgcgtcgc gacgaaattg gcttaacggc cagcgcttat
    12541 aatcatctgg tcagcaatgt ggcgcagtcg ttgtcgtccg ttgaacaggc atcccactct
    12601 gtcggctctg cctcatccga gatttcagcc ggcaacgacg atctctcggc gcgtaccgaa
    12661 gagcaggcag cgtcgctgga ggaaacggcg gccagtatgt ctgaactgag cgaaaccgtg
    12721 cgtcagacgg ctgaaaatac ccgccttgcc agccagctgt ccaaaaatgc gcgtgaaatc
    12781 tcggaagaca gctcgggcaa agtcaaaacc atgctgagca ccatgtccga tatcaaaagc
    12841 agttcagcga aaatcaacga cattatcgcg ttgattgaag gcgttgcctt ccagaccaat
    12901 atcctggcgc tgaatgcggc cgttgaagcc gcccgtgccg gtgagcaggg acgcggtttt
    12961 gccgtggtcg ccggagaggt gcgtaatctg gcacagcgct cttcttcttc tgcccgtgag
    13021 atcaaagcac tgatcgagtc ctccatgcgc tacgttgaaa ccggtgccgc tcaggctgaa
    13081 gaagtcggac aaaatatggg ccggatgaac gatgccgtgc gtcaggtaaa cgatctggtc
    13141 gatgagattg cggtggcggc aagcgaacag tcgcagggca ttggtcaggt acatgaagcg
    13201 gtcaatcaga tggacagcgt aacccaacaa aacgccgcac tggtggagca ggcttctgcc
    13261 gctgcgcgtt cgttaacgga gcagtccacc acgctgcaac agctggtggc cgcctttacc
    13321 atccgttcag ctcaggttgt cgccgctaag ccgcctttag ccgccgtgac ggccgcaccc
    13381 gtgctgaagc gtccacagct tgcggcggca ggtgcaggtg cgcaggaaga taactggcag
    13441 agcttctgat agtggcgaag cagtggcccg ggcggccgct gcttttaaaa ggttacgaac
    13501 ttctgtgcag cgtcaacggc gttgataacc agcgggcaac gcgtttgcct gccttaatgg
    13561 cgggtttttc aatccagaaa aacatcacgg aggccagcgc cacactgatg ctaatggaga
    13621 ggatgaaaat catcagattg tccgtccagg ctttatccgc caggctgttc atcagcaata
    13681 tcatcatcgg atagtggatg agatagagcg aatacgagat atcgccaaag aagatcagcg
    13741 tgcggttatg accactttcc gtgcggtaac ccagcatcac cgtgatgctc ataatggccg
    13801 ccgccagcca gaaaccgcca tgcaggccaa acggctgcgg cccaatcatc agcgctgtcg
    13861 caaacgccag taccagcccc acctgcagta ttctgcgcat ctgaggattc agctcaggga
    13921 gcttttgtct gacgattaat tcagccagca tcatccctaa gataaactcc atgcagatgg
    13981 tattgctgat aagtttgatc cacgcctgcc accagtgcgt caccgccat
//
