BGC0001511: ansamitocin P-3 biosynthetic gene cluster from Actinosynnema pretiosum subsp. pretiosum
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 82,944 nt. (total: 82,944 nt).
This entry is originally from NCBI GenBank KY489977.1.

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0001511
Short description | ansamitocin P-3 biosynthetic gene cluster from Actinosynnema pretiosum subsp. pretiosum
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- PKS (Unknown)

Loci
KY489977.1
via
Compounds

- ansamitocin P-3

Species Actinosynnema pretiosum subsp. pretiosum [taxonomy]
References

- [1] Identification and Engineering of Post-PKS Modification Bottlenecks for Ansamitocin P-3 Titer Improvement in Actinosynnema pretiosum subsp. pretiosum ATCC 31280. Ning X et al., Biotechnol J (2017) PMID:28881098

Chemical products information
ansamitocin P-3 Evidence:
Copy SMILES
C32H43Cl1N2O9
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
AQZ37086.1 | 2239 - 3120 (-) | oxidoreductase |  |  | copy AA seq copy Nt seq
AQZ37087.1 | 3191 - 3787 (+) | TetR-family transcriptional regulator |  |  | copy AA seq copy Nt seq
AQZ37088.1 | 4039 - 4305 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AQZ37089.1 | 4349 - 6601 (+) | ABC transporter transmembrane region protein |  |  | copy AA seq copy Nt seq
AQZ37090.1 | 6610 - 7860 (+) | Na+/H+ antiporter |  |  | copy AA seq copy Nt seq
AQZ37091.1 | 7959 - 8609 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AQZ37092.1 | 8779 - 9825 (-) | O-methyltransferase family 2 |  |  | copy AA seq copy Nt seq
AQZ37093.1 | 10015 - 13191 (+) | LuxR-family transcriptional regulator |  |  | copy AA seq copy Nt seq
AQZ37094.1 | 13402 - 18195 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AQZ37095.1 | 18205 - 28224 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AQZ37096.1 | 28226 - 29005 (+) | N-acetyltransferase |  |  | copy AA seq copy Nt seq
AQZ37097.1 | 29096 - 29992 (-) | N-methyltransferase |  |  | copy AA seq copy Nt seq
AQZ37098.1 | 29989 - 31524 (-) | epoxidase |  |  | copy AA seq copy Nt seq
AQZ37099.1 | 31536 - 32861 (-) | halogenase |  |  | copy AA seq copy Nt seq
AQZ37100.1 | 33118 - 34113 (+) | 3-hydroxybutyryl-CoA dehydrogenase |  |  | copy AA seq copy Nt seq
AQZ37101.1 | 34110 - 34382 (+) | acyl carrier protein |  |  | copy AA seq copy Nt seq
AQZ37102.1 | 34387 - 35490 (+) | butyryl-CoA dehydrogenase |  |  | copy AA seq copy Nt seq
AQZ37103.1 | 35601 - 36866 (+) | FkbH |  |  | copy AA seq copy Nt seq
AQZ37104.1 | 36859 - 37521 (+) | O-methyltransferase |  |  | copy AA seq copy Nt seq
AQZ37105.1 | 37699 - 40458 (+) | transcriptional activator |  |  | copy AA seq copy Nt seq
AQZ37106.1 | 40550 - 41620 (+) | acyltransferase MdmB |  |  | copy AA seq copy Nt seq
AQZ37107.1 | 41635 - 41982 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AQZ37108.1 | 42212 - 44224 (+) | carbamoyltransferase |  |  | copy AA seq copy Nt seq
AQZ37109.1 | 44620 - 44985 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AQZ37110.1 | 45362 - 45547 (+) | mobile element protein |  |  | copy AA seq copy Nt seq
AQZ37111.1 | 45953 - 46396 (-) | 3-dehydroquinate dehydratase II |  |  | copy AA seq copy Nt seq
AQZ37112.1 | 46608 - 47774 (+) | lipopolysaccharide biosynthesis protein RffA |  |  | copy AA seq copy Nt seq
AQZ37113.1 | 47963 - 61690 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AQZ37114.1 | 61687 - 71115 (+) | polyketide synthase |  |  | copy AA seq copy Nt seq
AQZ37115.1 | 71192 - 72400 (+) | glycosyltransferase |  |  | copy AA seq copy Nt seq
AQZ37116.1 | 72668 - 73693 (+) | 3-oxoacyl-[acyl-carrier protein] reductase |  |  | copy AA seq copy Nt seq
AQZ37117.1 | 73773 - 74237 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AQZ37118.1 | 74419 - 75039 (-) | transcriptional regulator TetR family |  |  | copy AA seq copy Nt seq
AQZ37119.1 | 75064 - 75657 (+) | cytochrome P450 |  |  | copy AA seq copy Nt seq
AQZ37120.1 | 76848 - 76976 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AQZ37121.1 | 77013 - 78002 (-) | RNA polymerase sigma factor |  |  | copy AA seq copy Nt seq
AQZ37122.1 | 78227 - 78859 (-) | putative methyltransferase |  |  | copy AA seq copy Nt seq
AQZ37123.1 | 78974 - 79447 (+) | Na+/H+ antiporter NhaA type |  |  | copy AA seq copy Nt seq
AQZ37124.1 | 79447 - 79743 (+) | Na+/H+ antiporter |  |  | copy AA seq copy Nt seq
AQZ37125.1 | 79728 - 80303 (-) | dihydrofolate reductase |  |  | copy AA seq copy Nt seq
AQZ37126.1 | 80390 - 81004 (+) | transcriptional regulator TetR family |  |  | copy AA seq copy Nt seq
AQZ37127.1 | 81256 - 82941 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Updated bioactivity data

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2018-08-06
Submitted

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains