BGC0001508 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001508 (Penicillium roqueforti)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	29,400	andrastin A	PKS	100%

BGC0001508 - Region 1 - T1PKS

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Location: 1 - 29,400 nt. (total: 29,400 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 29,401
Label		BGC0001508

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001508	1.00	Polyketide	andrastin A	Penicillium roqueforti
BGC0002619	0.37	Polyketide	mycophenolic acid	Penicillium brevicompactum
BGC0000104	0.36	Polyketide, Terpene	mycophenolic acid	Penicillium brevicompactum
BGC0001219	0.35	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0001360	0.33	Polyketide	mycophenolic acid	Penicillium roqueforti FM164
BGC0002736	0.33	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0001677	0.31	Polyketide	mycophenolic acid	Penicillium roqueforti
BGC0002616	0.31	Polyketide	mycophenolic acid	Penicillium roqueforti
BGC0002290	0.26	Other	biscognienyne B, eutypinic acid, compound 3, 4-hydroxy-3-prenylbenzoic acid, prenylhydroquinone, compound 15, compound 8, compound 7, compound 6, compound 11, compound 12, pestalodiol E	Biscogniauxia sp.
BGC0002734	0.26	Polyketide	2,4-dihydroxy-5,6-dimethyl benzaldehyde	Aspergillus terreus NIH2624

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001508	1.00	Polyketide	andrastin A	Penicillium roqueforti
BGC0002619	0.69	Polyketide	mycophenolic acid	Penicillium brevicompactum
BGC0000104	0.69	Polyketide, Terpene	mycophenolic acid	Penicillium brevicompactum
BGC0001219	0.68	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0001360	0.66	Polyketide	mycophenolic acid	Penicillium roqueforti FM164
BGC0002736	0.66	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0001677	0.64	Polyketide	mycophenolic acid	Penicillium roqueforti
BGC0002616	0.64	Polyketide	mycophenolic acid	Penicillium roqueforti
BGC0002290	0.60	Other	biscognienyne B, eutypinic acid, compound 3, 4-hydroxy-3-prenylbenzoic acid, prenylhydroquinone, compound 15, compound 8, compound 7, compound 6, compound 11, compound 12, pestalodiol E	Biscogniauxia sp.
BGC0002734	0.60	Polyketide	2,4-dihydroxy-5,6-dimethyl benzaldehyde	Aspergillus terreus NIH2624

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 29400:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

adrD

PKS_AT (913..1203): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 69.8
inactive: 51.5
Methoxymalonyl-CoA: 49.8
Methylmalonyl-CoA: 36.0
Propionyl-CoA: 13.7
Ethylmalonyl-CoA: 13.6
CHC-CoA: 11.9
2-Methylbutyryl-CoA: 11.6
Benzoyl-CoA: 10.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0