LOCUS       BGC0001506              2831 bp    DNA     linear   CON 13-JAN-2022
DEFINITION  Streptomyces sp. NRRL S-146 contig56.1, whole genome shotgun
            sequence.
ACCESSION   BGC0001506
VERSION     BGC0001506
KEYWORDS    .
SOURCE      Streptomyces sp. NRRL S-146
  ORGANISM  Streptomyces sp. NRRL S-146
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            JOAW01000056.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 02:09:11
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 2831
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..2831
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[599:2831]"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      600..2831
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     cand_cluster    1..2831
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..2831
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001506"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..2831
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..543)
                     /locus_tag="IH29_RS0109280"
     CDS             complement(1..543)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009313181.1"
                     /locus_tag="IH29_RS0109280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="membrane protein"
                     /protein_id="WP_031104468.1"
                     /transl_table=11
                     /translation="MTTTLIWIAVALVAIGLYLSWTAGRLDRLHARIDAARAALDAQLL
                     RRASVAQELATSGVLDPAASIVLYEAAHAARQAEEEQREVAESELSQALRAVFGEAPQV
                     EAVREAPGGEEAARELTEAVRRVPMARRFHNDAVRAARALRRHRKVRWFRLAGHAPFPM
                     AFEMDDEPPAALVDRAG"
     gene            complement(600..1031)
                     /locus_tag="IH29_RS0109285"
     CDS             complement(600..1031)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090021.1"
                     /locus_tag="IH29_RS0109285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_031104469.1"
                     /sec_met_domain="PF13471 (E-value: 3.8e-29, bitscore: 89.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMPVALAERRRLPVHRRALPLLAVGVARLLAKVRPARLRTVLEF
                     ARRGAAPATAAQALRAREEVVSVSLRCAGQGCLQRSIATALLCRMRGAWPTWCTGVRTH
                     PFAAHAWVEAEEQLVGEGHPKGHFKTLMSIPPLAEDRNR"
     gene            complement(1028..1195)
                     /locus_tag="IH29_RS54005"
     CDS             complement(1028..1195)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033530.1"
                     /locus_tag="IH29_RS54005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PqqD family peptide modification chaperone"
                     /protein_id="WP_234325512.1"
                     /sec_met_domain="PF05402 (E-value: 9.8e-13, bitscore: 36.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.2e-15,
                     bitscore: 44.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNTGAHVLRELLDGHQPAAIAGGLASRYGIDAQQAERDVSAVIE
                     RLRGSELVIS"
     gene            complement(<1258..2831)
                     /locus_tag="IH29_RS50070"
                     /pseudo=""
     CDS             complement(<1258..2831)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 64.2; E-value: 1.6e-19)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_078865739.1"
                     /locus_tag="IH29_RS50070"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="asparagine synthase-related protein"
                     /pseudo=""
                     /sec_met_domain="Asn_synthase (E-value: 5.9e-21, bitscore:
                     63.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSTGFVVLPDTAAAAVVRAAVPWASPQEYAHASGRPWLVGRWST
                     GEITVVTAGPVRVAVVGVCPVPAARLSELAARIRTVSDADALATSLPGSCHLVVSAHGE
                     VRFQGSATGLRRVFRTRADEVEVAADRADVLAAMTGAGIDEQALALRVATGGFLPPPLG
                     DRPLWAGISALAPDHCLVWEHERTREKRWWRPPAPELTLKAGAEAVRQALTSAFDDRAP
                     EQGRLSTDLSGGMDSTSLCFLAARGTPDLVTFRWGEAEAGNDDAAFATHAIGALDRAEH
