LOCUS       BGC0001505             10279 bp    DNA     linear   BCT 06-SEP-2018
DEFINITION  Sphaerospermopsis sp. LEGE 00249 sphaerocyclamide gene cluster,
            partial sequence.
ACCESSION   BGC0001505
VERSION     BGC0001505
KEYWORDS    .
SOURCE      Sphaerospermopsis sp. LEGE 00249
  ORGANISM  Sphaerospermopsis sp. LEGE 00249
            Bacteria; Cyanobacteria; Nostocales; Aphanizomenonaceae;
            Sphaerospermopsis; unclassified Sphaerospermopsis.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 02:08:57
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10279
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..189)
                     /gene="sphC"
     CDS             complement(1..189)
                     /codon_start=1
                     /gene="sphC"
                     /product="sphaerocyclamide synthesis protein SphC"
                     /protein_id="AVD53608.1"
                     /transl_table=11
                     /translation="MSIPKKTPANSSQPEPQLPAEIERKLLSTGLEDYGFWSQEMARQK
                     AQQTEPDKPFRRGRIWC"
     source          1..10279
                     /db_xref="taxon:1380707"
                     /isolation_source="freshwater"
                     /mol_type="genomic DNA"
                     /organism="Sphaerospermopsis sp. LEGE 00249"
                     /strain="LEGE 00249"
     misc_feature    <1..>10279
                     /note="sphaerocyclamide gene cluster"
     subregion       1..10279
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10279
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(204..407)
                     /gene="sphB"
     CDS             complement(204..407)
                     /codon_start=1
                     /gene="sphB"
                     /product="sphaerocyclamide synthesis protein SphB"
                     /protein_id="AVD53609.1"
                     /transl_table=11
                     /translation="MRLPKLSPPIKRPDIIYPHRSVDVIHGRVEDLVHIRMDLLHGANY
                     NDPAAFQNRSYQQIKSSCRCTF"
     gene            complement(531..2534)
                     /gene="sphA"
     CDS             complement(531..2534)
                     /codon_start=1
                     /gene="sphA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyanobactin: cyanobactin_synth"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 174.8; E-value: 6.1e-53)"
                     /gene_kind="biosynthetic"
                     /product="sphaerocyclamide synthesis protein SphA"
                     /protein_id="AVD53610.1"
                     /sec_met_domain="cyanobactin_synth (E-value: 2.8e-241,
                     bitscore: 790.3, seeds: 40, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.5e-41, bitscore:
                     131.9, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKSSIKTEIQKLWNLTQGDSQICVAILDGLVDQSHSCFNAANLT
                     RLPTLIQGEATANGSMSGHGTHVASIIFGQHNSSELQGIAPQCRGLILPIFGDNNRKLS
                     QLDLARAIEQAVNAGAHIINVSAGQLTDNGEAEGWLDRAVQLCKDNNVLIVAAAGNDGC
                     ECLHVPASLPTVLAVGAMDDQGKPIDFSNWGEIYQNQGILAPGSNILGAKPGGGTQKLS
