LOCUS       BGC0001508             29400 bp    DNA     linear   PLN 29-MAY-2017
DEFINITION  Penicillium roqueforti strain CECT 2905 andrastin A biosynthesis
            gene cluster, complete sequence.
ACCESSION   BGC0001508
VERSION     BGC0001508
KEYWORDS    .
SOURCE      Penicillium roqueforti
  ORGANISM  Penicillium roqueforti
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Penicillium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 02:09:28
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 29400
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..29400
                     /db_xref="taxon:5082"
                     /mol_type="genomic DNA"
                     /organism="Penicillium roqueforti"
                     /strain="CECT 2905"
                     /type_material="culture from type material of Penicillium
                     roqueforti"
     subregion       1..29400
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Polyketide"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..29400
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     mRNA            complement(join(<26..450,509..1111,1165..1233,1284..1497,
                     1556..>1771))
                     /gene="adrA"
                     /product="AdrA"
     gene            complement(<26..>1771)
                     /gene="adrA"
     CDS             complement(join(26..450,509..1111,1165..1233,1284..1497,
                     1556..1771))
                     /codon_start=1
                     /gene="adrA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 135.7; E-value: 3.7e-41)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative cytochrome P450 protein"
                     /product="AdrA"
                     /protein_id="ART41207.1"
                     /sec_met_domain="p450 (E-value: 1.9e-43, bitscore: 138.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAVDKLPLLAKLEPVSLIGLVLLSGLFFLLTATRKSDLPLVNGKR
                     PFEFGIAKARQRYLKNAHSLITAGLEKAGAFRIVTENGTRTILSPKYADDIRSHRDLSL
                     SAALVKEHHVNIAGFDAVKVTVTSDIIQDTVRTKLTQNLLNITEPMSEEATILLKAQWT
                     DSTEWHDVALRPKTLGIVAQLSSRVFLGDKVCRNPDWLRLTVNYTIDSLMAAAELRLWP
                     EMLRPIAAKFLPKCKKIRKQLEEARNIIQPVIDERRLAQQAAIKQGKPQERYHDAIQWL
                     AENTKDRTFEPAAMQLALSTAAIHTTTDLLTQTILDLCGREELVQELREEIISVFKDGS
                     WDKTTMYKLKLMDSVIKESQRVKPMAIAKMARCAEEDVKLSDGTIIPRGEIILVSCSKM
                     WDANVYPDPNTFDPHRFLKLRQQGSDQESFAQLVSPSPEHMGFGFGKHACPGRFFAAAE
                     LKVALCHIIMKYDFKVAEGCNPQVLKSGMRLAADPFARIAIRRRQEEISF"
     misc_feature    26..29346
                     /note="andrastin A biosynthesis gene cluster"
     mRNA            complement(join(<2990..3755,3811..4211,4266..4913,
                     4978..6691,6745..>7574))
                     /gene="adrC"
                     /product="AdrC"
     gene            complement(<2990..>7574)
                     /gene="adrC"
     CDS             complement(join(2990..3755,3811..4211,4266..4913,
                     4978..6691,6745..7574))
                     /codon_start=1
                     /gene="adrC"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 102; E-value:
                     6.8e-31)"
                     /gene_kind="transport"
                     /note="putative ABC transporter"
                     /product="AdrC"
                     /protein_id="ART41208.1"
                     /transl_table=1
                     /translation="MAPEEGDQAMSHEDKAACSSLNTTSSTELFDGAPSSENERLRIRQ
                     AAVDAMHHGSPKIDPQIWTDVTSHLSGSTTIDARQRDIFFENLTVHGKGSSLQIQKTVL
                     SALLYPIAYPVKRLMSIVGNKKPHNDRRTILHGFNGILNSGELLLVLGRPGSGCSTFLK
                     SLCGYLEGLDLDPVSEIQYRGVPFRVMIEKYRGDLVYNQEADHHFPNLTVGQTLEFAAH
                     ARAPHNQVGNSSRDQYVKSVVKVVMDTFGLSHTYDTNVGNDFVPGVSGGERKRVRTDTI
                     VGMNSIAETVLSRTSIAAWDNSTRGLDAATAVDFVRSLRTSAKLAGSCHAVAVYQASEG
                     LYNTFDKVILLYEGREIYFGPRQGAVAYFETMGWKRPPQQVSADFLTAITNPGERQPQV
                     GMENAVPRTPVEFESYWKNSPEHAELETSMRQYKMKTPLDSSEEIKLDEIKRLEQSNHA
                     RISSPYLLSVPMQIRLCIVRAWQRTRNDIPALIATAVAQTVVSLIIGSLFYNIPENTAG
                     LGQRASVLFLAVLTNALISLLEITTLYSQRLIVEKQAAYAFVHPFTEAIAEVIVDFPIK
                     LFRCLLSAIIVYFLANLRREASHFFIYIMFQLTAVMTMATIFRTLATVTRTIGQAMALA
                     GVVIICIAVYTGFTVPQFDMPPWFGWIRWLNPIFYTFEGIVSNEFHGRHFECVEYIPSL
                     SFEQGLSFTCSYVGSIAGERYVSGDAYIAGSYDYSYDHVWRNYGILVAFLVFFYVLYFW
                     LTELIPGTTPAHEVLIFRHGGVLQRLVRGDLERGESIRLQEVKSLASEVHSSKAEQKNT
                     FSWKGLSYDIPVKGGEKRLLDDVSGWVKPGSLTALMGVSGAGKTTLMNVLARRMTIGVV
                     TGDMFVNGRELDASFARNIGYVQQQDLHVETCTIREALRFSAALRQPQSVSMEEKYNFV
                     EEVIQLLGMQNFAEAVIGSPGDGLNMEQRKLLSIGVELAAKPQLLIFLDEPTSGLDSRS
                     SWAICAFMRKLADHGQPVLATIHQPSAVLFEQFDRLLFLAKGGRTVYFGDIGKQARTVL
                     EYLEDKGARHCGPTENPAEYMLEVIGGGTQGQSTSIDWVQAWKRSTEYNKLLGELDILA
                     SSPSNGVSADPYMVGEFAMPLLVQFYHVMKRDLQQYYRQPEYILAKFGAGVFCGVFIGF
                     SFWKSDNSSQGFQNVLFSLFLLCTIFSTLVNQIMPKFLSRRTLYELRERPARTYSWKVF
                     ILCQILVELPWQTLLGICTWASFYFSVYGSGQSSQRQGLVLLFTVQFFIFASTFAQLVV
                     AAVPSVVLGSMLATFTFLLCLLFNGTMQPPSALPRFWIFMNRVSPLTYYVGGISATALH
                     GRPIHCSNRELRVFDPPQGQNCGQYLAEYLKTAQGTLSNPLSTDQCQYCPLRVADQYLA
                     ARDISWDDRWRNFGIFWVYIIFNVIGAVLLYYLFRVLPYIRRNRTQKSRN"
     mRNA            join(<8917..9510,9709..10803,10896..11271,11326..12080,
                     12148..15886,15961..>16889)
                     /gene="adrD"
                     /product="AdrD"
     gene            <8917..>16889
                     /gene="adrD"
     CDS             join(8917..9510,9709..10803,10896..11271,11326..12080,
                     12148..15886,15961..16889)
                     /NRPS_PKS="Domain: SAT (14-165). E-value: 7.5e-12. Score:
                     37.1. Matches aSDomain: nrpspksdomains_adrD_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (388-808). E-value:
                     3.1e-150. Score: 492.6. Matches aSDomain:
                     nrpspksdomains_adrD_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (913-1203). E-value: 3.5e-52.
                     Score: 169.4. Matches aSDomain:
                     nrpspksdomains_adrD_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (1323-1419). E-value: 2.1e-11.
                     Score: 36.3. Matches aSDomain:
                     nrpspksdomains_adrD_PKS_DH.1"
                     /NRPS_PKS="Domain: PP-binding (1656-1721). E-value:
                     6.1e-14. Score: 44.2. Matches aSDomain:
                     nrpspksdomains_adrD_PP-binding.1"
                     /NRPS_PKS="Domain: cMT (1939-2124). E-value: 4.7e-58.