                     LVVPPGDLPSLFTDCDEPVDTEGPYPFARTLARTRHTARLLAGTGSRRHLAGHGGDELF
                     TPFPGYLHGLLRRRPLTALRHVRGSPVTKPPGGAARPTGSPTRPRPNADPLSGGACGRC
                     AHRPGPPVPPSRPPGRPCGTPRPGCSRSPATWHNTSRSWPCAPPPPGTGSWPACSPTTA
                     YSSTRPSSTTAWSKRSLRSGPTSTRVPGATSPCWPTRCVASSRSPCWAAPPRASSATRP
                     TADCAAT"
ORIGIN
        1 tcagccggcc cggtccacca gggccgccgg aggctcgtcg tccatttcga aggccatcgg
       61 gaagggcgcg tgaccggcca ggcggaacca gcgcaccttg cgatgccggc gcagggcccg
      121 ggccgcgcgt acggcgtcgt tgtggaagcg ccgggccatc ggcaccctgc ggaccgcctc
      181 ggtgagttcc cgggccgcct cctctccccc gggcgcctcc cgcaccgcct ccacctgcgg
      241 ggcctccccg aagaccgcac gcagcgcctg gctcagttcg ctctcggcca cttcccgctg
      301 ctcctcctcg gcctgccggg cggcgtgcgc ggcctcgtac agcacgatcg aggcggccgg
      361 gtcgagcacc cccgacgtcg cgagctcctg cgccaccgag gcgcgccgca gcagctgggc
      421 gtccagggcc gcgcgggcgg cgtcgatccg ggcgtgcaga cggtcgagcc ggccggcggt
      481 ccagctcagg tagagcccga tcgcgaccag ggctacggcg atccagatga gagtggtggt
      541 cacgggcggc aaggctagcg gcacgggggt ccccgccgtt cgccccgccc cacccgtgat
      601 cagcggttgc ggtcctccgc caggggcggg atggacatca gcgtcttgaa gtgccccttc
      661 gggtggccct cgccgacgag ttgctcctcc gcctcgaccc aggcgtgggc ggcgaagggg
      721 tgggtgcgca ccccggtgca ccaggtgggc caggcaccgc gcatacggca gagcagggcg
      781 gtggcgatgg agcgctgcag gcagccctgc ccggcgcagc gcaggctgac ggacacgacc
      841 tcctcgcggg ctctgagcgc ctgcgcggcc gtcgcgggtg cggcgccccg gcgggcgaac
      901 tcaagaacgg tgcgcagccg ggcgggtctg accttggcca gcagccgggc gacgcccacg
      961 gccagcaggg gcagggcccg gcggtgcacg gggagacggc gccgttcggc cagcgcgacg
     1021 ggcatgctca cgagatcacc agttccgagc ctcgcagtcg ctcgatcacg gcgctcacgt
     1081 cgcgttcggc ctgctgggcg tcgatcccgt accggctcgc gagcccgccg gcgatggcgg
     1141 cgggctggtg cccgtcgagc agttcgcgca gcacgtgggc gccggtgttg ttcaactgcc
     1201 agtagcggcc ggtgcgttcg ttgagcagga ccgtgccgtc gtcggtgtcg gtgggggcag
     1261 gttgcggcgc agtccgctgt tggcctcgtc gctgaactcg cccttggtgg agcggcccag
     1321 cacgggctgc gggacgatgc cacgcatcgc gtcggccagc aggggcttgt agcgccaggg
     1381 acccgcgtgc tcgtgggccc ggaccgcaag gaccgcttcg accacgcggt cgtcgaagaa
     1441 gggcgagtcg agctgtacgc cgtcgtcggc gaacacgcgg gccagctgcc ggtaccaggg
     1501 ggcggcggtg cgcacggcca ggagcgactg gtgttgtgcc aggtcgccgg agagcggctg
     1561 cacccgggtc gcggtgtccc gcagggcctc ccgggcggcc tcgatggcgg taccggtggc
     1621 ccaggacggt gcgcgcagcg tccacaggcc ccacccgaga gcgggtcggc gtttgggcgg
     1681 gggcgggtcg gtgagccggt cggcctggct gcgccaccag gcggcttcgt caccggggat
     1741 ccgcggacgt gccgcagggc ggtcagcgga cggcggcgga gcagtccgtg gaggtagccg
     1801 gggaacgggg tgaacagttc gtcgccgccg tgtccggcga ggtgtcggcg cgatccggtg
     1861 ccggccagca ggcgggccgt gtgccgggtg cgggcgaggg tgcgggcgaa cgggtagggc
     1921 ccctcggtgt ccaccggctc gtcgcagtcg gtgaacaggg aggggaggtc gccgggcggg
     1981 accacgaggt gctcggcccg gtcgagggcg ccgatggcgt gggtggcgaa ggcggcgtcg
     2041 tcgttgcccg cctcggcctc gccccatcgg aacgtcacca ggtcgggcgt gccccgggcg
     2101 gcgaggaagc acagcgaggt ggagtccatg ccgccggaca ggtccgtgct cagccggccc
     2161 tgctcgggcg cgcggtcgtc gaaggccgag gtgagagctt gccgcaccgc ctcggcgcct
     2221 gccttcaggg tcagttcggg ggctggtggc cgccaccagc gtttctctcg tgtccgctcg
     2281 tgttcccaca ccaggcagtg gtccggggcg agggcggata tgccggccca gaggggccgg
     2341 tcgcccagcg gcggcggcag gaacccaccg gtggccacac gcagggccag ggcctgttcg
     2401 tcgatcccgg caccggtcat cgcggcgagg acatcggccc ggtcggctgc cacctcgacc
     2461 tcgtccgcgc gggtgcggaa cacccggcgc agtccggtcg cgctgccctg gaagcgaacc
     2521 tccccgtggg ccgagacgac caggtggcag gagccgggga gggacgtggc gagcgcgtcc
     2581 gcgtcggaca ccgtccgtat gcgggcggcc agttcggaga gccgggcggc ggggacgggg
     2641 cagaccccga ccaccgccac ccgcaccgga cccgcggtga ccaccgtgat ctcgccggtg
     2701 gaccaacggc ccacgagcca cggccgcccc gaggcgtgcg cgtactcctg cggcgacgcc
     2761 cacggcacgg ccgcgcgaac gacggccgcc gctgccgtgt ccggcaggac cacgaacccg
     2821 gtgctgctca t
//