                     GTSFATPIVSGVAALLLSLQIQRGETPDPAKVRTALLETAIPCTTKDTDDVSRCLLGKL
                     NISGALQYFTGGTMSEELDTIDTVDSIEAAGCGCGGIDTTNITEPEPNPEEFIPDEIAE
                     VVPAIPATISATLTTATISNSRPTTPTTMSNRTSNYITASQAPSDLAEVNLVYALGTLG
                     YDFGSEARRDSFKQLMPGVQIDGTAIPANPYDARQMVDYLGDNLSEAKSLIWTLNLELT
                     PIYAIEPGGAFARDVYEILQQLLSGQIQPEDSENYVERVSIPGILSGRSVKLFSGQVVP
                     VIEVPNTRGLYGWKVNTLVEAAIQTVQAQATEAQEESIRRTLGSFLSRIYYDLRNLGTT
                     SQDRALNFASTNAFQAASTFAEAVATGMELDSITVEKSPFCRLDSDCWDVKLKFFDPEN
                     SRRAKKLFRFTIDVSDIIPVTLGEVRSWSTPY"
     gene            3299..3442
                     /gene="sphE"
     CDS             3299..3442
                     /codon_start=1
                     /gene="sphE"
                     /product="sphaerocyclamide synthesis protein SphE"
                     /protein_id="AVD53611.1"
                     /transl_table=11
                     /translation="MTKKNIRPQQVAPVERETISTSKDQSGQVTPSAQGVSYFPFAGDD
                     AE"
     CDS             complement(3476..4267)
                     /codon_start=1
                     /product="transposase"
                     /protein_id="AVG44180.1"
                     /transl_table=11
                     /translation="MPRQPRNLQSGYSYHITTRCNNRKFKLSRRECREVFLYAIKKALD
                     KYNFQLYALCIMSNHVHYLIAPKQPEELPKIMHFLNWYTAMCFNRMLRRTGHGSTSLTT
                     SFWEKRYYCDGFPSSDRNRVLNTLRYIHANPKAAKMRQSFFYDFSNYGSYERLTDDGLT
                     QWHPAFLRLGNSLEECAKKYKGFCQKYKPKEKTPTQYHWGSKLLAGVHLTNQGSTTNPK
                     KSKSRFSPPPSCQVSETPELTRVVRQFIEANRAPRDVEKDF"
     gene            4283..5155
                     /gene="sphF"
     CDS             4283..5155
                     /codon_start=1
                     /gene="sphF"
                     /product="sphaerocyclamide synthesis protein SphF"
                     /protein_id="AVD53612.1"
                     /transl_table=11
                     /translation="MTISENLFIGSQKNLHYINQHKHIFDVDHLYTLNIFDDFTQKVTH
                     WGLECSCKIQKDQLYPARFNLFRNQPNWQDYQTAINFFQQVAARTDVKITYHLIENFVG
                     NDFDFSKVHQILVGIDLRREFSASRLKFWFIISDYPQKLAKAISLCQSAEELQPFLVDN
                     SVVIGFDFDFNGGSEIEVYPSISKEKFQQLAKVLSPQALQLLDSCWSLIIGFSQGNPEK
                     ILYYRTSDPNNFIANLRNDLANRVHAYYREQPVQGTIVGLRENEIIAGRIENLNLYYQM
                     SSPITTNKN"
     CDS             5885..6568
                     /codon_start=1
                     /product="Uma2 family endonuclease"
                     /protein_id="AXU44625.1"
                     /transl_table=11
                     /translation="MISTTAISPILTIPPLENGDKLTRHEFERRYHAMANLKKAELIEG
                     VVYVASPLRIKSHGEPHAYIMTWLGVYKAATPGIGFADNATVLIDTDNEPQPDALLRIE
                     AGGQSRINQDDYVEGAPELIVEIAASSASYDLHEKLKVYRRNQVQEYLIWRVYDYQFDW
                     FRLQQGEYIQLQPNADNIICSQIFPGLWLDKIALLGGDLGKVLTVVQQGLASPEHENFI
                     SRLSS"
     CDS             complement(6561..7244)
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="AVD53613.1"
                     /transl_table=11