                     Score: 188.0. Matches aSDomain: nrpspksdomains_adrD_cMT.1"
                     /codon_start=1
                     /gene="adrD"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 80.5; E-value:
                     1.6e-24)"
                     /gene_kind="biosynthetic"
                     /note="polyketide synthase"
                     /product="AdrD"
                     /protein_id="ART41209.1"
                     /sec_met_domain="PP-binding (E-value: 1.1e-14, bitscore:
                     44.2, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 5.6e-151, bitscore:
                     492.6, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 6.4e-53, bitscore: 169.4,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 5.1e-11, bitscore:
                     31.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAEPPKTPGRPVCVVFGPQSSEIDETLFYISRNIDENPSLGFLKD
                     VLQELPSLWSPITDAWSSLSSIPGATQLTVLAECVQGTTAAPKSAMNVFMTPLTVIRQI
                     IDVWKFKEESQNRCRIVDAQGFCVGFLAAVAVASSNDSNEFEDIASTMIRLAVCIGAAV
                     DLDGILHGPARSVALRWKSDSEKEQLDRVLGSSSTAYISCFTDATSVTVTVAEDEVDDL
                     TKELGGHGLSVKIIDLKGRFHHSRHVTAVQYLADLCETDARFRLARTSPCVLPLRSNVD
                     GHVIGKRFAIHKTALESILTKPSQWAITVSAAFEQARETDDDLAFVVIGTGQFVPRLVR
                     TRVLDHLNNKWSDTKQHAILPNGIHRSSSTTRSRPSIDMAPIGPTVIPIAITGMGCRYA
                     QADSPEQLWEMLELGRCGVNALPNERFKMENLLREPKGPFWGNYLANPDVFDHRFFGIS
                     AREAEAMDPQQRLLLQVGYEAMESAGYCGLRTSNIPTDVGCYVGVGSDDYTDNVGSSNA
                     NAFSATGTLQAFCTGRLSHYFGWTGPSVVVDTACSSAAVSIHLACKALQTNECSIAVAG
                     GVNVMTSPRVTQNLAAASFLSPTGASKAFDASADGYCRGEGAGLVVLRPLKDAIHNGDP
                     ILAIIGGSAVNQGSNRSPITVPDSDSQISLYRKALVTSGVRPEDVTYVEAHGTGTQVGD
                     PIEFESIRKTFGRPARTERLYVGSVKDNIGHTETSSGVAGLLKTVLMMQKHQIPKQANF
                     VQLNPKIPTLDDAAIAIPTKSIHWPSAANSSSTAVAMVTNYGAAGSNAALVVKQYKAKS
                     GLSNPVSPLPSEVPVILAANTVESLRSYCKALLSSVCDAQLTSCQDTAYNLAIKQSRDM
                     DYVSAFSIPVDRPNELIAKLESISRETTNLEKQPAARLPVVLCFGGQNGNEATISEDLF
                     NQCELLQYHLTECEKVCQTLDLPSLFPSIFQPGPIEDTVSLHCILFSIQYASAKSWIDS
                     GLQVDRIIGHSFGQLTGLCVGGGLSLSDALYLVSERAKMIHSMWGSERGAMLLVEGSEV
                     EVQGLLNRAAEHMADVAVDVACVNGPRNTILAGDERSLQMIEKLSAKAPSILRTKRLKN
                     THAFHSRLVDNIVPPLTKVAQQLQYKPLSIPIEACSQYDDWTYVTPGKIVDHSRRRVDF
                     QTAVERVAQRIQGPAIWLEAGSASPIIPLVRRVIDTVAAFSNGHVYQALDLGGALAHRS
                     LSQATCNLWSRGVKVQFWQFHDSQAKSYNWINLPPYQFAQTRHWIGYDPNAFASLPEVK
                     PTVPSSDAPKEFVQLLTKQPTECVFAINTNDPLYQECTQGHAVLDQNLCPASLYFEIIV
                     RAAGLIRPENDISPAMPHLKDLAISAPLVLNPRGNVMLSLTRARVGDSTWSFSLFTRES
                     NKNKVTTHATGEISLHPFGQNTPLFVRLHSMNRLIDSSRVDSIANSRESSGLKGFAVYQ
                     AFRRVVNYADYYRGVEQVFATDHEAAGIVNLPSSRTKDASCDPMLVDNFIQVAGIHVNC
                     LSETKEDEVFVCTGVGEILIGEAFMTRDPNCSRSWAVYSNVDRSIKNKITCDTFVLDRE
                     TDKLAVTILSATFTSVSIAGLSRVLKKLNNQPDDKKVPLGQSLRDDSKVALNPTPQNAL
                     AAVPAPLHSAPDSGHFMVVQEMLCDLLGIASDELLPSSNLEDIGVDSLMRTEVLVEIKK
                     RFNFTIDTSSFVEIPDILTLVQTIFPDAATAPLTNGVHPSLQIETTEAVDSESNTHVIP
                     TPISDEEIHGLIDIAPGLFTDIQRSMVHSQSTQWDGFCESVYPRQMALVTAYVVEAFKS
                     LGVSLESFEAEHLIPQVPVLQQHSKVRSQLYSILQFSNLIRATDHGFVRTSVPVSTISS
                     DVLHEEIIRLYPQHTSEHNLLRTTGSRLSDCLSGAADPLSLLFQDAEARRLMEDVYTNA
                     PMFKAATNHLAQYLVNLLGRVDTTREIKILEIGGGTGGTTKALLSQLTAVPGLRFQYTF
                     TDLSSGLLALARKKFKHYSFMKYQVLNIERAPTPDMLGQYDIVLSSNCVHATRSLVQSC
                     SNINKLLRPDGLLCLIELTRNLFWFDLVFGLLEGWWLFEDGRQHALATEHVWKQTLSQS
                     GFQWVDWTYNDSQESNVLRVITASPTSAVILPPSPRSPLYLMNEETIVYGKNDGVELSA
                     DIYYPRDLQPIGKPRPIALLIHGGGHIMLSRRDIRSKQVRMLLNAGFLPVSVDYRLCPE
                     VSLTEGPMHDVCDALCWARHVLPSLTLGRPDIQPDGTQAVAVGWSTGAHLAMTLAWTSQ
                     QRGIAPPNAILAFYGPTDYEDSFWSQPNFPYGKNAASPEMRYDLWEGIYETPITAYNPP
                     VDQKALGGWMSPADPRSRIALHMNWKGQSLPMLLHGGRFWSDHKDGDCGEELPVPTLEE
                     IQAVSPLAQIRNGHYKTPTFIIHGTLDDLIPVEQAQRTSQELVTKGVEVQLRVVDKAVH
                     LFDIYPGFEKDQAASRAVEDGYEFLRDHVRY"
     aSDomain        8959..9411
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_adrD_SAT.1"
                     /evalue="7.50E-12"
                     /label="adrD_SAT.1"
                     /locus_tag="adrD"
                     /protein_end="165"
                     /protein_start="14"
                     /score="37.1"
                     /tool="antismash"
                     /translation="VFGPQSSEIDETLFYISRNIDENPSLGFLKDVLQELPSLWSPITD
                     AWSSLSSIPGATQLTVLAECVQGTTAAPKSAMNVFMTPLTVIRQIIDVWKFKEESQNRC
                     RIVDAQGFCVGFLAAVAVASSNDSNEFEDIASTMIRLAVCIGAAVDL"
     CDS_motif       9280..9303
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_adrD_0001"
                     /evalue="9.90E+01"
                     /label="PKSI-KS_m4"
                     /locus_tag="adrD"
                     /protein_end="129"
                     /protein_start="121"
                     /score="-2.5"
                     /tool="antismash"
                     /translation="DAQGFCVG"
     aSDomain        join(10279..10803,10896..11271,11326..11684)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_adrD_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="3.10E-150"
                     /label="adrD_PKS_KS.1"
                     /locus_tag="adrD"
                     /protein_end="808"
                     /protein_start="388"
                     /score="492.6"
                     /tool="antismash"
                     /translation="IAITGMGCRYAQADSPEQLWEMLELGRCGVNALPNERFKMENLLR
                     EPKGPFWGNYLANPDVFDHRFFGISAREAEAMDPQQRLLLQVGYEAMESAGYCGLRTSN
                     IPTDVGCYVGVGSDDYTDNVGSSNANAFSATGTLQAFCTGRLSHYFGWTGPSVVVDTAC
                     SSAAVSIHLACKALQTNECSIAVAGGVNVMTSPRVTQNLAAASFLSPTGASKAFDASAD
                     GYCRGEGAGLVVLRPLKDAIHNGDPILAIIGGSAVNQGSNRSPITVPDSDSQISLYRKA
                     LVTSGVRPEDVTYVEAHGTGTQVGDPIEFESIRKTFGRPARTERLYVGSVKDNIGHTET
                     SSGVAGLLKTVLMMQKHQIPKQANFVQLNPKIPTLDDAAIAIPTKSIHWPSAANSSSTA
                     VAMVTNYGAAGSNAALVVKQY"
     aSModule        10279..14490
                     /complete
                     /domains="nrpspksdomains_adrD_PKS_KS.1"
                     /domains="nrpspksdomains_adrD_PKS_AT.1"
                     /domains="nrpspksdomains_adrD_PKS_DH.1"
                     /domains="nrpspksdomains_adrD_PP-binding.1"
                     /iterative
                     /locus_tags="adrD"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       10738..10782
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_adrD_0002"
                     /evalue="1.20E-04"
                     /label="PKSI-KS_m3"
                     /locus_tag="adrD"
                     /protein_end="556"
                     /protein_start="541"
                     /score="14.5"
                     /tool="antismash"
                     /translation="GPSVVVDTACSSAAV"
     CDS_motif       11019..11057
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_adrD_0003"
                     /evalue="4.60E-05"
                     /label="PKSI-KS_m4"
                     /locus_tag="adrD"
                     /protein_end="617"
                     /protein_start="604"
                     /score="16.2"
                     /tool="antismash"
                     /translation="FDASADGYCRGEG"
     CDS_motif       join(11250..11271,11326..11351)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_adrD_0004"
                     /evalue="6.40E-05"
                     /label="PKSI-KS_m5"
                     /locus_tag="adrD"
                     /protein_end="697"
                     /protein_start="681"
                     /score="14.7"
                     /tool="antismash"
                     /translation="YVEAHGTGTQVGDPIE"
