LOCUS       BGC0001510             14535 bp    DNA     linear   BCT 02-MAY-2017
DEFINITION  Streptomyces hygrospinosus strain ACCC40033 anisomycin gene cluster,
            complete sequence.
ACCESSION   BGC0001510
VERSION     BGC0001510
KEYWORDS    .
SOURCE      Streptomyces hygrospinosus
  ORGANISM  Streptomyces hygrospinosus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 02:10:29
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..14535
                     /db_xref="taxon:516360"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces hygrospinosus"
                     /strain="ACCC40033"
     misc_feature    1..14535
                     /note="anisomycin gene cluster"
     protocluster    1..14535
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1722:13936]"
                     /cutoff="10000"
                     /detection_rule="(Glycos_transf_1 and Alpha-amylase and
                     Aminotran_3 and DXP_synthase_N)"
                     /neighbourhood="10000"
                     /product="pyrrolidine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1723..13936
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(Glycos_transf_1 and Alpha-amylase and
                     Aminotran_3 and DXP_synthase_N)"
                     /neighbourhood="10000"
                     /product="pyrrolidine"
                     /protocluster_number="1"
     cand_cluster    1..14535
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Glycos_transf_1 and Alpha-amylase and
                     Aminotran_3 and DXP_synthase_N)"
                     /kind="single"
                     /product="pyrrolidine"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..14535
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001510"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..14535
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="pyrrolidine"
                     /region_number="1"
                     /rules="(Glycos_transf_1 and Alpha-amylase and Aminotran_3
                     and DXP_synthase_N)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             426..1571
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /note="orf1661; r"
                     /product="putative phosphotransferase"
                     /protein_id="ARE72409.1"
                     /sec_met_domain="APH (E-value: 4.3e-17, bitscore: 52.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSQERQEHNREVLSVPGDAPPGSAEWVRGVLAAAWGGPWAGLPV
                     RPLVSDGAAPLSHTAGLWHVDLPGNGHVLKVQLNPDAARQRRFYPLKERIAAHCRGLGV
                     PVPAAVPAADGATSVWCQGLVCELSPCLDGAAVAWFTPAEAQEVVRTGLDLRTALDRLP
                     PGWSEELAPIPLPRLVDEEHWPTALRDAEERLLPLAEEGEGDWHRAAASVLRETVAAGH
                     LPREADVPAVGDPVPRPAVVHSDLHHHHFVLTDGGPGGGPRVQGVLDFDNVHVGDRLLD
                     LAWLAEAAGRVADPAERRRSLTAFTRTATDRGLLRPGEERLLMPLLVAHSLPVIVDIAK
                     DILERNILSPVWLGYFDLLSPARRGEIHRLLTAPAPSAPAR"
     gene            1723..3048
                     /gene="aniQ"
     CDS             1723..3048
                     /NRPS_PKS="Domain: Aminotran_3 (31-376). E-value: 4.6e-79.
                     Score: 257.7. Matches aSDomain:
                     nrpspksdomains_aniQ_Aminotran_3.1"
                     /codon_start=1
                     /gene="aniQ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     pyrrolidine: Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 338.5;
                     E-value: 8.8e-103)"
                     /gene_kind="biosynthetic"
                     /note="orf1660"
                     /product="putative aminotransferase"
                     /protein_id="ARE72410.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.5e-81, bitscore:
                     262.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAQESAASPWPTDLSAYCFEVPHSDDSLLFSSAKGVRLTDATGR
                     SFLDAMSGVFVSCFGYDCEPIAQAVQQQLHTMPFNPPLHGANQAALDLARALVDLAPEG
                     ITAAKLVNGGSESIEAAIRLARLYHRSHGRPDKVKVLSHYHGYHGATFGSLTLTGRPDV
                     SRFGPGLPGVVHVWPPDCLEEFWGVAPDRSAALAAEMIERTIEAEGADSVAALVIEPVI
                     HLRGMAIPSADYFARLRDICDRHDILLVFDEIVTGFGRTGQPFAAQTFGVTPDLMCVGK
                     GISGGYAPLAAVLIGERIAAVLGDADGARAFAPSHTYAANPMASAAGLAAVTLFHDGDY
                     LTKVRELAQYIEPRLRQLVAGRGTLRAIGLLYGAKLADADDGGQGPIGERVARACLRRG
                     LILRGQDDWFVLAPAFVTTRAEADEALGILGEALDEVCGAAR"
     aSDomain        1816..2850
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aniQ_Aminotran_3.1"
                     /evalue="4.60E-79"