                     /translation="MLYLIQVHTAIRFLHEFYIILGNIYIMSYSDFTLRKVKQTFGINT
                     IEDQKFLPEIQPIAASTTLTDFLVESLPLAIATGSEKARSELIISPVLLEVRKILQRKI
                     SLFSGTDFTVDSALGLNGVCDFVLSRSPEQLEVEAPAVMIVEAKKSDLNPGIGQCIAEM
                     IAAQKFNEINNQPIPTIYGSVTNGTVWRFLQLTEQTVTIDFTDYPLPPVDVILGILVWM
                     VTAAN"
     CDS             complement(7317..7652)
                     /codon_start=1
                     /product="Xisl protein"
                     /protein_id="AVG44181.1"
                     /transl_table=11
                     /translation="MEKLEQYRNYVKQVITEYAQLGSAKDEIEQQLIFDTFGDHYQLMY
                     VGWKNRKRQHGCVLHLDIKDHKIWIQHDGTEIGIADELVKLGVPKSDIVLAFHEPLVRQ
                     YTGFAVG"
     gene            8087..10279
                     /gene="sphG"
     CDS             8087..10279
                     /codon_start=1
                     /gene="sphG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyanobactin: cyanobactin_synth"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 99.1; E-value: 5.8e-30)"
                     /gene_kind="biosynthetic"
                     /product="sphaerocyclamide synthesis protein SphG"
                     /protein_id="AVG44182.1"
                     /sec_met_domain="cyanobactin_synth (E-value: 3e-213,
                     bitscore: 697.9, seeds: 40, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.7e-22, bitscore:
                     68.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLFTLNYYNTNYNNTIKTMPNLTDIPGISQIWTRTKGDPRIKIAI
                     LDGAADLERSCFQGANFSQFKPYWSEDIELNEEYYYYLKLHLEFNQQQKDKKDDPDHDK
                     EEAKKEREAFFASFPPAIRRRIELSSHATHISSTILGQHNTPAPGIAPLCTALNIPISF
                     AGDDFISPINLTHAINTALQWGANIIHIAACHPTQTGVAPDLFARAVKQCQDNNMLIVA
                     PGGNDKGECWCIPSILPGVITVGAMRDDGQPFKFSNYGGEYQNKGVMANGENILGAQPG
                     TEEPIKQKGTSCAAPIVTGISALLMSMQLQRGEQPNAEAVREAILNSAIPCNPEEVEEP
                     ERCLLGKLNIPGAFQLLTGERLEPHPQPLSYQGVQEPHPQPLSYEERGVTISRSQVLPG
                     NATSEALPLTIPSGRALEAAFPAGDWERETLVISQGINSSTDSITPSAASKLVYALGTI
                     GYDFGDEARRDSFKQLMPAVNMDGAIIPANPYDSRQMVDYLSANPTEAKPLIWTLNQEL
                     TPIYALEPVSGFAADIYETLILMLEGQIQPENSDDFVERVSIPARLTDRTVELFSGQVV
                     PVITLTNTRGMYGWKVNSLVDMAMQTVITEGTAPAQEIAMRKALSSFLNRVYYDLQNVG
                     QLAKDRALNFSVTNAFQAASSFSQAISTGMQLDSIEVEKSPFCRINSDCWDVKLKFFDP
                     ENGRRAKRVFLFTIDVSDRIPVTLGQVRSWSVAKSA"
ORIGIN
        1 ttaacaccaa atacgaccac gacggaaagg tttatcaggt tcagtttgct gggctttttg
       61 tctagccatt tcctgtgacc aaaaaccata atcctctaaa ccagtagata ataatttgcg
      121 ttcaatttct gctggtagtt gaggttctgg ttggctggaa tttgcgggag ttttctttgg
      181 tatactcata attttgataa ttcctaaaac gtacatctac aagaggactt aatttgctga
      241 taactgcgat tttgaaaagc agcaggatca ttatagttag caccatgtaa taaatccatg
      301 cgaatatgaa ctaaatcttc aactctgcca tgaatcacat caacagaccg atgaggataa
      361 ataatatccg gtctttttat tggtggggaa agtttaggta atctcataat caattgtaga
      421 ttttagattg taggttgggt tgacgcaagg aaacccaaca ttaaaaaact caacatgatc