     aSDomain        join(12000..12080,12148..12936)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_adrD_PKS_AT.1"
                     /evalue="3.50E-52"
                     /label="adrD_PKS_AT.1"
                     /locus_tag="adrD"
                     /protein_end="1203"
                     /protein_start="913"
                     /score="169.4"
                     /tool="antismash"
                     /translation="CFGGQNGNEATISEDLFNQCELLQYHLTECEKVCQTLDLPSLFPS
                     IFQPGPIEDTVSLHCILFSIQYASAKSWIDSGLQVDRIIGHSFGQLTGLCVGGGLSLSD
                     ALYLVSERAKMIHSMWGSERGAMLLVEGSEVEVQGLLNRAAEHMADVAVDVACVNGPRN
                     TILAGDERSLQMIEKLSAKAPSILRTKRLKNTHAFHSRLVDNIVPPLTKVAQQLQYKPL
                     SIPIEACSQYDDWTYVTPGKIVDHSRRRVDFQTAVERVAQRIQGPAIWLEAGSASPIIP
                     LVRRVIDTV"
     CDS_motif       12313..12414
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_adrD_0005"
                     /evalue="3.10E-10"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="adrD"
                     /protein_end="1029"
                     /protein_start="995"
                     /score="32.0"
                     /tool="antismash"
                     /translation="IIGHSFGQLTGLCVGGGLSLSDALYLVSERAKMI"
     aSDomain        13297..13584
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_adrD_PKS_DH.1"
                     /evalue="2.10E-11"
                     /label="adrD_PKS_DH.1"
                     /locus_tag="adrD"
                     /protein_end="1419"
                     /protein_start="1323"
                     /score="36.3"
                     /tool="antismash"
                     /translation="GHAVLDQNLCPASLYFEIIVRAAGLIRPENDISPAMPHLKDLAIS
                     APLVLNPRGNVMLSLTRARVGDSTWSFSLFTRESNKNKVTTHATGEISLHP"
     aSDomain        14296..14490
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_adrD_PP-binding.1"
                     /evalue="6.10E-14"
                     /label="adrD_PP-binding.1"
                     /locus_tag="adrD"
                     /protein_end="1721"
                     /protein_start="1656"
                     /score="44.2"
                     /tool="antismash"
                     /translation="VQEMLCDLLGIASDELLPSSNLEDIGVDSLMRTEVLVEIKKRFNF
                     TIDTSSFVEIPDILTLVQTI"
     aSDomain        15145..15699
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_adrD_cMT.1"
                     /domain_subtype="cMT"
                     /evalue="4.70E-58"
                     /label="adrD_cMT.1"
                     /locus_tag="adrD"
                     /protein_end="2124"
                     /protein_start="1939"
                     /score="188.0"
                     /tool="antismash"
                     /translation="TNHLAQYLVNLLGRVDTTREIKILEIGGGTGGTTKALLSQLTAVP
                     GLRFQYTFTDLSSGLLALARKKFKHYSFMKYQVLNIERAPTPDMLGQYDIVLSSNCVHA
                     TRSLVQSCSNINKLLRPDGLLCLIELTRNLFWFDLVFGLLEGWWLFEDGRQHALATEHV
                     WKQTLSQSGFQWVDWTYNDSQE"
     mRNA            complement(join(<17588..17889,17945..18044,18116..18270,
                     18322..18505,18567..>18836))
                     /gene="adrE"
                     /product="AdrE"
     gene            complement(<17588..>18836)
                     /gene="adrE"
     CDS             complement(join(17588..17889,17945..18044,18116..18270,
                     18322..18505,18567..18836))
                     /codon_start=1
                     /gene="adrE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 94.7;
                     E-value: 1.2e-28)"
                     /gene_kind="biosynthetic-additional"
                     /note="ketoreductase"
                     /product="AdrE"
                     /protein_id="ART41210.1"
                     /transl_table=1
                     /translation="MTQAQNYVIPPGSKVLVTGANGYIASHIVKALLDLGYLVRGTVRT
                     PMPWLAEYFERQCGLGRFELIVVSDFQQPDAFDESVKGVSGVIHVAQGLPSSTAAETVK
                     SATAYTVNGVINLFKAASTQRTIQRVVLTSSIVAAGYPTGKGFKLDADSWDESLEQASK
                     DGTTVPIYRACKIEGERQAWKWVEKNQPHFELNSVLPWLTLGKILHPNIGGSTMGYVSG
                     LLRGDTTPFKFLPLPWFVDVEDTARLHAIALLNPSVRSERLFATAAPFTWGDVIEILKR
                     IQPNNARIPAAPIQEEPTLGDVVPAARAEKLLRETFGQLGWTPLEVSLESGIARE"
     mRNA            join(<19553..19573,19633..20071,20131..20217,20281..>20504)
                     /gene="adrF"
                     /product="AdrF"
     gene            <19553..>20504
                     /gene="adrF"
     CDS             join(19553..19573,19633..20071,20131..20217,20281..20504)
                     /codon_start=1
                     /gene="adrF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     166; E-value: 1.7e-50)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative short chain dehydrogenase"
                     /product="AdrF"
                     /protein_id="ART41211.1"
                     /transl_table=1
                     /translation="MSLLQDIVVIITGSASGIGLATATAALSQGARILGVDVSSAPVSL
                     NEHPNYKFMQGDLTHETTPRQVVETCIKEFGGRIDGLLNIAGIMDQNSSVDSLSDYMWE
                     RCIAVNLTAPVKLMREVIPIMRQQQSGSIVNVGSKAATSGASSGVAYTASKHGLMGATK
                     NVAWRYKQEGIRCNAVCPGGVPTGIVQASDPSTWDKDALGTMSLIHQAHAADRQKGLGV
                     EAEDIADCLLFLISSQSKRINGAIIPIDNAWSVI"
     mRNA            complement(<21160..>22110)
                     /gene="adrG"
                     /product="AdrG"
     gene            complement(<21160..>22110)
                     /gene="adrG"
     CDS             complement(21160..22110)
                     /codon_start=1
                     /gene="adrG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic-additional"
                     /note="prenyltransferase"
                     /product="AdrG"
                     /protein_id="ART41212.1"
                     /sec_met_domain="ubiA (E-value: 1.1e-25, bitscore: 79.9,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTRGNEKEEAPPQAKILGSFPTGIAPYAELMRVHRLLGFYLNTSP
                     YLVGVAFCASISPTKIPITVLLHRTILLSIWSIFLRSAGCVWDDLIDMDLDSQISRTRT
                     RPLPRGAVSPKNAFLLTVTLFACGGSVLIYLPWPCAVDCLIITFFALLYPFGKRFTDYP
                     QITLVNIGWAIPMAMHSLGLDPLSQMKPTVCMFLFIGLVIIMIDVIYSRQDTEEDLKVG
                     VKSMAVRFRESIELLSYSLLYASTGFLAMAGFFTGLGLSFFVVSVGGHFCGFWVLLKAT
                     RVGNSYGVESYAKSAFFLATLFWLFGFVIEYCLRN"
     mRNA            complement(join(<22796..23278,23347..23717,23792..24063,
                     24124..>24428))
                     /gene="adrH"
                     /product="AdrH"
     gene            complement(<22796..>24428)
                     /gene="adrH"
     CDS             complement(join(22796..23278,23347..23717,23792..24063,
                     24124..24428))
                     /codon_start=1
                     /gene="adrH"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 241.6; E-value: 2.8e-73)"
                     /gene_kind="other"
                     /note="FAD-dependent monooxygenase"
                     /product="AdrH"
                     /protein_id="ART41213.1"
                     /transl_table=1
                     /translation="MEEGMEAPKFKVIIVGGSIAGLTLAHSLSQANIDHVVLEKRASIA
                     PQEGAFIGVWPNGAQILDQLGLYHSLEKLTAPLSRMHLSFPDGYSFSSLLPKTIHEIFK
                     YPIVSLDRQKVLEILFQNYPNKEKIITNQRVSEVRLLGDSASVVTEDGSVFQGDLIVGA
                     DGVHSRIRSEMWRLADELHPGMITPQERQTLTVEYACVFGISRAIPGLRSGEHINHYGD
                     KFCVITFHGKDGRVFWFIIQKLDRVYTYPNAPRYSPNDAAELCDKIQDVIIWRDITVGD
                     LWKTKLVSSMTALEEGLFETWSLNRIVILGDSVHKMTPNIGQGANTAIEDVAVLASLIN
                     RVVHADALHKPSESCIETMLQKYKTLRYERAKSTYERSRFGARFHTRDNWLKALVGRYV
                     FQYVGGLIENRTSKTLAGGNVIDFLPRPHRLETGCVTRLPKGQGRPQQQWTLLWVSSLV
                     LFLFLPWLRSYLPSATFW"
     mRNA            complement(join(<24904..25120,25173..>25693))
                     /gene="adrI"
                     /product="AdrI"
     gene            complement(<24904..>25693)