                     /label="aniQ_Aminotran_3.1"
                     /locus_tag="aniQ"
                     /protein_end="376"
                     /protein_start="31"
                     /score="257.7"
                     /tool="antismash"
                     /translation="SSAKGVRLTDATGRSFLDAMSGVFVSCFGYDCEPIAQAVQQQLHT
                     MPFNPPLHGANQAALDLARALVDLAPEGITAAKLVNGGSESIEAAIRLARLYHRSHGRP
                     DKVKVLSHYHGYHGATFGSLTLTGRPDVSRFGPGLPGVVHVWPPDCLEEFWGVAPDRSA
                     ALAAEMIERTIEAEGADSVAALVIEPVIHLRGMAIPSADYFARLRDICDRHDILLVFDE
                     IVTGFGRTGQPFAAQTFGVTPDLMCVGKGISGGYAPLAAVLIGERIAAVLGDADGARAF
                     APSHTYAANPMASAAGLAAVTLFHDGDYLTKVRELAQYIEPRLRQLVAGRGTLRAIGLL
                     YGAKL"
     gene            3045..4856
                     /gene="aniP"
     CDS             3045..4856
                     /codon_start=1
                     /gene="aniP"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     pyrrolidine: DXP_synthase_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1204:transketolase (Score: 205.2; E-value: 3.3e-62)"
                     /gene_kind="biosynthetic"
                     /note="orf1659"
                     /product="putative transketolase"
                     /protein_id="ARE72411.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 2e-09, bitscore:
                     26.8, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSALHALVQGPATAAAPRLTEPERAVVQRELDELARGGYTGPLLE
                     SLRKLAAAVPERLYDDSARVLLRMHEIAGSGNYQSNLSSLPLVRACFDLGLVPEDGPGP
                     AELIVGRGHIAPAFYAEHYVRGTFPFAPLATLHQGGLTGVVHQDLGFTNTMRYSLGVGV
                     AQAVSLAWELTRRGEDRKVVCLAGDGELQEGVVFECLRFAHEADLKNLILVVDTNDKGI
                     EPLLKPLSRGYLASYLDRVEEVDGLDTATVRDSLGALLAAPTSAALVCRTRKGDHSFKP
                     ATTAPATAPRPAKVSFANTSGAALAAYRERTGRELAVFTADMAARFGLRDKVPYTNTGL
                     AETLSLGLTLSLPEETVKVVATDAMYYMDSLSMLTEATTSVRNLLVLAGRSWGAWGGAH
                     NATNLLGQLLHTRVYEPVTAAEFAACLDRLDRHPDTTHVVSTVDAKFDPPPADCAGDVD
                     GGTWLTPPGDGPPRAAVVTFGYAGVLVAEANRDLGVPHLHCAALEPDLDARTLAQLGAC
                     EDLLTVEYNGVHGGFGERLRTTYLLPARVHGVRQDIANRVHDRQLRLHGMGPEQLDALL
                     RGLTGRPDATATTADGFEEGARATAHA"
     gene            4837..6225
                     /gene="aniO"
     CDS             4837..6225
                     /codon_start=1
                     /gene="aniO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     pyrrolidine: Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 82.5;
                     E-value: 5.9e-25)"
                     /gene_kind="biosynthetic"
                     /note="orf1658"
                     /product="glycosyl transferase"
                     /protein_id="ARE72412.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.7e-18,
                     bitscore: 56.6, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLHTHDYRAPETDGIVDGAILMHREMAELLTRRQSVAWHDLTGG
                     PGCVTAAGPGDVVYAGSGPYAFLYHHWRQRTGGRFRIVREVHTALWSGYWAQEELCAPL
                     VRPGDLVLFPTEYTRRLFVRHFPAVTEENSAVAYPMLDRLPRNGPVPAPEPGEALRIGY
                     LGALSLAKNFDQVVDVFARCHRESGGRASLVCAGKPNHPRWEADAVRTALAGQGVPPGA
                     VDLLGVLGQHRLADFFARIDVLLFPSTASRETLGRVVLEALAHGVPVVAADVGPAVELL
                     PARNLVPTVLDTTSEFTMSRVGPLGRIDEDVLTRKLLHRDYAPAAIRSAAPFQDEAFLH
                     ALAGAPDAHALEHDTTLPEALRVPARADFDPQRAVAQAERLFTDFFGHRDRAVHDALDA
                     HAAEHGSDGTAPGEWAALHDLVDRPGRNLADYRAFPRLLDALVLPPLTYRLAPQPVRAN
                     AGKE"
     gene            6231..7058
                     /gene="aniN"
     CDS             6231..7058
                     /NRPS_PKS="Domain: PKS_KR (10-195). E-value: 1.5e-21.
                     Score: 69.0. Matches aSDomain:
                     nrpspksdomains_aniN_PKS_KR.1"
                     /codon_start=1
                     /gene="aniN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     204.1; E-value: 4.2e-62)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf1657"
                     /product="short-chain dehydrogenase"
                     /protein_id="ARE72413.1"
                     /sec_met_domain="adh_short (E-value: 1.1e-40, bitscore:
                     129.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFATGFADKVALVVGGGRGIGSAVVEELARRGARVVVADTDTLP
                     SQYNHYQSTQVSGYADAQKLAARLTEEGLQVTAAQADATDEDQVSRLYADLAEQAGRLD
                     VVVNAFGVTHVCPVERMELAEFQRVVSGNLDGVFLSSKHAVPLLRDSGGGAIINFSSVS
                     GRSGFAKVAHYCAGKFGVVGFTAALAQEVARDGIRVNAVCPGIVRSNMWRYLLSEFVRP
                     GETEDECWERMRSMIPQREFQTPKDLAELVVYLAGATKVTGQAISVDGGMTAP"
     aSDomain        6261..6815
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_aniN_PKS_KR.1"
                     /evalue="1.50E-21"
                     /label="aniN_PKS_KR.1"
                     /locus_tag="aniN"
                     /protein_end="195"
                     /protein_start="10"
                     /score="69.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVVGGGRGIGSAVVEELARRGARVVVADTDTLPSQYNHYQSTQ
                     VSGYADAQKLAARLTEEGLQVTAAQADATDEDQVSRLYADLAEQAGRLDVVVNAFGVTH
                     VCPVERMELAEFQRVVSGNLDGVFLSSKHAVPLLRDSGGGAIINFSSVSGRSGFAKVAH
                     YCAGKFGVVGFTAALAQEVARD"
     CDS_motif       6267..6344
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aniN_0001"
                     /evalue="1.20E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="aniN"
                     /protein_end="38"
                     /protein_start="12"
                     /score="21.2"
                     /tool="antismash"
                     /translation="LVVGGGRGIGSAVVEELARRGARVVV"
     CDS_motif       6699..6761
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_aniN_0002"
                     /evalue="4.00E-04"
                     /label="PKSI-KR_m4"
                     /locus_tag="aniN"
                     /protein_end="177"
                     /protein_start="156"
                     /score="12.9"
                     /tool="antismash"
                     /translation="INFSSVSGRSGFAKVAHYCAG"
     CDS             7055..7681
                     /codon_start=1
                     /note="orf1656; m"
                     /product="hypothetical protein"
                     /protein_id="ARE72414.1"
                     /transl_table=11
                     /translation="MTLGTTAPWPGVGVGDASDAGAGAGWQWRGRPRSWSRTGESLHIE
                     APGGADLYALPGSYQADSLPLLQRTVTGDFTARTRISVEGSAFGDAAGLALHGGDGWLK
                     VCVERTKAGGWAVVTVLSRPASDEAMGPALDGPAAELLVTREGRRHAVLFRQRPQEDWR
                     FVRTFHGFADPELRLGVFVQAPFSPSAAALFGPLHLSPVPLGDRR"
     gene            7678..8859
                     /gene="aniL"
     CDS             7678..8859
                     /codon_start=1
                     /gene="aniL"
                     /note="orf1655"
                     /product="MFS transporter"
                     /protein_id="ARE72415.1"
                     /transl_table=11
                     /translation="MTRRTPRPGRDPLIAAALALSLLLGVVTGALGAALPLLRSAYGLD
                     DGSGTELVVLYNLGALLAIVLCGIGPRRLLGRALPPALLLAFAGSSAGMALAPTWGLLC
                     GFALVAGAGYGGLILHLNSYFAHPSRPRPALLLNVLHACFGAGATVGPLLVGQWGGTSG
                     LLLVAGALSLLLFRAAAATGEPVDRPEGAAARRPSGPLLAVLALLALLYAGVEAGIGAL
                     ESTHLTSSGYAPADAARATALFWAGLTVGRLVLPVAARRLHHPRLIGLCLLAATGALAA
                     TLLGSLAPVAYGLAGLALAAVFPTALAWANALLPDPRRVNSALLVANLVGSTVLPYLIG
                     LAAAPGSRATIPLALAGLTLLCGLTIAVAARLARRPVPPAPRPAPHNELETSP"
     gene            8856..9851
                     /gene="aniK"
     CDS             8856..9851
                     /codon_start=1
                     /gene="aniK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 248.8; E-value:
                     1.4e-75)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf1654"
                     /product="O-methyltransferase"
                     /protein_id="ARE72416.1"
                     /transl_table=11
                     /translation="MTSPQPVTDLMWAHWKTKTMLSAVEVGVFTELAKEPLPGPVLRDR
                     LGLHPRPATDFFDALVALGLLVRSDDRYANAPEAAEYLDRHRPASYLGGSFLTQCAGLA
                     DDLTEVLRTGRAARQARDGRDFYRAMYAASDSVRAFQKDMTALSMGPARAIAEKFPWER
                     YRSLADIGCAEGALPGHVLARHPHLTAVGFDLPPARAGFAEYTERLGVADRVTFQEGDF
                     FHDPLPSADVLVFGHVLHNWGQEEKLRLLRAAHRALPDGGAVLVYETLIDDERRSNAIG
                     LILSLIMHAEVPGGFDYTGAECRAWLREAGFSQTYVEHLEGPESMVVGIK"
     CDS             9848..10723
                     /codon_start=1
                     /note="orf1653; j"
                     /product="putative phosphatase"
                     /protein_id="ARE72417.1"
                     /transl_table=11
                     /translation="MSHPEEPGRDAAGADDLVMFWNLYEAGVDRHYGRDERWHLQRDLV
                     REHRPRVLMTTEGWAWQFNDRAFFEDAKSALDMDGVLFPAKTGCNLAVFWQHDVDLVAV
                     EEVAPELAQWHGHGSATLRLPGRSAPVRFVVAHLDPFSATNRRIESDHLRQYADPEAPH
                     PTLLAMDANTVPPGDPEPDWSTAPRHRRADHTVPGEDQADRAPLRRLLGTAEEPLFVDA
                     GAHRGDRSPTFGFHPPGEAPRRIDLFLLTPSLAPDLIAYRALDDPRLHPQGERPAASDH
                     RPITLRLRRH"
     gene            10765..11433
                     /gene="aniI"
     CDS             10765..11433
                     /codon_start=1
                     /gene="aniI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mac"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 104.8;
                     E-value: 7.9e-32)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf1652"
                     /product="acetyltransferase"
                     /protein_id="ARE72418.1"
                     /sec_met_domain="Mac (E-value: 2.8e-12, bitscore: 36.6,
                     seeds: 568, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPTPPDTPPAPGLSTPPAARPGPTTATEPSTGAQDAALDRIKAR
                     LASGELYSAHDPDLLPYRQRCMELLDQVNSTALGDVRTRERLLGDLLGRIEPGGWVMPR
                     FLCEFGFFIELGPRTRVNFDVMMLDCAPITLGADVLVAPRCQLFTANHPFDPDLRRTMW
                     EYAKPIAVGDRVWLGGGVTVLPGVTIGADTVVGAGSVVTKDLPPKVLAVGNPARIVREL
                     "
     gene            11439..12206
                     /gene="h"
     CDS             11439..12206
                     /codon_start=1
                     /gene="h"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115:HAD-superfamily hydrolase, subfamily IA, variant
                     (Score: 163.1; E-value: 1.2e-49)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf1651"
                     /product="hypothetical protein"
                     /protein_id="ARE72419.1"
                     /transl_table=11
                     /translation="MTHSPTPSPEAPQPSARYAAEAVVFDHDGILVDTIRPDYLACSAL
                     FEEHGATLPARMWAQEVCGRPDGYPRLFDVLLDSAGAPAGSGPSHSADRGTTGPGGHAA
                     LQERLSQLWERFMTPEHVRLLPGVRELLTRLRAAGLPVAVASAADAEWVRRWLGHFGIE
                     EYVDTVVGGDEVPRRKPDPAVYLAAAARLGVPPARCVAFEDSLTGVAAARAAGITVTAV
                     PTGLTRSLDYSAADHVLPGLWAVDLSRPPWTAR"
     gene            12203..13936
                     /gene="aniG"
     CDS             12203..13936
                     /codon_start=1
                     /gene="aniG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     pyrrolidine: Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1257:Alpha-glucosidase (Score: 450.4; E-value:
                     1.6e-136)"
                     /gene_kind="biosynthetic"
                     /note="orf1650; orf1649"
                     /product="alpha-glucosidase"
                     /protein_id="ARE72420.1"
                     /sec_met_domain="Alpha-amylase (E-value: 1.8e-64, bitscore:
                     208.0, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPGTPPGAPTTTAQDALPTGSAPGAGWWRHAVIYQVYPRSFADG
                     NGDGTGDLAGVLDRLPYLAQLGVDALWFTPWYPSPMADGGYDVADYRGIHPDFGTLDEA
                     ERLIAAARELGLRTLVDVVPNHVSSAHPWFRAALAAPPGSPERALFHFRPGRGPGGQEP
                     PNNWTSEFGGPAWTRTATSDGTPGEWYLHLFTPEQPDLNWSHPEVRSEYEAVLRFWFDR
                     GAAGVRVDTAIALAKDPDLPDLTDTPRPHPYIDRDELHDLYRSWRALADSYPDPRVLVG
                     ELWLPDAPERFARYLRPAELHTAFNFDFLSSPWAAGPLRARIDATLTTHAGVGAPATWV
                     LCNHDVTRTVTRYGRADTSFDLAAKTHGIPTDLSLGTRRARAAALLTLALPGSVYLYQG
                     EELGLPEVEDLPADRLRDPIHFRSGGTDPGRDGCRVPLPWSGTAPPFGFAPDGTEPWLP
                     QPERWSDLTVAAQDGAADSMLELYRAALRLRRTGPAAPDAPMRWLPSGPDVLAFRRGDL
                     LCVVNFGERPVALPAEHALLLASGPVPDRGLPPDTAAWLRAPGPGEPGSTTAQMWPSRR
                     A"
     gene            complement(13909..14535)
                     /gene="aniF"
     CDS             complement(13909..14535)
                     /codon_start=1
                     /gene="aniF"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 86.8; E-value:
                     2e-26)"
                     /gene_kind="regulatory"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="ARE72421.1"
                     /transl_table=11
                     /translation="MKRISVTVHTSDPLTETGILSFLRDDPCLEVIGREETRAGGVAVV
                     LTGRLHELAATKLRRLSRSTDQAVVLIAERLREPEMMAVVECGVRVVVWRHQATAPRLV
                     EAIHTAARGESQIPPDLLGRVLAQTSRLYRHTMSDGDQPPTLGLTPREVDVIKLVAEGL
                     GTREIADRLAYSERTVKNVLHAMMTRMHLRNRAHAVAYALREGHI"
ORIGIN
        1 tcaggtgccg tgcgctccgc ccgctcgggg caggtccggc gggccggcac gaccgcctgc
       61 cgggtgggcg gggtggctgc ggccggggcc gtcgccgacg atcgggcaac cggatgagga
      121 ccgttcgggc aacgccggcg ggccgttcgg tcctgacggg agggcagggc gggtggccgg
      181 ccggtcgagg accgtaaggc catcgcccct gcgcagccgc gaccggcggc ggcacggggt
      241 ggccgcggac gccgggcggg gcgagcagga ctccgcggcc gggcgcggga cgggtcggtc
      301 ggcgggcagg cgggcgacga tcgggcagcg gcccctgccc cggggaaggg accgttcgga
      361 tctggtccgg gggcggacga atgcggtgga gtggcacccg tagccgcctc gcgaacaggg
      421 acgacatgca cagtcaggaa cggcaggagc acaaccggga ggtcctctcg gtgcccggtg
      481 acgcgccgcc gggcagcgcg gagtgggtgc gcggcgtgct ggcggcggcc tggggcgggc
      541 cctgggccgg actgccggtc cggcccctcg tgtccgacgg ggccgcgccg ctcagccaca
      601 ccgccgggct gtggcacgtc gacctgcccg gcaacggtca tgtgctgaag gtccagttga
      661 accccgacgc cgcgcgacag cgccgcttct acccgctcaa ggaacggatc gcggcacact
      721 gccggggcct gggagtcccc gttccggcgg ccgtgccggc ggcggacggc gccaccagcg
      781 tgtggtgcca gggcctggtg tgcgaactca gcccctgcct ggacggcgcc gccgtggcgt
      841 ggttcacccc cgccgaggca caggaggtgg tccgcaccgg gctggacctg cgcaccgccc
      901 tggaccggtt gccgccgggg tggtcggagg aactggcacc gatcccgctg ccccgactgg
      961 tcgacgagga gcactggccg acggcgctcc gggacgccga ggagcggctg ctgcccctgg
     1021 ccgaggaggg cgagggcgac tggcaccgcg cggcggcctc ggtgctgcgc gagacggtgg
     1081 cggccggaca cctcccacgg gaggccgacg tgcccgccgt cggggacccc gtgccccggc
     1141 ccgcggtcgt ccacagcgac ctgcaccacc accacttcgt gctcaccgac ggcggtcccg
     1201 gcggcgggcc gcgggtccag ggcgtcctcg acttcgacaa cgtgcacgtc ggcgaccggc
     1261 tcctggacct ggcctggctg gccgaggccg ccggacgcgt cgccgatccc gcggaacggc
     1321 gccggtcgct gaccgcgttc acccggaccg cgaccgaccg cgggctgctg cgaccgggcg
     1381 aggaacggct gttgatgccg ctgctcgtgg cccactcgct gccggtgatc gtcgacatcg
     1441 ccaaggacat cctggaacgg aacatcctca gccccgtctg gctcggctac ttcgacctgc
     1501 tgtcgccggc gcgccgcggg gagatccacc gcctgctgac cgctcccgcc ccgtcggcgc
     1561 ccgcccggtg aggacgccgg accggtaccc ggaccgccgc tgaccgggcc cccgcggcga
     1621 ctcggtaccg tcctccccca tctttctgac gcctcgtcac tcatcgcggt cgcctccgca
     1681 gagtgctccg ttgctcatcc cccgcacaga aagagatccc gcatgcccgc acaggagtcc
     1741 gcggcttcgc cgtggccgac cgacctgtcc gcctactgct tcgaggtccc ccactccgac
     1801 gactcgctgc tcttcagctc cgccaagggc gtccgcctga ccgacgcgac cgggcgcagc
     1861 ttcctggacg ccatgtcggg cgtgttcgtg tcctgcttcg ggtacgactg cgagcccatc
     1921 gcccaggccg tccaacagca gctgcacacc atgccgttca accccccgct gcacggcgcc
     1981 aaccaggccg cgctcgacct ggcccgggcc ctggtcgacc tggcccccga gggcatcacg
     2041 gccgccaagc tggtcaacgg cggctcggag agcatcgagg ccgccatccg gctcgcccgc
     2101 ctctaccacc gctcgcacgg ccggcccgac aaggtcaagg tgctcagcca ctaccacggc
     2161 taccacgggg ccaccttcgg ctcgctcacc ctgaccggcc ggcccgacgt cagccgcttc
     2221 ggcccggggc tgcccggcgt cgtccacgtc tggccgccgg actgcctgga ggagttctgg
     2281 ggcgtcgcac cggaccgctc cgccgcgctg gccgcggaga tgatcgagcg gaccatcgag
     2341 gccgagggcg ccgactcggt ggccgccctg gtcatcgaac cggtcatcca cctgcgcggg
     2401 atggccatcc cgtcggccga ctacttcgcc cggctccgcg acatctgcga ccggcacgac
     2461 atcctgctcg tgttcgacga gatcgtcacc ggcttcggcc gcaccggcca gcccttcgcc
     2521 gcgcagacct tcggcgtcac ccccgacctg atgtgcgtcg gcaagggcat ctccggcggc
     2581 tacgcgccgc tggccgcggt cctgatcggc gagcggatcg ccgccgtgct cggtgacgcc
     2641 gacggagcgc gcgccttcgc cccctcccac acctacgccg ccaaccccat ggcgtcggcg
     2701 gcgggcctgg ccgcggtgac cctgttccac gacggcgact acctcaccaa ggtgcgcgag
     2761 ttggcgcagt acatcgagcc ccggctgcgg caactggtcg cggggcgcgg cacgctgcgc
     2821 gccatcggcc tgctgtacgg cgccaagctc gccgatgccg acgacggcgg gcagggcccg
     2881 atcggcgagc gggtcgcccg cgcctgtctg cggcggggcc tgatcctgcg cggtcaggac
     2941 gactggttcg tgctggcccc ggcgttcgtg accacccgcg ccgaggcgga cgaggccctg
     3001 gggatcctcg gcgaggccct ggacgaggtc tgcggggcgg cccgatgagc gccctgcacg
     3061 ccctcgtgca gggcccggcc acggccgcgg cgccccgcct caccgagccg gagcgggccg
     3121 tggtccagcg cgaactcgac gagctcgccc ggggcggcta caccggcccg ctgctggaga
     3181 gcctgcgcaa gctggccgcc gccgtgcccg agcggctcta cgacgacagt gcgcgggtgc
     3241 tgttgcggat gcacgagatc gccgggtccg gcaactacca gagcaacctg tcgtcgctgc
     3301 cgctcgtacg ggcctgcttc gacctcggcc tggtgcccga agacgggccg ggaccggccg
     3361 aactcatcgt cgggcgcggg cacatcgcgc cggcgttcta cgccgagcac tacgtccgcg
     3421 gcaccttccc gttcgccccg ttggccaccc tccaccaggg cggtctgacc ggcgtcgtcc
     3481 accaggacct gggcttcacc aacaccatgc gctacagcct gggggtgggc gtggcccagg
     3541 ccgtcagcct cgcctgggag ctgacccgcc gcggcgagga ccgcaaggtg gtctgcctgg
     3601 ccggcgacgg cgagttgcag gagggcgtgg tcttcgagtg cctgcgcttc gcccacgaag
     3661 cggacctgaa gaacctcatc ctggtcgtcg acaccaacga caagggcatc gagccgctcc
     3721 tcaagccgct cagccgcggc tacctggcca gctacctgga ccgggtcgag gaggtcgacg