      481 aaaactgtgt tgggttgcgc tgtcgcttaa cccaacctac tactacttaa ttaataagga
      541 gtagaccaag aacggacttc acccaaggtc acaggaataa tatcactcac atcaattgta
      601 aaccggaata gtttcttcgc acgacggcta ttttcaggat caaagaactt caattttaca
      661 tcccaacaat cgctatctaa acgacagaaa ggacttttct ctactgtaat actatccaat
      721 tccatacctg tagccacagc ttcagcgaag gtagaagccg cttggaaagc attcgtagaa
      781 gcaaaattta acgcccggtc ttgggaagtt gtacctaaat tgcgtaaatc ataataaata
      841 cggctgagga aactacccaa agtgcggcga atagactctt cttgggcttc tgtggcttgt
      901 gcttggactg tctgaatagc agcctcaacc aaggtgttaa ccttccaacc gtaaagcccc
      961 cgtgtgttgg gaacttcaat tacaggcaca acttgaccag aaaagagttt tacactgcgt
     1021 ccagataaaa taccgggaat actgactctc tctacataat tctcgctgtc ttctggttga
     1081 atttgtcccg ataataattg ttgtaaaatt tcatagacat ctctggcaaa agccccacct
     1141 ggttctatgg catagatagg agttaattct aaattcaatg tccaaattaa ggatttagcc
     1201 tcagaaagat tatctcctaa ataatctacc atctgccgcg catcataagg gttagcggga
     1261 attgctgttc cgtctatttg tactcccggc attagttgtt taaaagagtc tcttctggct
     1321 tctgaaccaa aatcataacc cagtgtacct aaagcataaa ctaggttaac ttcagcgagg
     1381 tcgctgggtg cttggctggc ggtgatgtag ttagatgtgc ggtttgacat agttgtaggt
     1441 gttgtaggtc tggaatttga tatagttgca gttgttaaag ttgcagaaat tgtcgctggt
     1501 atagccggaa caacttctgc tatttcatct gggataaatt cctccgggtt gggttcgggt
     1561 tcagtgatgt ttgttgtatc tatgccaccg caaccacaac cagcagcttc tatactgtcc
     1621 acggtgtcaa tagtatctaa ttcttcagac attgttcctc ctgtgaaata ttgcaatgca
     1681 ccggaaatat ttaacttgcc tagcaagcag cgactcacat cgtcggtatc cttggttgtg
     1741 caaggtatgg cagtttctaa taaggcggtt ctcaccttag cggggtcggg tgtttcaccg
     1801 cgttgaattt gcagacttag gagtaaagca gcgacaccgg aaacaatggg agtagcaaag
     1861 ctagtaccac tgagtttttg tgtccctcct ccgggttttg cccctaagat gtttgaccct
     1921 ggggcaagga tgccttgatt ttggtaaatt tctccccagt tgctaaagtc tatgggttta
     1981 ccttggtcat ccatcgcccc tactgctaat acagtgggta aggatgcggg gacgtgcaga
     2041 cattcgcaac catcattacc agcagcagcc acaattaaaa cattgttatc tttgcatagt
     2101 tgcacagccc tatctaacca gccttctgct tcaccattat cggtgagttg tccagcactg
     2161 acattgataa tatgcgctcc agcattgacg gcttgttcaa tggcgcgagc taaatctagt
     2221 tgagaaagtt tcctattatt gtcaccaaaa atagggagga ttaaccctcg acattgggga
     2281 gctattccct gtaattctga agaattatgt tgaccaaata tgatacttgc gacatgagtt
     2341 ccatgtccag acatagatcc gttagcagta gcttctccct gaataagtgt tggcaatctt
     2401 gttaaatttg ctgcattaaa gcaactatga gattgatcaa ccaatccgtc gagtatggct
     2461 acacatattt gtgaatcacc ctgtgtcaag ttccataatt tctggatttc cgttttaatt
     2521 gaggattttg gcatttaatt tgttaattat tcgcctaaat agttttttcc gccataaatg
     2581 tctattttat ggcattttta ttacgatagt gctttccaga acacaaaagt aattgtcata
     2641 ttgattcggc tgaaatgtca actcaattta catattttaa cgtatataat tttttattat
     2701 gtcaaaaaaa aaacggtttt aataagtgtt aattttctcc tttgctgtgg cttaaaatta
     2761 gtatttaaaa tttttgacag tgatttcctc gtcatgcaat agcaactaaa cagtaatgtc
     2821 aatagctcta atctactata agaaattatt atgaataatg tcttgcgttg aatcataatt
     2881 ggctgtacta ttgaaatcaa ggtagcttca cttagtcatc aaaagtaaaa accagaaatt
     2941 agatttaggt gtagatattg atgactatat tgccactctc aaaaagtcta atgttattcg
     3001 tattgtccca attgatgagg aaatttggct agaaagtgtc aaattagaat gggaacacaa
     3061 agatcctgtt gatagagtag ttgtagccgt tgccaaaata aaccaagcct ctattattac
     3121 agcagatcga aaaatagctg atttctaccc tttagtgatt tggtaaatca ctataaaaaa
     3181 gcttctggtg aattacaact cgttaaatta cccttcaaaa tcaatttaac gccttcacca
     3241 aaccagtctt cttcacatcg aagaagtgat ctaaacaaac aaaaaggaaa aaaacaccat
     3301 gactaagaaa aacatccgcc cccaacaagt tgctcccgta gaacgggaaa ccatctctac
     3361 ttctaaggat caaagtggtc aggtaacacc ctcggctcaa ggggtctctt acttcccatt
     3421 tgcaggcgac gacgcggagt aactcacctt aatctatcac ccacctccaa aaatatcaaa
     3481 agtctttttc tacatccctt ggcgcacggt tcgcctcgat gaattgacga acaacccttg
     3541 tcagttccgg ggtttccgat acctggcacg acgggggagg tgaaaaacga gacttagatt
     3601 ttttggggtt ggtggttgaa ccctgatttg tgagatgaac cccagccaac agcttactac
     3661 cccagtggta ttgggttggg gtcttctcct tgggtttata cttttgacaa aagcctttat
     3721 actttttggc acattcttct aagctgtttc ccagtcgtaa aaaagccgga tgccattgag
     3781 ttaaaccatc atcggttaag cgttcataac tgccataatt gctgaagtca tagaaaaaac
     3841 tctggcgcat tttggcagct ttaggattag cgtgaatata ccgtaaagta tttaatactc
     3901 tgtttctatc tgaagaagga aacccatcac agtaatatcg tttctcccaa aagcttgtgg
     3961 tgagcgaagt cgaaccatgt cctgttcttc ttaacatccg attaaaacac atcgccgtgt
     4021 accagttgag gaagtgcata attttgggta actcttctgg ctgtttaggt gcaatcaaat
     4081 aatgaacatg atttgacata atgcacaaag cataaagctg gaaattgtat ttatccaaag
     4141 ccttttttat tgcataaaga aacacctccc gacattcccg ccgtgataat ttgaatttgc
     4201 ggttattgca acgggtggta atgtgataag agtatccaga ctgtaaattt cgaggttgtc
     4261 taggcacaag aaggaattat aaatgactat ttctgagaat ttatttatag gtagccaaaa
     4321 aaatctacat tacatcaatc aacataaaca tatctttgat gttgaccatc tctacaccct
     4381 gaatattttc gatgatttta ctcaaaaagt tacacattgg ggattagaat gttcttgtaa
     4441 aatccaaaaa gatcaactgt atccggctcg atttaattta tttcgtaatc aaccaaattg
     4501 gcaagattat cagacagcta ttaatttttt tcagcaagta gcagccagga cagatgttaa
     4561 aataacttat catctcattg agaattttgt tggcaatgat ttcgatttca gtaaagtcca
     4621 ccagatatta gtaggtattg atttaagaag agaatttagt gcttctcgcc tcaaattttg
     4681 gtttatcatc agtgattatc cccaaaaatt agccaaggca atatccctat gtcaatctgc
     4741 tgaagaattg caaccatttt tggtagataa ttccgttgtc attggctttg actttgactt
     4801 caatggtggt agtgaaatcg aggtttatcc cagtattagc aaagaaaaat ttcaacaact
     4861 agccaaagtt ctgtcacccc aggctttaca acttttagat agctgttggt cattaattat
     4921 tggttttagc caaggcaacc ccgaaaaaat cctttattat cgtaccagtg accctaataa
     4981 ctttattgct aatttacgca atgatttagc taaccgagtt catgcctatt atcgagaaca
     5041 acctgtacag ggaacaattg taggactacg ggaaaatgaa ataatagctg ggaggataga
     5101 aaatttgaat ctgtattatc aaatgagttc tcctataacc accaacaaaa actaataaga
     5161 aaatgtaggt tgggttaagg gacagcgcaa cccaacaaaa ttaaatcaca aaatcaccaa
     5221 aacgttaaat aacatcatta aaatgcaatt tccagaagtc caaataaata aaactaaatg
     5281 cccaaaaaaa ttagataatt aaaacagatg ttgcaaaaag caggatttac attattacca
     5341 aagcggggaa aaggtagtca ttcttactgg attcatccac ttttaccaaa acctgtagtt