                     /gene="adrI"
     CDS             complement(join(24904..25120,25173..25693))
                     /codon_start=1
                     /gene="adrI"
                     /note="terpene cyclase"
                     /product="AdrI"
                     /protein_id="ART41214.1"
                     /transl_table=1
                     /translation="MEESSLLSAILDHRDALASVAEFLRILAGICWTLNYFSMLRTSRK
                     DKIPSTGIFPLCNDIGWEFIYAFIYPTASAHWEGGVRVWFLVHCIVIIFIIKYAHNEWD
                     HFPLIQRNLYFLYGVVTIGFAIGQYSFAREVGPDLGFFYGGVLCQTLASLGPIAQILSR
                     NSTRGASLLTWLLRAIATFGGFIKLTIYYLTGNAAGPWFESPMCKFYIGLTLVLDFTYP
                     ICYYVIQRQELANAQKEKKEKSK"
     mRNA            complement(join(<26297..27562,27626..>27850))
                     /gene="adrJ"
                     /product="AdrJ"
     gene            complement(<26297..>27850)
                     /gene="adrJ"
     CDS             complement(join(26297..27562,27626..27850))
                     /codon_start=1
                     /gene="adrJ"
                     /note="acetyltransferase"
                     /product="AdrJ"
                     /protein_id="ART41215.1"
                     /transl_table=1
                     /translation="MGFFSSTQPPRPATVPSDEIIPLHFWNTALCMRGTVLDISLKFDD
                     VLDTSKLRSALEELLEMKDWRQLGARLRMNPNGRLEYHIPTRFDASRPAFAMTNAQHET
                     SIADHPLGARIPHATSTPAIFPSPDVLSPLLRSEDAPKNIDDWICSDRPQLSIHIITFS
                     DATLITVTWLHTLTDVMGMALILNAWTALLRGNREAVPKLQGFRLDPLTELGQRTPAEK
                     YMHFNRVFGRKEFWWFIGLNVLDRLWYRQEERRTICIPAASLRNLCQQSSSEICASRGK
                     EEPVPFVSESDVLLGWWVRSLYSALGLRTDQTILVNNALNLRTSLHESFTSNNSAYMGN
                     ALCMSPTFLRGHQVADEPLGQIALRIRESVTEQRTPEQVEAMTALQMQTMEQTGYLALV
                     GDPRMMLLSCSNWHKARLFDIDFSSAVLQSSGPSSLQNPQHTGKPCYVNGVQHSANSFR
                     NVLSVIGKDAGGNWWLTGVLRTDAWTHIEKQLHKLGSS"
     mRNA            complement(join(<28297..28803,28897..29043,29112..29132,
                     29185..>29346))
                     /gene="adrK"
                     /product="AdrK"
     gene            complement(<28297..>29346)
                     /gene="adrK"
     CDS             complement(join(28297..28803,28897..29043,29112..29132,
                     29185..29346))
                     /codon_start=1
                     /gene="adrK"
                     /note="methyltransferase"
                     /product="AdrK"
                     /protein_id="ART41216.1"
                     /transl_table=1
                     /translation="MHPDSQLETAVKNGFDPKSLYSTELTKVNEPARTILEQYSKIPAE
                     KVLQHVKDLKDRAFEVFPYACIGQASFLELSIASSPCYPEMLDRVKKGDRLLDLGCAFG
                     QELRQLIYDGAPSQNLYGTDLRPEFLELGLDLFLDRSFIKSHFIDADVLDDKSALVTQL
                     TGELNIVYISLFLHVFDFETQIKVAKRVLDLLAPKAGSLIVCRVVACRDQAIGNATNAR
                     LPYYYHDLASWNRLWERVQEETGLKLKVDNWEQDDALAKKHPLEGIYMLGSSIRRE"
ORIGIN
        1 gccagagctg gaaattggga agagctcaga aagagatctc ttcttgcctt cttctaatag
       61 caattctggc aaatgggtcc gccgcaagtc tcataccaga tttcaacacc tgtgggttac
      121 atccctctgc caccttaaag tcgtacttca tgatgatatg acataaagcg actttgagct
      181 cggcggcagc gaagaatctt ccagggcaag cgtgttttcc aaagccgaat cccatatgct
      241 cgggggaggg agaaaccagt tgagcaaagc tctcttggtc tgagccctgt tggcgtagct
      301 tcaggaatcg atggggatca aaagtgttgg gatcggggta cacattcgcg tcccacattt
      361 tactgcagga aacaagaatt atctcacccc tcgggataat agtcccgtcg gaaagcttga
      421 catcctcctc ggcgcaacgt gccattttag ctattcacca tcgttggtta gcttgggctg
      481 ttttaaaatg agatgaatag ttccttaccg atcgccatgg gcttgactcg ctgagactcc
      541 ttgatcacac tgtccatcag tttgagcttg tacattgtgg tcttatccca actgccatct
      601 ttgaacacgg aaataatctc ttcccgcagt tcttggacaa gttcttctcg tccacaaaga
      661 tcaaggatag tctgcgtaag caggtcagtc gttgtgtgga tagctgcagt tgagagtgcc
      721 aattgcattg cggcaggttc gaaagtgcgg tctttggtat tctctgcgag ccactggatc
      781 gcatcatggt agcgctcctg gggcttcccc tgcttaattg ccgcctgctg ggccagtcga
      841 cgctcgtcaa taacaggttg aatgatgttg cgggcctcct caagctgctt gcgaatcttc
      901 ttgcatttag gtaaaaactt agccgcgatt gggcgcaaca tctcaggcca gagtcgaagt
      961 tcagcagcag ccatcaaaga gtcaatagtg tagttgacag tgagacgtag ccagtcggga
     1021 ttacggcaaa ctttgtcacc caaaaatact ctagaggata gctgggcgac tatgcctaga
     1081 gtcttgggtc tgagcgcaac atcatgccac tctaatgaaa taagtcagtt gtgtctgatt
     1141 gatatcatat ccagaagcat ttaccggtac tgtccgtcca ctgtgccttc aacaaaatag
     1201 tagcttcctc tgacatgggc tccgtaatat tcactgtttg tattagcaac tcttattgcc
     1261 aatgaagaat ttccatgtcg tacagagatt ctgagtgagc ttcgttcgga cagtgtcttg
     1321 aatgatatca gatgtcacag tgaccttgac tgcgtcgaac cctgcgatat tgacgtgatg
     1381 ttccttaact aaagcagcac tcaagctcag atcacggtgg cttcgaatat catcagcata
     1441 tttaggcgac aagatagttc tagtgccatt ttctgtcacg atccgaaatg caccagccta
     1501 gacctacgca ttagtaaccc caattatgta cccagatgag aattgaatca cataccttct
     1561 ctagaccagc cgtaattagg ctatgggcgt tcttcagata tcgttggcgg gctttggcaa
     1621 ttccaaactc aaagggtcgc tttccgttca caagagggag gtcggacttt cgtgttgctg
     1681 tcaataaaaa aaatagcccc gatagaagga ccaagccgat caggctcaca ggttccaact
     1741 tggccaataa tggtaacttg tcgacagcca ttgtgaaaga acacttggaa tgggagaaga
     1801 actagctttg gtcataaatt taaatgcaca gaagactgat aaccatgcta cctactcatg
     1861 atacattcgg agattgtata tatgaaaagg ttgtaaaata taatgcgggt tcataaccct
     1921 agcttggtaa cgagtaaaac attgcgcatt gcgcattgca gacgcaggct tgggccagta
     1981 gctgtatgtc agctccccca acatgagcgc atactctaca acatagaaat attgtccgct
     2041 tagcatacta acgaaatatg tgtcacaatg cactgttagc ccttgcagag agaggctggc
     2101 gctgtggttc ggtggcagat cgcacaggac tccattgcat gagataggca gtgactgatt
     2161 ccgttttacc tgtataccag ataagcatta caattttaag aattatttta acctaatctc
     2221 tccttgcatc ccatcccgcc tctagtattt acctccatat gtaacgatag ctgccgatgt
     2281 aatgctgaag taacgtcact agtatcacag tcacatccaa tagcgactac ctatagacat
     2341 atttgtggag gatactgacg atcaagcctt gcatatcctg caagatagag acagttgaat
     2401 aattgtaatc tgcatcagtt cgcgtatgta tagaatgtac cgggatacca aaacgccaag
     2461 aaaggatcgt cccgtcccga ttaaatacat gtgtgggtac atcttgtatt tggtatctct
     2521 gggaattcaa aatacagaaa acctgaatgt cccgatacat gtaaatatgc gatgaacaat
     2581 ttcagactgg gatatggccc ccgccgggcc ttaaacagag acactggttt ttgttatgcg
     2641 ctgcgacgat tttccgtcgc cttcgtataa acgaagtgtc ttcttattcg gtatctatac
     2701 caggcgcttc ttgtttacgc actgctcatc cagtagctac agcgaggcgg attattggtt
     2761 tatccgccca ttacgtaact cccgtcgtcc ccgtgccaag aagtacggca cccttgactt
     2821 cctaactgaa caaacatcca agtgagacgg cattaaactg gaattttcac acaaagatat
     2881 tataagagaa aatagaaaaa cgacaaaagg atcgagagaa gaatgaaaac aaatgaaagt
     2941 tgggtgagaa gagtggtgaa gaggaaagtg gagtaccgat atcagaaggt cagtttcgag
     3001 atttctgggt gcggttcctc cttatatagg gtagaactcg aaacagataa tagagtaaaa
     3061 cagcaccaat gacgttgaag atgatataca cccagaaaat tccaaagttt ctccatcggt
     3121 catcccagga gatatcccgg gcagcaagat actgatctgc tacccgaagt gggcaatatt
     3181 gacactgatc ggtagaaagc gggttggaga gcgttccttg tgctgttttg agatattccg
     3241 ccagatattg accgcaattc tgcccctgtg gtgggtcaaa gactctcagc tctcgattag
     3301 agcagtggat cggacgacca tgcaatgcag tggcactgat gccacccacg taataggtga
     3361 gaggcgaaac acgattcata aaaatccaga accgcggcaa tgcgctaggt ggctgcatgg
     3421 tgccgttgaa caagaggcac aggagaaatg tgaatgtagc cagcatgctc cctagaacca
     3481 cactggggac tgcagcaact acaagttggg caaaggttga tgcaaatatg aagaactgta
     3541 cggtgaacag aagaactagc ccctgccgct gggagctttg gccgctgccg taaaccgaaa
     3601 agtaaaatga ggcccaggta catatcccca acaaggtttg ccacggtagt tcaacgagga
     3661 tctgacacag aataaacacc ttccatgagt aagttctagc tggtctctct cgtagctcat
     3721 atagcgttcg tcgagagaga aacttcggca tgattctgct tgcagtcagt atcgtcagat
     3781 gttagcatca agcttggggc aaaggcatac tggttgacga gcgtggagaa tattgtgcac
     3841 aagaggaaca aactgaacag aacgttctga aagccttggc ttgaattatc agacttccag
     3901 aaggagaagc cgataaaaac accgcaaaaa acacccgcgc caaacttagc caaaatatat
     3961 tcgggttggc gataatattg ttgaaggtcg cgtttcatga catggtagaa ttgaactaaa