     3781 gcctggacac cgccaccgtc cgcgactccc tcggcgcgct gctggccgcg ccgacctccg
     3841 ccgcgctggt gtgccgcacc cgcaagggcg accacagctt caaacccgcc accaccgcgc
     3901 cggccaccgc accccgcccg gccaaggtct ccttcgccaa cacctccggc gcggcgctgg
     3961 ccgcctaccg ggagcgcacc ggacgcgaac tggccgtctt caccgccgac atggccgccc
     4021 gcttcgggct gcgcgacaag gtcccctaca ccaacaccgg gctcgcggag acgctgagcc
     4081 tgggcctgac cctgtccctg ccggaggaga ccgtcaaggt cgtcgcgacg gacgcgatgt
     4141 actacatgga ctccctgagc atgctcaccg aggccaccac cagcgtccgc aacctgctgg
     4201 tgctggccgg gcgcagctgg ggcgcctggg gcggcgccca caacgccacc aacctgctgg
     4261 ggcagttgct gcacacccgg gtctacgagc cggtcaccgc ggccgagttc gccgcctgcc
     4321 tggaccggct cgaccggcac ccggacacca cccacgtggt cagcaccgtc gacgccaagt
     4381 tcgacccgcc cccggcggac tgcgccggcg acgtggacgg ggggacctgg ctcaccccgc
     4441 ccggcgacgg accgccgcga gcggccgtgg tcaccttcgg ctacgccggg gtgctcgtcg
     4501 ccgaggccaa ccgcgacctg ggcgtgccgc acctgcactg cgcggccctg gagcccgacc
     4561 tggacgcccg cacgctcgcc caactcggcg cctgcgaaga cctgttgacc gtcgagtaca
     4621 acggcgtgca cggcggcttc ggcgagcggc tgcgcaccac gtacctgctg cccgcccggg
     4681 tgcacggcgt ccgccaggac atcgccaacc gcgtgcacga ccggcagttg cggttgcacg
     4741 gcatgggccc cgagcagctc gacgcgttgc tgcgcggcct caccggccgg cccgacgcca
     4801 ccgcgacgac ggccgacggc ttcgaggagg gcgcccgtgc gactgcacac gcatgactac
     4861 cgcgccccgg agaccgacgg catcgtcgac ggcgccatcc tgatgcaccg cgagatggcc
     4921 gagctgctga cccggcgtca gtcggtggcc tggcacgacc tgaccggcgg gcccgggtgc
     4981 gtcaccgcgg ccggacccgg cgacgtggtg tacgccggat cgggtccgta cgccttcctc
     5041 taccaccact ggcggcagcg caccggcggc cgcttccgga tcgtccgcga ggtgcacacc
     5101 gccctgtggt cgggctactg ggcgcaggag gagctgtgcg cgccgctggt gcgccccggt
     5161 gacctggtgc tcttccccac ggagtacacc cggcgcctgt tcgtccgcca cttccccgcc
     5221 gtcaccgagg agaactcggc ggtggcctac cccatgctgg accggctgcc ccgcaacggg
     5281 cccgtgcccg cgccggagcc gggagaggcg ctgcgcatcg gctacctcgg tgcgctgtcg
     5341 ctggccaaga acttcgacca ggtggtcgac gtcttcgccc gctgccaccg cgagagcggc
     5401 gggcgggcga gcctggtgtg cgcgggcaag cccaaccacc cccgctggga ggcggacgcc
     5461 gtccgcacgg ccctggccgg gcagggcgtc ccgcccggcg ccgtcgacct gctcggcgtc
     5521 ctcggacagc accggctcgc cgacttcttc gcccggatcg acgtgctgct cttccccagc
     5581 acggcctccc gggagaccct cggccgggtc gtgctggagg cactggccca cggcgtaccg
     5641 gtggtggccg ccgacgtcgg ccccgccgtg gaactgctgc ccgcccgcaa cctggtgccc
     5701 accgtcctcg acacgaccag cgagttcacc atgagccggg tcggtccgct gggccggatc
     5761 gacgaggacg tcctgacccg caagctcctg caccgcgact acgcaccggc cgccatccgc
     5821 agcgccgccc ccttccagga cgaagcgttc ctgcacgccc tggccggcgc accggacgcg
     5881 cacgccctgg agcacgacac cacgctgccc gaggcgctgc gcgtacccgc ccgcgccgac
     5941 ttcgacccgc aacgcgccgt ggcgcaggcc gagcggctgt tcaccgactt cttcgggcac
     6001 cgcgaccggg ccgtgcacga cgcgctggac gcccacgccg ccgagcacgg ctccgacggc
     6061 acggcccccg gtgagtgggc cgcactgcac gacctggtcg accggccggg ccgcaacctc
     6121 gccgactacc gggcgttccc ccggctcctg gacgccctgg tgctaccgcc gctgacctat
     6181 cgcctcgcgc cgcagccggt gcgcgcgaac gccggaaagg aatgaggaac atggacttcg
     6241 caacgggatt cgccgacaag gtggcgctgg tcgtgggggg tggccggggc atcggctcgg
     6301 ccgtggtcga ggagctcgcc cggcgcgggg cgcgcgtcgt ggtcgccgac accgacaccc
     6361 tgccctcgca gtacaaccac taccagtcca cgcaggtcag cggatacgcc gacgcccaga
     6421 agctcgccgc ccggctgacc gaggaggggc tccaggtcac cgcggcgcag gcggacgcca
     6481 ccgacgagga ccaggtcagt cggctgtacg cggacctcgc cgagcaggcc ggccgcctgg
     6541 acgtggtcgt caacgccttc ggcgtcaccc acgtctgccc ggtggagagg atggaactgg
     6601 ccgagttcca gcgcgtggtg tccggcaacc tcgacggcgt cttcctgtcg tcgaagcacg
     6661 ccgtgccgct gctgcgcgac tccggcggcg gtgccatcat caacttctcg tcggtgtcgg
     6721 gccgttcggg gttcgccaag gtcgcgcact actgcgccgg caagttcggg gtggtcggct
     6781 tcaccgcggc gctggcccag gaggtcgccc gcgacggcat ccgcgtcaac gccgtctgcc
     6841 ccggcatcgt ccgctccaac atgtggcgct acctgctctc ggagttcgtc cggcccggcg
     6901 agaccgagga cgagtgctgg gagcggatgc ggtcgatgat cccccagcgc gagttccaaa
     6961 cccccaagga cctcgcggag ctggtggtgt acctggccgg ggcgaccaag gtcaccggtc
     7021 aggcgatcag cgtcgacggc gggatgacgg ccccgtgacg ctcggcacca cagcaccgtg
     7081 gcccggcgtc ggagtcggcg acgcctccga cgccggggcc ggggccggct ggcagtggcg
     7141 gggccggccg cggtcctggt cgcgcaccgg ggagtccctg cacatcgagg ccccgggcgg
     7201 agcggacctg tacgccctgc ccggctcgta ccaggccgac tccctgccgt tgctgcaacg
     7261 gaccgtcacc ggcgacttca ccgcccggac ccggatcagc gtcgagggtt cggcgttcgg
     7321 ggacgcggcg ggcctggcgc tgcacggcgg cgacggctgg ctgaaggtgt gcgtggagcg
