BGC0001509: anikasin biosynthetic gene cluster from Pseudomonas fluorescens
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Location: 116,447 - 161,212 nt. (total: 44,766 nt).
This entry is originally from NCBI GenBank NZ_LVEJ01000013.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001509
Short description anikasin biosynthetic gene cluster from Pseudomonas fluorescens
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_LVEJ01000013.1
116447 - 161212
via
Compounds
  • anikasin
Species Pseudomonas fluorescens [taxonomy]
References
Chemical products information
anikasin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • A8O26_RS13955
  • WP_064118557.1
 116447 - 118405 (-) MacB family efflux pump subunit
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    • A8O26_RS13960
    • WP_064118558.1
    • macA
    		 118408 - 119556 (-) macrolide transporter subunit MacA
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      • A8O26_RS13965
      • WP_064118559.1
      		 119623 - 137451 (-) non-ribosomal peptide synthase/polyketide synthase
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        • A8O26_RS13970
        • WP_064118560.1
        		 137448 - 150464 (-) non-ribosomal peptide synthetase
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          • A8O26_RS13975
          • WP_064118561.1
          		 150721 - 157131 (-) non-ribosomal peptide synthetase
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            • A8O26_RS13980
            • WP_064118562.1
            		 157608 - 158402 (+) helix-turn-helix transcriptional regulator
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              • A8O26_RS13985
              • WP_064118563.1
              		 158577 - 159971 (+) efflux transporter outer membrane subunit
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                • A8O26_RS13990
                • WP_008079652.1
                		 160128 - 160733 (+) SCO family protein
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                  • A8O26_RS13995
                  • WP_064118564.1
                  		 160733 - 161212 (+) copper chaperone PCu(A)C
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                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    Unk01
                    Type
                    nrps-type1
                    Genes
                    A8O26_RS13965
                    Substrates
                    leucine (evidence: Structure-based inference, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk02
                    Type
                    nrps-type1
                    Genes
                    A8O26_RS13965
                    Substrates
                    alanine (evidence: Structure-based inference, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk03
                    Type
                    nrps-type1
                    Genes
                    A8O26_RS13965
                    Substrates
                    threonine (evidence: Structure-based inference, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk04
                    Type
                    nrps-type1
                    Genes
                    A8O26_RS13965
                    Substrates
                    leucine (evidence: Structure-based inference, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk05
                    Type
                    nrps-type1
                    Genes
                    A8O26_RS13965
                    Substrates
                    leucine (evidence: Structure-based inference, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk06
                    Type
                    nrps-type1
                    Genes
                    A8O26_RS13970
                    Substrates
                    serine (evidence: Structure-based inference, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk07
                    Type
                    nrps-type1
                    Genes
                    A8O26_RS13970
                    Substrates
                    leucine (evidence: Structure-based inference, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk08
                    Type
                    nrps-type1
                    Genes
                    A8O26_RS13970
                    Substrates
                    serine (evidence: Structure-based inference, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk09
                    Type
                    nrps-type1
                    Genes
                    A8O26_RS13970
                    Substrates
                    leucine (evidence: Structure-based inference, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk10
                    Type
                    nrps-type1
                    Genes
                    A8O26_RS13975
                    Substrates
                    isoleucine (evidence: Structure-based inference, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk11
                    Type
                    nrps-type1
                    Genes
                    A8O26_RS13975
                    Substrates
                    aspartic acid (evidence: Structure-based inference, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Annotation changelog

                    Entry version: 4

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Updated bioactivity data
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Added NRP substrate specificities
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2018-08-06
                    Submitted
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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