     4021 agaggcattg caaattcgcc gaccatgtag gggtcagcag acacaccgtt ggatggtgat
     4081 gaggcgagaa tgtcgagctc cccaagaagt ttgttgtatt cagtgctcct tttccatgcc
     4141 tgaacccagt cgatggacgt agactgccct tgggtgcccc ctccaatgac ctcgagcatg
     4201 tattcagcgg gctagaagag atggcatcag caaatttcaa gtatgtcagg agccgaagaa
     4261 ctcacatttt cagttgggcc acagtgacga gctcctttat cctcgagata ttctagaacc
     4321 gtccgagcct gtttaccgat atctccaaaa taaacagttc ttccgccttt ggcaagaaac
     4381 agcaaacgat caaattgctc gaataaaacg gcacttggtt ggtggattgt ggcgaggaca
     4441 ggctggccat ggtccgcaag tttcctcatg aacgcgcaga tagcccacga acttcgtgaa
     4501 tccaaaccac tggtaggctc gtcaagaaag atcaatagtt gaggcttggc agcaagctca
     4561 actccaatgc tgagcagttt cctttgttcc atgtttaagc catcaccggg acttccaata
     4621 actgcttctg cgaaattctg cattcccagc aactgaatca cctcctcaac aaaattatat
     4681 ttttcctcca ttgacacaga ttggggttgg cgtagtgctg cgctgaatcg aagggcctca
     4741 cggatggtac acgtctccac atgaagatct tgctgctgga catagccaat atttcgggca
     4801 aagctagcat caagttcgcg gccgttgaca aacatatctc ctgtaacaac tccgatagtc
     4861 atacgccgcg ctaaaacgtt cataagtgtt gttttcccag cacccgaaac gccctatatt
     4921 catgtcaatg cctgtgaggt ggaagtcatg gattcagaag agggaaataa tgcataccat
     4981 gagtgccgtg agtgatccag gtttgaccca accactaaca tcatccagaa gccgtttttc
     5041 accacctttg actggaatgt cgtaagagag tcctttccag ctgaaggtat tcttttgttc
     5101 tgcttttgat gaatggacct cagaggccaa tgattttacc tcctgcaaac gtatagactc
     5161 tccgcgttcc agatcacctc gaaccaacct ttggagcaca cccccatggc gaaagatcaa
     5221 gacttcgtgg gccggtgtgg ttcctgggat caactccgtg agccaaaagt aaagcacata
     5281 gaagaagaca agaaaagcaa ccaagatgcc ataattcctc cacacatgat cgtaggagta
     5341 atcgtaactg cctgcaatat atgcatcccc agagacatac cgctcccccg caatggatcc
     5401 cacatatgag caggtgaatg atagtccctg ctcgaaactt aagcttggaa tatattccac
     5461 acactcaaaa tggcgaccgt ggaactcatt ggagacaatg ccttcgaaag tgtaaaatat
     5521 cggattgagc catcggatcc atccaaacca tggcggcata tcgaactgag gaacggtaaa
     5581 cccagtgtac acagcaatgc agataatcac gactccagcc aaagccatag cttgtccgat
     5641 agtcctggta acggtagcca aagtgcgaaa tatcgtggcc attgtcataa ctgctgtgag
     5701 ctggaacata atgtagataa agaaatgaga ggcctctctc cggagatttg caagaaaata
     5761 tacgatgata gcagataaga ggcatcggaa aagtttgata gggaaatcca caataacttc
     5821 tgcaatggct tccgtgaaag ggtgcacaaa ggcataggca gcttgtttct ccacgatcaa
     5881 tctttggcta tatagagtgg tgatctccaa caaggatatc aaagcatttg tcaaaacagc
     5941 gagaaaaagg accgatgccc tctggccgag cccagcggta ttctctggta tattgtaaaa
     6001 aagagaccca atgatcaggg ataccaccgt ctgcgccact gccgtagcaa tcaaggccgg
     6061 gatatcattg cgagtgcgtt gccaagctct cacaatgcat agtctgattt gcataggcac
     6121 cgagagaaga tagggactag atattcgagc atgatttgat tgctcaaggc gcttaatttc
     6181 atccaatttg atctcctccg agctatcaag aggggtcttc atcttgtatt gtcgcattga
     6241 tgtctccagc tctgcatgct cggggctgtt cttccagtaa ctttcgaact ctactggggt
     6301 gcgggggact gcattttcca tgccaacttg tggttgtcgc tcgcctgggt tggtgatagc
     6361 tgtgaggaaa tccgcactca cttgttgggg tggtcgtttc catcccatcg tctcaaagta
     6421 tgcaacagcc ccttgacgag ggccaaaata tatttctcgc ccttcatata gaagaatgac
     6481 tttgtcgaag gtattgtaaa gaccttccga ggcttggtat acggcgactg catgacaaga
     6541 tcccgctagt ttggctgagg tacgaaggga ccgaacaaag tcgacagcag tggctgcatc
     6601 aagcccacgt gtgctgttat cccaggccgc aatcgaagtc cgtgacaaaa ccgtttccgc
     6661 aatactgttc ataccaacta ttgtatcagt tctcataccc tttccttctc ccctcttgct
     6721 ccaagccgaa cagaatgagc ttacctgacc ctctttcttt cccctccact gacgcctgga
     6781 acaaagtcgt tgccaacatt tgtgtcgtat gtgtgggaaa gaccaaatgt atccataacc
     6841 actttcacca cggatttgac atactggtct cgactcgaat tgcctacttg attatgcggt
     6901 gctcgtgcat gcgctgcaaa ctcaagtgtt tgaccaactg tcaagttcgg aaagtggtga
     6961 tccgcctctt ggttgtacac taaatccccc cggtactttt caatcatcac tctgaatggt
     7021 actcccctat actggatctc actgactggg tcgagatcta agccttcaag gtagccacat
     7081 agtgatttca agaacgttga gcacccacta cccggacgac cgagcaccag caacaattcg
     7141 ccgctgttta aaatcccgtt gaatccatgt aatattgttc ttcgatcatt gtgaggtttt
     7201 ttgttaccaa caatgctcat gagtcgtttg acagggtacg caatggggta tagaagggcg
     7261 gacagaacag ttttttggat ttgtagcgag gatccttttc catggaccgt caaattctca
     7321 aaaaaaatgt cccgttggcg ggcatctatc gtggtagaac cgctgaggtg agaagtcacg
     7381 tcggtccaga tctgagggtc gattttggga gatccatggt gcattgcgtc cactgcagcc
     7441 tgccgaatgc gaagccgctc attctcactt gatggtgctc cgtcgaataa ctctgtggag
     7501 cttgtcgtgt tcagagacga acacgcagct ttgtcttcgt ggctcatcgc ctggtcgcct
     7561 tcttctggag ccatgcgtga tgtggctgac aactgggttc ggatgaaaac ttggataatg
     7621 tttcaaaaga gtatccctgt atggggtgca attgcctaac taattgtgaa atttttgtac
     7681 tgggaaatta ccctctgtct gatcatcttc caattatttt tattccgtat gccttgcgtc
     7741 tgagctataa cagttcgacc aatgacggca ctagcatgac tagtaaattc tttaactcgg
     7801 gtgacattcc cccaatgctt gtctatgatt gcagagtatt gaaggctcgg tgaatgggga
     7861 agcataaaga agatactcca tagtaagccc aacctgtact caacccaaca tatattgatg
     7921 attcaaattt ggaactaatc gattcccaaa gctgccatgg ctatgtatgc tttagggcaa
     7981 gcaattattt gagccataat aaaaatgaga caacaaacta atcactttca gcctacggat
     8041 tactccatat agagtcagac ccaagcaaga tatatattta gcacgataaa gcaaggacta
     8101 tgctatcccc acggactctt tcttccctgg cacgggtgta gactaggcat tatctaacct
     8161 aggaaataaa taaacattca tgaatgcaag atgccaatgt cacattccga tgtgcctagc
     8221 atgaaataat tgactcgtat taaaatataa attagaaata aattaaacat ccgaaaagaa
     8281 aaccttaaac aaatcaacaa atcagcgaaa taccgtatgg agtacgtact ccgtacggca
     8341 gggcgaacta gaattcgaga gaataccaat tgataccact ccaaagaatg aaatgacaac
     8401 ttaagcgtac catacatact ccgtacatat gtatgtaata tatttattga gtgtagttaa
     8461 aaaagtctga tgcctcagaa gtttgtcggg ggttccgtcc catagtctat cttcatcagc
     8521 cagccacccc cgagaaggtg agccctggat atctgtatat tcgccataag gtgctgatcc
     8581 attgaagatc ccgcagctgg gtggatattg cgtgcagaat cgctgtgtct tcagctttag
     8641 agtcaaacag caagggagag acactgctat atcgggttat ctatcatcta tggtgagtcc
     8701 gtacatgctt ttggttcaga tattgtatgc aggtcgtatc ggtatttgtt tttctaaacc
     8761 ctcggttttc cattataacc ttgatgtgcc tcgatggaca aggttccttc ttgacactga
     8821 aacctgttca acatcaggta ccaacttggg agtatctgcc tgtcttcgct ttgtcttatt
     8881 cctcacaata atcttgcttt acatattcaa cttgccatgg ccgaaccacc caaaaccccg
     8941 ggtcggcccg tctgtgttgt tttcggcccc cagagttccg agattgatga aactttattt
     9001 tacatcagcc gcaacatcga cgaaaatcca tcgttgggat tcctcaagga tgtcttgcaa
     9061 gaactaccgt cgctatggtc gcccattaca gatgcttggt cctctttatc ctcaatccct
     9121 ggagcgacac aacttacagt gcttgctgaa tgtgttcagg ggacgacagc tgctcccaaa
     9181 agtgcaatga atgtgttcat gacgcctctt actgttattc gacagataat cgatgtgtgg
     9241 aaattcaaag aagagtccca gaacaggtgc agaatcgtgg atgcccaggg gttttgtgtc
     9301 ggcttcttag cggcggtcgc agtcgctagc tcgaatgatt ccaacgaatt tgaggacatc
     9361 gcatccacta tgatccgatt ggcagtttgc attggagcag cagttgacct ggatggcatc
     9421 ttgcatggtc cggcccgatc tgttgctttg agatggaagt cggatagtga gaaagaacaa
     9481 ctcgatcgag tgttgggtag ctcttcaacg gtgcgtaaca tatccacccc gccaataatc
     9541 ccatgttatt ctacttcaaa ttatcttccc tctgcttaat agtgggttac gaggttgtgg
     9601 gagtatcaac gggggggaca catattgata tgggtatcat gtgacttgat attgggccga
     9661 ggatccacat acgtgatgaa cggataatct aatatcgaca acacataggc ctacatctcc
     9721 tgctttacgg atgcaacctc agtcacagtc acagtcgcgg aagatgaagt ggatgatttg
     9781 accaaggagc taggaggtca tggattgtcg gtgaaaatca ttgacctgaa gggaagattt
     9841 catcattcga gacatgtcac agctgttcaa taccttgcag atctttgtga gacagatgcc
     9901 aggttcaggt tagcaaggac tagtccctgt gttcttccac tgaggtctaa tgtcgatggc
     9961 catgtgattg ggaaacgatt tgccattcac aaaactgccc tagaatcaat cctgaccaag
    10021 ccatcacagt gggctataac tgtttcagcc gcatttgagc aagcgagaga gacagatgac
    10081 gatttagcct tcgtggtcat tggaactggc cagtttgttc cacgtctagt cagaacccgc
    10141 gttctagatc acttgaacaa caagtggtca gacacaaaac aacatgcaat tctgccaaat
    10201 ggaatccaca gatcatcttc cacaactcga tcgaggcctt caattgatat ggcccctatc
    10261 ggcccgacag tgatcccaat tgccatcact ggcatggggt gccgatatgc ccaagcggat