     7381 caccaaggcc ggtggctggg cggtggtcac cgtactgtcc cgcccggcgt ccgacgaggc
     7441 catgggcccc gcgttggacg gccccgccgc cgagctgctg gtgacccgcg agggccgtcg
     7501 gcacgcggtc ctcttccgcc aacggccgca ggaggactgg cggttcgtcc gcaccttcca
     7561 cggcttcgcg gacccggagc tgcggctcgg cgtgttcgtc caggcgccct tctcgccgtc
     7621 cgcggcggcc ctcttcgggc cgctgcacct gagccccgtg ccgctgggcg accgccggtg
     7681 acccggcgca ccccccggcc cgggcgcgac ccgctgatcg cggcggcgct ggcgctctcc
     7741 ctgctcctcg gtgtggtcac cggcgcgctg ggggcggcgc tgccgctgct gcggtcggcc
     7801 tacgggctgg acgacggcag cggcacggaa ctggtcgtgc tctacaacct cggcgcgctg
     7861 ctcgccatcg tcctctgcgg gatcggcccc cgccgcctgc tgggccgggc gctgccgccc
     7921 gccctgctgc tggcgttcgc gggcagcagc gcgggcatgg ccctggcgcc gacctggggc
     7981 ctgctgtgcg gcttcgccct ggtcgccggt gccggctacg gcgggctgat cctgcacctg
     8041 aacagctact tcgcccaccc ctcccggccc cggccggcgt tgctgctcaa cgtgctgcac
     8101 gcctgcttcg gcgcgggggc cacggtgggc ccgctgctgg tgggccagtg gggcgggacg
     8161 tccggactgc tgctggtcgc cggcgcactg tccctactgc tgttccgggc cgcggcggcc
     8221 accggggagc ccgtcgaccg tcccgagggg gccgccgccc ggcgcccgtc gggcccgctg
     8281 ctcgccgtcc tcgccctcct ggcgctgctg tacgcgggcg tcgaggccgg gatcggcgcg
     8341 ctggagtcga cccacctgac ctcctccgga tacgcaccgg ccgacgcggc gcgggccacg
     8401 gcactgttct gggccgggct caccgtcggc cggctggtcc tgccggtggc ggcgcgccgg
     8461 ctccaccacc cccggctgat cggcctgtgc ctgctcgccg ccaccggggc gctggccgcc
     8521 accctgctcg gctccctggc gccggtggcg tacggactgg ccgggctggc cctggccgcg
     8581 gtcttcccca ccgcgctggc ctgggcgaac gccctgctgc ccgatccccg tcgggtcaac
     8641 tccgcactgc tggtggccaa cctcgtcggc agcaccgtcc tgccctacct catcggcctg
     8701 gcggcggccc ccggcagccg ggccacgatc cccctcgcgc tcgccggtct gacgctgctg
     8761 tgcggtctga ccatcgccgt cgccgcccgc ctggcccgca ggcccgtgcc cccggcaccg
     8821 cgaccggcgc cccacaacga actggagacc tccccatgac ctcaccgcag cccgtcaccg
     8881 acctgatgtg ggcccactgg aagaccaaga cgatgctcag cgccgtcgag gtcggggtct
     8941 tcaccgaact ggccaaggag ccgctgcccg gccccgtgct ccgcgaccgg ctgggcctgc
     9001 acccgcggcc cgccaccgac ttcttcgacg ccctggtcgc cctcgggctg ctggtgcgct
     9061 ccgacgaccg gtacgccaac gcacccgagg cggcggagta cttggaccgc caccggccgg
     9121 cgagctacct cggcggcagc ttcctcaccc agtgcgccgg cctggccgac gacctcaccg
     9181 aggtgctgcg caccggccgg gccgcccgcc aggcccggga cggccgggac ttctaccggg
     9241 ccatgtacgc cgcgtcggac tcggtgcgcg ccttccagaa ggacatgacc gcgctcagca
     9301 tgggcccggc acgggccatc gcggagaagt tcccctggga gcgctaccgt tcgctggccg
     9361 acatcgggtg cgccgagggc gcgttgcccg gccacgtcct ggcccgtcac ccccacctga
     9421 ccgccgtcgg cttcgacctg cccccggcgc gggcgggctt cgcggagtac accgaacgcc
     9481 tcggggtcgc cgaccgcgtc accttccagg agggcgactt cttccacgac ccgctcccct
     9541 ccgccgacgt gctggtcttc ggccacgtcc tgcacaactg ggggcaggag gagaagctgc
     9601 ggctgctgcg cgccgcccac cgggcgctgc cggacggcgg ggcggtactg gtctacgaga
     9661 cgctcatcga cgacgagcgg cgcagcaacg ccatcgggct gatcctcagc ctcatcatgc
     9721 acgccgaggt ccccggcggc ttcgactaca ccggcgccga gtgccgggcg tggctgcgcg
     9781 aggcgggctt ctcccagacg tacgtcgagc acctggaagg ccccgagtcc atggtcgtgg
     9841 gcatcaaatg agccaccccg aagagccggg ccgggacgcg gccggcgccg acgacctggt
     9901 gatgttctgg aacctctacg aagcgggcgt cgaccgccac tacggccgcg acgaacgctg
     9961 gcacctgcaa cgggacctgg tgcgggagca ccgcccccgg gtgctgatga ccaccgaggg
    10021 gtgggcctgg cagttcaacg accgcgcctt cttcgaggac gccaagtccg ccctcgacat
    10081 ggacggcgtg ctcttccccg ccaagaccgg ctgcaacctg gccgtgttct ggcagcacga
    10141 cgtggacctg gtcgcggtgg aggaggtcgc gccggaactc gcccagtggc acggccacgg
    10201 cagcgccacc ttgcggctgc ccggccggtc ggcgcccgtg cggttcgtcg tggcccacct
    10261 cgacccgttc agcgcgacga accggcgcat cgaatccgac cacctgcgcc agtacgccga
    10321 ccccgaggcg ccccacccca cgctgctggc catggacgcc aacacggtgc cgccggggga
    10381 ccccgagccg gactggtcca ccgcgccccg ccaccggcgc gccgaccaca cggtgcccgg
    10441 cgaggaccag gcggaccggg ccccgctgcg gcgcctgctc ggcaccgcgg aggaaccgct
    10501 gttcgtcgac gcgggcgccc accgcggcga ccggtccccg acgttcggct tccacccgcc
    10561 gggcgaggcg ccccggcgca tcgacctgtt cctgctgacc ccctccctcg ccccggacct
    10621 gatcgcgtac cgggccctgg acgacccccg gctgcacccg cagggcgagc ggccggcggc
    10681 ctccgaccac cggccgatca ccctccggct gcgccgtcac tgagcggccc ggacgcccgc
    10741 ccgcagaaag gcaccccgca cccgatgaaa ccgacgcccc ccgacacccc gcccgccccc
    10801 ggcctctcca cgccaccggc ggcgcgcccc gggccgacca cggccaccga gccgtccacc
    10861 ggtgcccagg acgccgcact ggaccggatc aaggcccggc tcgccagcgg tgagctgtac
    10921 tcggcccacg accccgacct gctcccctac cgccagcgct gcatggagtt gctggaccag