     5401 ctatctggca aagacagcaa agatgcaaaa ccttatcaag agaaagatat aatagaaagt
     5461 atcaaagaac ttgaacaatt agaaaaagca gataaactat gaaatatagt attttaattc
     5521 aatggtctga cgaagatcaa gcctatattg cctttttacc tgagtgggga aaatatgcta
     5581 aaacccacgg agaaagctat gaagaagctc tagaaaatgc caaggaagtg ttagaagatt
     5641 tggtgtatgg ctataatcaa atcggtaagc ccatacccca accccaaata ttacaaaaaa
     5701 taacttaaaa aagacataat ctgacaataa tgatatctat tggttagatg taggttgggt
     5761 taagcgacag cgcaacccaa caacattaaa tcacaaaatc accgaaatgt tggttaacat
     5821 cctggaaatc ctggatatcc tgattggtga caatttcatt ttctgcaaaa tttgagcaaa
     5881 ttttatgata tctactactg caatttctcc catcttaact attcctcccc tagaaaacgg
     5941 cgacaaatta acccgtcatg aatttgaacg gcgttatcat gccatggcga atctcaaaaa
     6001 agccgaatta attgaaggag tagtttacgt ggcatcacca ttaagaatca aaagtcatgg
     6061 agaaccccat gcttatatta tgacttggct gggagtttat aaagcagcta caccgggcat
     6121 aggtttcgcc gataatgcca cagtgctaat agatacagat aacgaaccac aaccggatgc
     6181 tttattaaga attgaagcag gaggacaatc aagaataaat caagatgatt atgtagaagg
     6241 tgcgccagaa ttaatagtag aaattgctgc ttctagtgct tcctatgatt tacatgaaaa
     6301 actcaaagtt tatcgtcgta atcaagtcca agaatattta atctggcgag tttatgacta
     6361 tcaatttgat tggtttaggt tacaacaagg ggagtatatt caacttcaac ccaatgcaga
     6421 taatataatt tgttcccaaa tattcccagg tttatggtta gataaaatag cattattagg
     6481 aggagattta ggaaaagtgt taaccgttgt ccagcagggt ttagcaagtc cagaacatga
     6541 gaattttatt agtagattat ctagttagca gcagttacca tccaaactaa aattcctaaa
     6601 atgacatcaa caggaggaag gggataatct gtaaaatcaa ttgttacagt ttgttccgtt
     6661 aattgtagaa atcgccaaac agtaccatta gtgacgctac cataaattgt aggaatgggt
     6721 tgattattaa tttcattaaa tttttgagca gcaatcattt ccgcaataca ctggccaata
     6781 cccggattta agtctgattt tttagcttcc acaatcataa ctgctggtgc ttccacttct
     6841 aactgttcgg gtgaacgact cagaacaaaa tcacaaactc cattcaatcc taaagccgaa
     6901 tctacagtaa aatctgtacc agagaataga ctaatttttc tttgtaatat cttacgaacc
     6961 tctagtaaaa ccggactaat gattaactca gaacgtgctt tttcacttcc tgtcgctata
     7021 gctaatggta aactttccac taaaaaatca gtcagggttg tactagcagc tattggttgg
     7081 atttctggca gaaacttttg atcttcaatg gtgtttatgc caaaggtttg cttgactttt
     7141 ctgagggtaa aatcactgta tgacataatg taaatatttc caagaatgat gtaaaattca
     7201 tgtaaaaatc ttatagcggt atgcacttga atgagataca gaatttaacc aaaaaccata
     7261 cacagaagaa ctttcacttc tgttccctgt tccctgttcc ctgctatata tgaaaatcaa
     7321 ccaacagcaa aacctgtata ttgtctcacc aaaggttcat gaaatgctaa aacaatatct
     7381 gattttggca ctcctaattt aactaactca tccgctatac caatttcagt tccatcatgt
     7441 tgtatccaaa ttttatgatc tttaatatct aaatgcaaaa cacaaccatg ctgccgtttt
     7501 ctatttttcc aacccacata catcaattga taatgatcac caaaagtatc aaaaatcaat
     7561 tgttgttcaa tttcatcttt agctgaacct aattgagcat attctgtgat cacttgtttg
     7621 acataattgc gatattgttc tagtttttcc atgctacaat tacctcctga actggatcat
     7681 aaatcatgat tttaatttgg gaacgctcaa caactgtttt aataaactgc aattgaaaga
     7741 aagagtaata aattcctgaa ggaacagcta aatatgaaac tcgttgtggt tgttgttctt
     7801 ctaatgccaa atgataatta aaaaattgtc aaatggcttc atgaaattga gagatattag