    10321 tctccagagc aactatggga gatgctcgag ctggggcggt gtggtgtcaa cgcacttccc
    10381 aacgagcgat tcaagatgga aaaccttctt cgcgagccaa aagggccatt ctggggaaac
    10441 tatctagcta atccagatgt gtttgatcat cgcttctttg gaatttcggc ccgagaagcg
    10501 gaggctatgg acccccagca acgactactc cttcaggtag ggtatgaggc tatggagtca
    10561 gctggatatt gtggtcttcg cacctccaat atcccaaccg acgtcggttg ttatgttggt
    10621 gtcggctcgg acgactatac tgacaatgtt ggatcaagca acgcgaacgc cttttcagct
    10681 acaggaacac tccaggcgtt ctgtactggc cgtcttagtc actatttcgg gtggactggg
    10741 ccatcggtgg tggttgacac cgcatgctcc tcagctgcgg tgtctattca tcttgcatgc
    10801 aaggtaagat tccatattca attctactcc tcaaaccacg atattctcgg acgacgaaga
    10861 agtgactgac tcggtgatct ggtaacaaac tgcaggcact tcaaactaat gaatgttcta
    10921 ttgccgtggc gggcggcgta aatgtcatga ccagccccag agtgacacaa aatctggcgg
    10981 cagcctcctt tctctcacct actggtgctt ccaaggcctt cgatgcgagt gccgatggtt
    11041 attgtcgtgg agagggggcg gggctggtcg ttctacgacc cttgaaagac gcaattcata
    11101 acggagaccc cattcttgcc atcattggtg ggtcggcggt caatcagggg tccaaccgct
    11161 ctccaatcac tgtcccagac tcggattccc agatatccct ttatcggaag gccctcgtga
    11221 catctggggt tcgtccagaa gacgtcactt atgttgaggc gcatggcaca ggtttgtcaa
    11281 gccacactaa caatttgaga tatattcact aatacaaata acaaggcaca caagtaggtg
    11341 acccaattga atttgagagc atccgcaaaa cgtttggaag acctgcgcgc accgaaaggc
    11401 tttatgtcgg atctgtcaaa gataacatcg gccacactga aacctcttca ggtgtagctg
    11461 gcctactaaa gactgtcctg atgatgcaga aacaccagat accgaagcag gccaatttcg
    11521 ttcaactgaa ccccaagatt cccacattgg acgatgcagc aatcgcaatt ccaaccaagt
    11581 ctatccactg gccctccgct gctaattcat cttcgactgc tgtggcgatg gtgaccaatt
    11641 acggagctgc aggaagcaac gcggctcttg ttgtgaaaca atacaaagca aaatctggcc
    11701 tttcgaatcc agtttctccc ctccctagtg aggtgcccgt tattctagca gccaacaccg
    11761 ttgaatcact cagatcatac tgcaaagctc tgctttcaag cgtctgcgat gcacaactga
    11821 ccagttgtca agacacagcc tataacttgg caatcaagca gagcagagac atggactacg
    11881 tttcagcatt cagcattcct gtagatcgac ccaacgagct tattgcgaag cttgagtcaa
    11941 tatcacgtga gactacaaat cttgagaaac aaccggcggc ccgtctgccc gtcgtcttgt
    12001 gctttggtgg gcaaaatggg aacgaagcaa ccatttccga agacctgttt aatcagtgtg
    12061 aactgcttca atatcacttg gtaagccttg gaaatatctc gatttctcaa tgttttgttt
    12121 gctaacagtc catctgcgct gtcttagacg gaatgtgaaa aagtttgtca aactcttgac
    12181 cttccgagcc tctttccgag tatcttccaa cctggcccaa ttgaagatac cgtcagcctt
    12241 cactgcattt tgttctcaat ccaatatgca tcagcaaagt catggataga ttccggactg
    12301 caagtggacc gaattatagg ccatagcttt ggtcaactta ctggactctg tgtcggtggc
    12361 gggttgagcc tttcggatgc tctttatctt gtctcggagc gagccaagat gatccacagc
    12421 atgtggggct ctgagcgtgg agctatgctc ctagtggagg gttcagaggt ggaggtacag
    12481 ggtttgctga atcgtgcagc agagcatatg gcagatgtgg cagtggatgt ggcttgtgtc
    12541 aacggcccac gtaataccat attggcggga gacgagcgat ccctacaaat gattgagaaa
    12601 ctgtcggcga aagccccctc catccttcgc acaaagagat tgaagaacac acatgctttc
    12661 cattcccgcc tggtcgataa cattgttcct cccctgacca aggtagccca gcagcttcaa
    12721 tacaagccat tgtctatccc tattgaggct tgttctcagt atgatgactg gacttatgtt
    12781 accccaggca agattgtgga tcacagccgc agacgagttg acttccagac agccgttgag
    12841 cgggtggccc agaggattca aggccctgct atctggctgg aggcgggatc cgcatctccc
    12901 atcatcccgt tggtacgacg ggttatcgat acagtggcag ccttttcaaa tgggcatgtc
    12961 taccaggcgc tcgacttggg aggcgcactg gcccacagaa gcctttcaca ggctacgtgc
    13021 aacctttggt ctagaggtgt gaaggtacag ttctggcagt tccacgattc ccaagccaag
    13081 agctacaact ggatcaacct cccaccttac cagtttgctc aaacacgtca ctggattgga
    13141 tacgacccaa atgccttcgc gtcgttgcct gaagtcaagc caactgtgcc ttcttctgat
    13201 gccccgaaag agtttgtgca gctgctcaca aagcagccga ccgagtgtgt gtttgccatt
    13261 aatacgaatg accctcttta tcaggagtgt acacaaggcc atgcagtact tgatcaaaac
    13321 ctctgccctg cctctctcta ctttgagatt attgttcgag cggcgggact gattcgccca
    13381 gaaaacgata tatcaccagc catgcctcac ctgaaagacc ttgccatttc ggctccgctt
    13441 gtgctcaacc ctaggggaaa tgttatgttg agtcttactc gcgcccgggt gggtgactcc
    13501 acatggtcat tctccctctt cactcgtgag tccaacaaga ataaagtcac cacacatgca
    13561 accggtgaga tcagcttgca ccccttcggc cagaatacac ctctcttcgt tcgacttcac
    13621 tccatgaacc gattgattga ttcttctcga gtggactcca tcgccaattc acgagagtcg
    13681 agcggtctta aaggattcgc cgtatatcaa gccttccgca gagttgtcaa ttacgctgat
    13741 tattatcgtg gcgttgaaca agtgttcgcg actgatcatg aggccgctgg aatcgtgaac
    13801 cttccctcgt cccggacaaa ggacgcgtca tgtgatccaa tgctcgtcga caatttcatt
    13861 caagtcgctg gaatccacgt caactgtctt tcggagacaa aagaagatga ggtttttgtt
    13921 tgcactgggg ttggggaaat attgattgga gaggctttca tgacccggga tcccaattgc
    13981 tcgcgttcgt gggctgtata ctctaacgtg gaccgatcta tcaagaataa gatcacttgt
    14041 gatacgtttg tcctagatcg ggagaccgat aaacttgctg tcaccattct ttcggcaaca
    14101 tttaccagtg tctccatcgc cggtctttcc cgggtactca agaaattgaa caatcaaccc
    14161 gacgacaaaa aagtgcctct aggccagtct cttcgcgatg actccaaggt tgcactcaat
    14221 cctacccctc agaatgcact agccgctgtt ccggctcctc tccactctgc cccggatagt
    14281 ggacacttta tggtcgtcca ggagatgctc tgtgatctat taggaattgc ctccgatgag
    14341 ttgttgccat catcgaatct cgaagacatt ggtgttgatt cgttgatgcg aactgaggtt
    14401 ttggtggaga taaagaagag attcaatttc accattgaca cttcctcctt cgttgagatc
    14461 cccgatatcc taacgctggt gcagacaatt ttccccgatg ccgcaactgc tcctctcaca
    14521 aatggagttc acccgtcatt gcaaatcgag actacagaag cagttgactc ggagagcaat
    14581 acccatgtta tcccaacccc aatttccgat gaagaaatac atggcctcat tgacattgca
    14641 ccgggccttt tcactgatat tcagagaagt atggtgcaca gtcaatctac ccaatgggac
    14701 gggttttgtg aatccgtata tcccagacag atggcccttg tcacagctta tgtggtagag
    14761 gctttcaaat ccctcggtgt ctccctggag agctttgagg ctgagcatct tatcccacag
    14821 gtgccggttc ttcaacagca tagcaaggtt cgaagccagc tttattccat cttgcagttt
    14881 tccaatctca tccgggctac tgaccatggc tttgtgcgaa cttcggttcc cgtatccacc
    14941 atttcgtccg atgtattgca cgaggaaatt attcgcctct atccccagca tacatctgaa
    15001 cacaatctgc tgaggacaac gggctcgcga ctcagtgact gcttaagcgg agccgccgac
    15061 ccactttctc ttctctttca agatgcagag gctcgtcgac tgatggagga tgtatacacg
    15121 aacgctccaa tgttcaaggc tgcaactaac cacctagccc aatatcttgt caacctcctt
    15181 ggccgcgtgg ataccaccag agaaattaag attctcgaga ttggaggtgg cactgggggc
    15241 acaaccaaag ctttgttaag tcagctgact gccgttcctg gtcttcgttt ccaatacaca
    15301 ttcacggacc tatcctcggg gctcctggct ctggcacgca agaagttcaa gcattacagc
    15361 ttcatgaaat accaagtcct caacattgaa cgggctccta ccccagacat gctcggtcaa
    15421 tatgatatcg tcctatccag caactgtgtg cacgcaaccc gcagtctcgt tcaatcgtgt
    15481 tccaatatca acaagcttct acggccagac gggcttcttt gcctaatcga gctcacacgc
    15541 aacttattct ggtttgatct tgtcttcggt ctgctggagg gctggtggct ctttgaggat
    15601 ggtcggcaac acgcccttgc gaccgaacac gtgtggaaac aaactctttc ccaatcgggt
    15661 ttccaatggg tggactggac atacaatgac tcccaagaat ccaatgtgct tcgggtgatc
    15721 actgcgtcac caacctcggc tgtcatttta cccccgtccc ccaggagccc cttatatctc
    15781 atgaacgaag agactattgt gtacggcaag aacgatggcg tggagctctc tgcagacatt
    15841 tactatcctc gggatcttca gcctattgga aaaccccgtc caattggtat gtagacgaac
    15901 ttgttcccag tcctctttcc tcgaaccgtg acaaccctcc ttcttacact cgacaaacag
    15961 ctcttcttat ccatggcggc gggcatatta tgctctcgcg ccgggacatc cgcagcaagc
    16021 aagtcagaat gctcttgaat gcgggattct tgccagtcag tgttgattac cgactctgcc
    16081 cagaggtttc cctgaccgaa ggcccaatgc atgatgtatg cgatgctctt tgttgggctc
    16141 gccatgtcct gcccagttta actcttggtc gtcctgatat ccaaccagac ggaactcaag
    16201 cggtagcggt tggctggtct actggtgccc atctggccat gacattggct tggacttctc
    16261 agcagagggg catagccccg cctaacgcta tcctcgcatt ctacggccca acagactatg
    16321 aagactcttt ttggtcccag cccaatttcc cttacggaaa gaatgccgcc tcgccagaaa
    16381 tgcgatacga cctgtgggaa ggcatatatg agacgccaat cactgcctac aatcctccgg
    16441 tcgaccaaaa ggcccttgga ggctggatgt caccggcgga tcctcgcagc cgaattgcgt
    16501 tgcacatgaa ctggaaagga caaagcctgc ctatgttgct tcacggcggc cgcttctggt
    16561 cggatcataa agatggcgac tgtggagagg agttgcccgt tccgacactt gaggaaatcc
    16621 aagcagtgag ccctctggca cagattcgca atgggcatta caagacgccc actttcatca