    10981 gtcaacagca ccgcgctcgg cgacgtccgc acccgcgagc ggctcctggg cgacctgctg
    11041 ggccgcatcg aaccgggcgg ctgggtgatg ccccgcttcc tgtgcgagtt cgggttcttc
    11101 atcgagctcg gccccaggac gagggtcaac ttcgacgtga tgatgctgga ctgcgccccc
    11161 atcaccctcg gcgcggacgt cctggtcgcc ccccgctgcc agctcttcac cgccaaccac
    11221 cccttcgacc ccgacctgcg ccgcaccatg tgggagtacg ccaagcccat cgccgtgggg
    11281 gaccgggtct ggctcggcgg cggcgtgacc gtcctgccgg gcgtgacgat cggcgcggac
    11341 accgtggtgg gcgccggcag cgtcgtcacc aaggacctcc cgccgaaggt gctcgccgtc
    11401 ggcaaccccg cccgcatcgt ccgggagctg tgaccgccgt gacccactcc cccacgccct
    11461 cccccgaggc tccgcagccg tccgcgcggt acgcggccga ggcggtcgtc ttcgaccacg
    11521 acggcatcct ggtcgacacg atccggcccg actacctggc ctgctcggcc ctgttcgagg
    11581 agcacggcgc gaccctgccc gcacggatgt gggcgcagga ggtgtgcggg cggccggacg
    11641 gctacccgcg cctgttcgac gtcctgctgg actccgccgg cgcaccggcc ggatcgggcc
    11701 cgtcgcactc cgcggaccgc ggcacgaccg gtccgggcgg ccacgcggcg ctccaggagc
    11761 gcctgtcgca gctgtgggag cgcttcatga ccccggagca cgtccgcctc ctgccgggcg
    11821 tgcgggagtt gctgacgcgg ctgcgcgccg ccgggctgcc ggtggccgtc gcctcggccg
    11881 ccgacgccga gtgggtgcgg cgctggctgg gccacttcgg catcgaggag tacgtagaca
    11941 ccgtggtggg cggcgacgag gtgccgcgcc gcaagcccga tcccgccgtc tacttggcgg
    12001 ccgcggcccg gctcggcgta ccgccggcgc gctgcgtcgc cttcgaggac tcgctgaccg
    12061 gggtcgccgc cgcgcgggcc gccgggatca ccgtgaccgc cgtccccacc gggctgaccc
    12121 gttccctgga ctactccgcg gccgaccacg tgctgcccgg cctgtgggcc gtggacctga
    12181 gccgcccgcc gtggaccgcc cgatgagccc cgggaccccg cccggggcgc cgaccaccac
    12241 ggcgcaggac gccctcccga cggggtccgc ccccggggcc ggctggtggc gccacgcggt
    12301 catctaccag gtgtacccgc gcagcttcgc cgacgggaac ggcgacggca ccggcgacct
    12361 cgccggcgtc ctggaccgcc tgccgtacct ggcccaactg ggcgtcgacg cactgtggtt
    12421 cacgccctgg tacccctccc cgatggccga cggcggctac gacgtggcgg actaccgcgg
    12481 catccacccc gacttcggga ccctcgacga ggccgagcgg ctcatcgccg cggcgcgcga
    12541 gttggggttg cgcaccctcg tcgacgtcgt gcccaaccac gtctccagcg cccacccgtg
    12601 gttccgcgcg gcgctcgccg cgccccccgg cagccccgag cgcgccctgt tccacttccg
    12661 cccgggccgc ggcccgggcg gccaggagcc gcccaacaac tggacctccg agttcggcgg
    12721 ccccgcctgg acccgcaccg ccacctccga cggcaccccc ggcgagtggt acctgcacct
    12781 gttcaccccg gagcagcccg acctcaactg gagccacccc gaggtcaggt cggagtacga
    12841 ggccgtgctg cgcttctggt tcgaccgggg cgccgccggc gtgcgcgtcg acaccgcgat
    12901 cgccctggcc aaggacccgg acctgcccga cctgacggac accccccggc cgcaccccta
    12961 catcgaccgc gacgagctcc acgacctgta ccgctcgtgg cgcgccctcg ccgactccta
    13021 ccccgacccc cgcgtcctgg tcggcgagct ctggctgccc gacgcccccg agcggttcgc
    13081 ccgctacctg cgccccgcag aactccacac cgccttcaac ttcgacttcc tgagcagccc
    13141 gtgggccgcc ggaccgctgc gcgcccgcat cgacgccacc ctcaccaccc acgcgggcgt
    13201 cggcgccccc gcgacctggg tgctgtgcaa ccacgacgtg acgcgcaccg tcacccgcta
    13261 cggccgcgcc gacacctcgt tcgacctcgc cgccaagacc cacggcatcc ccaccgacct
    13321 gtccctgggg acccgccgcg cccgggccgc cgccctgctc acgctggccc tgcccggctc
    13381 cgtctacctc taccagggcg aggaactggg cctgccggag gtcgaggacc tccccgcgga
    13441 ccggctgcgc gacccgatcc acttccgctc cggcggcacc gacccggggc gcgacggctg
    13501 ccgggtcccg ctcccctggt ccggcaccgc cccgccgttc ggcttcgccc cggacggcac
    13561 cgagccctgg ctgccgcagc ccgagcggtg gagcgacctg acggtggcgg cccaggacgg
    13621 tgccgcggat tcgatgctgg agctgtaccg cgccgccctg cggctgcgcc gcacgggccc
    13681 ggccgcgccg gacgccccga tgcggtggct gcccagcggg cccgacgtcc tcgccttccg
    13741 gcgcggcgac ctgctgtgcg tggtcaactt cggggagcgg ccggtcgccc tgcccgcgga
    13801 gcacgccctg ctcctcgcca gcggtcccgt tcccgaccgc ggcctgccgc ccgacaccgc
    13861 cgcctggctg cgcgcccccg gccccggcga accgggatcg acgaccgctc agatgtggcc
    13921 ctcccggagg gcgtaggcga ccgcgtgggc ccggttgcgc aggtgcatgc gggtcatcat
    13981 cgcgtgcagg acgttcttga ccgtccgttc cgaataggcc agccggtccg cgatctcacg
    14041 ggtgcccagc ccctccgcga cgagcttgat gacgtccacc tcccggggcg tgagccccag
    14101 cgtcggtggc tggtcgccgt cgctcatcgt gtgccggtac aggcggctgg tctgcgccag
    14161 cacgcggccc agcaggtccg gcgggatctg gctctcgccg cgcgcggcgg tgtggatcgc
    14221 ctccaccagc cggggggcgg tggcctggtg acgccagacg accacccgta ccccgcactc
    14281 gacgacggcc atcatctccg gctcccgcag tcgttcggcg atgagcacga cggcttggtc
    14341 ggtactgcgc gacaaccggc gcagtttggt cgccgccaac tcgtgcagac ggccggtgag
    14401 gacgacggcg acgccaccgg cccgggtctc ctcgcggccg atgacttcga ggcagggatc
    14461 gtcgcgtagg aaactgagaa ttccggtttc ggtcagcgga tcggacgtgt ggacggttac
    14521 ggatatgcgc ttcac
//
