BGC0001504 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001504 (Amycolatopsis sp. AA4)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	13,734	amycomicin	PKS	100%

BGC0001504 - Region 1 - T1PKS

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Location: 1 - 13,734 nt. (total: 13,734 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 13,735
Label		BGC0001504

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001504	1.00	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001219	0.33	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0002631	0.32	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001749	0.29	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001124	0.29	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0002347	0.27	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus
BGC0002233	0.27	Polyketide	trichoxide	Trichoderma virens Gv29-8
BGC0002180	0.27	Polyketide	(+)-asperlin, (2Z,4Z,6E)-octa-2,4,6-trienoic acid	Aspergillus nidulans FGSC A4
BGC0002731	0.27	Polyketide	nanangenine A, nanangenine B, nanangenine C	Aspergillus nanangensis
BGC0002266	0.27	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001504	1.00	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001219	0.66	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0002631	0.65	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001749	0.63	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001124	0.62	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0002347	0.60	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus
BGC0002233	0.60	Polyketide	trichoxide	Trichoderma virens Gv29-8
BGC0002180	0.60	Polyketide	(+)-asperlin, (2Z,4Z,6E)-octa-2,4,6-trienoic acid	Aspergillus nidulans FGSC A4
BGC0002731	0.60	Polyketide	nanangenine A, nanangenine B, nanangenine C	Aspergillus nanangensis
BGC0002266	0.60	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus

Similar known gene clusters from MIBiG 4.0

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 13734:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CU254_21755

AMP-binding (15..419): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GFGCVGINTK
Nearest Stachelhaus code(s):: Val DFFCVGIVHK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

CU254_21765

PKS_AT (544..834): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 166.8
inactive: 105.8
Methylmalonyl-CoA: 62.3
Methoxymalonyl-CoA: 59.3
Propionyl-CoA: 48.2
Ethylmalonyl-CoA: 38.7
CHC-CoA: 33.9
2-Methylbutyryl-CoA: 31.1
Isobutyryl-CoA: 31.0
fatty_acid: 30.9
Benzoyl-CoA: 21.1
Acetyl-CoA: 13.8
trans-1,2-CPDA: 11.0
3-Methylbutyryl-CoA: 0.0