    16681 tacacggaac ccttgatgat ctcattccag tggaacaggc ccaaaggaca tcacaggagc
    16741 tggttacgaa gggcgttgag gtacaactcc gagttgtgga taaggcagta cacctgtttg
    16801 acatttatcc tggttttgaa aaagaccagg cagcttctcg ggctgttgaa gatggttatg
    16861 agtttttgcg tgatcatgtt cgatattagt cgatcggcac tctcgatgtt taattgtatc
    16921 ttaattctac ctggtgataa tcatcacatt aatataagaa tgaacctttc ggatgctctt
    16981 acaatgtctt tctgtatcaa tctagcttta gtatcagtcc tcttcctatg atcatgttca
    17041 tacaggtatc acttatggta tatattttga ccacagcggc gtcccccata tattctgcca
    17101 ccactacatg cattctggtt tacatagtaa aaaacatgta ttttgatcag aaaaattcgt
    17161 atattctacc tgattactat aggatttcat cccttgacgg taaagcggct gatgaaattt
    17221 tgctattggt ttacatataa cttgtaggta tctgctgtct tgctactatt atatggggag
    17281 tcaaggccag aaggcggtgt gggcaggtgt cgaggcagaa aatgtgccca attaggaagg
    17341 tgaaactgaa atttcaggca gagaggggtc gatctacagt agccggggat cgctgtagcc
    17401 ctccccgatc ttttaacgca agtcttgaag tcagagggaa agatccccta atgggcatgg
    17461 tatttttgat ctagtaaccc ttcgttttga atttcaatcg agatatgaac tgtcacaaca
    17521 tcacaataat ctaccattgt actcgattag tccgaccata tcatcttcaa ccaccggacc
    17581 tcatcggtta ctctcttgcg ataccgctct ctaggctgac ttccagtggg gtccagccaa
    17641 gctgtccaaa agtctcacga agcaatttct cggctcttgc tgctgggacg acatctccga
    17701 gcgtcggttc ctcttgtata ggagcagctg gaatacgagc attattgggt tggattcttt
    17761 tgagaatttc aatgacatcc ccccatgtga atggagctgc agtagcgaag agtcgctcgg
    17821 agcgcacgct aggattgagc agagctatgg cgtggagacg agcagtgtct tccacatcca
    17881 caaaccaagc tagcaaagta ctttagtcaa taataggtct gtcaatttga tttggaatac
    17941 taacgcagtg gaaggaattt gaatggcgtg gtatctcctc tgagtagtcc agagacatat
    18001 cccatggttg aaccaccgat gttcggatga agaattttgc ccaacttcga aagaatccgt
    18061 ggttagttca acttttgacg tcgtatataa acatatgatt ctcgataaga ctcactgtaa
    18121 gccatggaag aacggaattg agctcaaagt gtggttggtt cttctcaacc catttccacg
    18181 cttgtctctc tccttcgatc ttacatgctc gatagatggg tacagtggtt ccatctttag
    18241 atgcctgttc gaggctttca tcccatgaat ctatatagat tctgtcagcc taggtttgtt
    18301 atctattgac agttgcctta ccagcatcta acttgaaccc ttttccggta gggtagcctg
    18361 ccgctacgat agaagaagtg aggacaactc gctgaattgt gcgttgtgta gatgcagcct
    18421 tgaaaagatt gatgactcca ttcacagtat aagctgttgc gcttttcacg gtttctgcag
    18481 cagtgctaga aggtaagcct tgagcctaga catctatttg gttaacacat attgttgtca
    18541 gaaccactag taccaaagaa acatacaaca tgaatgactc ccgatacacc cttcacgctc
    18601 tcatcaaaag catcgggctg ctgaaagtcc gaaacaacaa tgagttcgaa acgtcctaaa
    18661 ccgcactgtc tctcgaaata ctccgccagc catggcatag gcgtgcgtac cgtgcctcga
    18721 accagataac caagatctaa tagagccttg acgatgtgcg aggcaatgta gccattcgct
    18781 ccagtaacga ggactttaga gcctggtgga atgacatagt tctgagcctg cgtcattctg
    18841 ttgttcaaga agctttctcg gatactggga tttgcttgaa actcgtagta aattgctcat
    18901 gccaccttca actgtgccac aaagactccc acgatcgaaa acagcggtca gatagatagt
    18961 tgaccaaata tacaatgcgg tctttgccgt attattacga ctagtaatta gggcccagaa
    19021 tacctcccac aggggccgag gccaaaacac gatctatcaa ctgagctaat ttttggagct
    19081 ctgcagtcca acgtgcatta acgcgcagtc cttaaatcat gtggctgagc tgagtaactt
    19141 tgttcttttg gtgtgtcaca atgtgtattg ctttttcctt gttgatcttg agatcgacac
    19201 aaagagctcc actgctccgc atgttgcaga aggtggcttt attgcatgca agataagcac
    19261 cataacatag agttatagag gcgtgttgca tctggtcccc ttgcctcgta tagtcacatt
    19321 tctagtcagt ctgtgaatga tgttcaggat acacgtgatg atcatagatt tctctgtcat
    19381 atgcggggcc aagaaataat ttgaagacac ggcctggata aggtactgca aaggttagtg
    19441 ggtgtaaacc tagagactgc actcaaagac tgtttccagg gtctactttt acctcccaat
    19501 cgaattggac tgtcatttct ctttttcttc tgttgctcat tataccaaag ttatgtcgct
    19561 gcttcaagac attgtaatgc cccagctgct aacatctctc atcgtccaaa tttcttacta
    19621 attgcgttct aggttgtgat aatcaccggt agcgcctctg gaattggact ggcaacagcc
    19681 acagcagctc taagccaagg ggcgagaatt ctaggtgttg atgtctcatc agcacctgtc
    19741 tcactcaatg aacatccaaa ttacaaattc atgcaaggtg atctcaccca tgagacgaca
    19801 ccaaggcagg tggtagagac ctgtatcaaa gagtttggtg gacgaatcga tggtctgctc
    19861 aacattgctg gtatcatgga ccagaattcc agcgttgata gtctctcaga ttatatgtgg
    19921 gaacgatgca ttgcagtcaa tttgacagct ccagtgaagc tcatgcgtga ggttattcct
    19981 attatgcgac agcaacagag tggtagtatt gtcaacgtcg gcagcaaggc agctacgagt
    20041 ggtgcttcgt ccggcgttgc ttacacagct agtgagtata tccatatgaa tcgaggtatg
    20101 catcagcata gtgacagacc tactttccag gtaaacatgg gctgatgggc gcaaccaaaa
    20161 atgttgcatg gaggtacaaa caagagggaa ttcgctgcaa tgccgtttgt cccgggggta
    20221 cgtggaccaa catatgctat taagatcaaa tttgtgttag aagcttatga tttacactag
    20281 gagttccaac cggtatagta caggcctctg acccaagcac ttgggacaag gatgcactag
    20341 gaacaatgtc tctaattcac caggcacatg ctgctgatag gcagaaagga ctgggggttg
    20401 aggctgagga tattgccgac tgtcttctat tcctgatctc tagtcagagc aagagaatta
    20461 acggggcaat cattcccatc gacaacgcct ggtctgtgat ctaactggag attcgttttg
    20521 aattttggat tcggtaacgg gaggaaagct gaatgaacca aacgttgggc ttgaaatctt
    20581 aataaaattc aattgaaaat ttacttctcg atatatatga agactgcgaa agtgtatagc
    20641 gctagtcagg tattaagtct cgagttcttg atccaatctg tgtgccattg ttcacctaac
    20701 ccacctgagt cacgtgaaat ctccaccggt tggttgaact tccaaggttg cttatcagtg
    20761 attacttaat ggtcttgaga atacgcatca taaataccgg aggcttaatt acatttagat
    20821 ctttttaagg cgttattaga cagatatact gtactacata ttctatggat gcatagaata
    20881 atatactatt agcgtttcat taaggtgtta tcccttcctg attccactgg atggttaatg
    20941 agaggtgttg acgagaaatg actggtggaa agttggtatt ggtgaggtat tggtgaggct
    21001 taaaaccaaa ttacagaagt tgacccaacc ggtggagata agataggcca tcagtcacgt
    21061 gacttggggt gggccaccag ttaggtgaac aatggcacac acgttggata aactgtcgtc
    21121 tccccgttac cttcgcaagt agagaaccat caaagtcatc tagttacgca ggcaatattc
    21181 aatcacaaat ccaaacaacc aaaacaaagt agcaaggaag aaagcggact tggcgtagga
    21241 ttcaactcca tacgagttcc ctacccgagt cgctttaagg agaacccaga acccgcagaa
    21301 atgaccgccg acagacacca cgaaaaatga caggccaagt ccagtgaaga atcctgccat
    21361 cgcgaggaat ccggtggatg cataaaggag agaatatgac aggagctcga tggactccct
    21421 gaaacggacc gccatgctct tcacgccgac cttcaagtcc tcctccgtat cctggcgcga
    21481 ataaattaca tcaatcatga tgatgaccaa tccaataaac aggaacatgc acacagttgg
    21541 tttcatctgg gatagaggat ctaatccgag actgtgcatt gccatcggaa tggcccatcc
    21601 gatgttcacc aaagtgatct ggggatagtc ggtgaatcgc ttgccgaagg ggtacaataa
    21661 tgcaaaaaat gtgattataa ggcaatccac ggcgcagggc catggaagat atatcaaaac
    21721 actgccccca caggcgaaga gagtcacagt gagaaggaaa gcgttcttcg gggatactgc
    21781 gcctcgtggc agtggtcggg ttctggttcg agatatctgg ctatccaagt ccatatcgat
    21841 aagatcatcc caaacacacc cagcacttcg aaggaaaata gaccagatgg atagaagtat
    21901 ggtgcggtgc aagagaacag tgattggtat ctttgtgggt gagatggatg cgcaaaaggc
    21961 aacacccaca agataagggg atgtattcag gtaaaagccc aacagtcgat gaacacgcat
    22021 caactcggca tagggtgcta ttccagtggg aaacgagcca aggattttgg cctgtggtgg
    22081 ggcttcttct ttttcattcc ctcgtgtcat cgtggcatat gaaaatggaa ttcggggatg
    22141 aggacttcag cgaatactga accactgtgc gaaatgggcg aaatgcagag gcaacaatgg
    22201 tgtagatatg tagtgaaggc gtatcgacag ccaaatatta aatgataaag gggacagtag
    22261 agaaagaagt ttatgaatta tatcggtaaa ggtcacttca ggtatcagat aagtcaaatc
    22321 gaagtggaaa gtattcaagg acacatctgt aaaagtctaa caacaagagc atccctttcg
    22381 ccatcgagat cattccttgg gccctctttg gctccactga ttgcatggcc agctaattct
    22441 tattccattt gagcgagctt ttgttggctg gttacagatg catggatcta ctgcattagc
    22501 tcgattattc catactatat ttataaaact agatttatat gcacaccccc ttgtgtaatt
    22561 atgtggtgtt cagctagcct gccttgcgcc tttgccttcg tcgatcaatt tatgataatg
    22621 atactagtca ggcccactag tatttttaga ataattcgaa agcgaataat ctcatcgggt
    22681 tgatgatcga cacccgatac ttgaattatc tttgtactga cactgtcaca tatgaaacac
    22741 aaatacacaa gttccttcac aaagatctgc aaaaatgttt tctgctgaga agtattcacc
    22801 agaaggtggc cgaaggcaga tatgatctaa gccaaggtaa aaacaagaat aagaccagag
    22861 aggaaaccca gagtagcgtc cactgctgct gaggccttcc ttggcctttg ggaagacgtg
    22921 tcacacaccc agtctcaagc ctgtgcggcc gcggaagaaa atcaataacg ttcccccctg
    22981 ccagagtctt ggatgtccgg ttctctatga ggccaccaac gtattggaac acatatcggc
    23041 ccaccagagc cttaagccag ttgtctcgag tatggaatcg agcgccaaat ctcgagcgtt
    23101 cgtatgtgct tttcgcacgt tcgtatcgga gagtcttgta tttttggagc attgtctcga
    23161 tgcagctttc tgatggtttg tgcaaggcat ctgcgtgaac tacccgattt atcagagatg
    23221 caaggacggc aacatcttca atagctgtgt ttgcgccttg tccgatattg ggtgtcatct
    23281 ggcgaagagg aaacattgtt agatcattgg aaatccagtt catccaggat agctggcaga
    23341 tctcaccttg tgtacgctat ccccaaggat gactattcga ttcaagctcc acgtttcaaa
    23401 aagcccctcc tcgagtgccg tcattgacga taccagcttg gtcttccaga ggtcccctac
    23461 ggtgatatcc cgccatatga tcacgtcttg aatcttgtca cacagctccg ctgcatcatt
    23521 aggagaatac cgaggagcgt taggataggt gtaaacgcgg tccaattttt ggataatgaa
    23581 ccaaaacaca cgaccatcct ttccgtggaa ggtaatcaca cagaatttgt cgccgtaatg
    23641 gtttatatgc tctccgcttc ggagtccggg tattgctcgt gatattccga acacacatgc
    23701 gtattcaacc gtaagagcta acgggaagaa attcaggagt cagttgaagt ctccaaagta
    23761 atcaatttcc gaagaggacg atgttgccta ctttgccttt cttggggtgt gatcattcct
    23821 gggtgtagtt catctgccag tcgccacatt tcagagcgta tacggctgtg gacaccatcc
    23881 gcgccgacaa tcaggtctcc ttggaataca cttccatcct ctgttaccac actggcactg
    23941 tcgcccaata accgcacttc ggatactctc tggttggtaa tgattttttc cttgtttgga
    24001 tagttctgaa ataatatttc aagaaccttt tgccggtcga gtgagacgat ggggtactta
    24061 aatctacgtt tgagtagtca gaatttgttt gatatctggg tttcagagac attgggaagc
    24121 aacatttcat gaattgtctt tggcaggaga ctgctaaatg agtatccgtc ggggaaggaa
    24181 agatgcatgc gacttagtgg tgcagtgagc ttttccagac tgtggtagag accaagttga
    24241 tcgagtatct gtgctccatt aggccagact ccaataaagg caccttcctg gggagcaatg
    24301 ctagctctct tttcgagaac gacgtggtcg atattggctt gggacaaaga atgggctaat
    24361 gtcaacccag cgatagaccc cccaacaatg atgactttga acttgggagc ttccatgcct
    24421 tcctccatgt ctgcatttag aaaaagacaa atctttctag tgctacatat aatgatgttg
    24481 ttggcggtga agaatgtcgg agataaatga agttacgaaa cagggacgtg taccgcttca
    24541 cttgataggt acaatgcaag ttattgttgg ctttccccct tgatgatcaa tatgccttgc
    24601 tatgtgcggt tttcctattt cctttttcct ttttgggttc gtcccttttt tatctataaa
    24661 atgttccaat gcgcgcaatc ctcgctcctt gcagatactt gttttttttt ataggatttt
    24721 attgatgtat tgtgacactt cttgagcttc gtaaatatgt gatttcatgc taaatacata
    24781 gaccggagat gtaagacttt tgaacgcaac ccaactttca tccttgccga accacctagc
    24841 attataccgt actcctcaca gaacaacttg tcatccagct atcatgcttc atgatggctt
    24901 ttcctatttg ctcttctcct ttttctcctt ctgagcattg gccaactcct gacgctgaat
    24961 gacatagtaa cagatcggat aggtgaaatc aagaaccaag gtcaacccga tatagaactt
    25021 gcacattggg ctttcaaacc aaggtcctgc agcatttcca gtgaggtaat agatagtcaa
    25081 cttaatgaat ccaccaaaag tagcaatcgc tctcaatagc cttttatcat gtcaatgacg
    25141 aatgcaaaca gctgatctag ctttgaactt accaagtcaa tagggaagca ccgcgggtac
    25201 tattccgaga aagaatctga gcaattggcc ccaggcttgc cagcgtttga cacagcacac
    25261 ccccgtagaa aaatcccaag tcaggcccaa cctctcgcgc aaacgaatat tggccgatgg
    25321 cgaagccaat agtcactact ccatatagga agtaaaggtt ccgttgaatg aggggaaagt
    25381 ggtcccactc attgtgcgca tatttgatga tgaagatgat gacgatgcaa tgaaccaaaa
    25441 accagactcg gactcctcct tcccaatgag cgctcgcggt tgggtagata aaggcatata
    25501 tgaattccca cccaatgtca ttgcagagag gaaagatacc tgtgctggga atcttgtctt
    25561 ttcgcgacgt gcgcaacatg ctgaagtagt ttaaagtcca gcaaattcca gccagaattc
    25621 ggagaaattc tgcgacagat gccaaggcat ctctatgatc caatattgct gagagcaggc
    25681 tcgattcctc cattgttggt gctttgtgta gaggatctca gatgagcagt tttgtcaaca
    25741 gaatttcgaa aatgagaacg agtgtgtctt caggtgcagg atatggttct actttcggtg
    25801 atatccgatg ccaacgcatg ctaatgcaag gactgatccg atctacaagt ctactaagtc
    25861 gtcatgtaat tagagttgat acggacttta aacgtactat tttacatatc aatggatcgt
    25921 cactgcacct gctatgtaaa tagctgtatc acatttcagg tatgcacaca cacataacat
    25981 accgtatagc cgtatttgat tatgggtcta gtccgtcccg tgcggcccga gacgggatct
    26041 cacgctaaaa caatttcgtt tcggttttcg agtattttag ttgtatgtgt atttatgtac
    26101 tccgtataga acatatctca cgctctgtat tttatatcgg gataatgtgc ttaaccaata
    26161 cattactctt acaggaaagg caagtatcgc aaccttggaa atacaaatcc aagagattaa
    26221 attcaagtca ccgtacaccg atataaaaaa acatcacatg aatatagctc attaattgtg
    26281 atactttgaa tacaacctag ctcgacccca atttgtgcaa ttgtttttcg atatgcgtcc
    26341 atgcatcggt tcgtagaaca ccggttaacc accaattccc gccagcatcc tttcctataa
    26401 ctgaaagaac gttgcgaaat gaatttgcgg agtgctgaac tccattcaca tagcatggct
    26461 ttcctgtatg ttgagggttc tgcaggctcg acggacccga gctttgtaac acggccgacg
    26521 agaagtctat gtcaaagaga cgggccttgt gccagttgga gcaagatagc agcatcatcc
    26581 gaggatcgcc gaccaaggcc agatagcctg tctgttccat cgtctgcatt tgaagtgctg
    26641 tcatcgcctc gacctgctct ggggttcgct gttccgttac agattctcga atccggagag
    26701 caatttggcc taacggctcg tcggcaacct gatggccgcg tagaaaggtc ggcgacatgc
    26761 acagtgcatt tcccatgtat gcactattgt tggacgtaaa ggattcatgc aaagatgtcc
    26821 gcaggtttag cgcattgttc actaggatag tttggtccgt cctgagcccc agcgcgctgt
    26881 aaagactccg cacccaccat cccaacagca catcgctttc actcacaaag ggcactggct
    26941 cttctttccc gcgtgaagcg cagatctcac tggatgattg ctggcagagg ttccgcaaac
    27001 tggcggcggg aatacaaatg gtacgccgct cctcctggcg gtaccacagt ctgtcaagaa
    27061 cattcaatcc gataaaccac cagaactctt tgcggccaaa cacacggttg aaatgcatgt
    27121 atttttccgc tggggtgcgc tggccgagtt ctgtgagcgg gtctagtcgg aaaccttgta
    27181 gcttgggaac cgcctctctg ttccctcgaa gtagagcagt ccacgcattc aaaattaatg
    27241 ccattcccat aacatccgtc agtgtgtgta gccatgtgac agtaattagt gtggcgtcac
    27301 tgaaggtgat gatatgtata gatagttggg gccggtctga acagatccag tcatcaatat
    27361 ttttgggtgc gtcttcgctg cgtaataaag ggcttaacac atcaggtgat ggaaagatgg
    27421 caggcgtgct ggttgcatgt ggtattctgg cgccaagggg gtggtcggca atgcttgtct
    27481 cgtgctgagc attggtcatg gcgaaagccg gccgcgaggc gtcgaaacgc gttggaatat
    27541 gatattcaag tcttccattt ggctatcagg tcgttccggg tcagcattaa gcgtgtaaat
    27601 cggaggccgg tctcaaacca cccacgttca tacgcaatcg agcacccagc tgtctccaat
    27661 ctttcatctc gagcagttcc tcgagcgcac tgcgcagttt tgatgtatcc aacacatcat
    27721 caaatttcag cgagatatcc aaaaccgtgc cgcgcataca taaagcagta ttccagaaat
    27781 ggagagggat gatctcatcg ctcggcacgg tggcaggtcg aggtggttgt gtgctagaaa
    27841 agaatcccat gattgcatca ctcttgggta aagatataac atatcaggag agagaagaag
    27901 aaccttctaa gttcaggctt tatgttgtca ctatccttat cataccgtta catggataat
    27961 acatataaac tcgtcttttt tgattgtatc gtacgtactt ggtatttaaa atagtggaac
    28021 ttcgatacat aaatacatct atccgtacgt atgcatgcat gtacaggtaa ctagtgaagg
    28081 cggcgtatta cctgttgttc aaataaaatg acaatgaaca aatatgatgc atagtcacat
    28141 acttgtcttt agttagtcct gcttaaatca gaatcaggtt gtctcgttgc cagcgttcag
    28201 ttcgccatcc ctgccgtgat cgtcaattca aattacgacg tatacaatac agccacttgc
    28261 aaatgtttca ttgtgatgta ctacagacga gcagccctac tcccggcgaa tcgatgaacc
    28321 cagcatatag atgccctcta gagggtgctt ctttgccaaa gcatcatcct gttcccagtt
    28381 gtcgactttt agctttagtc ccgtctcttc ctgcacacgc tcccacagcc ggttccaact
    28441 agccaagtca tggtaataat atggcaggcg cgcgttggtg gcgttcccta tcgcttggtc
    28501 ccgacaggcc acaacccgac acacgatgag tgaaccggcc ttcggggcaa gcaaatcaag
    28561 taccctcttg gctaccttga tttgtgtttc aaagtcaaag acatgaagga aaagggagat
    28621 atagacaatg ttgagctcgc ctgtcagctg agtaacgaga gcagatttat catcgaggac
    28681 atcggcatcg atgaaatggg acttgataaa tgagcgatcc aggaacaagt caaggccaag
    28741 ctcaaggaac tcaggacgaa ggtccgttcc atacagattt tgcgatgggg cgccgtcata
    28801 gatctgaatt tccggaatta ttctgattag ccggctctgg ttaaggtggg aaagatgcaa
    28861 tcgtcggatg ttattcattt gctcgacaca acttaccaat tgtcgcagtt cctgtccaaa
    28921 tgcacatccc aagtcaagta gtctgtctcc cttcttgaca cggtcaagca tctcaggata
    28981 acatggggac gatgcgatgc tcagctcaag gaatgaggct tgtccaatac aggcataagg
    29041 gaactaacac gtatgcaaat cagccaacaa ccctttgacc tcagaaaaga tggacttaga
    29101 ggagatctca caacttcaaa ggcacgatct ttctactgag tgtcaataaa tgttatcgtt
    29161 cacgtgtggg gttgagccac aaaccaaatc tttcacatgt tgcaaaacct tctccgctgg
    29221 aatcttgctg tattgctcga gaatcgttct cgctggctca ttgaccttcg tcaactctgt
    29281 actgtagaga ctctttgggt caaagccgtt tttgacggcg gtctcgagtt gggaatccgg
    29341 atgcatgata gatcttgata taaggaaggc cgagaggaaa ggtattggat ttcaaatatg
//