     7861 atgtaccaat aaaactctta atttccaccg ctattttttc tccttctctt tcagcagcta
     7921 aaacttgctc tgcatcgaga tcaatataca tttccacatc accgacttct atccttaaag
     7981 gatcatctgt aatcacccaa ccctcttttt ataaccctat cctaacagca tcatgaaaaa
     8041 tatctttagc tggcattaac tttatgtaaa attatacttt taaagaatac tttttaccct
     8101 taattattat aacaccaatt acaacaacac aatcaaaacc atgcctaacc tgacagacat
     8161 ccccggaatt tcccaaattt ggacacgcac aaaaggcgac ccccggatta aaattgctat
     8221 ccttgacggt gctgcggact tagaacgtag ttgttttcaa ggtgcaaatt ttagtcaatt
     8281 taaaccctac tggtcagaag atattgaact caacgaagaa tattattatt atctcaagtt
     8341 acatttagaa tttaaccaac aacaaaaaga taaaaaagac gacccagacc acgacaaaga
     8401 agaagcgaaa aaagaacgag aagcattttt tgcctccttt cctcctgcta ttagacgacg
     8461 gatagaatta tcaagtcatg ctacccacat ttctagcact atcttagggc aacacaacac
     8521 acccgcccca gggattgctc ctttatgtac agcattaaat attcccattt ccttcgctgg
     8581 tgatgatttt atttccccca tcaacctcac ccacgccatt aatacagctt tgcaatgggg
     8641 tgcaaatatc atccatatcg ctgcttgtca ccctacccaa accggagtag caccagattt
     8701 atttgcccgt gctgtgaaac aatgccaaga taacaatatg ttaattgttg ccccaggtgg
     8761 taatgataaa ggggaatgtt ggtgtattcc ctctattctt cctggtgtga ttacagtggg
     8821 tgcaatgcga gatgatggtc aaccgtttaa atttagtaat tatggcggag aatatcaaaa
     8881 taaaggggta atggccaacg gtgaaaatat tttaggtgcc caaccgggaa cggaagaacc
     8941 tatcaaacaa aaaggtacaa gttgcgctgc acccattgtc acaggtattt ctgccttatt
     9001 aatgagtatg caattgcaac ggggtgaaca acccaacgcc gaagcagtgc gggaagcgat
     9061 tttaaatagt gctattccct gtaaccccga agaagtggaa gaaccggaac gctgtttatt
     9121 aggtaagttg aatattcccg gtgcgtttca attattgacg ggagaaaggt tagaacctca
     9181 cccccaaccc ctctcctacc agggagtaca agaacctcac ccccaacccc tctcctatga
     9241 ggagagggga gtaacaatct ctcgttccca ggttctacct gggaatgcta catcagaggc
     9301 tctgcctcta actataccgt caggcagagc cttggaggca gcattcccag ccggagactg
     9361 ggaacgagaa actttagtta ttagccaggg aattaattcc tcaactgatt ctattacccc
     9421 tagtgcggct tctaaacttg tctatgcttt gggtactatt ggttatgact ttggtgatga
     9481 agccagaagg gactctttta aacaattaat gccagcagtg aatatggacg gggcaattat
     9541 ccctgctaac ccctatgata gccggcaaat ggttgattac ttgtcagcaa atcctacgga
     9601 agctaaacct ttaatttgga ctcttaacca agaactaact cccatttatg ctttagaacc
     9661 tgtgagtggt tttgccgcag atatctatga aactctcatt ttaatgttag agggacaaat
     9721 tcaaccagaa aatagtgatg attttgtgga acgggtgagt attcctgcaa ggttaacaga
     9781 tagaactgta gagttatttt ctggtcaagt tgtgcctgta attactctaa ctaatactag
     9841 gggaatgtat ggctggaaag tcaatagttt ggtagatatg gcaatgcaaa ctgtaattac
     9901 agaaggcaca gcaccagccc aagaaatagc tatgagaaag gctttgagta gtttcttaaa
     9961 tcgagtttac tatgatttgc aaaatgtagg acaattggct aaagatcggg cgttaaattt
    10021 ttctgtaact aatgcttttc aagctgcttc tagtttttct caagctattt ctacagggat
    10081 gcagcttgat agtattgaag tggaaaaaag tcctttctgt cgcattaata gtgattgttg
    10141 ggatgtgaaa ttaaagtttt ttgacccgga aaatggacgt agagcgaaga gagtttttct
    10201 gtttactatt gatgttagtg acagaattcc tgtaacttta ggtcaagttc gttcttggtc
    10261 tgtggcaaaa tcagcataa
//
